| Staff Details | ||||
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| Personal Information | ||
| Name | Williams, David Clive | |
| Main Department | Biochemistry | |
| College Title | Associate Professor | |
| clive.williams@tcd.ie | ||
| College Tel | +353 1 896 2596 | |
| Web | http://www.tcd.ie/Biochemistry/research/c_williams.php | |
| Fax | +353 1 677 2400 | |
| Representations |
| Details | Date |
| Member and sometime Chair of The National Committee for Biochemistry | 1993-96,00-03 |
| Secretary and Member of The Neurochemical Group Committee of The Biochemical Society | 1990-95 |
| Member of HRB Mental Health and Neurology, and Post-doctoral Fellowship Research Grants Committees | 1991-2 |
| Trustee of The Irish Area Section of The Biochemical Society FEBS Fund for Graduate students | 1987-92 |
| External examiner for research degrees in St Andrews, Leeds, Cardiff, Galway, Cork, Aarhus, etc | |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| Member of the Society for Neuroscience | 2000 | |
| Member and Council Member of European Society for Neurochemistry | 1990 | |
| Member of The International Society for Neurochemistry | 1990 | |
| Royal Irish Academy | 1995 | |
| The Biochemical Society | 1970 |
| Expertise Ireland Description of Research Interests |
| Current Research Interests and Projects Areas of Research: Protein Structure-Function Relationships Biotechnology especially in vitro Toxicology and Pharmaceutical Chemistry Neurochemistry Current research: Characterisation of drug and substrate binding sites on the serotonin transporter using photo-affinity labelling Characterisation of the dependence of serotonin transporter function on cholesterol and heterogeneity of SERT in collaboration with Patrick Schloss ( Mannheim) Demonstration of an in vitro test for excitotoxicity based on early response gene measurement in collaboration with Bayer Toxicology, BIBRA International and Roger Griffiths (St Andrews). Characterisation of a new class of apoptotic agents in collaboration with Dr Daniela Zisterer. In silico drug design in collaboration with David Lloyd Current Research Centre Interactions in College. Centre for Structural Biology and Molecular Design (http://www.tcd.ie/Biochemistry/scbmd/index.php) Trinity College Institute for Neuroscience ( http://www.trinityneuroscience.com/C_Williams.html |
| Research Interests | |||
| 5-HYDROXYTRYPTAMINE | 5-HYDROXYTRYPTAMINE UPTAKE | ANTIDEPRESSANT DRUGS | ANTIEPILEPTIC DRUGS |
| ANTIESTROGENS | ANTIPROLIFERATIVE ACTION | APOPTOSIS | ASTROCYTES |
| BCR-ABL | BENZODIAZEPINE BINDING-SITES | BENZODIAZEPINES | BINDING-SITES |
| BRAIN | BRAIN GABA TRANSPORTER | C-JUN N-TERMINAL KINASE | CALMODULIN |
| CANCER | CASPASES | CELL CYCLE | CELL PROLIFERATION |
| CHOLESTEROL | CONVULSIONS | DIFFERENTIATION | DOPAMINE TRANSPORTER |
| ESTROGEN-RECEPTOR | GABA TRANSPORTER | GLIA | GLIAL-CELLS |
| GLUTAMATE | HEXACHLOROCYCLOHEXANE | HEXACHLOROCYCLOHEXANE ISOMERS | HIGH-AFFINITY UPTAKE |
| INSECTICIDES | L-GLUTAMATE TRANSPORTER | LIGAND | LINDANE |
| MITOCHONDRIA | NEURONS | PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE | PHOSPHOLIPASE-A2 |
| PLATELET PLASMA-MEMBRANE | PYRROLO-1,5-BENZOXAZEPINES | PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS | RECEPTOR LIGANDS |
| RECEPTORS | SEROTONIN TRANSPORTER | STEROID-BIOSYNTHESIS |
| Publications |
| Peer Reviewed |
| McGee, MM, Gemma, S, Rammunno, A, Zisterer,DM, Fatterusso, C, Catalanotti, B, Butini, S, Fiorini,I, Pisano, C, Cucco, C, Novellino, E, Nacci, V, Williams, DC and Campiani, G, Pyrolo [1,5] benzoxathiazepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target., Journal of Medicinal Chemistry, 48, (13), 2005, p4367 - 4377 Notes: [PMID: 15974589] Url DOI |
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| SCANLON, SM, WILLIAMS, DC, SCHLOSS, P, MEMBRANE CHOLESTEROL MODULATES SEROTONIN TRANSPORTER ACTIVITY, BIOCHEMISTRY, 40, 2001, p10507 - 10513 | |
| WOODS, MJ, WILLIAMS, DC, MULTIPLE FORMS AND LOCATIONS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, BIOCHEMICAL PHARMACOLOGY, 52, 1996, p1805 - 1814 | |
| PHILLIPS, OM, WOOD, KM, WILLIAMS, DC, KINETICS OF THE INTERACTION OF SERTRALINE WITH THE HUMAN-PLATELET PLASMA-MEMBRANE 5-HYDROXYTRYPTAMINE CARRIER, EUROPEAN JOURNAL OF PHARMACOLOGY, 146, 1988, p299 - 306 | |
| PHILLIPS, OM, WILLIAMS, DC, MULTIPLE AFFINITY STATES FOR [H-3]IMIPRAMINE BINDING-SITES ON HUMAN-PLATELET MEMBRANES, EUROPEAN JOURNAL OF PHARMACOLOGY, 100, 1984, 247 - 248 |
| Non Peer Reviewed | |
| Moynagh, P.N., O'Neill, L.A.J. & Williams, D.C., Modulation of the peripheral-type benzodiazepine acceptor by IL-1 and PMA, Neurochem. Int., 21, 1992, pC63 | |
| More Publications>>> | |
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