| Project title |
The Hag genes of Porphyromonas gingivalis |
| Summary |
We are currently analysing the roles of the HagB and HagC outer membrane proteins of P. gingivalis in adhesion and tissue invasion. This study involves creating deletion mutants of the HagB and HagC genes, and a double HagB/C mutant. The pathogenicity of these mutants will be assessed using in vitro and in vivo infection models. This study is being carried out in collaboration with Prof, Ann Progulske-Fox, university of Florida. |
| Funding Agency |
TCD and Dublin Dental University Hospital |
| Programme |
1252 Studentship |
| Type of Project |
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| Date from |
2010 |
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| Project title |
The role of Tor kinase in filamentation in Candida albicans and Candida dubliniensis |
| Summary |
Our recent studies have highlighted the role of nutrients and the nutrient sensing kinase Tor1 in regulating filamentation and virulence in the fungal pathogen C. dubliniensis. In this study we will examine the role of mutations in the Tor kinase pathway that lead to Tor hyperactivity. It is our hypothesis that Tor hyperactive strains of C. albicans will resemble the less virulent pathogen C. dubliniensis. These data will indicate whether Tor agonists have potential as antifungal agents. |
| Funding Agency |
Science Foundation Ireland |
| Programme |
Research Frontiers Programme |
| Type of Project |
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| Date from |
2011 |
| Date to |
2015 |
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| Project title |
The TLO genes of Candida dubliniensis |
| Summary |
The genome of the fungal pathogen Candida albicans contains a family of ~14 telomeric TLO genes encoding putative transcription factors. The closely related non-pathogenic species C. dubliniensis contains only two orthologous genes, suggesting that the increased gene number in C. albicans may contribute to the increased virulence of this species. Using a combination of mutant construction, transcript profiling and ChIP-Chip analysis, this study aims to determine the role of these gene in the biology and virulence of Candida species. |
| Funding Agency |
TCD and Science Foundation Ireland (to Prof. D. Sullivan) |
| Programme |
Research Frontiers Programme |
| Type of Project |
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| Date from |
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O'CONNOR L, CAPLICE N, COLEMAN DC, SULLIVAN DJ, MORAN GP, DIFFERENTIAL FILAMENTATION OF CANDIDA ALBICANS AND C. DUBLINIENSIS IS GOVERNED BY NUTRIENT REGULATION OF UME6 EXPRESSION, EUKARYOTIC CELL, 9, 2010, p1383 - 1397
Url TARA - Full Text
DOI |
| STOKES C., MORAN G.P., SPIERING M.J., COLE G.T., COLEMAN D.C. AND SULLIVAN D.J., LOWER FILAMENTATION RATES OF CANDIDA DUBLINIENSIS CONTRIBUTE TO ITS LOWER VIRULENCE IN COMPARISON WITH CANDIDA ALBICANS, FUNGAL GENETICS AND BIOLOGY, 44, (9), 2007, p920 - 931 |
| MORAN, GP, IDENTIFICATION AND EXPRESSION OF MULTIDRUG TRANSPORTERS RESPONSIBLE FOR FLUCONAZOLE RESISTANCE IN CANDIDA DUBLINIENSIS, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 42, 1998, p1819 - 1830 |
| MORAN, GP, ANTIFUNGAL DRUG SUSCEPTIBILITIES OF ORAL CANDIDA DUBLINIENSIS ISOLATES FROM HUMAN IMMUNODEFICIENCY VIRUS (HIV)-INFECTED AND NON-HIV-INFECTED SUBJECTS AND GENERATION OF STABLE FLUCONAZOLE-RESISTANT DERIVATIVES IN VITRO, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 41, 1997, p617 - 623 |
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Last Updated:19-JUN-2013 |