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Professor Andrew Bowie

Professor of Innate Immunology (Biochemistry)
Head of School (Sch Office - Biochemistry & Immunology)
      
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Professor Andrew Bowie

Professor of Innate Immunology (Biochemistry)

 agbowie@tcd.ie

 3531896 2435

Head of School (Sch Office - Biochemistry & Immunology)


Andrew Bowie obtained his PhD in Biochemistry from Trinity College Dublin in 1997. After postdoctoral training with Prof Luke O'Neill, he was appointed as lecturer in the Department of Pharmacology in UCD, before returning to TCD in 2001 to establish the first and only Immunology undergraduate degree course in Ireland, which he coordinated from 2002 - 2006. He served as Director of Research in the School of Biochemistry and Immunology from 2005 - 2009, and as Head of Immunology from 2011 - 2017. In 2008 he was elected a Fellow of TCD, and in 2014 a member of the Royal Irish Academy. He is actively involved in both undergraduate and postgraduate Immunology teaching, and has graduated 14 PhD students to date. His research discoveries and scholarly activities have significantly contributed to TCD's global reputation as a place of excellence for Immunology teaching and research and in 2017 he was awarded the Irish Society for Immunology Public Lecture Medal for his outstanding contribution to Irish Immunology. He is a global leader in the research fields of innate immunity and viral evasion, and his research occupies a unique space at the interface between virology, immunology and disease pathogenesis. He has raised research funding of >€9m (direct costs to PI) since 2001, from national and international funding agencies including Science Foundation Ireland, the EU and the US National Institutes of Health, and also from private industry. Work in his laboratory has shed light on how pattern recognition receptors (PRRs) recognise pathogens, leading to the induction of interferons and cytokines, which control infection locally as well as coordinating the adaptive immune response. He also investigates how PRRs and other innate immune sensors drive inflammation, and discovered one of the key cellular sensors of DNA in 2010, IFI16, which has subsequently been shown to be critical in understanding viral pathogenesis of diverse viruses including HIV and herpes viruses. He has recently identified novel roles for a number of innate immune proteins in regulating inflammation via cytokine modulation, and is currently exploring their mechanisms of action. His seminal discoveries have redefined our understanding of how pathogens engage with human cells, and he has regularly published research papers, opinion pieces and reviews in leading international journals including Nature Immunology, Immunity, The Journal of Experimental Medicine, Nature Reviews Immunology, PNAS, PLoS Pathogens and The EMBO Journal.
  Biochemistry   Cellular Biology   CYTOKINES   DNA SENSING   DNA transcription and translation   Eukaryotic gene regulation   Host, Pathogen interactions   Immune system   Immunology, Immunotherapy   Infectious diseases   Inflammation   Innate Immunity   INTERLEUKIN-1 SIGNAL TRANSDUCTION   Intra and intercellular signalling   Molecular Biology   NF-kappaB   PATTERN RECOGNITION RECEPTORS   Protein sequence, function and expression   Regulatory methods of gene expression   Signal Transduction   Toll-Like Receptors   Viral Evasion   Virology and viral pathogenesis   VIRUSES
Details Date From Date To
Royal Irish Academy 15 March 2014
The International Cytokine and Interferon Society
CampaniÒ«o, André and Baran, Marcin and Bowie, Andrew G. and Longley, Daniel B. and Harrison, Timothy and McGouran, Joanna F., Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling, Communications Chemistry, 8, (1), 2025, Notes: [Cited by: 0; All Open Access, Gold Open Access], Journal Article, PUBLISHED  DOI
Shanahan KA, Davis GM, Doran CG, Sugisawa R, Davey GP, Bowie AG., SARM1 regulates NAD+-linked metabolism and select immune genes in macrophages., The Journal of Biological Chemistry, 300, (2), 2024, p105620 , Journal Article, PUBLISHED  DOI
Gewaid H, Bowie AG., Regulation of type I and type III interferon induction in response to pathogen sensing., Current opinion in immunology, 87, 2024, p102424 , Journal Article, PUBLISHED  DOI
Ryoichi Sugisawa, Katharine A. Shanahan, Gavin M. Davis, Gavin P. Davey, Andrew Bowie, SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms, iScience, 27, (6), 2024, p109940 , Journal Article, PUBLISHED  DOI
Joanna L. Turley, Ross W. Ward, Jorge Huete-Carrasco, Natalia Muñoz-Wolf, Kate Roche, Lei Jin, Andrew Bowie, Mats Andersson, Ed Lavelle, Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity, Cell Reports Medicine, 5, (5), 2024, p101560 , Journal Article, PUBLISHED
Huang, Y. and Bergant, V. and Grass, V. and Emslander, Q. and Hamad, M.S. and Hubel, P. and Mergner, J. and Piras, A. and Krey, K. and Henrici, A. and Ã-llinger, R. and Tesfamariam, Y.M. and Dalla Rosa, I. and Bunse, T. and Sutter, G. and Ebert, G. and Schmidt, F.I. and Way, M. and Rad, R. and Bowie, A.G. and Protzer, U. and Pichlmair, A., Multi-omics characterization of the monkeypox virus infection, Nature Communications, 15, (1), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Martiáñez-Vendrell, X. and Bloeme-ter Horst, J. and Hutchinson, R. and Guy, C. and Bowie, A.G. and Kikkert, M., Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E, Viruses, 16, (6), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Al Hamrashdi, M. and Perez, C.S. and Haas, D.A. and Vishwakarma, J. and Pichlmair, A. and Bowie, A.G. and Brady, G., Molluscum contagiosum virus protein MC089 inhibits interferon regulatory factor 3 activation, Journal of General Virology, 105, (8), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Muñoz-Wolf, N. and Ward, R.W. and Hearnden, C.H. and Sharp, F.A. and Geoghegan, J. and O'Grady, K. and McEntee, C.P. and Shanahan, K.A. and Guy, C. and Bowie, A.G. and Campbell, M. and Roces, C.B. and Anderluzzi, G. and Webb, C. and Perrie, Y. and Creagh, E. and Lavelle, E.C., Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles, Cell Reports Medicine, 4, (1), 2023, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Phelan, T. and Lawler, C. and Pichlmair, A. and Little, M.A. and Bowie, A.G. and Brady, G., Molluscum Contagiosum Virus Protein MC008 Targets NF-kB Activation by Inhibiting Ubiquitination of NEMO, Journal of Virology, 97, (3), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
  

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Bowie, A.G., Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2, Biochemistry Society Transactions, 36, (3), 2008, pp449-452 , Notes: [PMID: 18481979], Conference Paper, PUBLISHED
M. Schröder and A. G. Bowie, An arms race: Innate anti-viral responses and counter-acting viral strategies., Biochemistry Society Transactions, Biochemistry Society Transactions, 35, (6), 2007, pp1512-1514 , Notes: [PMID: 18031256], Conference Paper, PUBLISHED
Bowie, A. and O'Neill, L.A.J., Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp125S , Notes: [PMID: 9057023], Conference Paper, PUBLISHED
Bowie, A. and O'Neill, L.A.J., Vitamin C inhibits NF kappa B activation in endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp131S. , Notes: [PMID: 9057029], Conference Paper, PUBLISHED
A. Bowie, P. N. Moynagh and L. A. O'Neill, Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells, 24, (1), 1996, pp2S , Notes: [PMID: 8674662], Conference Paper, PUBLISHED
A. Bowie, P. N. Moynagh and L. A. O'Neill, The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1, 23, (1), 1995, pp109S , Notes: [PMID: 7758669], Conference Paper, PUBLISHED
Brennan, P., Bowie, A. and O'Neill, L.A.J., The Effect of Thiol Modifiers on the Activation of NF kappa B by Interleukin-1., 21, (4), 1993, pp390S , Notes: [PMID: 8131967], Conference Paper, PUBLISHED

  


Award Date
Highly cited researcher (Clarivate, top 1% by citations) 2018
Irish Society for Immunology Public Lecture Award Medal 2017
Elected to the Royal Irish Academy 2014
Elected Fellow of TCD 2008
Sheldon Wolff Prize in Cytokine Research 1999
Placed first in class (B.A. (Mod)). 1993
My research focuses on innate immune sensing and signalling mechanisms, and their modulation by viruses. We are looking at how viruses are sensed by, and subvert and evade, pattern recognition receptor (PRR) signalling pathways, such Toll-like receptors (TLRs), RIG-I-like receptors (RLRs) and cytosolic DNA sensors. We discovered that the PYHIN protein IFI16 is a cytosolic DNA sensor, and current work examines mechanisms whereby IFI16, and other PYHIN proteins act not only as nucleic acid sensors, but also as direct viral restriction factors and regulators of host innate immune gene promoters. We also investigate how PRRs and other innate immune sensors drive inflammation through the recognition of nucleic acid such as mislocalised self-DNA.