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Dr. Brenda Mc Manus

Experimental Officer (Dental Science)

 bmcmanu@tcd.ie

 


Biography

Dr. Brenda McManus is an Experimental Officer in Microbiology and Principal Investigator in the School of Dental Science. She completed her doctoral research in 2009 which investigated the population structure and clade-specific antifungal resistance of the pathogenic yeast, Candida dubliniensis. Her postdoctoral research predominantly investigated the association of microbial organisms with oral disease in specific patient cohorts and antimicrobial drug resistance. Brenda's current role involves monitoring of water network disinfection processes, providing clinical diagnostic support and development of whole genome sequence-based research in Dublin Dental University Hospital. In 2019 she was awarded an Emerging Investigator Award for Health from the Health Research Board to investigate the role of microbial organisms in the oral cavity in diabetic foot disease and to evaluate the potential of electrochemically activated solutions for foot ulcer disinfection. Her other research interests include the use of whole genome sequencing to investigate potential sources of infection, microbial population biology and antimicrobial drug resistance. Brenda's current research primarily investigates the population biology of pathogenic organisms Staphylococcus, Candida and Enterococcus.

Research Tags

  DNA   Drug Resistance   Epidemiology   Gene Cloning   Gene Expression   Genetic/Molecular epidemiology   Genomics   Molecular Cloning   Molecular population genetics   Nucleic Acids   Oral diseases and Oral medicine   Oral microbiology   Population structure and dynamics

Research Projects

 Comparison of staphylococci from the oro-nasal cavity, periodontal pockets and foot ulcers of patients with type II diabetes: a potential oro-nasal microbial reservoir for foot ulcer infections

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Basic Basic Basic
Aloba BK, Kinnevey PM, Monecke S, Brennan GI, O'Connell B, Blomfeldt A, McManus BA, Schneider-Brachert W, Tkadlec J, Ehricht R, Senok A, Bartels MD, Coleman DC., An emerging Panton-Valentine leukocidin-positive CC5-meticillin-resistant Staphylococcus aureus-IVc clone recovered from hospital and community settings over a 17-year period from 12 countries investigated by whole-genome sequencing., The Journal of hospital infection, 132, 2023, p8-19 , Journal Article, PUBLISHED  DOI
GREALY L, WILSON P, GILLEN C, DUFFY E, HEALY M-L, DALY B, POLYZOIS I, VAN HARTEN M, DIUGALL A, BRENNAN GI, COLEMAN DC, McMANUS BA, IMMERSION OF DEBRIDED DIABETIC FOOT ULCER (DFU) TISSUE IN ELECTROCHEMICALLY GENERATED PH NEUTRAL HYPOCHLOROUS ACID SIGNIFICANTLY REDUCES THE MICROBIAL BIOBURDEN: WHOLE-GENOME SEQUENCING OF Staphylococcus aureus, THE MOST PREVALENT SPECIES RECOVERED, JOURNAL OF HOSPITAL INFECTION, 138, (August), 2023, p42 - 51, Notes: [10th June 2023; Pub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Egan SA, Kavanagh NL, Shore AC, Mollerup S, Samaniego Castruita JA, O'Connell B, McManus BA, Brennan GI, Pinholt M, Westh H, Coleman DC., Genomic analysis of 600 vancomycin-resistant Enterococcus faecium reveals a high prevalence of ST80 and spread of similar vanA regions via IS1216E and plasmid transfer in diverse genetic lineages in Ireland., The Journal of antimicrobial chemotherapy, 77, (2), 2022, p320-330 , Journal Article, PUBLISHED  DOI
McMANUS BA, ALOBA BK, EARLS MR, BRENNAN GI, O'CONNELL B, MONECKE S, EHRICHT R, SHORE AC, COLEMAN DC, MULTIPLE DISTINCT OUTBREAKS OF PANTON-VALENTINE LEUKOCIDIN (PVL)-POSITIVE COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT Staphylococcus aureus (CA-MRSA) IN IRELAND INVESTIGATED BY WHOLE-GENOME SEQUENCING, JOURNAL OF HOSPITAL INFECTION, 108, (February 2021), 2021, p72 - 80, Notes: [28th November 2020; Epup ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
McMANUS BA, DALY B, POLYZOIS I, WILSON P, BRENNAN GA, FLEMING TE, GREALY LD, HEALY M-L, COLEMAN DC, COMPARATIVE MICROBIOLOGICAL AND WHOLE-GENOME ANALYSIS OF STAPHYLOCOCCUS AUREUS POPULATIONS IN THE ORO-NASAL CAVITIES, SKIN AND FIABETIC FOOT ULCERS OF PATIENTS WITH TYPE 2 DIABETES REVEALS A POSSIBLE ORO-NASAL RESERVOIR FOR ULCER INFECTION, FRONTIERS IN MICROBIOLOGY, 11, (748), 2020, p1-10 , Journal Article, PUBLISHED  DOI  URL  URL
McMANUS BA, O'CONNOR AM, EGAN SA, FLANAGAN PR, COLEMAN DC, FIRST DESCRIPTION OF ARGININE CATABOLIC MOVILE ELEMENT (ACME) TYPE VI HARBORING THE kdp OPERON ONLY IN Staphylococcus epidermidis USING SHORT AND LONG READ WHOLE GENOME SEQUENCING: FURTHER EVIDENCE OF ACME DIVERSITY, INFECTION GENETICS AND EVOLUTION, 71, (July), 2019, p51 - 53, Notes: [18th March 2019; Epub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL  Other
O'CONNOR AM, McMANUS BA, COLEMAN DC, FIRST DESCRIPTION OF NOVEL ARGININE CATABOLIC MOBILE ELEMENTS (ACMEs) TYPES IV AND V HARBORING A kdp OPERON IN Staphylococcus epidermidis CHARACTERIZED BY WHOLE GENOME SEQUENCING, INFECTION, GENETICS AND EVOLUTION, 61, (July), 2018, p60 - 66, Notes: [19th March 2018: Epub ahead of print; pii:S1567-1348(18)30111-4], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL  Other
O'CONNOR AM, McMANUS BA, KINNEVEY PM, BRENNAN GI, FLEMING TE, CASHIN PJ, O'SULLIVAN M, POLYZOIS I, COLEMAN DC, SIGNIFICANT ENRICHMENT AND DIVERSITY OF THE STAPHYLOCOCCAL ARGININE CATABOLIC MOBILE ELEMENT ACME IN STAPHYLOCOCCUS EPIDERMIDIS ISOLATES FROM SUBGINGIVAL PERI-IMPLANTITIS SITES AND PERIODONTAL POCKETS, FRONTIERS IN MICROBIOLOGY, 9, (1558), 2018, p1 - 15, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
McMANUS BA, O'CONNOR AM, KINNEVEY PM, O'SULIVAN M, POLYZOIS I, COLEMAN DC, FIRST DETAILED CHARACTERIZATION OF THE STRUCTURAL ORGANIZATION OF TYPE III ARGININE CATABOLIC MOBILE ELEMENTS (ACMEs) HARBORED BY STAPHYLOCOCCIS EPIDERMIDIS BY WHOLE GENOME SEQUENCING, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61, (10), 2017, p1-5:e01216-17 , Notes: [31st July 2017; Epub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
BRENNAN GI, ABBOTT Y, BURNS A, LEONARD F, McMANUS B, O'CONNELL B, COLEMAN DC, SHORE AC, THE EMERGENCE AND SPREAD OF MULTIPLE LIVESTOCK-ASSOCIATED CLONAL COMPLEX 398 METHICILLIN-RESISTANT AND METHICILLIN-SUSCEPTIBLE Staphylococcus aureus STRAINS AMONG ANIMALS AND HUMANS IN THE REPUBLIC OF IRELAND, 2010-2014, PLOS ONE, 11, (2), 2016, p1-11: e0149396 , Notes: [Published on the 17th of February 2016], Journal Article, PUBLISHED  DOI  URL
  

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Aoife O'Connor, Characterisation of Staphylococcal and Candida Populations from Healthy and Diseased Oral and Subgingival Sites in Healthy and Diseased Individuals With and Without Implants and in Patients with Periodontal Disease Reveals a High Prevalence and Diversity of the Arginine Catabolic Mobile Element ACME in Oral Staphylococcus epidermidis, 2017, Thesis, ACCEPTED
Molecular Epidemiology of Candida species. in, editor(s)Ashbee, HR. & Bignell, EM. , Handbook of Pathogenic Yeasts., Berlin Heidelberg, Springer Verlag, 2010, pp19 - 39, [Moran, G.P., McManus, B.A., Coleman, D.C. & D.J. Sullivan], Notes: [Chapter 2 e-ISBN 978-3-642-03150-2], Book Chapter, PUBLISHED
BA MCMANUS, E MCGOVERN, G MORAN, D SULLIVAN, J NUNN, P COSTIGAN, P FLEMING, C HEALY, DC COLEMAN., Retrospective Candida albicans population analysis in Irish APECED patients. , International Association of Dental Research-Irish Division, Dublin Dental University Hospital, Dublin, October 2010, Oral Presentation, PRESENTED
Brenda A. McManus, David C. Coleman, Emily C. Deasy, Gráinne I. Brennan, Brian O' Connell, Stefan Monecke, Ralf Ehricht, Bernadette Leggett, Anna C. Shore, Comparison of SCCmec, antimicrobial resistance genes and clonal lineages of Staphylococcus epidermidis and Staphylococcus haemolyticus from humans and companion animals, International Symposium on Staphylococci and Staphylococcal Infections, Chicago, IL, USA, 26th-29th August 201, Poster, PRESENTED
Peter M Kinnevey, Aoife M O'Connor, Phillipa Cashin, Peter Slickers, Ioannis N Polyzois, Michael O'Sullivan, Brenda A McManus, David C Coleman, Characterization of arginine catabolic mobile elements (ACME) in Staphylococcus epidermidis isolates from patients with healthy and diseased subgingival sites, periodontal pockets and dental implants, International Symposium on Staphylococci and Staphylococcal Infections, South Korea, August 2016, Poster, PRESENTED
Aoife O'Connor, Brenda McManus, Michael O'Sullivan, Ioannis Polyzois, David C. Coleman, Characterisation of Candida and staphylococcal populations recovered from subgingival sites of healthy and diseased teeth and dental implants, European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam, Holland, Arpil, 2016, Poster, PRESENTED

  

Research Interests

Description Of Research Interests

Brenda's interests mainly lie in clinically-based translational research, with particular regard to epidemiology, infection prevention and control, and antimicrobial resistance. Brenda is focused on identifying potential endogenous sources of infection such as periodontal tissues, the oro-nasal cavity or gastrointestinal tract. She is particularly interested in the application of whole genome sequence-based tools to such research, which primarily focuses on the microbial organisms Staphylococcus, Enterococcus and Candida.