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Dr. Mary Canavan

Assistant Professor (Biochemistry)
Assistant Professor (Clinical Medicine TBSI)
      
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Dr. Mary Canavan

Assistant Professor (Biochemistry)

 canavam1@tcd.ie

 

Assistant Professor (Clinical Medicine TBSI)


My research focuses on understanding the immunological mechanisms which drive the development of autoimmune diseases, such Rheumatoid Arthritis and Inflammatory Bowel Disease. We explore the role of innate and adaptive immunity in the pathogenesis these diseases. By using physiologically relevant ex-vivo models, across multiple disease stages, we aim to identify new biomarkers for disease onset, therapeutic response and disease severity. Finally, we collaborate with several pharmaceutical companies, clinicians, translational scientists and patients to maximise the impact of our work and ensure the successful translation of our findings from bench to bedside.
  Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Inflammation   Innate immunology   Rheumatology and rheumatological disorders
Project Title
 Tissue Specific Immune Memory Mediates Disease Progression and Disease Flare in Rheumatoid Arthritis
From
01/09/2024
To
31/08/2028
Summary
Funding Agency
SFI
Project Title
 Restoration of Immunological Tolerance in Rheumatoid Arthritis via Metabolic Reprogramming of Dendritic Cells
From
To
Summary
Funding Agency
HRB
Programme
Investigator Led Project
Project Title
 Restoration of Immunological Tolerance in Rheumatoid Arthritis via Metabolic Reprogramming
From
01/01/2024
To
31/12/2024
Summary
Funding Agency
Trinity College Dublin Deans Award
Project Title
 Synovial T cell Memory Responses in Rheumatoid Arthritis Disease Progression
From
01/09/2023
To
31/08/202023
Summary
Funding Agency
Irish Research Council
Project Title
 Ongoing Examination of the PD-1 Pathway throughout the Evolution of Rheumatoid Arthritis
From
01/03/2023
To
01/03/2027
Summary
Funding Agency
Health Research Board

Details Date
Organizer of Immunology Research Forum (IRF) Monthly seminar series in the area of Immunology hosted in Trinity Biomedical Sciences Institute December 2022 to Present Date
Director: Centre for Arthritis and Rheumatic Diseases Responsible for strategic oversight in line with charities objectives. October 2020 - Present Date
Chair: Research Advisory Committee | Irish Cancer Society I have full oversight and responsibility for all research activities and investments of the charity, and must ensure alignment with our strategic plan. May 2023 to Present Date
Director : Irish Cancer Society I am responsible for the overall governance of the charity and ensuring the charities strategic goals are reached. September 2021 to Present Date
Associate Editor: BMC Rheumatology BMC Rheumatology editorial member responsible as part of a team for manuscripts in the Pre-clinical and Translational Science section. May 2017 to Present Date
Barker BE, Hanlon MM, Marzaioli V, Smith CM, Cunningham CC, Fletcher JM, Veale DJ, Fearon U, Canavan M., The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis., Frontiers in medicine, 10, 2023, p1029021 , Journal Article, PUBLISHED  DOI
Jenkins, B.J. and Blagih, J. and Ponce-Garcia, F.M. and Canavan, M. and Gudgeon, N. and Eastham, S. and Hill, D. and Hanlon, M.M. and Ma, E.H. and Bishop, E.L. and Rees, A. and Cronin, J.G. and Jury, E.C. and Dimeloe, S.K. and Veale, D.J. and Thornton, C.A. and Vousden, K.H. and Finlay, D.K. and Fearon, U. and Jones, G.W. and Sinclair, L.V. and Vincent, E.E. and Jones, N., Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity, Cell Metabolism, 35, (7), 2023, p1132-1146.e9 , Notes: [cited By 18], Journal Article, PUBLISHED  DOI
Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022, Journal Article, PUBLISHED
Floudas A, Smith CM, Tynan O, Neto N, Krishna V, Wade SM, Hanlon M, Cunningham C, Marzaioli V, Canavan M, Fletcher JM, Mullan RH, Cole S, Hao LY, Monaghan MG, Nagpal S, Veale DJ, Fearon U., Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis., Annals of the rheumatic diseases, 2022, pannrheumdis-2021-221761 , Journal Article, PUBLISHED  DOI
Viviana Marzaioli, Mary Canavan, Alex Donnolly, Siobhan Wade, Alexander Fraser, Tim O'Sullivan, Sinead Harney, Arthritis Ireland, Douglas J. Veale, Ursula Fearon, Knowledge of disease, diagnosis, adherence and impact of research in an Irish cohort of patients with inflammatory arthritis, HRB Open Research, 4, 2021, p60 , Journal Article, PUBLISHED  DOI
Canavan M, Marzaioli V, Bhargava V, Nagpal S, Gallagher P, Hurson C, Mullan R, Veale DJ, Fearon U, Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium., Frontiers in immunology, 2021, Journal Article, PUBLISHED  DOI
Hanlon MM, Canavan M, Barker BE, Fearon U., Metabolites as drivers and targets in Rheumatoid Arthritis., Clinical and experimental immunology, 2021, Journal Article, PUBLISHED  DOI
Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021, Journal Article, PUBLISHED  DOI
Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ, Fearon U., ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis, Cells, ;10(3):, (64), 2021, pdoi: 10.33-, Journal Article, PUBLISHED
Canavan M, Wade SM, Veale DJ, Fearon U, Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al., Annals of the rheumatic diseases, 2020, Journal Article, PUBLISHED  DOI
  

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