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Trinity College Dublin

Personal Information
College Photo Name Doherty, Derek
Main Department Immunology
College Title Associate Prof & Head of Immunology
E-mail derek.doherty@tcd.ie
College Tel  
 
Biography
The following ongoing research projects in my laboratory are fundamental studies aimed at developing new therapies for infectious and immune-mediated diseases and cancer
  • Studies on human pyrophosphate-specific γδT cells and their interactions with other cells in the stimulation and regulation of immune responses
  • Functional studies on human glycolipid-specific, CD1d-restricted T cells (NKT cells) and their reciprocal interactions with dendritic cells
  • Functional studies on human NKT cells and their roles in B cell maturation and antibody production in health and in systemic lupus erythematosus.
  • Studies on roles of γδT cell subsets in immunity and immunodeficiency in human immunodeficiency virus infection.
  • An investigation of a possible role for natural killer cells and innate T cells in the immunology, pathology and treatment of hepatitis B virus infection
  • An investigation into the mechanisms employed by the hepatitis C virus to evade the host immune response
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Member of the Irish Society of Immunology
Secretary 2000-2004.
2000 Current
Reviewer of grant applications submitted to:
  • The Health Research Board (Committee for Immunology
  • Pathology and Mechanisms of Disease 2001
  • Enterprise Ireland Biotechnology and Macro/Microbiology Panel (2001)
  • Science Foundation Ireland (Biochemistry Committee 2006)
  • the Medical Research Council
  • the Wellcome Trust
  • the Michael McGough Foundation for Liver Disease in Children
  • SPARKS (Sport aiding medical research for kids)
  • the Biotechnology and Biological Sciences Research Council (UK) and Multiple Sclerosis Ireland.
Current
 
Description of Research Interests
  • Leukocyte biology: functional studies on human leukocytes with a particular interest in “innate lymphocytes” (natural killer cells, CD1-restricted T cells and gamma delta T cells) and dendritic cells.
  • Immunology of the human liver: examination of the healthy liver as a specialised organ of the immune system and investigation of immune mechanisms that contribute to pathologies associated with hepatitis B, hepatitis C, hepatic malignancies and autoimmune liver diseases
  • Immunology and genetics of human disease: including rheumatoid arthritis, systemic lupus erythematosus, cystic fibrosis, alpha-1-antitrypsin deficiency, primary antiphospholipid syndrome and schizophrenia
  • Teaching: course design, delivery and assessment of undergraduate level immunology, biochemistry, physiology, genetics and cell biology, co-director of an MSc programme in Immunology and Global Health at NUI Maynooth, research supervisor and examiner at BSc, MSc, PhD and MD levels, author of textbook chapters.
 
Research Interests
ADIPOSE-TISSUE ADJUVANT THERAPY ADJUVANTS AUTOIMMUNE DISEASES
B-CELLS CANCER CELL-MEDIATED IMMUNE RESPONSES DENDRITIC CELLS
GAMMA DELTA TCR HEPATITIS B HEPATITIS-C HEPATOCELLULAR-CARCINOMA
HIV HUMAN LIVER IMMUNE SYSTEM IMMUNODEFICIENCY
INFECTIOUS DISEASES INNATE IMMUNITY LEUKOCYTE LIPIDS
LYMPHOCYTES NATURAL-KILLER-CELLS
 
Publications and Other Research Outputs
Peer Reviewed
Oliveira AL, Hayakawa H, Schor D, Leite AC, Espíndola OM, Waters A, Dean J, Doherty DG, Araújo AQ, Hall WW, High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection., Journal of Immunology, 183, 2009, p2957-2965
DOI
Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901
DOI
Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8
Notes: [PMID: 18372499]
DOI  URL
Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40
DOI  URL
Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72
Notes: [PMID: 16924493 ]
DOI  URL
More Publications and Other Research Outputs >>>
 

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Last Updated:24-APR-2014