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Professor Brian Mc Murry

Fellow Emeritus (Chemistry)
CHEMISTRY BUILDING


  (+/-)-PENTALENIC ACID   (2-CHLOROETHYL)NITROSOUREAS   1,3-DICARBONYL COMPOUNDS   1,4-DIAZABICYCLO<2.2.2>OCTANE   2+2 PHOTOCYCLOADDITION   2-CYCLOHEXENONE   2-PYRIDINONE DERIVATIVES   3-METHYLADENINE DNA GLYCOSYLASE   4-HYDROXYCINNAMAMIDE DERIVATIVES   5-FLUOROURACIL   9-ALKOXYPURINES   ABSORPTION   ACID DERIVATIVES   ACYCLIC NUCLEOSIDES   AGENTS   ALKYLATING-AGENTS   ALKYLTRANSFERASE   ALPHA,BETA-UNSATURATED KETONES   AMIDE CONFORMERS   ANALOGS   ATASE   BREAST   CALCIUM-CHANNEL   CELL-LINES   CHLOROETHYLNITROSOUREA   CLEAVAGE   COLON   CROSS-LINK   DACARBAZINE   DERIVATIVES   DNA-DAMAGE   DOUBLE MICHAEL REACTION   ETHERS   FACILE   HERPES-SIMPLEX VIRUS   HETEROCYCLIC ENAMINES   HUMAN-TUMOR-CELLS   HYPOIODITE   INACTIVATION   INHIBITORS   ISOMERS   LUNG-TUMORS   MALIGNANT-MELANOMA   MALONONITRILE   MAMMALIAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE   MECHANISM   METHYLATING AGENTS   METHYLENE-COMPOUNDS   MGMT   MICE   MOLECULES   N-ISOPROPYLIDENEHYDRAZINOCARBONYL DERIVATIVES   NITROSOUREA   NMR   NUCLEAR MAGNETIC-RESONANCE   O-6-METHYLGUANINE   PHOTOADDITIONS   PHOTOCHEMISTRY   POTENT   PSEUDOSUBSTRATES   PURINE   PYRANO<2,3-D>PYRIMIDINE   RAT   REAGENTS   REGIOCHEMICAL CONTROL   REPAIR   RESIDUES   REVERSE-TRANSCRIPTASE INHIBITORS   SUBSTITUTED CYCLIC ENONES   SUBSTITUTED ETHYLENES   SYSTEMS   THEORETICAL APPROACH   THERAPEUTIC INDEX   TYROSINE   TYROSINE KINASE   TYRPHOSTINS   VIRUS
Sergio Lopez, Geoffrey P. Margison, R. Stanley McElhinney, Alessandra Cordeiro, T. Brian H. McMurry, Isabel Rozas, Towards more specific O6-Methylguanine-DNA methyltransferase (MGMT) inactivators, Bioorganic & Medicinal Chemistry, 19, (5), 2011, p1658 - 1665, Journal Article, PUBLISHED  TARA - Full Text
T.Brian H. McMurry , ,, DNA Repair ., 6, 2007, p1161 - 1169, Notes: [ Full title: MGMT inhibitors-The Trinity College-Paterson Institute experience; a chemist's perception], Journal Article, PUBLISHED
M. Ranson, M.R. Middleton, J. Bridgewater, S.M. Lee, M. Dawson, D. Jowle, G.Halbert, S. Waller, H. McGrath, L. Gumbril, R.S. McElhinney, T.B.H. McMurry, and G.P. Margison, Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors, Clinical Cancer Research, 12, 2006, p1577 - 1584, Journal Article, PUBLISHED
T.Shibata, N. Glynn, T B.H.McMurry, R.S.McElhinney, G.P.Margison and DM.Williams., 'Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT), Nucleic Acid Research, 34, 2006, p1884 - 1891, Journal Article, PUBLISHED
J.E.McCormick, R.S.McElhinney, T.B.H.McMurry. and J.E.O'Brien, N,N'-Transphthaloylyation in a mono-protected diamine, Synthesis, 2005, p983 - 988, Journal Article, PUBLISHED
VM.Clemons, J.Kelly, A.J.Watson, A.Howell, R.S.McElhinney, T.B.H.McMurry, and G.P.Margison, O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenographs, British Journal of Cancer, 93, 2005, p1152 - 1156, Journal Article, PUBLISHED
M.K.Seery, S.M.Draper, J.M.Kelly, T.McCabe, and T.B.H.McMurry, The Synthesis, Structural Characterization, and Photochemistry of some 3-Phenylindenones, Synthesis, 2005, p470 - 474, Journal Article, PUBLISHED
Michael K. Seery, Sylvia M. Draper, John M. Kelly, Thomas McCabe, Brian T.H. McMurry, The synthesis, structural characterization and photochemistry of some 3-phenylindenones, Synthesis, 3, 2005, p470 - 474, Journal Article, PUBLISHED  DOI
V.A.Barvaux, P.Lorigan, M.Ranson, A.M.Gillum, R.S.McElhinney, T.B.H.McMurry, and G.P.Margison, Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA-alkyltransferase, Mol. Cancer Ther., 3, 2004, p1215 - 1220, Journal Article, PUBLISHED
V.A.Barvaux, M.Ranson, R.Brown, R.S.McElhinney, T.B.H.McMurry, and G.P.Margison, Dual repair modulation reverses temozolomide resistance in vitro, Mol. Cancer Ther., 3, 2004, p123 - 123, Journal Article, PUBLISHED
  

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