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Professor Dominick J H Mc Cabe

Clinical Professor (Clinical Medicine)

 djmccabe@tcd.ie

 


Biography

Professor Dominick McCabe, Chairman, Vascular Neurology Research Foundation, has a long track record in clinical and translational research in General and Vascular Neurology / Stroke Medicine. His world-class research group at AMNCH has an international reputation for conducting studies on translational platelet science, haemostasis and thrombosis, and vascular imaging in patients with ischaemic cerebrovascular disease (CVD) and carotid stenosis. Prof. McCabe has been involved in clinical research since 1996. He designed and conducted several studies on translational platelet science in CVD for his PhD at University College London. He has an in-depth knowledge of this field, and has established the international multidisciplinary OATS-I consortium. His research group have published numerous peer-reviewed articles in this field, and are currently participating in 16 local, national or international collaborative studies in ischaemic cerebrovascular disease and aspects of general neurology. For further references please view the Academic Unit of Neurology website at https://www.tcd.ie/medicine/neurology/

Research Projects

 REVEALED
 CONVINCE
 ESCAPE
 'Ireland Natalizumab (Tysabri®) Observational Program (iTOP)
 TYGRIS Study

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Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Association of British Neurologists 2002 2021
British Association of Stroke Physicians 2004 2018
American Stroke Association & The American Heart Association 2004 2021
Irish Institute of Clinical Neuroscience, 2004 to date; Treasurer Committee Member 2013 2021
Irish Heart Foundation, Council on Stroke (Neurology Committee)and Council on Stroke Treasurer 2010 2021
Irish Consultant Neurologists Association 2006 2021
World Stroke Organisation 2008 2021
Fellow of the European Stroke Organisation 2008 2021
American Academy of Neurology, Corresponding Active Member 2010 2021
'Regional Stroke Neurology Lead', HSE Dublin Mid Leinster Region 2010 2021
Irish National Clinical Advisory Group on Stroke Medicine 2012 2021
Irish National Neurology Programme Clinical Advisory Group 2013 2021
Irish National Stroke Audit Steering Group 2012 2021
European Stroke Organisation 'Conference Support Group' 2015 2021
HRB-Stroke Clinical Trials Network, Ireland, Network Lead Investigator at AMNCH / TCD, September 2014 2021
Murphy SJX, Lim ST, Hickey F, Kinsella JA, Smith DR, Tierney S, Egan B, Feeley TM, Murphy SM, Collins DR, Coughlan T, O'Neill D, Harbison JA, Madhavan P, O'Neill SM, Colgan MP, O'Donnell JS, O'Sullivan JM, Hamilton G, McCabe DJH., Profile of von Willebrand factor antigen, von Willebrand factor propeptide and ADAMTS13 and their relationship with cerebral micro-embolic signal status in patients with carotid stenosis., Thrombosis and Haemostasis, 121, (1), 2021, p86 - 97, Journal Article, PUBLISHED
Offiah C, Delaney S, Smith DR, Murphy SJX, Ryan DJ, Collins DR, McCarthy AJ, Egan B, Cox D, McCabe DJH., Performance metrics of the AGGRESTAR PL-12® platelet function analyser in patients with TIA or ischaemic stroke on commonly-prescribed antiplatelet regimens., Thrombosis and Haemostasis: Research, 5, (2), 2021, p1 - 8, Journal Article, PUBLISHED
Bonati LH, Kakkos S, Berkefeld J, de Borst GJ, Bulbulia R, Halliday A, van Herzeele I, Koncar I, McCabe DJH, Lal A, Ricco J-B, Ringleb P, Taylor-Rowan M, Eckstein H-H., Guideline on Endarterectomy and Stenting for Carotid Artery Stenosis. Eur Stroke J 2021; 6(2): I (doi: 10.1177/23969873211026990. Epub 2021 Jun 18), European Stroke Journal, 6, (2), 2021, Journal Article, PUBLISHED
Murphy SJX, Lim ST, Kinsella JA, Tierney S, Egan B, Feeley TM, Murphy SM, Walsh RA, Collins DR, Coughlan T, O'Neill D, Harbison JA, Madhavan P, O'Neill SM, Colgan MP, Cox D, Moran N, Hamilton G, Meaney JF, McCabe DJH, Relationship between 'on-treatment platelet reactivity', shear stress and cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis, Journal of Neurology, 267, (1), 2020, p168 - 184, Journal Article, PUBLISHED
Murphy SJX, Lim ST, Kinsella JA, Tierney S, Egan B, Feeley TM, Dooley C, Kelly J, Murphy SM, Walsh RA, Collins DR, Coughlan T, O'Neill D, Harbison JA, Madhavan P, O'Neill SM, Colgan MP, Meaney JF, Hamilton G, McCabe DJH., Simultaneous assessment of plaque morphology, cerebral micro-embolic signal status and platelet biomarkers in patients with recently symptomatic and asymptomatic carotid stenosis., Journal of Cerebral Blood Flow and Metabolism, 40, (11), 2020, p2201 - 2214, Journal Article, PUBLISHED
Murphy OC, Wrigley S, Walsh RA, Freir DB, McCarthy AJ, O'Dowd S, McCabe DJH., Assessment of the adequacy of counselling regarding reproductive-related issues in women of childbearing age on anti-epileptic drugs., QJM An International Journal of Medicine, 114, (4), 2020, p233 - 237, Journal Article, PUBLISHED
Naylor AR, McCabe DJH., New data and the COVID-19 pandemic mandate a rethink of antiplatelet strategies in patients with TIA or minor stroke associated with atherosclerotic carotid stenosis. , European Journal of Vascular and Endovascular Surgery, 59, 2020, p861 - 865, Journal Article, PUBLISHED
Lim ST, Thijs V, Murphy SJX, Fernandez-Cadenas I, Montaner J, Offiah C, Marquardt L, Kelly PJ, Bath PM, Lim SY, Ford GA, Norrving B, Cox D, Prodan CI, Barber PA, Werring DJ, Perry R, Zgaga L, Dawson J, McCabe DJH., Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis., Journal of Neurology, 267, 2020, p3021 - 3037, Journal Article, PUBLISHED
Doherty RJ, Caird J, Crimmins D, Kelly P, Murphy S, McGuigan C, Tubridy N, King MD, Lynch B, Webb D, O'Neill D, McCabe DJH, Boers P, O'Regan M, Moroney J, Williams DJ, Cronin S, Javadpour M., Moyamoya disease and Moyamoya syndrome in Ireland: Patient demographics, mode of presentation, and outcomes of EC-IC bypass surgery., Irish Journal of Medical Science, 190, 2020, p335 - 344, Journal Article, PUBLISHED
Murphy, S.J.X., Naylor, A.R., Ricco, J.-B., Sillesen, H., Kakkos, S., Halliday, A., de Borst, G.J., Vega de Ceniga, M., Hamilton, G., McCabe, D.J.H., Optimal Antiplatelet Therapy in Moderate to Severe Asymptomatic and Symptomatic Carotid Stenosis: A Comprehensive Review of the Literature, European Journal of Vascular and Endovascular Surgery, 57, (2), 2019, p199-211 , Journal Article, PUBLISHED
  

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Awards and Honours

Award Date
"Distinction" for Poster Presentation, 16th European Stroke Conference, Glasgow 2007
'The Allison Medal' for Best Platform Presentation, Irish Neurological Association Annual Meeting 1999
Best Poster Presentation, Irish National Scientific Meeting 1998
The 'Irish Registrar Prize in Neurology' 1998

Research Interests

Description Of Research Interests

I have successfully established an independent research programme in translational platelet science and haemostasis research in cerebrovascular disease at the Royal Free Campus, ION, and at Tallaght University Hospital(TUH)-AMNCH / TCD, with established links to 31 world-class collaborating centres in Ireland, UK, EU, USA and Canada. Since my appointment to TUH-AMNCH in 2006, as Principal Investigator (PI), Co-PI or Collaborator, I successfully secured €4,407,672 to fund the collaborative research programme that I lead on site at TUH-AMNCH / TCD I am the named author/collaborator on 99 peer-reviewed publications; first or senior author on 56, including publications in several leading high-impact factor journals in Neurology, Stroke Medicine, Haematology, Haemostasis and Thrombosis.