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McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022,
Notes: [10.1016/j.bmcl.2022.128545 ],
Journal Article,
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TARA - Full Text
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Introduction to Aromatic Chemistry in, editor(s)Chris Rostron, Jill Barber , Pharmaceutical Chemistry, Second Edition, Oxford University Press, 2021, pp208 - 243, [Mike Southern],
Book Chapter,
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Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism, Chemical communications, 56, 2020, p3915 - 3918,
Journal Article,
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S.J. Connon and J.M. Southern, 'Substituted Pyrimidine Derivatives useful in the Treatment of Autoimmune Diseases', Rouse, WO2016050804 (A1), 2020,
Patent,
GRANTED
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Mangan D., Mcnabola N., Clark E.H., Bermudez I., Wonnacott S., Southern J.M., Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues, Organic and Biomolecular Chemistry, 17, (46), 2019, p9892 - 9905,
Journal Article,
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Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP. , In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acid Research, 45, (4), 2017, p2029 - 2039,
Journal Article,
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David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott and J. Mike Southern, A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties, Organic and Biomolecular Chemistry, 14, 2016, p10787 - 10798,
Journal Article,
PUBLISHED
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Neasa McNabola, Cornelius J. O'Connor, Mark D. Roydhouse, Michael D. Wall, J. Mike Southern, A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes, Tetrahedron, 71, (28), 2015, p4598 - 4603,
Journal Article,
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O'Connor, CJ, Roydhouse, MD, Przybyl, AM, Wall, MD, Southern, JM, Facile Synthesis of 3-Nitro-2-substituted Thiophenes, JOURNAL OF ORGANIC CHEMISTRY, 75, (8), 2010, p2534-2538 ,
Journal Article,
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Southern, J. Mike; O'Neil, Ian A.; Kearns, Peter, A concise synthesis of highly functionalised 4-thiosugar derivatives, Synlett, 14, 2008, p2158 - 2160,
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