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Personal Information
College Photo Name O'Brien, Fergal
Main Department Trinity Centre for Bioengineering
College Title Adjunct Associate Professor
College Tel  
Fax +353 1 402 2149
Prof. Fergal O'Brien is a graduate in mechanical engineering from Trinity College, Dublin. He subsequently carried out research for his PhD in the area of bone biomechanics between RCSI and TCD (awarded 2001). Following his PhD, he was a Fulbright Scholar and carried out research in orthopaedic tissue engineering at Massachusetts Institute of Technology in collaboration with in Harvard Medical School. In May, 2003 he left the US to take up a position as Lecturer in Anatomy in RCSI. He has subsequently developed one of the largest tissue engineering/regenerative medicine groups in Ireland and has been involved in the acquisition of over EUR12 million in grant funding, has published over 100 articles in peer-reviewed international journals, filed 6 patents and graduated 16 PhD students since 2003. He has been awarded a number of scientific honours including a Fulbright Scholarship (2001), New Investigator Recognition Award by the Orthopaedic Research Society (2002), Science Foundation Ireland, President of Ireland Young Researcher Award (2004), Engineers Ireland Chartered Engineer of the Year (2005) and in 2009, a European Research Council (ERC) Investigator Award (Eur 2 million). He is a Chartered Engineer and Fellow of the Institution of Engineers of Ireland (Engineers Ireland). He has served as a reviewer for over 50 scientific journals and a grant reviewer for agencies in Europe, Australia, Canada and USA. He is currently Treasurer of the Biomedical Division of Engineers Ireland, Committee Member of the Bioengineering Section of the Royal Academy of Medicine in Ireland, Editorial Consultant for the Journal of Biomechanics and Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials. For more information and current news on the Bone & Tissue Engineering Research Group in RCSI: Office Contact Details: Email: Tel. 01-4022149, Fax. 01-4022355
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Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Member of the Institution of Engineers of Ireland Chartered Engineer, 2005 1996 present
Member of the European Society for Engineering and Medicine Council Member, 2004 Newsletter Editor, 2004 Website Editor, 2004 2002 present
Member of the European Society of Biomechanics 2002 present
Member of the American Society for Bone and Mineral Research 2005 present
Member of the Anatomical Society of Great Britain and Ireland 2003 present
More Memberships>>>
Awards and Honours
Award Date
Engineers Ireland, Chartered Engineer of the Year Award 2005
Science Foundation Ireland, President of Ireland Young Researcher Award 2004
New Investigator Recognition Award for Outstanding Scientific Paper, 48th Annual Meeting of the Orthopaedic Research Society, Dallas, Texas 2002
Fulbright Scholarship 2001
Co-author on paper which won Genzyme Award for Excellence in Cartilage Research 2007, ?Tracking bone marrow stromal cells with iron oxide labelling and its effects on multilineage differentiation potential?, International Cartilage Repair Society 2007
More Awards and Honours>>>
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Description of Research Interests
Regenerative medicine: tissue engineering of bone and cartilage, scaffolds, bioreactors and stem cell biology. Mechanical behaviour of bone, bone remodelling, bone quality and osteoporosis.
Research Interests
BONE-DENSITY BONE-RESORPTION Bioengineering Biological Engineering
Biological Modeling Biological Polymers Biomaterials Biomechanics
Biomechanics, Biomedical Engineering Biomedical Engineering Biomedical Research, Multidisciplinary Biopolymeric Materials
Bioreactors Biotechnology Bone Bone Diseases
CARTILAGE Cell and tissue development Cell and tissue maintenance, repair and ageing Cell signalling, proliferation & differentiation
Cellular Biology Chemicals/Materials Composite materials Engineering underpinning biomedicine
FRACTURES Fatigue/Fracture Materials technology, engineering Maxillofacial surgery
Mechanical Engineering Mechanical Properties, Materials Medical Devices Medical Devices Engineering
Medical Sciences, Research Musculoskeletal System OSTEOPOROSIS Orthopaedic surgery
Orthopedics Osteoporosis SCAFFOLD Stem Cell
Stem Cell Biology TISSUE ADAPTATION Tissue Culture bone microdamage
bone remodelling and repair osteoporosis tissue engineering
Research Projects
Project title Website
Summary See here for Project descriptions
Funding Agency European Research Council, SFI, Enterprise Ireland, IRCSET, Health Research Board
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Publications and Other Research Outputs
Peer Reviewed
Murphy CM, Haugh MG, O'Brien FJ, The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering., Biomaterials, 31, (3), 2010, p461-6
Mohsin, S.; O’Brien, F.J. and Lee, T.C. , Osteonal crack barriers in ovine compact bone, Journal of Anatomy, 208, (1), 2006, p81 - 89
Notes: [PMID: 16420381]
O’Brien, F.J.; Hardiman, D.A.; Hazenberg, J.; Mercy, M.V.; Mohsin, S.; Taylor, D. and Lee, T.C., The behaviour of microcracks in compact bone, European Journal of Morphology, 42, (1-2), 2005, p71 - 79
Notes: [PMID: 16123026 ]
O'Brien, F.J.; Brennan, O.; Kennedy; O.D. and Lee, T.C., Microcracks in cortical bone: how do they affect bone biology?, Current Osteoporosis Reports , 3, 2005, p39 - 45
Notes: [Invited Article PMID: 16036100 ]
O'Brien, F.J.; Taylor, D and Lee, T.C., The effect of bone microstructure on the initiation and growth of microcracks. , Journal of Orthopedic Research, 23, (2), 2005, p475 - 480
Notes: [PMID: 15734265]
More Publications and Other Research Outputs >>>

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Last Updated:23-APR-2014