Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Aisling Dunne

Associate Prof in Neuroinflammation (Biochemistry)

 aidunne@tcd.ie

 3531896 2437

Associate Prof in Neuroinflammation (Physiology)

 (3531896) 2437


Representations

Details Date
External PhD Examiner - NUI Maynooth 2015
External PhD Examiner - NUI Maynooth 2014
External PhD Examiner - University of Cambridge 2013

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Standing Committee Member: Irish Society of Immunology 2018 present
British Society of Immunology Member 2011
Vozza, E.G. and Kelly, A.M. and Daly, C.M. and O†Rourke, S.A. and Carlile, S.R. and Morris, B. and Dunne, A. and McLoughlin, R.M., Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis, Cell Death Discovery, 10, (1), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Vozza, E.G. and Daly, C.M. and O'Rourke, S.A. and Fitzgerald, H.K. and Dunne, A. and McLoughlin, R.M., Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival, mBio, 15, (1), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Shanley, L.C. and Mahon, O.R. and O'Rourke, S.A. and Neto, N.G.B. and Monaghan, M.G. and Kelly, D.J. and Dunne, A., Macrophage metabolic profile is altered by hydroxyapatite particle size, Acta Biomaterialia, 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Shanley, L.C. and Fitzgerald, H.K. and O†Rourke, S.A. and Dunne, A., Endogenous drivers of altered immune cell metabolism, Experimental Biology and Medicine, 247, (24), 2022, p2192-2200 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
O'Rourke SA, Neto NGB, Devilly E, Shanley LC, Fitzgerald HK, Monaghan MG*, Dunne A.*, Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages, Atherosclerosis, 352, 2022, p35 - 45, Journal Article, PUBLISHED  DOI
Nuno Neto, Sinead O'Rourke, Mimi Zhang, Hannah Fitzgerald, Aisling Dunne and Michael Monaghan, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, eLife, 11, 2022, pe77373 , Journal Article, PUBLISHED
Fitzgerald, H.K.; O'Rourke, S.A.; Desmond, E.; Neto, N.G.B.; Monaghan, M.G.; Tosetto, M.; Doherty, J.; Ryan, E.J.; Doherty, G.A.; Nolan, D.P.; Fletcher, J.M.; Dunne, A, The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells, Antioxidants, 11, 2022, p164-, Journal Article, PUBLISHED  DOI
Shanley, L.C. and Mahon, O.R. and Kelly, D.J. and Dunne, A., Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages, Acta Biomaterialia, 133, 2021, p208-221 , Notes: [cited By 6], Journal Article, PUBLISHED  TARA - Full Text  DOI
Campbell, N.K. and Fitzgerald, H.K. and Dunne, A., Regulation of inflammation by the antioxidant haem oxygenase 1, Nature Reviews Immunology, 21, (7), 2021, p411-425 , Notes: [cited By 219], Journal Article, PUBLISHED  DOI
Olwyn R. Mahon, David C. Brow, Tomas Gonzalez-Fernandez, Pierluca Pitaccoc, Ian T. Whelan, Stanislas Von E, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston. H. G. Mills , Daniel J. Kelly and Aisling Dunne, Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner, Biomaterials, 239, 2020, p119833-, Journal Article, PUBLISHED  TARA - Full Text  DOI
  

Page 1 of 7

  

Awards and Honours

Award Date
Trinity Innovation Awards 2018: 'Inventors' Category Nominee. This category recognized academics whose innovative research has led to commercial success. Dec 2018

Research Interests

Description Of Research Interests

In recent decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs), which are conserved microbial structures sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns (DAMPs). The sterile inflammation that ensues either resolves the initial insult or leads to disease. A key focus of my research has been to identify the mechanisms via which PAMPs and DAMPs activate specific host immune responses and to identify new strategies to treat inflammatory disease. Our work to date on novel PAMPs, for example from Bordetella pertussis (the causative agent of whooping cough), has implications for vaccine design. We have identified a vaccine candidate that acts both as an adjuvant (to boost innate immune responses) and as an antigen (to target the adaptive immune system). Antigens containing both of these properties have never before been described for B.pertussis. This work has been patent protected and we are taking steps to commercialise the products of this research. My work in the field of sterile inflammation has focused on DAMPs that are implicated in osteoarthritis (OA), atherosclerosis and neurodegenerative disease. In particular, my group has carried out a significant amount of work delineating the molecular and inflammatory pathways driven by OA disease-associated particulates. We have identified potential new therapeutic targets to treat OA-associated inflammation and have now extended our work to assess immune responses to orthopedic implant materials which can cause a form of sterile inflammation known as periprosthetic osteolysis. Furthermore, we are collaborating extensively with the Trinity Centre for Engineering and AMBER to assess immune responses to novel biomaterials which are intended to replace traditional biomaterials.