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Professor Adrian Bracken

Professor Of (Genetics)
29 WESTLAND ROW
      
Profile Photo

Professor Adrian Bracken

Professor Of (Genetics)
29 WESTLAND ROW

 Adrian.Bracken@tcd.ie

 3531896 4121


In 2021, I was elected an EMBO Member for outstanding achievement in the life sciences. My lab has made several seminal discoveries in the field of cancer epigenetics. In particular, we provided key contributions to the understanding of the molecular mechanisms of how Polycomb group proteins regulate cell-fate decisions in stem cells and in cancer. For example, in 2018, my lab discovered a new family of vertebrate specific Polycomb group proteins, called PALI1 and PALI2, that link nuclear receptor signalling and chromatin biology (Conway et al., Molecular Cell) and we are exploring how different Polycomb Repressive complexes (PRC2.1 and PRC2.2) interplay to direct deposition of the H3K27me3 epigenetic modification (Healy et al., 2019 and Glancy et al., 2023; Molecular Cell). My lab recently studied an incurable childhood cancer called 'H3-K27M-mutant diffuse midline glioma' and demonstrated that EZH2 inhibitor drugs are a mechanistically anchored treatment strategy, based on modelling the consequences of the H3-K27M cancer causing gene on the underlying biology (Brien et al., Nature Genetics, 2021). My lab is also focused on genetic predisposition to cancer and we are using our expertise in chromatin biology to explore the contribution of regulatory elements in the 'non-coding genome'. Additionally, several exciting ongoing projects in the lab are studying the roles of chromatin regulators in developmental disorders and cancer.
  Cancer Genetics   Cellular identity   Chromatin biology   Epigenetics   Gene expression control   Polycomb proteins   Stem Cell Biology   The EZH2 oncogene
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English Fluent Fluent Fluent
Italian Medium Medium Fluent
Lagan E., Gannon D., Silva A.J., Bibawi P., Doherty A.M., Nimmo D., McCole R., Monger C., Genesi G.L., Vanderlinden A., Innes J.A., Jones C.L.E., Yang L., Chen B., van Mierlo G., Jansen P.W.T.C., Pednekar C., Von Kriegsheim A., Wynne K., Sanchez-Rivera F.J., Soto-Feliciano Y.M., Carcaboso A.M., Vermeulen M., Oliviero G., Chen C.-W., Phillips R.E., Bracken A.P., Brien G.L., A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma, Molecular Cell, 85, (11), 2025, p2110 - 2127.e7, p2110-2127.e7 , Journal Article, PUBLISHED  DOI
McCole R, Nolan J, Reck DM, Monger C, Rustichelli S, Conway E, Brien GL, Wang C, Deevy O, Neikes HK, Bashore FM, Mooney A, Flavin R, Vandenberghe E, Flanigan SF, Pasini D, Davidovich C, Vermeulen M, James LI, Healy E, Bracken AP., A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells., Cell reports, 44, (1), 2025, p115192 , Journal Article, PUBLISHED  DOI
Daniel I Angelov, James P. Nolan, Gráinne Holland, David Reck, Darragh Nimmo, Craig Monger, Elisabeth Vandenberghe, Adrian P. Bracken, Abstract P10: B-cell lymphoma CRISPR screens: NSD2 loss confers EZH2 inhibition resistance, while AEBP2 is a specific genetic dependency, Blood Cancer Discovery, 5, (2_Supplement), 2024, pP10 - P10, pP10-P10 , Journal Article, PUBLISHED  DOI
James P. Nolan, Daniel Angelov, Darragh Nimmo, Gráinne Holland, Molly Davies, Eugène Dillon, David Reck, Craig Monger, Chun"Wei Chen, Gerard L. Brien, Elisabeth Vandenberghe, Eric Conway, Adrian P. Bracken, A Novel Form of AEBP2-Containing PRC2.2 Is a Genetic Dependency in Germinal Centre B-Cell Lymphoma and Its Targeting Can Overcome Acquired Resistance to EZH2 Inhibition, Blood, 144, (Supplement 1), 2024, p4121 - 4121, p4121-4121 , Journal Article, PUBLISHED  DOI
Glancy E, Wang C, Tuck E, Healy E, Amato S, Neikes HK, Mariani A, Mucha M, Vermeulen M, Pasini D, Bracken AP, PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1, MOLECULAR CELL, 2023, Journal Article, PUBLISHED
Evan Healy, Rachel McCole, Craig Monger, Gerard L. Brien, Cheng Wang, Hannah K. Neikes, Frances Potjewyd, Michiel Vermeulen, Lindsey I. James, Adrian P. Bracken, Canonical PRC1 Recruitment Is Promoted by EZH1-PRC2 Independent of H3K27me3 in Quiescent Cells, SSRN Electronic Journal, 2022, Journal Article, PUBLISHED  DOI
Evan Healy, Rachel McCole, Craig Monger, James P. Nolan, Eric Conway, Gerard L. Brien, Cheng Wang, Hannah K. Neikes, Frances Potjewyd, Michiel Vermeulen, Aoibhinn Mooney, Richard Flavin, Elisabeth Vandenberghe, Lindsey I. James, Adrian P. Bracken, EZH1-PRC2 Identifies a Potential Reservoir for Disease Relapse in Quiescent Cancer Cells Refractory to EZH2 Enzymatic Inhibition, Blood, 140, (Supplement 1), 2022, p3049 - 3050, p3049-3050 , Journal Article, PUBLISHED  DOI
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP., Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells., Nature Genetics, 53, (8), 2021, p1221 - 1232, Journal Article, PUBLISHED  TARA - Full Text
Glancy, E. and Ciferri, C. and Bracken, A.P., Structural basis for PRC2 engagement with chromatin, Current Opinion in Structural Biology, 67, 2020, p135-144 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Seoighe C, Bracken AP, Buckley P, Doran P, Green R, Healy S, Kavanagh D, Kenny E, Lawler M, Lowery M, Morris D, Morrissey D, O'Byrne JJ, Shields D, Kolch W, The future of genomics in Ireland " focus on genomics for health, 2020, Journal Article, PUBLISHED
  

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Healy E, Bracken AP., PIC-king apart PRC1-mediated repression., Trends in genetics : TIG, 41, (1), 2025, p4-5 , Journal Article, PUBLISHED
Healy E, Bracken AP., If You Like It Then You Shoulda Put Two "RINGs" on It: Delineating the Roles of vPRC1 and cPRC1, Molecular Cell, 77, (4), 2020, p685-687 , Journal Article, PUBLISHED
(ed.), Anticancer innovative therapy: Highlights from the ninth annual meeting, Cytokine Growth Factor Rev., Milan, Italy., 51, January, 2019, 2020, 1 - 9 p, Proceedings of a Conference, PUBLISHED
Brien GL, Bracken AP., The 3D Genome: EZH2 Comes into the Fold., Trends in Molecular Medicine, 25, (5), 2019, p362 - 365, Journal Article, PUBLISHED
Streubel G, Bracken AP., MED23: a new Mediator of H2B monoubiquitylation., The EMBO Journal, 34, (23), 2015, p2863-2864 , Journal Article, PUBLISHED
Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Lim, D.A., Meshorer, E., Pombo, A., Sander, M., Xu, G.L., Stem cell epigenetics: Looking forward, Cell Stem Cell, 14, (6), 2014, p706-709 , Journal Article, PUBLISHED
Turner SA, Bracken AP., A "complex" issue: deciphering the role of variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145-146 , Journal Article, PUBLISHED

  


Award Date
Elected an EMBO Member for outstanding achievement in the life sciences (Nominated by Nobel Prize Winner Thomas Cech). June 2021
Irish Research Council Advanced Laureate Awardee 2019-2023
Elected Fellow of Trinity College Dublin (FTCD) 2018-
EUROLIFE Distinguished Lecture Prize Awardee 2016