Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Jean Fletcher

Associate Prof in Translational Immunolo (Biochemistry)
Associate Prof in Translational Immunolo (Clinical Medicine)
      
Profile Photo

Dr. Jean Fletcher

Associate Prof in Translational Immunolo (Biochemistry)

 fletchj@tcd.ie

 3531896 4437

Associate Prof in Translational Immunolo (Clinical Medicine)


Jean Fletcher is an Associate Professor in Translational Immunology, a position held between the School of Medicine and the School of Biochemistry and Immunology. She completed a PhD in Immunology at University College London, relocated to Ireland in 2005, and took up the position of Ussher Assistant Professor in 2012. Her research has focused on understanding the immune dysregulation underlying various autoimmune diseases including multiple sclerosis, rheumatoid arthritis, psoriasis, and hidradenitis suppurativa. A key theme of her group is understanding how the Treg:Th17 cell axis is regulated by various factors including metabolism and immuno-modulatory therapies. Underpinned by strong clinical collaborations, her research aims to predict treatment responses and identify new therapeutic targets for autoimmune and inflammatory diseases, thus ultimately improving outcomes for patients. Her work has been funded by HRB, SFI, the City of Dublin Skin and Cancer Hospital Charity, the British Skin Foundation, and industrial partnerships.
  Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Autoimmunity   HIDRADENITIS SUPPURATIVA   IMMUNE FUNCTION   Immune regulation   Immune system   IMMUNE-RESPONSE   IMMUNITY   Immunoassays   IMMUNOLOGICAL MECHANISMS   IMMUNOLOGICAL REGULATION   Immunology   Immunology, Immunotherapy   Immunotherapy   Multiple Sclerosis   MULTIPLE-SCLEROSIS   Regulatory T cells   Rheumatology and rheumatological disorders   T cells   Th17 cells   Tumour Biology/ Immunology
Project Title
 Dysregulation of pathogenic T cells in multiple sclerosis
From
2006
To
2009
Summary
Funding Agency
HRB
Programme
Postdoctoral Fellowship
Project Title
 The role of CD39+ regulatory T cells in autoimmune disease
From
2009
To
2014
Summary
Funding Agency
SFI
Programme
Starting Investigator Grant

Details Date
External examiner for UCL: I was invited to act as external examiner for the MSc and MRes in Experimental Translational Immunology at UCL due to my extensive experience in translational immunology research and research led teaching . This role involves reviewing exam papers and research projects, attending Board of Examiner meetings and providing recommendations for the course and an annual report. 2022
Scientific advisor for H-Strong biobank: I was invited to as as scientific advisor for this UK based biobank of samples from HS patients due to my expertise in HS research and sample collection. 2023
External examiner for PhD (PhD candidate Ushani Srenathan, King"s College London) I was invited as external examiner for this PhD viva due to my expertise in T cell immunology and rheumatoid arthritis 28-Nov-2018
External examiner for PhD (PhD candidate Andrea Iannello, University of Turin, Turin, Italy. I was invited as external examiner for this candidate due to my expertise in multiple sclerosis research. 17-Dec-2018
Language Skill Reading Skill Writing Skill Speaking
Afrikaans Basic Basic Basic
English Fluent Fluent Fluent
Details Date From Date To
British Society for Immunology 2000 present
Irish Society for Immunology 2005 present
Biochemical Society 2005 present
Smith CM, Hambly R, Gatault S, Iglesias-Martinez LF, Kearns S, Rea H, Lynam-Loane K, Kirthi S, Hughes R, Kolch W, Fletcher JM, Kirby B., Unique B- and plasma cell signature differentiates hidradenitis suppurativa from psoriasis and atopic dermatitis., Frontiers in immunology, 17, 2026, p1768249 , Journal Article, PUBLISHED  DOI
Tynan Ó, Brugman AAI, Smith C, Canavan M, O'Rourke AM, Floudas A, Anton D, Wade S, Sundanum S, Fletcher JM, Orr C, Veale DJ, Fearon U., RA and PsA synovial tissue single-cell analysis demonstrates differential fibroblast populations with distinct phenotypes and functional capacities., Annals of the rheumatic diseases, 2026, pS0003-4967(26)00197-4 , Journal Article, PUBLISHED  DOI
Ryan KM, O'Rourke A, Sheridan C, Balcells Quintana M, Moran B, Fletcher JM, McLoughlin DM, Harkin A., Flow-cytometric analysis of immune cell populations in patients with depression: relationship with depression severity and electroconvulsive therapy therapeutic outcomes., Frontiers in cellular neuroscience, 19, 2025, p1693999 , Journal Article, PUBLISHED  DOI
Connolly, Sarah A.; Walsh, Aaron; Ledwith, Anna E.; McCarthy, Karen N.; O'Rourke, Sinead A.; Murphy, Dearbhla M.; Blasinska, Anna; Dunne, Aisling; Fletcher, Jean M.; Mills, Kingston H.G.; McManus, Ross; Sheedy, Frederick J.; Basdeo, Sharee A., BNT162b2 mRNA vaccination attenuates innate immune function in humans, Clinical Immunology, 276, 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
MacMahon Copas AN, McComish SF, Petrasca Andreea, McCormack R, Ivers D, Stricker A, Fletcher JM, Caldwell MA., CD4+ T cell-associated cytokines induce a chronic pro-inflammatory phenotype in induced pluripotent stem cell-derived midbrain astrocytes., Glia, 2024, Journal Article, PUBLISHED  DOI
Leacy EJ, Teh JW, O'Rourke AM, Brady G, Gargan S, Conlon N, Scott J, Dunne J, Phelan T, Griffin MD, Power J, Mooney A, Naughton A, Kiersey R, Gardiner M, O'Brien C, Mullan R, Flood R, Clarkson M, Townsend L, O'Shaughnessy M, Dyer AH, Moran B, Fletcher JM, Zgaga L, Little MA, RITA Ireland Vasculitis Biobank., Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination., International journal of molecular sciences, 25, (10), 2024, p5239 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Campbell C, Mayatra JM, Neve AJ, Fletcher JM, Johnston DGW., Inflammasomes: emerging therapeutic targets in hidradenitis suppurativa?, The British journal of dermatology, 2024, pljae262 , Review Article, PUBLISHED  DOI
Petrasca Andreea, Hambly R, Molloy O, Kearns S, Moran B, Smith CM, Hughes R, O'Donnell M, Zaborowski A, Winter D, Fletcher JM, Kirby B, Malara A., Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa., PloS one, 18, (2), 2023, pe0281688 , Journal Article, PUBLISHED  DOI
Barker BE, Hanlon MM, Marzaioli V, Smith CM, Cunningham CC, Fletcher JM, Veale DJ, Fearon U, Canavan M., The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis., Frontiers in medicine, 10, 2023, p1029021 , Journal Article, PUBLISHED  DOI
Smith CM, Hambly R, Gatault S, Iglesias-Martinez LF, Kearns S, Rea H, Marasigan V, Lynam-Loane K, Kirthi S, Hughes R, Fletcher JM, Kolch W, Kirby B., B-cell-derived transforming growth factor-ß may drive the activation of inflammatory macrophages and contribute to scarring in hidradenitis suppurativa., The British journal of dermatology, 188, (2), 2023, p290-310 , Journal Article, PUBLISHED  DOI
  

Page 1 of 8
Corrigan M, O'Rourke AM, Moran B, Fletcher JM, Harkin A., Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin., Neuronal Signal, 7, (2), 2023, pNS20220054-, Review Article, PUBLISHED

  


Award Date
First prize for the best oral presentation at the Irish Society for Immunology 2008 Annual Congress. 2008
Fellow of Trinity College Dublin 2021