| Staff Details | ||||
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| Personal Information | ||
| Name | Mitchell, Kevin | |
| Main Department | Genetics | |
| College Title | Assoc Prof in Developmental Neurobiolo | |
| kevin.mitchell@tcd.ie | ||
| College Tel | +353 1 896 3067 | |
| Web | http://www.gen.tcd.ie/mitchell | |
| Awards and Honours | |
| Award | Date |
| Summer Scholarship from the American Ireland Fund | 1990 |
| National Science Foundation Predoctoral Fellowship | 1992 - 1995 |
| Howard Hughes Medical Institute Postdoctoral Fellowship | 1998 |
| Jane Coffin Childs Fund for Medical Research Postdoctoral Fellowship | 1998 - 2001 |
| Wellcome Trust grant to fund the international conference ‘Life and Death of the Brain’ held in Trinity College Dublin, Ireland. | 1999 |
| More Awards and Honours>>> | |
| Description of Research Interests |
| Dr. Mitchell and colleagues are currently trying to identify guidance signals and receptors using a gene-trapping method in mice to screen for novel transmembrane proteins involved in axon guidance in the developing brain. Genes encoding these proteins are identified by bioinformatics and targeted with a vector that simultaneously mutates the gene and incorporates reporter genes to visualise the axonal projections of cells that normally express it in the brain. Any wiring defects resulting from mutation of these genes are therefore readily apparent in the mutant animals. They are also investigating the mechanism of action of a number of such signals and receptors in more detail to understand at a cellular level how they exert their effects on nerve growth and guidance. A current focus is on the role of transmembrane semaphorins, especially in the development of appropriate connections between thalamus and cortex. |
| Research Projects | |
| Project title | Science Foundation Ireland Investigator Grant |
| Summary | “Molecular genetic analyses of thalamocortical connectivity” €802,000 |
| Funding Agency | SFI |
| Programme | |
| Type of Project | |
| Date from | 2010 |
| Date to | 2015 |
| Person Months | |
| Project title | Science Foundation Ireland Investigator Grant |
| Summary | “Cortical connectivity, from genes to behaviour” €250,000 |
| Funding Agency | SFI |
| Programme | |
| Type of Project | |
| Date from | 2008 |
| Date to | 2009 |
| Person Months | |
| Project title | Health Research Board Project Grant |
| Summary | “Semaphorin and plexin genes in the etiology of epilepsy”. €298,000 |
| Funding Agency | HRB programme |
| Programme | |
| Type of Project | |
| Date from | 2007 |
| Date to | 2010 |
| Person Months | |
| Project title | Science Foundation Ireland Research Frontiers Grant |
| Summary | “Chemical genetic dissection of transmembrane semaphorin signaling in the CNS”. Collaboration With Dr. Isabella Graef, Stanford University. €192,837 |
| Funding Agency | SFI |
| Programme | |
| Type of Project | |
| Date from | 2007 |
| Date to | 2010 |
| Person Months | |
| Project title | Wellcome Trust Project Grant |
| Summary | “A comparative functional genomic screen for novel axon guidance molecules in fly and mouse”. With Dr. Guy Tear, King’s College London. Total: €594,027. To Trinity College Dublin: €334,516 |
| Funding Agency | Weelcome Trust |
| Programme | |
| Type of Project | |
| Date from | 2005 |
| Date to | 2008 |
| Person Months | |
| More Research Projects>>> | |
| Publications |
| Peer Reviewed |
| Mitchell K.J. and Porteous, D.J., Rethinking the genetic architecture of schizophrenia, Psychological Medicine , 41, (1), 2011, p19-32 Url TARA - Full Text DOI |
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| Tawarayama H, Yoshida Y, Suto F, Mitchell KJ, Fujisawa H., Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers., Journal of Neuroscience, 30, (20), 2010, p7049-7060 Notes: [PMID: 20484647] Url TARA - Full Text DOI |
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| Mitchell K., Journal club. A neurodevelopmental geneticist explores how one mutation can lead to multiple diseases., Nature, 464, (7792), 2010, p1107 Notes: [PMID: 20414273] DOI |
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| Mitchell KJ, Porteous DJ. , GWAS for psychiatric disease: is the framework built on a solid foundation? , Molecular Psychiatry, 14, (8), 2009, p740-741 DOI |
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| Mitchell, K.J.*, Pinson, K.I.*, Kelly, O.G., Brennan, J., Zupicich, J., Scherz, P., Leighton, P.A., Goodrich, L.V., Lu, X., Avery, B.J., Tate, P., Dill, K., Pangilinan, E., Wakenight, P., Tessier-Lavigne, M., and Skarnes, W.C. , Functional analysis of secreted and transmembrane proteins critical to mouse development, Nature Genetics , 28, (3), 2001, p241 - 249 Notes: [PMID: 11431694] DOI |
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| More Publications>>> | |
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