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Trinity College Dublin

Personal Information
College Photo Name Moran, Gary
Main Department Dental Science
College Title Associate Professor
E-mail gmoran@tcd.ie
College Tel +353 1 6127245
Web http://sites.google.com/site/dduhmicrobiology/home
Fax +353 1 612 7295
Notes Preferred Email: gpmoran@dental.tcd.ie
 
Representations
Details Date
Founding member of the Dublin Academy of Pathogenomics and Infection Biology (DAPI) 2010-present
Meetings Secretary of the British Society of Medical Mycology 2006-2009
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
British Society for Medical Mycology 1994 Present
Internation Association of Dental Research (IADR) 1998 Present
American Society for Microbiology 2000 Present
Society for General Microbiology 2007 Present
Dublin Academy of Pathogenomics and Infection Biology 2010 Present
More Memberships>>>
 
Awards and Honours
Award Date
Irish Division of International Association of Dental Research (IADR) Elida Gibbs Award 1998
F.S. Stewart prize (Awarded by Dept. of Microbiology, TCD, for highest grade in moderatorship exam) 1994
EMBO Short-term Fellowship 1997
 
Description of Research Interests
My research interests focus on oral microbiology, including: 1) The pathogenic yeast Candida albicans, responsible for oral and systemic fungal infections - I am interested in the control of filamentation in this fungus and investigating the genetic basis for its superior virulence compared to the closely related species Candida dubliniensis 2) The periodontal pathogen Porphyromonas gingivalis. We have started a project investigating the role of the Hag genes, encoding non-fimbrial adhesins in this organism, responsible for periodontal disease.
 
Research Interests
Candida species Genomes, Genomics Molecular Biology Periodontal disease
Porphyromonas gingivalis Tissue Culture antifungal drug resistance comparative genomics
fungal morphogenesis in vitro models of infection transcriptomics virulence factors
 
Research Projects
Project title The Hag genes of Porphyromonas gingivalis
Summary We are currently analysing the roles of the HagB and HagC outer membrane proteins of P. gingivalis in adhesion and tissue invasion. This study involves creating deletion mutants of the HagB and HagC genes, and a double HagB/C mutant. The pathogenicity of these mutants will be assessed using in vitro and in vivo infection models. This study is being carried out in collaboration with Prof, Ann Progulske-Fox, university of Florida.
Funding Agency TCD and Dublin Dental University Hospital
Programme 1252 Studentship
Type of Project
Date from 2010
Date to
Person Months


Project title The role of Tor kinase in filamentation in Candida albicans and Candida dubliniensis
Summary Our recent studies have highlighted the role of nutrients and the nutrient sensing kinase Tor1 in regulating filamentation and virulence in the fungal pathogen C. dubliniensis. In this study we will examine the role of mutations in the Tor kinase pathway that lead to Tor hyperactivity. It is our hypothesis that Tor hyperactive strains of C. albicans will resemble the less virulent pathogen C. dubliniensis. These data will indicate whether Tor agonists have potential as antifungal agents.
Funding Agency Science Foundation Ireland
Programme Research Frontiers Programme
Type of Project
Date from 2011
Date to 2015
Person Months


Project title The TLO genes of Candida dubliniensis
Summary The genome of the fungal pathogen Candida albicans contains a family of ~14 telomeric TLO genes encoding putative transcription factors. The closely related non-pathogenic species C. dubliniensis contains only two orthologous genes, suggesting that the increased gene number in C. albicans may contribute to the increased virulence of this species. Using a combination of mutant construction, transcript profiling and ChIP-Chip analysis, this study aims to determine the role of these gene in the biology and virulence of Candida species.
Funding Agency TCD and Science Foundation Ireland (to Prof. D. Sullivan)
Programme Research Frontiers Programme
Type of Project
Date from
Date to
Person Months


 
Publications and Other Research Outputs
Peer Reviewed
O'CONNOR L, CAPLICE N, COLEMAN DC, SULLIVAN DJ, MORAN GP, DIFFERENTIAL FILAMENTATION OF CANDIDA ALBICANS AND C. DUBLINIENSIS IS GOVERNED BY NUTRIENT REGULATION OF UME6 EXPRESSION, EUKARYOTIC CELL, 9, 2010, p1383 - 1397
TARA - Full Text
STOKES C., MORAN G.P., SPIERING M.J., COLE G.T., COLEMAN D.C. AND SULLIVAN D.J., LOWER FILAMENTATION RATES OF CANDIDA DUBLINIENSIS CONTRIBUTE TO ITS LOWER VIRULENCE IN COMPARISON WITH CANDIDA ALBICANS, FUNGAL GENETICS AND BIOLOGY, 44, (9), 2007, p920 - 931
MORAN, GP, IDENTIFICATION AND EXPRESSION OF MULTIDRUG TRANSPORTERS RESPONSIBLE FOR FLUCONAZOLE RESISTANCE IN CANDIDA DUBLINIENSIS, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 42, 1998, p1819 - 1830
MORAN, GP, ANTIFUNGAL DRUG SUSCEPTIBILITIES OF ORAL CANDIDA DUBLINIENSIS ISOLATES FROM HUMAN IMMUNODEFICIENCY VIRUS (HIV)-INFECTED AND NON-HIV-INFECTED SUBJECTS AND GENERATION OF STABLE FLUCONAZOLE-RESISTANT DERIVATIVES IN VITRO, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 41, 1997, p617 - 623
More Publications and Other Research Outputs >>>
 

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Last Updated:17-APR-2014