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Dr. Arun Bokde

Associate Professor (Psychiatry)
Associate Professor (Trinity Inst. of Neurosciences (TCIN))
Associate Professor (School Office - Medicine)
LLOYD INSTITUTE
      
Profile Photo

Dr. Arun Bokde

Associate Professor (Psychiatry)
LLOYD INSTITUTE

 Arun.Bokde@tcd.ie

 3531896 4104

Associate Professor (Trinity Inst. of Neurosciences (TCIN))

Associate Professor (School Office - Medicine)


Arun Bokde is Associate Professor in Neuroimaging in the Discipline of Psychiatry, School of Medicine, at Trinity College Dublin. He leads the Cognitive Systems Group, is a principal investigator in the Trinity College Institute of Neuroscience (TCIN), and a member of the Global Brain Health Institute (GBHI). His initial appointment at Trinity College Dublin was as SFI Stokes Lecturer in Biostatistical Imaging. Arun Bokde is the coordinator of the consortium NETHATE (https://nethate-itn.eu) funded by EU-H2020 Marie Sk"odowska-Curie Actions. The project he leads is to investigate the neural underpinnings of hate. He is a member of the multi-centre consortium Imaging in Genetics (IMAGEN), a study of high-risk behaviors and mental disorders in adolescence. In addition, he is a member in the Neonatal and Children"s Brain Consortium Ireland (https://nbci.ie), focused on research in the neonatal brain and neonatal brain injury. Before coming to Trinity College Dublin he was a Research Scientist at Ludwig Maximilian University in Munich, Germany; and previously he was a Postdoctoral Research Fellow at the National Institute on Aging and at the National Institute of Mental Health, both at the National Institutes of Health (USA). His first post-doctoral position was at Northwestern University (USA). He obtained his PhD degree at the University of Texas at Austin. He has published widely on the risk factors that lead to the development of mental health disorders in young and older populations.
  Age related diseases   Ageing, memory and other cognitive processes   Ageing, stroke, dementia   Alzheimer's disease   Biostatistical methods   Development, prevention and treatment of mental disease or disorder   Human Learning and Memory   Imaging Techniques   Imaging, image processing   Neurodegeneration   Neurogenetics   Neuropharmacology   Neuropsychology   Psychiatry   Vision
Project Title
 NETHATE: Network of Excellence of Training on HATE
From
1 September 2020
To
30 August 2024
Summary
The vision for the NETHATE (Network of Excellence of Training on HATE) ETN is to bring together an interdisciplinary team of world-leading European researchers to tackle a highly ambitious and relevant research project on the nature of hate. It will also examine the dynamics of its spread in both offline and online fora, mitigation and reconciliation strategies, and the impact on victims and bystanders. The research and training programme will deliver doctoral training of 15 ESRs and high-impact research outputs. The complementary research skills and training expertise within this inter-sectoral ETN will ensure that the ESRs trained will become Europe's next generation of researchers, teachers and practitioners in understanding the roots and impacts of hate, as well as mitigation strategies, which will support the development of a sustainable democratic culture across the EU.
Funding Agency
European Union
Programme
Horizon 2020- Marie Sklodowska-Curie Actions
Project Type
Innovative Training Networks
Person Months
12
Project Title
 Development of an innovative method for diagnosis of Neonatal Encephalopathy
From
1 Oct 2022
To
30 Sept 2026
Summary
During development the brain builds a series of large scale critical neural networks in which neurons extend axons to target areas of the brain and through processes of growth and retraction these axons establish stereotypic patterns of connectivity. The development process of the brain is a plastic process where a complex interaction between genes and environment take place leading impacting the developmental pathways of the brain. Increasingly, magnetic resonance imaging (MRI) is being used to obtain information about the location and size of the lesion and their association with motor and language impairments. The proposed research project will seek to develop improved and more effective measurements tools to detect and quantify neonatal lesions in newborns with neonatal encephalopathy.
Funding Agency
China Scholarship Council & Trinity College Dublin
Project Title
 Effects of Brain Training in Older Healthy Subjects
From
May 2010
To
Dec 2011
Summary
Executive function (EF) is a neurocognitive umbrella term for skills such as planning, working memory, impulse control, inhibition, and mental flexibility. Normal aging is characterised by declines in EF. The proposed integrated executive function adaptive training task specifically trains multiple components of the brain's executive function system simultaneously.
Funding Agency
SFI, HEA
Project Title
 The application of magnetic resonance imaging to the study of memory processes in young and older healthy adults, and older adults with mild cognitive impairment.
From
June 2009
To
September 2011
Summary
In general emotional events are remembered better than non-emotional ones. Many neuroimaging studies have suggested that the encoding of emotionally arousing stimuli into declarative memory relies upon the activation of the amygdala and the hippocampus. Outlined in the seminal work of Osgood, Suci and Tannenbaum a half century ago (1957) were the basic parameters of emotion- hedonic valence and arousal. The authors conducted a factor analysis of the verbal descriptions individuals ascribe to objects, reducing them to three different dimensions, namely valence, arousal and dominance, and it is the latter two of the three that have since been consistently shown to differentiate emotional value. Valence refers to the pleasantness or unpleasantness of a stimulus- the appetitive or defensive motivation; while arousal generally refers to its excitability or the strength of the motivating factor- its potential to illicit a behavioural response. In this study the focus will be on which of the two factors, valence or arousal, contributes more greatly to the enhancement of memory by emotion, and whether they are supported by the same or different brain areas.
Funding Agency
HRB, SFI
Project Title
 Neuronal Coordination
From
Sept 2010
To
Aug 2015
Summary
Funding Agency
Goverment of State of Hesse, Germany
Project Type
Research

Page 1 of 2
Details Date
Dementia and Neurodegeneration Network Ireland (DNNI) Multidisciplinary Consensus Panel since 2017
Reviewer for scientific journals and grant applications. since 2000
2015 Discover Science Night. 25-Sep-2015
2014 Discover Science Night. 26-Sep-2014
Co-Lead of Organizing Committee for workshop 'Neuroimaging in Dementia' May 2013
Co-Lead of Organizing Committee for workshop 'Application of neuroimaging in Alzheimer's disease' July 2013
Co-Lead of Organizing Committee for workshop 'Application of neuroimaging in Alzheimer's disease' September 2013
Co-Lead of Organizing Committee for workshop 'Introduction to theory and application of neuroimaging' September 2014
Co-Lead of Organizing Committee for workshop 'Neuroimaging - Theory and Practical Course' June 2015
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Medium Medium
Spanish Fluent Medium Fluent
Details Date From Date To
Society of Neuroscience (USA) 1998
German Society for Neuroscience 2001
Organization of Human Brain Mapping 2002 2014
Neuroscience Ireland 2014
Chen SD, You J, Zhang W, Wu BS, Ge YJ, Xiang ST, Du J, Kuo K, Banaschewski T, Barker GJ, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Lemaitre H, Paus T, Poustka L, Hohmann S, Millenet S, Baeuchl C, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, IMAGEN Consortium, Feng JF, Dong Q, Cheng W, Yu JT., The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders., Nature human behaviour, 2024, Journal Article, PUBLISHED  DOI
Gros G, Miranda Marcos R, Latrille A, Saitovitch A, Gollier-Briant F, Fossati P, Schmidt L, Banaschewski T, Barker GJ, Bokde ALW, Desrivières S, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Paillère Martinot ML, Artiges E, Nees F, Papadopoulos Orfanos D, Poustka L, Hohmann S, Holz N, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Lemaitre H, Vulser H, IMAGEN Consortium., Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood., Brain structure & function, 229, (1), 2024, p15-29 , Journal Article, PUBLISHED  DOI
Ge YJ, Wu BS, Zhang Y, Chen SD, Zhang YR, Kang JJ, Deng YT, Ou YN, He XY, Zhao YL, Kuo K, Ma Q, Banaschewski T, Barker GJ, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Lemaitre H, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, IMAGEN Consortium, Feng JF, Tan L, Dong Q, Schumann G, Cheng W, Yu JT., Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits., Nature human behaviour, 8, (1), 2024, p164-180 , Journal Article, PUBLISHED  DOI
Tortora L., de Vries J., Bokde A., Interpersonal and Institutional Betrayal: A Trust Game, Molecules to Mind Trinity Neuroscience Research Day, Trinity College Institute of Neuroscience, 05-03-2024, 2024, pp15 , Poster, PUBLISHED  TARA - Full Text
Viard A, Allen AP, Doyle CM, Naveau M, Bokde ALW, Platel H, Eustache F, Commins S, Roche RAP., Autobiographical Cerebral Network Activation in Older Adults Before and After Reminiscence Therapy: A Preliminary Report., Biological research for nursing, 2023, p10998004231210982 , Journal Article, PUBLISHED  DOI
Liao Z, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Paillère Martinot ML, Artiges E, Nees F, Papadopoulos Orfanos D, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Paus T, IMAGEN Consortium., Hemispheric asymmetry in cortical thinning reflects intrinsic organization of the neurotransmitter systems and homotopic functional connectivity., Proceedings of the National Academy of Sciences of the United States of America, 120, (42), 2023, pe2306990120 , Journal Article, PUBLISHED  DOI
Prignitz M, Banaschewski T, Bokde ALW, Desrivières S, Grigis A, Garavan H, Gowland P, Heinz A, Martinot JL, Paillère Martinot ML, Artiges E, Papadopoulos Orfanos D, Poustka L, Hohmann S, Fröhner JH, Robinson L, Smolka MN, Walter H, Winterer JM, Whelan R, Schumann G, Nees F, Flor H, On Behalf Of The Imagen Consortium., The Role of Empathy in Alcohol Use of Bullying Perpetrators and Victims: Lower Personal Empathic Distress Makes Male Perpetrators of Bullying More Vulnerable to Alcohol Use., International journal of environmental research and public health, 20, (13), 2023, p6286 , Journal Article, PUBLISHED  DOI
de Matos K, Cury C, Chougar L, Strike LT, Rolland T, Riche M, Hemforth L, Martin A, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Paillère Martinot ML, Artiges E, Nees F, Papadopoulos Orfanos D, Lemaitre H, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Frouin V, IMAGEN Consortium, Bach Cuadra M, Colliot O, Couvy-Duchesne B., Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability., Brain structure & function, 228, (6), 2023, p1459-1478 , Journal Article, PUBLISHED  DOI
Nweze T, Banaschewski T, Ajaelu C, Okoye C, Ezenwa M, Whelan R, Papadopoulos Orfanos D, Bokde ALW, Desrivières S, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Nees F, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Walter H, Schumann G, Hanson JL, IMAGEN Consortium., Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach., Journal of child psychology and psychiatry, and allied disciplines, 64, (8), 2023, p1159-1175 , Journal Article, PUBLISHED  DOI
Dongerdiye R, Bokde M, More TA, Saptarshi A, Devendra R, Chiddarwar A, Warang P, Kedar P., Targeted next-generation sequencing identifies eighteen novel mutations expanding the molecular and clinical spectrum of PKLR gene disorders in the Indian population., Annals of hematology, 102, (5), 2023, p1029-1036 , Journal Article, PUBLISHED  DOI
  

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Award Date
Sigma Gamma Tau, Member 1987
Arun Bokde investigates how large-scale brain networks function and how they are associated with both normal cognition, such as memory and attention, and breakdowns that lead to brain disorders. He leads the Cognitive Systems Group, is a principal investigator in the Trinity College Institute of Neuroscience (TCIN), and a member of the Global Brain Health Institute (GBHI). Arun Bokde is the coordinator of the consortium NETHATE (https://nethate-itn.eu) funded by EU-H2020 Marie Sk"odowska-Curie Actions. The project he leads is to investigate the neural underpinnings of hate. He is a member in the Neonatal and Children"s Brain Consortium Ireland (https://nbci.ie), focused on research in the neonatal brain and neonatal brain injury. He uses functional and structural neuroimaging in infants to study normal neurodevelopment and the impact of brain lesions on the developmental pathway and consequent behavioural and cognitive impairments. Bokde is co-PI (Ireland) for the the IMAGEN study, which is the first multicentre functional and structural genetic-neuroimaging study of a cohort of 2000 +14 year old adolescents. Cognitive, behavioural, clinical and neuroimaging data from the adolescents and their families and teachers have been gathered and the participants have been followed-up for 9 years - the third follow-up investigation is on-going. Bokde is investigating how stress modulates the development of brain networks, both within the thin cortical grey matter layer and the white matter regions that contain the 'cables' of the brain networks. He has close, long-standing collaborations with clinicians at St James's Hospital, Tallaght University Hospital, and St Patrick's University Hospital. The collaborations enhance the communication and translation of research into the clinical context as well as feedback into research activities.