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Dr. Stephen Smith

Associate Professor (Clinical Microbiology)
SIR PATRICK DUN LAB


  Antibiotics   Biological Markers   Brain   Cell Communication   Diagnostics   Digestive System   DNA   E.coli   Eschericia coli   Extracellular Matrix   Gastrointestinal Diseases/Disorders   Gene Expression   Gene Regulation   Genetically Modified Organisms   Genomes, Genomics   Infectious Diseases   Infectious Diseases/Agents   Meningitis   Microbial Biotechnology, Microbial Modelling   Molecular Biology   Molecular Genetics   Nucleic Acids   Pathogenesis   Proteins and Macromolecules   Proteomics   Recombinant DNA   Respiratory System   Salmonella   Urogenital System
 High throughput analysis of enterobacterial invasion
 E. coli sepsis; better treatment options using genomics
 E. coli sepsis; better treatment options using genomics

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Basic Basic Basic
Details Date From Date To
Member Society for General Microbiology UK
Member American Society for Microbiology
miR-CATCH: MicroRNA Capture Affinity Technology in, editor(s)Mouldy Sioud , RNA Interference: Challenges and Therapeutic Opportunities, Methods in Molecular Biology,, Springer, 2014, [Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen G.J. Smith, Catherine M. Greene], Book Chapter, PUBLISHED
Miajlovic H, Cooke NM, Moran GP, Rogers TR, Smith SG., Response of Extraintestinal Pathogenic Escherichia coli to Human Serum Reveals a Protective Role for Rcs-Regulated Exopolysaccharide Colanic Acid., Infect Immun, 2014, p298 - 205, Journal Article, PUBLISHED
Miajlovic H, Smith SG., Bacterial self-defence: how Escherichia coli evades serum killing., FEMS Microbiol Lett., 354, 2014, p1 - 9, Journal Article, PUBLISHED
Hassan T, Smith SG, Gaughan K, Oglesby IK, O'Neill S, McElvaney NG, Greene CM., Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique., Nucleic Acids Research, 41, (6), 2013, pe71 , Journal Article, PUBLISHED
Sanjay H. Chotirmall, Stephen G. Smith, Cedric Gunaratnam, Sonya Cosgrove, Borislav D. Dimitrov, Shane J. O'Neill, Brian J. Harvey, Catherine M. Greene, Noel G. McElvaney, , Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis, The New England Journal of Medicine, 366, 2012, p1978 - 1986, Journal Article, PUBLISHED
Vivienne Mahon, Robert P. Fagan, Stephen G.J. Smith, Snap denaturation reveals dimerization by AraC-like protein Rn, Biochimie, 94, 2012, p2058 - 2061, Journal Article, PUBLISHED
Rowe SE, Mahon V, Smith SG, O'Gara JP, A novel role for SarX in Staphylococcus epidermidis biofilm regulation, Microbiology, 157, (4), 2011, p1042 - 1049, Journal Article, PUBLISHED
15. Chotirmall SH, Smith SG, Gunaratnam C, Cosgrove S, Dimitrov BD, O'Neill SJ, Harvey BJ, Greene CM, McElvaney NG. , Estrogen Induces Mucoid Conversion of Pseudomonas aeruginosa and Promotes Infective Exacerbations in Females with Cystic Fibrosis. , Irish Journal of Medical Science , 180, 2011, p453 - 454, Journal Article, PUBLISHED
Cooke NM, Smith SG, Kelleher M, Rogers TR., Major differences exist in frequencies of virulence factors and multidrug resistance between community and nosocomial Escherichia coli bloodstream isolates., Journal of Clinical Microbiology, 48, 2010, p1099 - 1114, Journal Article, PUBLISHED
Emer P. Reeves, Michael Williamson, Barry Byrne, David A. Bergin, Stephen G. J. Smith, Peter Greally, Richard O'Kennedy, Shane J. O'Neill, and Noel G. McElvaney, IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis, J. Immunol, 184, 2010, p1642 - 1652, Journal Article, PUBLISHED
  

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Microbial Recognition by Epithelium in, editor(s)David Proud , The Pulmonary Epithelium in Health and Disease, John Wiley & Sons, Ltd, 2008, pp169 - 185, [CM. Greene, S.G. J. Smith], Book Chapter, PUBLISHED
Dorman CJ, Stereotypic and stochastic issues in bacterial virulence gene expression, Eighth European Workshop Conference on Bacterial Protein Toxins, Kloster Banz, Germany, 1997, Invited Talk, PUBLISHED

  

My laboratory investigates how gram-negative bacteria, in particular E. coli and Salmonella, attach to and invade human cells. We are currently using Cellomics-based approaches to more accurately quantify bacterial invasion. This methodology also generates information on the kinetics of invasion and the cellular location of the invading bacteria. We are also interested in the gene regulatory mechanisms that govern attachment by E. coli e.g. the Rns virulence regulator.Invasion of cellular barriers by bacteria can be a prelude to entrance into the bloodstream. We are using transcriptomics to identify genes in E. coli that are regulated in response to human serum and its anti-bacterial components. More recently, and in collaboration with the Royal College of Surgeons in Ireland, we have shown that human estrogen can modulate the virulence of Pseudomonas aeruginosa.