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Dr. Stephen Smith

Associate Professor (Clinical Microbiology)

  Antibiotics   Biological Markers   Brain   Cell Communication   Diagnostics   Digestive System   DNA   E.coli   Eschericia coli   Extracellular Matrix   Gastrointestinal Diseases/Disorders   Gene Expression   Gene Regulation   Genetically Modified Organisms   Genomes, Genomics   Infectious Diseases   Infectious Diseases/Agents   Meningitis   Microbial Biotechnology, Microbial Modelling   Molecular Biology   Molecular Genetics   Nucleic Acids   Pathogenesis   Proteins and Macromolecules   Proteomics   Recombinant DNA   Respiratory System   Salmonella   Urogenital System
 High throughput analysis of enterobacterial invasion
 E. coli sepsis; better treatment options using genomics
 E. coli sepsis; better treatment options using genomics

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Basic Basic Basic
Details Date From Date To
Member Society for General Microbiology UK
Member American Society for Microbiology
Miche􏰀al Mac Aog􏰀ain, Helen Miajlovic, Geraldine Moloney, Sanjay H. Chotirmall, Thomas R. Rogers and Stephen G. J. Smith, Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection, JMM Case Reports, 3, 2016, p1 - 4, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Helen Miajlovic, Micheál Mac Aogáin, Cathal J. Collins, Thomas R. Rogers, Stephen G. J. Smith, Characterization of Escherichia coli bloodstream isolates associated with mortality, Journal of Medical Microbiology, 65, (1), 2016, p71-79 , Journal Article, PUBLISHED  URL
R. D. Moriarty, A. Cox, M. McCall, S. G. J. Smith, D. Cox1, Escherichia coli induces platelet aggregation in an FcγRIIa-dependent manner, Journal of Thrombosis and Haemostasis, 14, 2016, p1 - 10, Journal Article, PUBLISHED  URL
C.M. Murphy, S. Paré, G. Galea, J.C. Simpson, S.G.J. Smith ,, Accurate and semi-automated analysis of bacterial association with mammalian cells, Journal of Microbiological Methods, 122, 2016, p8 - 12, Journal Article, PUBLISHED  URL
miR-CATCH: MicroRNA Capture Affinity Technology in, editor(s)Mouldy Sioud , RNA Interference: Challenges and Therapeutic Opportunities, Methods in Molecular Biology,, Springer, 2015, pp365 - 373, [Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen G.J. Smith, Catherine M. Greene], Book Chapter, PUBLISHED
Miajlovic H, Cooke NM, Moran GP, Rogers TR, Smith SG., Response of Extraintestinal Pathogenic Escherichia coli to Human Serum Reveals a Protective Role for Rcs-Regulated Exopolysaccharide Colanic Acid., Infect Immun, 2014, p298 - 205, Journal Article, PUBLISHED  TARA - Full Text
Miajlovic H, Smith SG., Bacterial self-defence: how Escherichia coli evades serum killing., FEMS Microbiol Lett., 354, 2014, p1 - 9, Journal Article, PUBLISHED  TARA - Full Text
Pares S, Smith SG, Functional Analysis of the PagN protein of Salmonella enterica , American Society for Microbiology, Boston, 16/05/2014, 2014, Poster, PUBLISHED
Hassan T, Smith SG, Gaughan K, Oglesby IK, O'Neill S, McElvaney NG, Greene CM., Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique., Nucleic Acids Research, 41, (6), 2013, pe71 , Journal Article, PUBLISHED  TARA - Full Text
Sanjay H. Chotirmall, Stephen G. Smith, Cedric Gunaratnam, Sonya Cosgrove, Borislav D. Dimitrov, Shane J. O'Neill, Brian J. Harvey, Catherine M. Greene, Noel G. McElvaney, , Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis, The New England Journal of Medicine, 366, 2012, p1978 - 1986, Journal Article, PUBLISHED

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Microbial Recognition by Epithelium in, editor(s)David Proud , The Pulmonary Epithelium in Health and Disease, John Wiley & Sons, Ltd, 2008, pp169 - 185, [CM. Greene, S.G. J. Smith], Book Chapter, PUBLISHED
Dorman CJ, Stereotypic and stochastic issues in bacterial virulence gene expression, Eighth European Workshop Conference on Bacterial Protein Toxins, Kloster Banz, Germany, 1997, Invited Talk, PRESENTED


My laboratory investigates how gram-negative bacteria, in particular E. coli and Salmonella, attach to and invade human cells. We are currently using Cellomics-based approaches to more accurately quantify bacterial invasion. This methodology also generates information on the kinetics of invasion and the cellular location of the invading bacteria. We are also interested in the gene regulatory mechanisms that govern attachment by E. coli e.g. the Rns virulence regulator.Invasion of cellular barriers by bacteria can be a prelude to entrance into the bloodstream. We are using transcriptomics to identify genes in E. coli that are regulated in response to human serum and its anti-bacterial components. More recently, and in collaboration with the Royal College of Surgeons in Ireland, we have shown that human estrogen can modulate the virulence of Pseudomonas aeruginosa.