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Dr. Nigel John Stevenson

Assistant Professor in Immunology (Biochemistry)


  ANTIVIRAL ACTIVITY   CELL SIGNALLING   HEPATITIS B   HEPATITIS C   HIV   IMMUNOLOGY   Innate immunology   INTERFERON ALPHA
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Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight à , Stevenson NJ., Control of HIV infection by IFN-alpha: implications for latency and a cure., Cellular and molecular life sciences : CMLS, 75, (5), 2018, p775-783 , Review Article, PUBLISHED  DOI
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764, Journal Article, PUBLISHED  DOI
Raftery N and Stevenson NJ, Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway., Cellular and Molecular Life Sciences, 74, (14), 2017, p2525-2535 , Review Article, PUBLISHED  DOI
Mahony R, Ahmed S, Diskin C, Stevenson NJ, SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?, Cellular and Molecular Life Sciences, 73, (17), 2016, p3323 - 3336, Review Article, PUBLISHED
Murray C1, Griffin ÉW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A, Cunningham C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C., Brain, Behaviour and Immunity,, 48, 2015, p274 - 286, Journal Article, PUBLISHED  TARA - Full Text  URL
Lui PY, Jin DY, Stevenson NJ., MicroRNA: master controllers of intracellular signaling pathways., Cellular and Molecular Life Sciences, 72, (18), 2015, p3531 - 3542, Review Article, PUBLISHED  URL
HCV Immune Evasion in, Hepatitis C Virus: Molecular Pathways and Treatments, OMICS group, 2014, [Napoletano S, Bannan C, Bergin C and Stevenson NJ], Notes: [http://esciencecentral.org/ebooks/hepatitis/hcv-immune-evasion.php], Book Chapter, PUBLISHED  DOI
Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-, Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Kelly A, Fahey R, Keogh C, Stevenson NJ, CarrollA , Siddachari R, Geoghegan J, Hegarty JE, Ryan EJ, O'Farrelly C, Cd141+ (bdca-3+) interferon lambda (ifn-λ)-producing dendritic cells are depleted in hepatitis C virus-infected liver, Immunology, 2011, 135, 2011, pp111 , Conference Paper, PUBLISHED
Stevenson NJ, Ryan EJ, Keogh CA, Lloyd AT, Cormican P, Hegarty JE, O'Farrelly C. , Hepatitis C virus (HCV) regulates signal transducer and activator of transcription (STAT) protein expression to escape interferon-alpha (IFN-alpha) responses. , Immunology, 125, (1), 2008, pp71 , Conference Paper, PUBLISHED
Armstrong MA, McClurg AE, Stevenson NJ, Hawkins SA, Johnston JA. , Timing of exposure to interferon beta can alter conventional dendritic cell precursor cell differentiation by upregulating IKBzeta and downregulating NFkB2/p52. , Immunology, 120, (1), 2007, pp36 , Conference Paper, PUBLISHED
Stevenson NJ, Addely M, Greaves D, Johnston J. , Chemokines regulate innate immunity and chemotaxis through Suppressor Of Cytokine Signalling (SOCS) proteins., Clinical Immunology, 2006, ppS127 , Conference Paper, PUBLISHED
Stevenson NJ, Haan S, McClurg A, Armstrong MA, Heinrich P, Johnston JA. , The chemoattractants IL-8 and fMLP regulate G-CSF signalling by inducing suppressor of cytokine signalling (SOCS)-1 expression., Immunology, 116, (1), 2005, pp73 , Conference Paper, PUBLISHED
Stevenson NJ, Haan S, McClurg AE, McGrattan MJ, Armstrong MA, Heinrich PC, JA Johnston, The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine, Journal of Immunology, 173, (5), 2004, pp3243 - 3249, Conference Paper, PUBLISHED