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Professor Matthew Campbell

Professor 0f Neurovascular Genetics (Genetics)
Professor 0f Neurovascular Genetics (Trinity Inst. of Neurosciences (TCIN))
      
Profile Photo

Professor Matthew Campbell

Professor 0f Neurovascular Genetics (Genetics)

 Matthew.Campbell@tcd.ie

 3531896 2484/1482

Professor 0f Neurovascular Genetics (Trinity Inst. of Neurosciences (TCIN))


  AGE-RELATED MACULOPATHY   Alzheimer's Disease   BLOOD-BRAIN-BARRIER   Cell signalling, proliferation & differentiation   Cellular Biology   ENDOTHELIAL CELLS   Genetics   INFLAMMATION   Molecular Biology   Molecular Genetics   Neurobiology   neurodegeneration   Neuroscience   siRNA technology   TIGHT JUNCTIONS   Transgenics   Vision
Project Title
 Eye-D: Therapeutic target identification for degenerative eye disease
From
1/11/2021
To
31/10/2025
Summary
This project is focused on identifying the molecular cause of blindness including age related macular degeneration (AMD), glaucoma and inherited retinal diseases. It is an industry academic consortium and involves collaboration with Roche, Eli Lilly and Progressive Vision as well as a collaboration with the Irish charity Fighting Blindness Ireland.
Funding Agency
SFI
Programme
SFI-SPP
Project Title
 Retina Rhythm:Investigating the role of the inner retina in age-related macular degeneration (AMD)
From
1/7/2020
To
30/6/2025
Summary
This is an ERC project focused on identifying the earliest causes of age related macular degeneration (AMD). The central hypothesis is that AMD is driven by a dysfunction of blood vessels in the inner retina and that regulating the integrity of these vessels may stabilise the condition.
Funding Agency
European Research Council
Programme
Consolidator Award
Project Type
Basic research

Details Date
Member of the scientific review committee of Moorfields Eye Charity, UK. 2020 - present
Editorial board member for Investigative Ophthalmology and Vision Science (IOVS) 2022
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Associate Editor, Fluids and Barriers of the CNS 2021 Present
Member of the Executive committee of FutureNeuro 2016 Present
Member of the SAB of the Alternating Hemiplegia of Childhood (AHCF) charity 2024 Present
Member of the SAB of the Moorfields Hospital Charity 2020 Present
Vice Chair, Sight Research UK, SAB 2024 Present
Associate Editor, IOVS 2022 2024
Member of International Society for Eye Research. 2010-present: International Brain Barriers Society (IBBS). 2014 Present
Behan, Claire and Greene, Chris and Hanley, Nicole and Salla, Carme Vila and Brennan, Declan and Connolly, Ruairi and Sweeney, Kieron and O'Brien, Donncha and Farrell, Michael and Meaney, James and Henshall, David C. and Campbell, Matthew and Doherty, Colin P., Restoration of blood brain barrier integrity post neurosurgical resection in drug resistant epilepsy, Epilepsy and Behavior, 168, 2025, Notes: [Cited by: 1], Journal Article, PUBLISHED  DOI
Garcia-Gallardo, Angela and Campbell, Matthew, Understanding the Blood-Brain Barrier: From Physiology to Pathology, Advances in Experimental Medicine and Biology, 1477, 2025, p1 â€" 33 , Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Nicolle, Simon and Barker, Mike and Barrett, John and Campbell, Matthew and Wojno-Picon, Justyna and Atkinson, Stephen J. and Aylott, Helen and Kessedjian, Hripsimee and He, Yanan and Messenger, Cassie and Roberts, Emma and Spitzfaden, Claus and Le, Joelle and Zinn, Nico and Werner, Thilo and DÃŒmpelfeld, Birgit and Bantscheff, Marcus and Somers, Don O. and Reid, Heather and Thang, Kevin and Gobbetti, Thomas and Lewis, Huw D., Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors, Journal of Medicinal Chemistry, 68, (2), 2025, p1883 â€" 1900 , Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Dudek, Katarzyna A. and Paton, Sam E. J. and Binder, Luisa Bandeira and Collignon, Adeline and Dion-Albert, Laurence and Cadoret, Alice and Lebel, Manon and Lavoie, Olivier and Bouchard, Jonathan and Kaufmann, Fernanda Neutzling and Clavet-Fournier, Valerie and Manca, Claudia and Guzmán, Manuel and Campbell, Matthew and Turecki, Gustavo and Mechawar, Naguib and Flamand, Nicolas and Lavoie-Cardinal, Flavie and Silvestri, Cristoforo and Di Marzo, Vincenzo and Menard, Caroline, Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced bloodâ€"brain barrier alterations, Nature Neuroscience, 28, (4), 2025, p766 â€" 782 , Notes: [Cited by: 8; All Open Access, Green Open Access, Hybrid Gold Open Access], Journal Article, PUBLISHED  DOI
Lemarchant, Sighild and Engelhardt, Britta and Cicchetti, Francesca and Bix, Gregory J. and Janus, Annette and Godfrin, Yann and Blasco, HélÚne and Campbell, Matthew and de Rus Jacquet, Aurélie, Restoring brain barriers: an innovative approach for treating neurological disorders, Fluids and Barriers of the CNS, 22, (1), 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Hashimoto, Yosuke and Campbell, Matthew, Key Claudins at the Blood-Retina Barriers, Advances in experimental medicine and biology, 1468, 2025, p447 â€" 451 , Notes: [Cited by: 1], Journal Article, PUBLISHED  DOI
Reddy, Avril and Greene, Chris and Hashimoto, Yosuke and Kiang, Anna-Sophia and Hudson, Natalie and Adamson, Peter and Santos-Ferreira, Tiago and Campbell, Matthew, Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease, Molecular Therapy Methods and Clinical Development, 33, (2), 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Campbell, Matthew and Ritter, Thomas, A fantastically encapsulated idea, Molecular Therapy, 33, (5), 2025, p1864 , Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Hashimoto Y, Greene C, Hanley N, Hudson N, Henshall D, Sweeney KJ, O'Brien DF, Campbell M., Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier., Fluids and barriers of the CNS, 21, (1), 2024, p52 , Journal Article, PUBLISHED  DOI
Hashimoto Y, Campbell M., Eyes on glutamate in angiogenesis and barrier formation., Neuron, 112, (12), 2024, p1895-1897 , Journal Article, PUBLISHED  DOI
  

Page 1 of 15
1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016, Conference Paper, PUBLISHED
10. C Doherty, E Wallace, M Campbell, P Humphries, Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury., Neurology 2012, SAINT JAMES HOSPITAL DUBLIN (IRELAND), 2012, Conference Paper, PUBLISHED
12. GA Grant, C Wilson, M Campbell, S Li, P Humphries, A Johnson, Reversible Opening of the Blood-brain Barrier by Targeted Suppression of Claudin 5 To Enhance Drug Delivery into Brain Tumors. , Annals of Neurology , 2012, Conference Paper, PUBLISHED
Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179, Meeting Abstract, PUBLISHED

  


Award Date
Science Foundation Ireland, Young Researcher of the year 2020
European Research Council Consolidator Award 2020
Irish Research Council Laureate Award. 2018
Association for Ocular Pharmacology and Therapeutics, National Eye Institute (NEI) award 2015
Association for Research in Vision and Ophthalmology, NEI travel Award 2015
Genentech/ARVO fellowship in recognition of my research on AMD 2015
Science Foundation Ireland, President of Ireland Young Researcher Award (PIYRA) 2013
"Pro-Retina" travel award for XVth International Symposium on Retinal Degenerations 2012
Appointed Senior Research Fellow, TCD 2012
Roche Research Award, Smurfit Institute of Genetics 2010
Fighting Blindness Ireland Research Scholarship 2002
Fellow of the Szeged Academy of Science, Hungary 2021
Fellow of TCD 2018