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Trinity College Dublin

Personal Information
Name Doherty, Derek
Main Department Immunology
College Title Associate Prof & Head of Immunology
E-mail derek.doherty@tcd.ie
College Tel  
Notes 01-8963326
 
Biography
A graduate of Trinity College Dublin, I completed a PhD at King's College London and postdoctoral research in the University of Washington, Seattle and University College Dublin before holding lecturing positions at NUI Maynooth and subsequently Trinity College Dublin.
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Committee member of the Irish Society for Immunology; secretary 2000-2004. 2000 2004
 
Description of Research Interests
Our research is aimed at finding out how the immune system can protect against or cause disease in humans and how it can be manipulated for the development of novel therapies. We are particularly interested in "innate lymphocytes" (natural killer cells, natural killer T cells and gamma/delta T cells), which appear to be "master regulators" of the immune system and which are defective in many infectious and immune-mediated diseases and cancers. In collaboration with clinical colleagues, we are studying innate lymphocytes in patients with hepatitis B and C, HIV, chronic lymphocytic leukaemia, lung cancer, post-operative infection and sepsis, coeliac disease and antibody deficiencies. Our results show that various innate lymphocyte populations can be manipulated to promote the generation of desirable immune responses for the treatment of disease.
 
Research Interests
ADIPOSE-TISSUE ADJUVANT THERAPY ADJUVANTS AUTOIMMUNE DISEASES
B-CELLS CANCER CELL-MEDIATED IMMUNE RESPONSES DENDRITIC CELLS
GAMMA DELTA TCR HEPATITIS B HEPATITIS-C HEPATOCELLULAR-CARCINOMA
HIV HUMAN LIVER IMMUNE SYSTEM IMMUNODEFICIENCY
INFECTIOUS DISEASES INNATE IMMUNITY LEUKOCYTE LIPIDS
LYMPHOCYTES NATURAL-KILLER-CELLS
 
Publications and Other Research Outputs
Peer Reviewed
Oliveira AL, Hayakawa H, Schor D, Leite AC, Espíndola OM, Waters A, Dean J, Doherty DG, Araújo AQ, Hall WW, High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection., Journal of Immunology, 183, 2009, p2957-2965
DOI
Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901
DOI
Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8
Notes: [PMID: 18372499]
DOI  URL
Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40
DOI  URL
Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72
Notes: [PMID: 16924493 ]
DOI  URL
More Publications and Other Research Outputs >>>
 

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Last Updated:02-SEP-2014