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Dr. Adam Dyer

Clinical Lecturer (Medical Gerontology)
      
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Dr. Adam Dyer

Clinical Lecturer (Medical Gerontology)

 dyerad@tcd.ie

 


Adam Dyer is an ICAT fellow and SpR in Geriatric Medicine/GIM. Adam graduated from Medicine (TCD) in 2017 and holds Masters degrees in Neuroscience (Intercalated MSc) and Medical Gerontology (Research MSc) in addition to a Postgraduate Certificate in Statistics. Adam has published over 70 journal papers and his translational immunology research focuses on exploring the impact of age and frailty on immune system variability and how this variability influences the pathogenesis and progression of age-related disease - in particular cognitive impairment and dementia due to Alzheimer Disease (AD). Current funded PhD and research projects are focussed on: (i) exploring the impact of age, frailty and geriatric syndromes on innate immune responses (FRAIL-INNATE), (ii) understanding vaccine response variability in older adults with frailty (NH-IMMUNE), (iii) translating high sensitivity biomarkers to disentangle the roles of neurodegeneration, peripheral and CNS inflammation on AD progression (TIDE-AD Study) and (iv) using sero-epidemiology to elucidate the complex relationships between common infections, cognitive function and AD progression in older adults (DRIVE-AD Study). A current focus in particular is in the measurement of novel biomarkers in geriatric medicine using high-sensitivity immunological techniques, with much of this work based clinically in the Tallaght Institute for Memory and Cognition (TIMC), with the laboratory component in Prof Nollaig Bourke's laboratory at Trinity Translational Medicine Institute (TTMI). Adam's research has won numerous awards at local (e.g Colm O'Morain Medal, TUH), National (e.g William Stokes Award, RPCI; IGS President's Prize) and international (e.g Stefania Maggi Award, EuGMS) levels. Adam is an Associate Editor for Age & Ageing and additionally sits on the Clinical Guidelines Committee of the EuGMS in addition to regular peer-reviewer for international journals.
Project Title
 Defining the Role of Viral Infections in Early Alzheimer Disease (DRIVE-AD)
From
January 2024
To
July 2025
Summary
Alzheimer Disease (AD) affects >60,000 individuals in Ireland and is characterised by remarkable variation in clinical presentation and disease outcomes. There is an urgent need to understand the biological determinants of this variability so personalised approaches for AD prevention and treatment can be developed. Despite strong circumstantial evidence over the past two decades that viral infections (influenza, herpesviruses, viral pneumonia) increase AD risk, definitive real-world evidence is lacking. DRIVE-AD will deploy a high-throughput, low-cost assay to determine prior exposure to 50 common viral infections " several previously implicated in AD. DRIVE-AD aims to provide the first large-scale definitive evidence linking viral exposures to AD in humans to inform potential vaccination and anti-viral treatment strategies in older adults at risk of, or living with Alzheimer Disease
Funding Agency
Meath Foundation; Dean's Research Initiative
Project Title
 COVID-19 in Nursing Home Residents: Predicting Disease Severity, Outcomes and Antiviral Immune Responses (NH-COVAIR & NH-IMMUNE Studies)
From
2020
To
2025
Summary
Examines anti-viral immune responses in older nursing home residents including in vitro (PBMC stimulations in lab) and in vivo (SARS-CoV2 vaccine) responses. In addition to advancing understanding of the pathogenesis of viral infection in severely frail older adults, these insights offer to inform vaccine development/deployment strategies; biological sampling completed at baseline, 5 weeks & 6 months post-vaccine
Funding Agency
Meath Foundation
Project Title
 Exploring Novel Biomarkers of Brain Health in Diabetes (ENBIND)
From
2019
To
2024
Summary
Explores the relationship of novel bioengineering (e.g spatiotemporal gait analysis) and immunology (e.g circulating pro-inflammatory cytokines, peripheral blood immune cell responses to pathogenic amyloid ß-42) markers with cognitive function in midlife type 2 diabetes. Wave 1 (N = 150) completed; Wave 2 currently underway 2022-24 (ENBIND-II) seeking to examine the relationship between these markers and longitudinal cognitive trajectories in middle-aged adults with type 2 diabetes
Funding Agency
Meath Foundation
Project Title
 Translating Inflammatory Biomarkers to Predict Disease Progression and Adverse Events in Mild-Moderate Alzheimer Disease (TIDE-AD)
From
2021
To
2023
Summary
Will examine the ability of systemic inflammatory biomarkers to predict clinical progression and adverse events over 18 months in older adults with mild-moderate Alzheimer Disease. TIDE-AD will also examine the impact of systemic inflammatory events to result in persistent immune dysregulation in older adults with mild-moderate Alzheimer Disease by assessing over >1,000 individual plasma and CSF samples from older 534 older adults with subjective memory complaints, mild cognitive impairment due to Alzheimer Disease and mild-moderate dementia due to Alzheimer Disease
Funding Agency
Meath Foundation
Project Title
 Investigating the Impact of Age and Frailty on Innate Immune Responses (FRAIL-INNATE
From
2021
To
2023
Summary
Explores innate Anti-Viral immune responses in older adults living with frailty; examines how increasing frailty states are associated with alterations in innate immune responses to various agonists using whole blood immunomonitoring; recruitment based in St James's Hospital & Tallaght University Hospital
Funding Agency
TCD & TTMI Building Engagements in Health Research

Details Date
Committee Member, EuGMS Clinical Guidelines Committee 2025
Associate Editor, Age & Ageing 2025
SpR Representative, Irish Gerontological Society (IGS) National Executive Committee (NEC) 2021
Editorial Fellow, Age & Ageing (Journal) 2022
Editorial Board Member, BMC Geriatrics 2021
Details Date From Date To
British Geriatrics Society 2022 Present
Irish Gerontological Society 2021 Present
Dyer AH, Dunne J, Dolphin H, Morrison L, O'Connor A, Fullam S, Kenny T, Fallon A, O'Dowd S, Bourke NM, Conlon NP, Kennelly SP; TIMC"BRAiN Study Group., Clinical performance of the fully automated Lumipulse plasma p-tau217 assay in mild cognitive impairment and mild dementia, Alzheimers Dement (Amst) ., 2025, Journal Article, PUBLISHED  DOI
Adam H Dyer, Helene McNulty, Aoife Caffrey, Shane Gordon, Eamon Laird, Leane Hoey, Catherine F Hughes, Mary Ward, J J Strain, Maurice O'Kane, Fergal Tracey, Anne M Molloy, Conal Cunningham, Kevin McCarroll, Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study, Neurobiol Aging, 2024, Journal Article, PUBLISHED  DOI
Adam H Dyer, Claire Murphy, Helena Dolphin, Laura Morrison, Robert Briggs, Brian Lawlor, Sean P Kennelly; NILVAD Study Group, Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer's disease, European Geriatric Medicine, 2024, Journal Article, PUBLISHED  DOI
Helena Dolphin, Adam H Dyer, Laura Morrison, Susan D Shenkin, Tomas Welsh, Sean P Kennelly, New horizons in the diagnosis and management of Alzheimer"s Disease in older adults, Age and Ageing, 53, (2), 2024, Journal Article, PUBLISHED  DOI
Belinda Hernández, Adam H Dyer, Ciaran Finucane, Bernardo Nipoti, Roman Romero-Ortuno, Richard Reilly, Rose Anne Kenny, The Impact of Type 2 Diabetes on Peripheral and Cerebral Haemodynamic Responses to Active Stand, The Journals of Gerontology: Series A, 2024, Journal Article, PUBLISHED  DOI
Emma J Leacy 1, Jia Wei Teh 2, Aoife M O'Rourke 3, Gareth Brady 1, Siobhan Gargan 4, Niall Conlon 5, Jennifer Scott 1, Jean Dunne 5, Thomas Phelan 1, Matthew D Griffin 2 6, Julie Power 7, Aoife Mooney 5, Aifric Naughton 5, Rachel Kiersey 5, Mary Gardiner 5, Caroline O'Brien 5, Ronan Mullan 4 8, Rachael Flood 4 8, Michael Clarkson 9, Liam Townsend 10, Michelle O'Shaughnessy 2 9, Adam H Dyer 11, Barry Moran 3, Jean M Fletcher 3, Lina Zgaga 12, Mark A Little 1; RITA Ireland Vasculitis Biobank, Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination, 2024, Journal Article, PUBLISHED  DOI
Laura Morrison, Adam H Dyer, Helena Dolphin, Isabelle Killane, Nollaig M Bourke, Matthew Widdowson, Conor P Woods, James Gibney, Richard B Reilly, Sean P Kennelly, Discrete Relationships between Spatiotemporal Gait Characteristics and Domain-Specific Neuropsychological Performance in Midlife, Sensors, 2024, Journal Article, PUBLISHED  DOI
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Aoife Fallon, Sean O'Dowd, Nollaig M Bourke, Sean P Kennelly, Performance of plasma p-tau217 for the detection of amyloid-ß positivity in a memory clinic cohort using an electrochemiluminescence immunoassay, Alzheimer's Research & Therapy, 2024, Journal Article, PUBLISHED  DOI
L Morrison, AH Dyer, H Dolphin, I Batten, C Reddy, M Widdowson, CP Woods, J Gibney, NM Bourke, SP Kennelly, Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes, Brain, Behavior, & Immunity - Health, 41, (November), 2024, p100862-, Journal Article, PUBLISHED  DOI
Connolly E, O'Connor A, Dolphin H, Dyer AH, Fallon A, O'Dowd S, Kennelly SP, Projected Annual Lecanemab Treatment Eligibility in an Irish Regional Specialist Memory Clinic, International Journal of Geriatric Psychiatry, 2024, Journal Article, PUBLISHED
  

Page 1 of 8
R Penfold, AH Dyer, Editor's View: June 2023, AGE AND AGEING, 2023, Journal Article, PUBLISHED
Midlife Diabetes and the Risk of Dementia: Understanding the Link in, editor(s)Colin R. Martin, Victor R. Preedy , The Neuroscience of Dementia, Elsevier, 2020, [Sean Kennelly, Adam H Dyer], Book Chapter, PUBLISHED

  


Award Date
William Stokes Award 2025
Presidents Prize, Irish Gerontological Society 2024
Stefania Maggi Award, European Geriatric Medicine Society 2024
OMorain Research Medal & Bursary (TUH) 2022
Presidents Prize, Irish Gerontological Society 2019
Connolly Norman Medal in Mental Disease (TCD) 2017
John Fleetwood Medal in Gerontology 2016
De Renzy Prize in Public Healthy and Primary Care 2016
George Mullet Prize in Clinical Psychiatry 2016
Novartis Prize in Neuroscience 2015
Amulree Prize in Geriatric Medicine, Runner Up 2015
Sheppard Memorial Prize in General Practice 2015
Mary Ward Prize in Traffic Medicine 2015
Health Research Board Student Scholar 2015
Walter Smith Prize in Pharmacology & Therapeutics 2014
British Pharmacological Society Undergraduate Prize 2014
William Fearon Medal in Biochemistry 2013
Scholar of Trinity College Dublin 2013
Henry Hutchinson Medical Scholarship 2012
John Purser Medal in Physiology and Biochemistry 2012