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Personal Information
College Photo Name Mitchell, Kevin
Main Department Genetics
College Title Assoc Prof in Developmental Neurobiolo
E-mail kevin.mitchell@tcd.ie
College Tel +353 1 896 3067
Web http://www.gen.tcd.ie/mitchell
 
Awards and Honours
Award Date
Summer Scholarship from the American Ireland Fund 1990
National Science Foundation Predoctoral Fellowship 1992 - 1995
Howard Hughes Medical Institute Postdoctoral Fellowship 1998
Jane Coffin Childs Fund for Medical Research Postdoctoral Fellowship 1998 - 2001
Wellcome Trust grant to fund the international conference ‘Life and Death of the Brain’ held in Trinity College Dublin, Ireland. 1999
More Awards and Honours>>>
 
Description of Research Interests
Dr. Mitchell and colleagues are currently trying to identify guidance signals and receptors using a gene-trapping method in mice to screen for novel transmembrane proteins involved in axon guidance in the developing brain. Genes encoding these proteins are identified by bioinformatics and targeted with a vector that simultaneously mutates the gene and incorporates reporter genes to visualise the axonal projections of cells that normally express it in the brain. Any wiring defects resulting from mutation of these genes are therefore readily apparent in the mutant animals. They are also investigating the mechanism of action of a number of such signals and receptors in more detail to understand at a cellular level how they exert their effects on nerve growth and guidance. A current focus is on the role of transmembrane semaphorins, especially in the development of appropriate connections between thalamus and cortex.
 
Research Projects
Project title Science Foundation Ireland Investigator Grant
Summary “Molecular genetic analyses of thalamocortical connectivity” €802,000
Funding Agency SFI
Programme
Type of Project
Date from 2010
Date to 2015
Person Months


Project title Science Foundation Ireland Investigator Grant
Summary “Cortical connectivity, from genes to behaviour” €250,000
Funding Agency SFI
Programme
Type of Project
Date from 2008
Date to 2009
Person Months


Project title Health Research Board Project Grant
Summary “Semaphorin and plexin genes in the etiology of epilepsy”. €298,000
Funding Agency HRB programme
Programme
Type of Project
Date from 2007
Date to 2010
Person Months


Project title Science Foundation Ireland Research Frontiers Grant
Summary “Chemical genetic dissection of transmembrane semaphorin signaling in the CNS”. Collaboration With Dr. Isabella Graef, Stanford University. €192,837
Funding Agency SFI
Programme
Type of Project
Date from 2007
Date to 2010
Person Months


Project title Wellcome Trust Project Grant
Summary “A comparative functional genomic screen for novel axon guidance molecules in fly and mouse”. With Dr. Guy Tear, King’s College London. Total: €594,027. To Trinity College Dublin: €334,516
Funding Agency Weelcome Trust
Programme
Type of Project
Date from 2005
Date to 2008
Person Months


More Research Projects>>>
 
Publications and Other Research Outputs
Peer Reviewed
Mitchell K.J. and Porteous, D.J., Rethinking the genetic architecture of schizophrenia, Psychological Medicine , 41, (1), 2011, p19-32
TARA - Full Text
Tawarayama H, Yoshida Y, Suto F, Mitchell KJ, Fujisawa H., Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers., Journal of Neuroscience, 30, (20), 2010, p7049-7060
Notes: [PMID: 20484647]
TARA - Full Text
Mitchell K., Journal club. A neurodevelopmental geneticist explores how one mutation can lead to multiple diseases., Nature, 464, (7792), 2010, p1107
Notes: [PMID: 20414273]
DOI
Mitchell KJ, Porteous DJ. , GWAS for psychiatric disease: is the framework built on a solid foundation? , Molecular Psychiatry, 14, (8), 2009, p740-741
DOI
More Publications and Other Research Outputs >>>
 

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Last Updated:02-SEP-2014