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Trinity College Dublin

Personal Information
College Photo Name Frodl, Thomas
Main Department Psychiatry
College Title Stokes Professor
College Tel +353 1 896 3799
Positions and Employment 1992-1998 Study of Medicine at Free University of Berlin and University of Munich 1998-2003 Registrar and Senior Registrar in Psychiatry, Dept. Of Psychiatry and Psychotherapy, University Munich, Germany 2003-2004 Senior Registrar in Neurology, Dept. of Neurology, University of Munich 2005-2008 Consultant in General Psychiatry, Dept. of Psychiatry, University of Munich 2004-2008 Senior Lecturer / Assistant Professor, Dept. of Psychiatry, University of Munich 2008- Professor & Chair of Integrated Neuroimaging, Psychiatry, Trinity College, University of Dublin
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Irish College of Psychiatrists 1/1/2010
Medical Council, Specialist Register 8/2008
German Society for Neuropsychopharmacology 2003
Centre for Integrative Psychotherapy (CIP), Munich 1/1/2008
Awards and Honours
Award Date
Hormosan Research Award of the German Society of Psychiatry, Psychotherapy and Neurology 2005
Association of European Psychiatrists Congress Price 2005
Organon Award of the Society of Biological Psychiatry 2006
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
German Fluent Fluent Fluent
Description of Research Interests
My research focus is within 3 main areas: A. Translational research starting from experimental studies in mice or rats and applying new and established neuroimaging techniques or blood markers (like genetic or functional genetic biomarkers) to clinical populations in order to gain inside into the pathophysiology of disease, vulnerability and resilience. It will be important to explore the effects of stress and of peripheral stress blood markers on brain function and structure and to examine the impact of functional genetics, e.g. epigenetics on brain structure and function. In the past I carried out multi/disciplinary studies in patients with major depression and ADHD. Currently, we are carrying an HRB funded project on biomarkers of adult ADHD patients longitudinally followed from childhood to adulthood. Recently, I received major funding for translational research within the area of stress, neuroplasticity and ageing within the EU-multi-institutional training program - 4.3 MIO in total and about 730.000 Euro personal funding. This network program is prestigious apart for the science also in terms of close working relationships with other universities like Turku (Finland), Lund (Sweden), Nottingham (UK), Brussels (Belgium) and Magdeburg (Germany). 2. Clinical research programs implementing biological methods: Identifying fundamental brain network alterations in psychiatric disorders such as depression, ADHD, schizophrenia and dementia using neuroimaging and neurophysiological methods that further can be applied to clinical research programs in order to examine biological underpinnings of therapy response and finding markers for therapy response and differential diagnosis. An open question is for example to explore the role that gene x environmental interactions play in therapy response and how this information could be used for therapy guidance. Currently, my research group is carrying out trials on exercise in healthy controls and in patients with major depression. I have a written proposal for a clinical program using neuroimaging and blood investigations as primary outcome measures in a sample of patients receiving either psychotherapy or optimized pharmacotherapy. Moreover, I run several clinical trials that included the use of neuroimaging techniques like fMRI and Single Photon Emission Tomography in Munich. 3. Health service research: Still there is strong need to explore which clinical programs within a service deliver enduring quality for the health of a population and thus also have benefits on the longer term for the resources of a service, e.g. by saving money that can be used then for novel developments of clinical programs. For example it is still a matter of debate whether early intervention or home treatment have enduring benefits or whether they just reduce the need for inpatient therapies. Thus I will be very keen to investigate the clinical and wider health outcomes of programs such as early intervention for psychosis, CBT for psychosis, suicide prevention, crisis intervention, home treatment within naturalistic and clinical trials. A broader view is also to compare the efficacy of the modern Dublin mental health service compared to for example a more traditional health service in Germany. At present I have experience in carrying out health service research in the area of learning disability and have experience with measures for quality control and risk assessment as well as prevention of risks for staff and patients within a service.
Research Interests
ADHD Ageing, memory and other cognitive processes Alzheimer's disease Anatomy
Antidepressants Attention Deficit Hyperactivity Disorder (ADHD) Bipolar disorder Brain theory,brain mapping
Childhood and mental health DNA transcription and translation Dementia Depression
Development, prevention and treatment of mental disease or disorder Developmental and mental disorders Emotional, behavioural and cognitive disorders Exercise and cystic fibrosis
Health informatics Human genetics Learning disabilities Mood and Anxiety Disorders
Neurobiology Neurodegeneration Neurodevelopmental Disorders Neuroendocrine Immunology
Neurogenetics Neuroimaging Neurophysiology Neuroplasticity
PSYCHIATRIC-SYMPTOMS PSYCHIATRY Personal Therapy Psychiatric Disorders
Psychiatric genetics Psychiatry Psychotherapy RNA processing, stability and degradation
Rehabilitation Schizophrenia
Research Projects
Project title Brain Imaging Return to Health, rebirth
Summary European International Training Network on developing markers for neuroplasticity relevant to stress-related psychiatric disorders
Funding Agency EU
Programme Marie Cury
Type of Project
Date from 1/4/2014
Date to 31/3/2017
Person Months 96

Project title Clinical and biological outcome of adults with childhood diagnosed Attention Deficit/Hyperactivity Disorder (ADHD)
Summary Attention deficit/hyperactivity disorder (ADHD) is one of the most common mental health disorders in children (5-10% prevalence) and persists in 50-80% of cases into adulthood. In adults it significantly impairs activities of daily living, such as academic, social, occupational, and family functioning and results in a high rate of criminal offences and drug abuse. Research in adult ADHD is at the start and knowing more about the clinical, neuropsychological, social and neurobiological outcome related to maintenance of and remission from ADHD symptomatology in adults is important. Neuroimaging and neuropsychological studies have helped better to understand cognitive dysfunctions in ADHD. Our careful literature review has identified that High Angular Resolution Diffusion Imaging (HARDI)-tractography to measure brain fibre bundles, Arterial Spin Labelling (ASL) as well as functional MRI (fMRI) resting state, decision making fMRI and combining these with neuropsychological assessments of attention and working memory would be novel and the most appropriate methods to use in our study. The aim of the present project is to examine the clinical, neuropsychological and social outcome as well as microstructural and functional imaging changes associated with these outcome variables. Specific aims are to investigate whether clinical variables during childhood will predict the outcome and which changes in resting state ASL, decision-making fMRI and HARDI-tractography will be associated with remission or maintenance of ADHD. Altogether clinical, neuropsychological and neuroimaging data will show a good sensitivity and specificity to diagnose ADHD.
Funding Agency Health Research Board
Programme Patient-oriented research
Type of Project Research
Date from 1/10/2011
Date to 30/09/2014
Person Months 48

Project title Functional as well as structural brain connectivity and epigenetic changes in major depressive disorder associated with remission and persistence of symptoms over a 5 year course
Summary In this project we will intimately investigate dynamic structural, diffusion and functional brain changes in tandem with changes in epigenetics of the glucocorticoid and serotonin transporter system during the long-term course of the disease in order to understand the development from depression to remission and to identify causes for treatment failure. Moreover, we will examine the relationship between epigenetics and brain imaging changes. Longitudinal changes during the disease course in hippocampal subfield volumes, diffusion tensor imaging, task-related fMRI and epigenetics together have never been a matter of investigation.
Funding Agency Health Research Board
Programme Patient-oriented research
Type of Project research
Date from 1/10/2014
Date to 30/09/2017
Person Months 36

Project title SFI Stokes Professorship
Summary Aim of the research program is to identify biomarkers for stress-related psychiatric disorders using integrated research approaches with neuroimaging, proteomics, trasncriptomics and genomics
Funding Agency Science Foundation Ireland (SFI)
Programme Stokes Professorship Programme
Type of Project
Date from 1/9/2008
Date to 31/8/2014
Person Months 132

Project title Neural and stress correlates of resilience in an exercise-cognitive-behavioural programme
Summary To investigate the impact of an exercise program that lastet for 16 weeks on brain structure and function. Idea was to identify markers for neuroplasticity and to identify strategies leading to resilience
Funding Agency Meath Foundation
Programme Research
Type of Project
Date from 1/1/2012
Date to 31/12/2013
Person Months 18

More Research Projects>>>
Publications and Other Research Outputs
Peer Reviewed
Hennig-Fast, K, Meister, F, Frodl, T, Beraldi, A, Padberg, F, Engel, RR, Reiser, M, Möller, HJ, Meindl, T, A case of persistent retrograde amnesia following a dissociative fugue: neuropsychological and neurofunctional underpinnings of loss of autobiographical memory and self-awareness., Neuropsychologia, 46, (12), 2008, p2993-3005
Notes: [PMID: 18619985]
Frodl, T, Möller, HJ, Meisenzahl, E, Neuroimaging genetics: new perspectives in research on major depression?, Acta psychiatrica Scandinavica, 118, (5), 2008, p363-372
Notes: [PMID: 18644006]
Meisenzahl, EM, Koutsouleris, N, Bottlender, R, Scheuerecker, J, Jäger, M, Teipel, SJ, Holzinger, S, Frodl, T, Preuss, U, Schmitt, G, Burgermeister, B, Reiser, M, Born, C, Möller, HJ, Structural brain alterations at different stages of schizophrenia: A voxel-based morphometric study., Schizophrenia research, 104, (1-3), 2008, p44-60
Notes: [PMID: 18703313]
Meisenzahl, EM, Schmitt, G, Gründer, G, Dresel, S, Frodl, T, la Fougère, C, Scheuerecker, J, Schwarz, M, Boerner, R, Stauss, J, Hahn, K, Möller, HJ, Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study., Pharmacopsychiatry, 41, (5), 2008, p169-175
Notes: [PMID: 18763218]
Frodl, T, Jäger, M, Smajstrlova, I, Born, C, Bottlender, R, Palladino, T, Reiser, M, Möller, HJ, Meisenzahl, EM, Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study., Journal of psychiatry & neuroscience : JPN, 33, (5), 2008, p423–430
Notes: [PMID 18787661]
More Publications and Other Research Outputs >>>

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Last Updated:01-OCT-2014