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Personal Information
Name Kelly, Vincent Patrick
Main Department Biochemistry
College Title Asst Prof/Academic Co-Ordinator
College Tel +353 1 896 3507
In November 2005, I joined the staff of the School of Biochemistry & Immunology having secured an SFI principle investigator award to study the role of a transfer RNA modification in tyrosine biosynthesis. The scope and direction of the work has diversified since to include studies on cancer and immunology using cell based and transgenic models. I performed my postdoctoral studies in the laboratory of Prof. Masayuki Yamamoto, Tsukuba, Japan where I gained expertise in mouse transgenics. My interest in transfer RNA arose from my time in Banyu Pharmaceuticals (a subsidiary of Merck) in Japan where I worked with Dr. Susumu Nishimura, generating a knockout mouse for the seleocysteine tRNA gene. My PhD was performed in the laboratory of Prof. John Hayes, at the University of Dundee, Scotland. My project focused on characterizing the AFAR1 enzyme (an Aldo-Keto Reductase family member) and research on a novel related enzyme called AFAR2, which I discovered can produce the hypnotic gamma-hydroxybutyrate, a chemical that is vital for sleep and hibernation.
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Biochemical Society Sept 2000 Present date
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Japanese Basic Basic Medium
Description of Research Interests
Our laboratory researches on RNA. In particular we are interested in modified nucleotides and their impact on basic metabolism. The research techniques that the laboratory use are varied and include cell culture, the generation of transgenic animals, HPLC and protein purification.
Research Interests
Animal Biotechnology Animal Reproduction Embryology Immunology, Immunotherapy
Research Projects
Project title Q-base; an essential nutrient for tyrosine biosynthesis.Implications for the disease phenylketonuria and transfer RNA biology.
Summary Ireland has the highest incidence in the world of the metabolic disease phenylketonuria (PKU). Individuals with PKU have abnormally high levels of phenylalanine in their blood because their bodies cannot break down phenylalanine to tyrosine. Babies in particular are at risk of developing severe mental retardation, hence why this disease is routinely screened for in new-born infants. We are studying a molecule found in everyday food called queuine. Animals with no queuine are unable to convert phenylalanine to tyrosine in the same way as individuals with PKU. Understanding why this is true will open up a whole new understanding of the PKU disease and could provide novel drug targets. It is even possible that administering the queuine molecule itself to PKU sufferers could be of therapeutic potential.
Funding Agency Science Foundation Ireland
Type of Project Basic Research
Date from November 2005
Date to November 2009
Person Months 168

Publications and Other Research Outputs
Peer Reviewed
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+
Enhancing the Teaching and Learning of Labortatory Sciences through a Virtual Learning Environment. in, editor(s)Marcus-Quinn A, Bruen C, Allen M, Dundon A, Diggins Y , The Digital Learning Revolution in Ireland : Case Studies from the National Learning Resources Service. , Cambridge, UK, Cambridge Scholars Publishing,, 2012, pp181 - 194, [Robinson GA, Nic A' Bháird N, Kelly VP]
Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M., Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia., Blood, 20, (1), 2011, p986 - 996
Rakovich A, Rakovich T, Kelly VP, Lesnyak V, Eychmüller A, Rakovich YP, Donegan JF, Photosensitizer methylene blue-semiconductor nanocrystals hybrid system for photodynamic therapy., Journal of nanoscience and nanotechnology, 10, (4), 2010, p2656-2662
Boland C, Hayes PA, Santa-Maria I, Nishimura S and Kelly VP, Queuosine formation in eukaryotic tRNA occurs via a mitochondrial localized heteromeric transglycoslase. , Journal of Biological Chemistry, 284, (27), 2009, p18218-18227
Notes: [ PMID: 19414587]
TARA - Full Text  DOI
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Last Updated:24-SEP-2014