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Dr. Steven Gray

Clinical Senior Lecturer (Clinical Medicine)
Clinical Senior Lecturer (Molecular Medicine Ireland)
      
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Dr. Steven Gray

Clinical Senior Lecturer (Clinical Medicine)

 

Clinical Senior Lecturer (Molecular Medicine Ireland)


Steven Gray graduated from Trinity College Dublin in 1992. He joined the laboratory of Tomas J. Ekstrom at the Karolinska Institute in 1996 and received his PhD in 2000 (Thesis Title: The IGF-axis in liver disease: Modulation of expression by histone deacetylase inhibitors). He moved to the Van Andel Research Institute in Michigan, USA where he continued his studies on the therapeutic potential of histone deacetylase inhibitors in the treatment of cancer. He also spent some time as a visting fellow at Harvard Medical School, Boston working on epigenetic therapies for neurodegenerative disease. Returning to Europe Dr Gray spent some time at the German Cancer Research Centre (DKFZ - Heidelberg), and subsequently moved to Copenhagen to work for Novo Nordisk as part of the research team of Prof Pierre De Meyts at the Hagedorn Research Institute working on epigenetic mechanisms underpinning diabetes pathogenesis. Dr Gray is currently a senior clinical scientist at St James's Hospital in the Deprtment of Clinical Oncology at the Thoraacic Oncology Research Group at St. James's Hospital headed by Dr. Sinead Cuffe and Professor Stephen Finn, and holds an adjunct assistant professorship with the Dept of Clinical Medicine (TCD).
  CANCER   CANCER BIOPSIES   CANCER CELL-LINE   CANCER CELLS   CANCER CHEMOTHERAPY   CANCER CLASSIFICATION   CANCER DEVELOPMENT   CANCER INVASION   CANCER SUSCEPTIBILITY GENE   CANCER-CELLS   CANCERS   CARCINOMA   CARCINOMA CELL-LINES   CARCINOMA, RENAL CELL   CARCINOMA-CELLS   CARCINOMAS   CELL   Cellular Biology   CHROMATIN   Cloning of Cells   Cytogenetics   DNA MARKERS   DNA METHYLATION   EPIDERMAL GROWTH FACTOR RECEPTOR   Epigenetics   GENE EXPRESSION   GENE EXPRESSION ANALYSIS   GENE-EXPRESSION   Genetics   GENOME   Genomes, Genomics   GENOMICS   GROWTH FACTOR RECEPTOR   Histology   Histology, Cytochemistry, Histochemistry   HISTONE   HISTONE DEACETYLASE COMPLEX   INSULIN   INSULIN RESISTANCE   INSULIN-LIKE GROWTH FACTOR I AND II   Life Sciences   METASTASIS   Molecular Biology   Molecular Genetics   Systematic Biology   Tissue Culture   Transcription
Details Date
Steering Committee Mesothelioma Research Network Steering Group (UK) (2018 - 2022) 2018-2022
Senior Board Member BMC Pulmonary Medicine 2020-present
Section Editor: Clinical Epigenetics (https://clinicalepigeneticsjournal.biomedcentral.com/about/editorial-board) 2018-present
Associate Editor Molecular and Structural Endocrinology (specialty section of Frontiers in Endocrinology) 2018-present
Associate Editor: BMC Cancer 2019-present
Associate Editor: PLoS One 2018-present
Editorial Board: International Journal of Oncology 2016-present
Editorial Board: Cancers (MDPI) 2017-present
Editorial Board: Cells (MDPI) 2019-present
Grant reviewer Australian National Health and Medical Research Council (NHMRC) (2010, 2012, 2017) Austrian Science Fund (2011, 2019) Bulgarian Science Foundation (2008) British Lung Foundation (2010, 2020) Cancer Research UK (2009) Czech Science Foundation (2012) Cyprus Research Promotion Foundation (2011) The Dutch Organisation for Health Research and Development (ZonMw) (2017) The Eli and Edythe Broad Foundation - Broad Medical Research Program (2012) Enterprise Ireland Commercialisation Fund (2005, 2006, 2008) Eureka Eurostars Technical Experts (2015-2020) EU - H2020-Marie Skłodowska-Curie Actions (Reviewer -2020, 2021 ; Rapporteur, 2021) Fondation contre le Cancer - Belgium (2016) Fondazione Pisa - Italy (2016) Fondazione Regionale Per La Ricerca Biomedica [Lomardy Region] (2020, 2022) France's National Research Agency -ANR [Agence Nationale de la Recherche] (2008, 2011) German Research Foundation (2009) 2009-2022
Grant Reviewer (2): German-Israeli Foundation (2011) HRB Medical Charities Research Group (2008) IASLC (2011, 2012, 2013 on behalf of Professor Kenneth J. O'Byrne) INNOVATION FUND DENMARK (2015). Italian Telethon Foundation (2008) Multiple Sclerosis Society (UK) (2012) MRC Medical Research Council (2020) The Netherlands Organisation for Scientific Research (NWO) - VENI program (2013) National Science Centre Poland (OPUS) (2015, 2017) OeNB Anniversary Fund (Austria) (2014, 2015) OTKA - Hungarian Scientific Research Fund (2014, 2015) Prostate Cancer UK (2014) Prostate Cancer Research Centre (2019) Wellcome Trust (2009) Worldwide Cancer Research (2021) Swiss Cancer League (2010, 2018) 2004-2022
Ad Hoc Journal Reviewer for the following: Acta Neuropathologica, Aging, Antioxidants & Redox Signaling, BBA-Reviews on Cancer, BBA - Gene Regulatory Mechanisms, BioEssays, BMC Medical Genetics, BMC Urology, British Journal of Cancer, British Journal of Clinical Pharmacology, British Journal of Pharmacology, Cancer, Cancers (MDPI),Cancer Epidemiology, Cancer Immunology Research, Cancer Letters, Cancer Research, Clinical and Experimental Rheumatology, Cell Biochemistry and Biophysics, Cellular & Molecular Life Sciences, CNS & Neurological Disorders-Drug Targets (CNSND-DT), Clinical Cancer Research, Clinical Lung Cancer, Cytokine, Diabetologia, E-Biomedicine, Epigenetics, European Journal of Cell Biology, European Journal of Pharmacology, Experimental Cell Research, Expert Opinion On Investigational Drugs, Expert Opinion on Therapeutic Targets
Ad hoc reviewer for various journals (2): Future Oncology - Epigenomics, Frontiers in Systems Biology, Genes & Cancer, Genome Medicine, Hormone & Metabolic Research, Inflammation & Allergy - Drug Targets, International Journal of Cancer, International Journal of Immunogenetics, Irish Journal of Medical Science, Journal of Cellular & Molecular Medicine, Journal of Experimental and Molecular Pathology, Journal of Hematology & Oncology, The Journal of Pathology, Journal of Nucleic Acids, Journal of Thoracic Oncology, Life Sciences, Lung Cancer, Mini-Reviews in Medicinal Chemistry, Molecular Cancer Research, Molecular and Cancer Therapeutics, Molecular Therapy
Ad Hoc reviewer for the following journals (3): Neurogenetics, Neurological Research, Neuropsychiatric Disease and Treatment, the Open Diabetes Journal, Oncology Reports, OncoTarget, PLoS One, Pharmaceutical Patent Analyst, Pharmacological Research, Pharmacogenomics, Phytotherapy Research, Progress in Lipid Research, Stem Cells, Theranostics, Translational Research, Trends in Neurosciences, Trends in Molecular Medicine
Panel Member: The International Cancer Genome Consortium (workgroup: Renal Cancer) 2008-2010
Deputy Editor for the Epigenetic Regulators section of the Targeted Proteins database and Epigenetic Regulators section of the CBD Protein Systems journal (launched 2008) 2008 - present
Editorial Board Member The Open Diabetes Journal (Bentham http://www.bentham.org/open/todiaj/EBM.htm) from 2008 2008-2014
Founding Editorial Board Member "Clinical Epigenetics" 2009-present
Member of the Editorial Academy for the "International Journal of Oncology" https://www.spandidos-publications.com/pages/ijo/editorial 2016-present
Editorial Board member "World Journal of Experimental Medicine" (2011-2019) 2011-2019
Editorial Board member "Frontiers in Epigenomics" (Guest Associate Editor & Review Editor) http://www.frontiersin.org/Epigenomics
Editorial Board Member "Frontiers in Systems Physiology" (Review Editor, Systems Biology) http://www.frontiersin.org/systems_physiology
Panel Member: The International Cancer Genome Consortium (workgroup: Renal Cancer) 2008 to present
Editorial Board member World Journal of Biological Chemistry Dec 2013
Invited "ad hoc" contributor to Trends in Genetics Short In Brief Articles section (2001-2002)
Independent Reporter for GenomeBiology (www.genomebiology.com) (2001)
Details Date From Date To
British Thoracic Oncology Group 2005 present
iMiG (International Mesothelioma Interest Group)
ETOP (European Thoracic Oncology Program) - www.etop-eu.org
ToPCaP (Transdisciplinary Prostate Cancer Partnership) - http://topcapteam.org/
Gray, Steven G. and O'Connor, Diarmuid and Mutti, Luciano and Meirson, Tomer, Reducing pERKs to Break †RAS†istance to Sotorasib, Journal of Thoracic Oncology, 20, (3), 2025, p259 â€" 261 , Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Martina Haberecker, Jan H. Rüschoff, Charitini Andriakopoulou, Steven G. Gray, Kristiaan Nackaerts, Marc de Perrot, Luka Br"i", Ernest Nadal, Sotirios Tsimpoukis, Luca Ampollini, Joachim G.J.V. Aerts, Michaela B. Kirschner, Kim Monkhorst, Birgit Weynand, Fatemeh Bavaghar-Zaeimi, Miroslav Samaržija, Roger Llatjos, Stephen P. Finn, Enrico Maria Silini, Jan H. von der Thüsen, Patrick Vagenknecht, Zoi Tsourti, Keith M. Kerr, Roswitha Kammler, Solange Peters, Paul Baas, Isabelle Opitz, Rolf A. Stahel, Alessandra Curioni"Fontecedro, Rolf A. Stahel, Anita Hiltbrunner, Rosita Kammler, Patrick Vagenknecht, Miriam Christoffel, Barbara Ruepp, Urania Dafni, Zoi Tsourti, Panagiota Zygoura, Katerina Vervita, Georgia Dimopoulou, Charitini Andriakopoulou, Androniki Stavrou, Jan H. Rüschoff, Martina Haberecker, Susanne Dettwiler, Fabiola Prutek, Christiane Mittmann, Isabelle Opitz, Paul Baas, Isabelle Opitz, Bart Vrugt, Martina Friess, Alessandra Matter, Chloé Spichiger-Häusermann, Michaela B. Kirschner, Paul Baas, Kim Monkhorst, Kristiaan Nackaerts, Eric Verbeken, Birgit Weynand, Liesbet M. Peeters, Luca Ampollini, Marcello Tiseo, Enrico Maria Silini, Letizia Gnetti, Marc de Perrot, Fatemeh B. Zaeimi, Luka Br"i", Miroslav Samaržija, Sven Seiwerth, Marko Jakopovi", Ernest Nadal, Enriqueta Felip, Roger Llatjós, Susana Lorente, Konstantinos Syrigos, Ioannis Vamvakaris, Sotirios Tsimpoukis, Paraskevi Boura, Steven G. Gray, Stephen P. Finn, Mutaz Mohammed Nur, Anne"Marie Baird, Nesa Marti, Sinéad Cuffe, Kathy Gately, Joachim G.J.V. Aerts, Jan H. von der Thüsen, Prevalence and Clinical Association of CD276 (B7-H3) Expression in Pleural Mesothelioma: Results From the European Thoracic Platform Mesoscape Project, JCO Precision Oncology, (9), 2025, Journal Article, PUBLISHED  DOI
Ciara S. McNevin, Anna Keogh, Mutaz Mohammed Nur, Brianán McGovern, Julie McFadden, Anne"Marie Baird, Karen A. Cadoo, Sarah Mc Carron, Cathal Ó"Brien, Martin P. Barr, Steven G. Gray, Orla Sheils, Lesley Ann Sutton, Sinéad Flanagan, Lorelei A. Mucci, Konrad H. Stopsack, Stephen P. Finn, Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort, Clinical Cancer Research, 2025, Journal Article, PUBLISHED  DOI
Gray, Steven G. and Meirson, Tomer and Mutti, Luciano, Based on the Real-World Results From Australia, Immunotherapy Is Not a Good Option for Patients With Mesothelioma, Journal of Thoracic Oncology, 19, (4), 2024, p541 â€" 546 , Notes: [Cited by: 7; All Open Access, Bronze Open Access], Journal Article, PUBLISHED  DOI
Gray, Steven G. and Mutti, Luciano and Meirson, Tomer, Encouraging Fussy Eaters in EGFR-Mutated Lung Cancer, Journal of Thoracic Oncology, 19, (8), 2024, p1125 â€" 1127 , Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Keenan, Catherine E. and Kelleher, Robbie and Gray, Steven G., Environmental pollution, epigenetics, and cancer, 2023, 175 â€" 194pp, Notes: [Cited by: 5], Book, PUBLISHED  DOI
Orumaa, Kristen and Gray, Steven G., Oncohistones, 2023, 65 â€" 83pp, Notes: [Cited by: 0], Book, PUBLISHED  DOI
Baird, A.-M. and Gray, S.G., Epigenetics of cisplatin resistance, 2023, 577-611pp, Notes: [cited By 1], Book, PUBLISHED  DOI
Alharbi B, Qanash H, Binsaleh NK, Alharthi S, Elasbali AM, Gharekhan CH, Mahmoud M, Lioudakis E, O'Leary JJ, Doherty DG, Mohamed BM, Gray SG., Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition, Scientific Reports, 13, 2023, p7462-, Journal Article, PUBLISHED
Oner E, Gray SG, Finn SP., Cell Viability Assay with 3D Prostate Tumor Spheroids., Methods in molecular biology (Clifton, N.J.), 2645, 2023, p263-275 , Journal Article, PUBLISHED  DOI
  

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Award Date
Invited Speaker EFBIC Diabetes Workshop "Shifting paradigms in diabetes" February 26th 2009
My research mainly involves using epigenetic targeting agents to examine fundamental mechanisms underpinning the regulation of (i) Receptor Tyrosine Kinases (RTKs); (ii) inflammation and (iii) cellular metabolism in thoracic malignancy and to study their potential therapeutic efficacy in the treatment of lung cancer and mesothelioma. Research in my laboratory also tries to understand the role of epigenetics and epigenetic mechanisms underpinning drug resistance in lung cancer and mesothelioma. In addition to the above my research also involves the study of non-coding RNA repertoires (lncRNAs and circRNAs) in lung cancer and mesothelioma for their potential utility as candidate biomarkers for the early prediction of thoracic malignancy, and to study their roles in lung cancer biogenesis and resistance to therapy.