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Trinity College Dublin

Personal Information
College Photo Name Ehrhardt, Carsten
Main Department Pharmacy
College Title Associate Professor
E-mail carsten.ehrhardt@tcd.ie
College Tel +353 1 896 2441
Fax +353 1 896 2810
 
Biography
Dr. Carsten Ehrhardt is Associate Professor in Pharmaceutics and Pharmaceutical Technology in the School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin. He holds a degree in Pharmacy from Hamburg University (Germany), and a Ph.D. in Biopharmaceutics from Saarland University (Saarbrücken, Germany). In September 2003, Carsten was appointed Lecturer in Biopharmaceutics at Saarland University and in August 2004, he accepted an offer for his current position. Carsten holds positions as Adjunct Assistant Professor at the School of Pharmacy, University of Southern California (USA) and as Professeur Invité at the Faculty of Pharmacy, Université Claude Bernard Lyon 1 (France). He is the former Director of Research in the School of Pharmacy and Pharmaceutical Sciences, TCD (2008-2012). Carsten is the recipient of honours and awards from the German Pharmaceutical Society (DPhG), American Physiological Society (Respiratory Chapter) and the Galenus Foundation. Carsten’s research is focused on transport mechanisms and cell physiology of alveolar and bronchial epithelial barriers and the development of advanced drug delivery systems for pulmonary targeting. He is (co-)author of 1 book, 45 articles in peer-reviewed journals, 12 invited review articles, 11 book chapters and 206 abstracts, and has been invited to give 70 presentations at research institutions, international conferences and workshops.
 
Representations
Details Date
Adjunct Assistant Professor, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA February 2008 - present
Professor Invité, Laboratoire de Pharmacie Galénique Industrielle, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, France March 2010 - present
Chair, Drug Delivery: Emerging Therapies Networking Group, International Society for Aerosols in Medicine 2011 - 2013
Chair, Imaging, Modeling, and Physiology of Aerosols in the Lung, International Society for Aerosols in Medicine 2013 - 2015
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Gesellschaft für Wehrmedizin und Wehrpharmazie, VdSO 1997 Present
Deutsche Pharmazeutische Gesellschaft, DPhG 2000 Present
American Association of Pharmaceutical Scientists, AAPS 2002 Present
International Society for Aerosols in Medicine, ISAM 2003 Present
American Physiological Society, APS 2006 Present
 
Awards and Honours
Award Date
International Research Collaboration Award, University of Sydney 2013
Fellowship, Trinity College Dublin 2013
Galenus Support Award 2012, Galenus Privatstiftung 2012
Galenus Support Award 2011, Galenus Privatstiftung 2011
Galenus Support Award 2010, Galenus Privatstiftung 2010
More Awards and Honours>>>
 
Languages
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Italian Medium Basic Basic
Spanish Basic Basic Basic
 
Description of Research Interests
I have established an international reputation in my field of expertise, “Inhalation Drug Delivery and Pulmonary Biopharmaceutics”. The aim of this field of scientific endeavour is to describe the behaviour of drug and biological molecules following their administration to the lung as inhaled aerosols. The field has become increasingly important over the last 20 years as the incidence of lung-related diseases and the morbidity due to these conditions is increasing a more than 5% per year. My research is primarily preclinical using both cell and animal models, which allows a wide array of discovery and development works. The technical expertise of my laboratory ranges from pharmaceutics to pharmacokinetics, pharmacology, physiology, cell & molecular biology to pathology and immunocytochemistry. Recently, we started multidisciplinary, translational investigations into the role that drug transporters play in the pathogenesis of tobacco-related chronic obstructive pulmonary disease (COPD). Previously, we have been successfully developing the following research projects: - Lung cellular disposition of inhaled beta-2 agonists for asthma therapy - Investigation of drug transporter expression in proximal and distal lung - Characterisation of delta-ENaC expression and function in airway epithelia - Determination of the role of OCTN1 in tobacco smoke-related COPD - Novel lipid-based drug delivery systems for pulmonary delivery of sCT I am an internationally recognised leader in the field of in vitro models of respiratory epithelial barriers and my laboratory has been credited with pioneering work on the development of primary cultures of human alveolar epithelial cells. The unique combination of cell physiological basis and pharmaceutical application has lead to numerous research collaborations, nationally and internationally, as well as to a continuous stream of visitors to my laboratory. I am PI of TBSI and an SFI Strategic Research Cluster - the Irish Drug Delivery Network (commenced December 2007), which brings together expertise from several leading academic institutions (UCD, UCC, RCSI and TCD) and a number of Irish drug delivery companies.
 
Research Interests
AEROSOL ALPHA1-ANTITRYPSIN DEFICIENCY ALVEOLAR EPITHELIAL-CELLS ALVEOLAR EPITHELIUM
Asthma, Cystic Fibrosis, obstructive airways, interstitial lung diseases, pulmonary fibrosis BRONCHIAL EPITHELIUM Biomedical sciences Biopharmaceutical aspects of drug delivery systems
Cell and tissue development Drug delivery technology, gene delivery Drug development and evaluation IN VITRO MODEL
IN-VITRO CULTURE INHALATION In vitro testing, trial methods LIPOSOMES
LUNG Membrane and protein trafficking Membrane transport, structure and dynamics Physiological and physiochemical barriers to drug absorption
Physiology Respiratory System
 
Publications and Other Research Outputs
Peer Reviewed
N Demling, C Ehrhardt, M Kasper, M Laue, L Knels, EP Rieber, Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of alveolar epithelial type I cells, Cell Tissue Res, 323, (3), 2006, p475 - 488
KJ Kim, Z Borok, C Ehrhardt, BC Willis, CM Lehr, ED Crandall, Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers, J Appl Physiol, 98, (1), 2005, p138 - 143
C Ehrhardt, C Kneuer, C Bies, CM Lehr, KJ Kim, U Bakowsky, Salbutamol is actively absorbed across human respiratory epithelial cell layers, Pulm Pharmacol Ther, 18, (3), 2005, p165 - 170
S Anabousi, M Laue, CM Lehr, U Bakowsky, C Ehrhardt, Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy, Eur J Pharm Biopharm, 60, (2), 2005, p295 - 303
C Ehrhardt, KJ Kim, CM Lehr, Isolation and culture of human alveolar epithelial cells, Methods Mol Med, 107, 2005, p207-216
More Publications and Other Research Outputs >>>
 

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Last Updated:01-SEP-2014