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Dr. Gareth Brady

Ussher Assistant Professor (Clinical Medicine)

 bradyg1@tcd.ie

 


Biography

My research career to date has been consistently focused on a strategy of using viruses to understand host immunity since I began post-graduate research, completing a PhD in 2005 on the investigation of novel immunoregulatory sequences in the genome of Vaccinia Virus with Professor Luke O'Neill (TCD). I then accepted a six month industrial placement in Opsona Therapeutics leading an independent project to establish several assays and reagents for screening anti-inflammatory compounds partially based on viral strategies of immune evasion and returned to academia. In late 2006, I began a post-doctoral Leukemia and Lymphoma Research (LLRF) fellowship in the Section of Virology, Imperial College London with Professor Paul Farrell analyzing mechanisms of genetic cross-regulation during Epstein Barr Virus (EBV) immune evasion and discovered a complex regulatory control pathway manipulated by the virus to control Runx1 and Runx3 gene expression. On completion of my EBV research, I wished to pursue a long-standing interest to begin research on the only known human-adapted poxvirus Molluscum Contagiosum Virus (MCV) which, despite the fact that the virus appeared incredibly adept at silencing local immunity and inflammation to go largely unnoticed during long term infections, had remained largely unexplored. To pursue this, I returned to Ireland on a Marie Curie career development IEF fellowship under the mentorship of Professor Andrew Bowie in Trinity College Dublin. I became an Ussher Assistant Professor of Vascular Biology in Trinity College Dublin in 2017 and am continuing my research on inflammation signalling and my group is developing novel anti-inflammatory compounds using autoimmune vasculitis as a model for their activity. Additionally, my recent research involves developing seroassay tools for SARS-CoV2 and understanding both the immune response to this virus in COVID-19 and how the virus evades this response.

Research Tags

  INNATE IMMUNITY

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Italian Basic Basic Medium

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Biochemical Society 2000 Present
Irish Society of Immunology (also on the Committee, Head of Outreach) 2013 Present
McGrath, J. and Kenny, C. and Nielsen, C.S. and Domegan, L. and Walsh, C. and Rooney, P. and Walsh, S. and Conlon, N. and Brady, G. and Ibrahim, A. and Dunne, J. and McCormack, W. and Corcoran, N. and Allen, N. and Fleming, C. and Bergin, C., SARS-CoV-2 epidemiology, antibody dynamics, and neutralisation capacity in Irish healthcare workers in the era of booster COVID-19 vaccinations, Frontiers in Medicine, 10, (1078022), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Gordon Greville, Sinead Cremen, Shauna O'Neill, Sarah Azarian, Gareth Brady, William McCormack, Adam H Dyer, Nollaig M Bourke, Olivier Touzelet, David Courtney, Ultan F Power, Paul Dowling, Tom K Gallagher, Connor G G Bamford, Mark W Robinson, Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis, Clin Exp Immunol ., 2023, Journal Article, PUBLISHED
Phelan, T. and Lawler, C. and Pichlmair, A. and Little, M.A. and Bowie, A.G. and Brady, G., Molluscum Contagiosum Virus Protein MC008 Targets NF-kB Activation by Inhibiting Ubiquitination of NEMO, Journal of Virology, 97, (3), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
McGrath, J. and O'Doherty, L. and Conlon, N. and Dunne, J. and Brady, G. and Ibrahim, A. and McCormack, W. and Walsh, C. and Domegan, L. and Walsh, S. and Kenny, C. and Allen, N. and Fleming, C. and Bergin, C., Point of care detection of SARS-CoV-2 antibodies and neutralisation capacityâ€"lateral flow immunoassay evaluation compared to commercial assay to inform potential role in therapeutic and surveillance practices, Frontiers in Public Health, 11, (1245464), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Leacy, E., Batten, I., Sanelli, L., McElheron, M., Brady, G., Little, M.A., Khouri, H., Optimal LC-MS metabolomic profiling reveals emergent changes to monocyte metabolism in response to lipopolysaccharide, Frontiers in Immunology, 14, 2023, Journal Article, PUBLISHED  DOI
AL Hamrashdi, M. and Brady, G., Regulation of IRF3 activation in human antiviral signaling pathways, Biochemical Pharmacology, 200, (115026), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dyer AH, Noonan C, McElheron M, Batten I, Reddy C, Connolly E, Pierpoint R, Murray C, Leonard A, Higgins C, Reilly P, Boran G, Phelan T, McCormack W, O'Neill D, Fallon A, Brady G, O'Farrelly C, Bourke NM, Kennelly SP., Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents, Journal of the American Medical Directors Association, 2022, Journal Article, PUBLISHED  DOI  URL
Kusiak, A. and Brady, G., Bifurcation of signalling in human innate immune pathways to NF-kB and IRF family activation, Biochemical Pharmacology, 205, (115246), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Emma Leacy, Gareth Brady, Niall Conlon, Jennifer Scott, Jean Dunne, Thomas Phelan, William J McCormack, Matthew D Griffin, Alan Kennedy, Alyssa Verrelli, Eamonn Molloy, Declan O'Sullivan, Julie Power, Michael Clarkson, Lina Zgaga, Michelle O'Saughnessy, Mark A Little, Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient, HRB Open Res, 4, (6), 2021, Journal Article, PUBLISHED  TARA - Full Text  DOI
Phelan, T. and Dunne, J. and Conlon, N. and Cheallaigh, C.N. and Abbott, W.M. and Faba-Rodriguez, R. and Amanat, F. and Krammer, F. and Little, M.A. and Hughes, G. and Bergin, C. and Kerr, C. and Sundaresan, S. and Long, A. and McCormack, W. and Brady, G., Article dynamic assay for profiling anti-sars-cov-2 antibodies and their ace2/spike rbd neutralization capacity, Viruses, 13, (7), 2021, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
  

Page 1 of 4
Brady, G., Macarthur, G. J., and Farrell, P. J., Epstein-Barr virus and Burkitt lymphoma. , Postgraduate medical Journal, 84, 2008, p372-377 , Review Article, PUBLISHED

  

Awards and Honours

Award Date
National Irish Times Science writing award 2000
Young Investigator Award International RUNX Conference, Ja Jolla, San Diego 2011
Best Research Prize, Irish Society for Immunology (ISI) meeting 2014
Best Research Presentation Prize NF Kappa B 2014 workshop at Pitlochry. 2014
Roche Gold Medal for Best Researcher. 2015
Best Poster Presentation Prize, Irish Society for Immunology (ISI) meeting 2015
Best Basic Science Presentation, Irish Nephrology Society meeting 2018
Allergan Innovation Award 2020 2020
Provost's Award for Excellence in Supervision of Research Students 2022

Research Interests

Description Of Research Interests

My interests are centered on Viral Immune Evasion, understanding novel aspects of inflammatory signalling and Innate Immunity an the development of Novel anti-inflammatory therapeutics. My research Group the Translational Inflammation Research Group (TIRG) which currently consists of 4 PhD students, two post-doctoral researchers (one currently being hired) a research assistant and a 5-month Spanish Erasmus student. Our SFI-Frontiers funded research focuses on understanding how the human-adapted poxvirus Molluscum Contagiosum Virus evades human immunity and the therapeutic potential of peptides derived from the virus. Our Allergan and SFI-funded COVID research is focused on developing seroassay tools for SARS-CoV to monitor pre- and post-vaccination immune responses in the population in addition to understanding how the virus is detected by and evades the immune system. Our Vasculitis UK funded research focuses on understanding the innate immune signalling of autoantibody-stimulated inflammation in monocytes in an ANCA vasculitis model of disease.