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Ms. Brooke Tornifoglio

Assistant Professor (Mechanical, Manuf & Biomedical Eng)

 btornifo@tcd.ie

 


Biography

Originally from Boston, Massachusetts, USA, Brooke graduated from the University of Connecticut, Storrs, CT, USA with a BSc in Biomedical Engineering and Minor in Electronics and Systems in May 2017. After her undergraduate degree, she moved to Dublin to complete her MSc in Bioengineering at Trinity College Dublin. Here, she finished with Honours and came joint-first in class for her research `Non-Invasive Characterisation of the Intervertebral Disc Microenvironment through Magnetic Resonance Imaging and Finite Element Analysis" in August 2018. Brooke then started her PhD in Mechanical, Manufacturing and Biomedical Engineering at Trinity College Dublin and her work `An investigation into diffusion tensor imaging-derived metrics in arterial tissue as biomarkers for disease progression, plaque rupture and graft recellularisation" has been recognised nationally and internationally by numerous awards. In September 2022 she started a post doctoral position aiming to translate magnetic resonance quantitative susceptibility mapping at the carotid arteries to the clinic for in vivo imaging. In July 2023, Brooke started as an Assistant Professor in Biomedical Engineering in the Department of Mechanical, Manufacturing and Biomedical Engineering here at Trinity College Dublin. Brooke"s work aims to bridge biomedical engineering and the clinic, with a particular focus on investigating imaging methodologies which capture the microstructure and microenvironment of tissue in the context of biomechanics and device design.

Research Tags

  Bioengineering   Bioengineering and radiologic imaging   BIOMECHANICS   Biomechanics, Biomedical Engineering   Imaging Techniques   Imaging, image processing   Medical Devices   Medical/Diagnostic Imaging

Representations

Details Date
Paper reviewer for Nonlinear Engineering. Modeling and Application

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
PRO of Engineers Ireland Academic Society
Member of European Mechanics Society
Member of European Society of Magnetic Resonance in Medicine and Biology
Angelica S Federici, Brooke Tornifoglio, Caitríona Lally, Orquidea Garcia, Daniel J Kelly, David A Hoey, Melt electrowritten scaffold architectures to mimic tissue mechanics and guide neo-tissue orientation, Journal of the Mechanical Behavior of Biomedical Materials, 150, 2024, p1 - 15, Journal Article, PUBLISHED  TARA - Full Text  DOI
Tornifoglio B., Johnston R.D., Stone A.J., Kerskens C., Lally C., Microstructural and mechanical insight into atherosclerotic plaques: an ex vivo DTI study to better assess plaque vulnerability, Biomechanics and Modeling in Mechanobiology, 2023, Journal Article, PUBLISHED  TARA - Full Text  DOI
Brooke Tornifoglio, Alan J. Stone, Pattie Mathieu, Emma Fitzpatrick, Christian Kerskens, Caitriona Lally, Measuring Vascular Graft Cellularity Non-Destructively: Merging Magnetic Resonance Imaging and Tissue Engineering, Advanced Materials Technologies, 2023, Journal Article, PUBLISHED
Kian F Eichholz, Pierluca Pitacco, Ross Burdis, Farhad Chariyev-Prinz, Xavier Barceló, Brooke Tornifoglio, Ryan Paetzold, Orquidea Garcia, Daniel J Kelly, Integrating Melt Electrowriting and Fused Deposition Modeling to Fabricate Hybrid Scaffolds Supportive of Accelerated Bone Regeneration, Advanced Healthcare Materials, 13, 2023, p1 - 14, Journal Article, PUBLISHED
Matthew Laffey, Brooke Tornifoglio, Caitríona Lally, Development and Initial Characterisation of a Localised Elastin Degradation Ex Vivo Porcine Aortic Aneurysm Model, Applied Sciences, 13, (17), 2023, Journal Article, PUBLISHED
Alice Hanly, Robert D Johnston, Claire Lemass, Ann Jose, Brooke Tornifoglio, Caitriona Lally, Phosphotungstic acid (PTA) preferentially binds to collagen- rich regions of porcine carotid arteries and human atherosclerotic plaques observed using contrast enhanced micro-computed tomography (CE-µCT), Frontiers in Physiology, 14, 2023, Journal Article, PUBLISHED
Tornifoglio B., Stone A.J., Kerskens C., Lally C., Ex Vivo Study Using Diffusion Tensor Imaging to Identify Biomarkers of Atherosclerotic Disease in Human Cadaveric Carotid Arteries, Arteriosclerosis, Thrombosis, and Vascular Biology, 42, (11), 2022, p1398 - 1412, p1398-1412 , Journal Article, PUBLISHED  TARA - Full Text  DOI
B Tornifoglio, A. J. Stone, P. Mathieu, E. Fitzpatrick, C. Kerskens, C. Lally, Exploring DTI-derived metrics to non-invasively track recellularisation in vascular tissue engineering, 2022, Journal Article, PUBLISHED  DOI
E. Fitzpatrick, R. Gaul, C. Smekens, P. Mathieu, B. Meehan, B. Tornifoglio, P.A. Cahill, C. Lally, A short-term decellularisation technique for porcine carotid arteries that conveys a structural stimulus to cells, 2022, Journal Article, PUBLISHED  DOI
Ruth E. Levey, Brooke Tornifoglio, Alan J. Stone, Christian Kerskens, Scott T. Robinson, Fergal B. Coulter, Robert Bagnall, Raymond O"Connor, Eimear B. Dolan, Peter Dockery, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Paul Johnson, Eoin O"Cearbhaill, Caitríona Lally, Garry P. Duffy, Towards a Whole Sample Imaging Approach Using Diffusion Tensor Imaging to Examine the Foreign Body Response to Explanted Medical Devices, Polymers, 2022, Journal Article, PUBLISHED  DOI
  

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Awards and Honours

Award Date
Awarded Government of Ireland Postdoctoral Fellowship 2023
First place for Best Presentation at the annual meeting of The British and Irish Chapter of ISMRM in Cardiff, Wales 2022
Finalist for the Engineers Ireland Biomedical Research Medal at the 27th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland 2022
Recipient of the Women in STEM Conference Support Award by Cerenovus at the 11th European Solid Mechanics Conference at the National University of Ireland, Galway 2022
Nominated for the Trinity Teaching Award for Postgraduate Students 2021
Second place for Best non-neuro oral presentation at MRFest21 at The British and Irish Chapter of ISMRM 2021
First place for Best Diffusion Talk at the Postgraduate meeting of The British and Irish Chapter of ISMRM 2020
First place for Best Cardiovascular Research Oral Presentation (mature researcher category), at the 26th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland 2020
Recipient of the Student Support Grant at the 36th Annual Scientific Meeting of ESMRMB, Rotterdam, Netherlands 2019
First place for Best Cardiovascular Research Oral Presentation (early researcher category), at the 25th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland 2019

Research Interests

Description Of Research Interests

The Biomedical Imaging and Biomechanics lab is a research laboratory based in Biomedical Engineering at Trinity College Dublin. We are affiliated with the Department of Mechanical, Manufacturing and Biomedical Engineering Department and the Trinity Centre for Biomedical Engineering. Our focus is on discovering improved imaging-derived biomarkers to aid clinical decision making. By investigating imaging methods to characterise the underlying microstructure and microenvironment of tissues and linking these to experimental ground truths, we aim to bridge the gaps between imaging, biomechanics, device design and tissue engineering. In doing so, our research zeroes in on the clinical translation of preclinical findings.