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Professor Mathias Senge

Chair of Organic Chemistry (Chemistry)

Prof. Senge was born in Silbach, Germany in 1961. After service in the Air Force he studied chemistry in Freiburg, Amherst, Marburg, and Lincoln and graduated from the Philipps Universität Marburg in 1986. After a Ph.D. thesis in plant biochemistry with Prof. Horst Senger in Marburg (1989) and a postdoctoral fellowship with Prof. Kevin M. Smith at UC Davis, he moved to the Freie Universität Berlin and received his habilitation in Organic Chemistry in 1996. From 1996 on he was a Heisenberg fellow at the Freie Universität Berlin and UC Davis and held visiting professorships at Greifswald and Potsdam. In 2002 he was appointed Professor of Organic Chemistry at the Universität Potsdam and since 2005 holds the Chair of Organic Chemistry at Trinity College Dublin. He was the recipient of fellowships from the Studienstiftung des Deutschen Volkes and the Deutsche Forschungsgemeinschaft; recently he was named a Science Foundation Ireland Research Professor. His main interests are the chemistry and biochemistry of tetrapyrroles, photobiology, crystallography, and medicinal and bioorganic chemistry.
  Biochemistry, metabolism   Biomedical sciences   Biomolecules, Bioplastics, Biopolymers   Biopharmaceutical aspects of drug delivery systems   Bioreactors   Catalysis   Chemical Biology   Chemistry and Health   Conformational analysis of molecules   Crystal engineering   Crystallography   Design and synthesis of drugs   Development of drugs for malaria, Cancer and inflammatory diseases   Development, prevention and treatment of mental disease or disorder   Drug development   Drug development and evaluation   Drug discovery   Enzymology and catalysis   Fine chemicals, dyes and inks   Hetrocyclic chemistry   Hydrogen bonding   Malaria   Medicinal Chemistry   Molecular electronics   Neurochemistry and neuropharmacology   New materials, supramolecular structures   Oesophageal cancer   Optical materials   Organic chemistry   Organometallic chemistry   Orphan drugs   Pharmacologically active heterocycles   Photobiology   Photochemistry and photophysics   Photodynamic Cancer Therapy   Photodynamic Therapy   Photomedicine   Photonic Networks   Photosynthesis   Photovoltaic systems, cells and modules manufacturing   Plant Biochemistry   Plant physiology   Porphyrin Chemistry   Pro drug systems   Protein chemistry, structure and folding   Radiotherapy, Biological response modifiers and chemoprevention   Recognition and targeting   Schizophrenia   Solid state chemistry   Synthesis and new molecules
 Tetrapyrroles in Biology, Chemistry, and Medicine

Details Date
Over 140 invited presentations at universities, research centers and international scientific meetings.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Details Date From Date To
ACS, American Chemical Society
ASP, American Society for Photobiology
ESP, European Society for Photobiology
EPA, European Photochemical Association
EPPM, European Platform of Photomedicine and Photodiagnosis (2008-
GDCh, Gesellschaft Deutscher Chemiker
SPP, Society for Porphyrins and Phthalocyanines, National Representative of the Republic of Ireland 2009-
Reviewer for Journals: Acta Crystallographica; Angewandte Chemie; Australian Journal of Chemistry; Beilstein Journal of Organic Chemistry; Bioconjugate Chemistry; Bioorganic Medicinal Chemistry; Bioorganic Medicinal Chemistry Letters; Bulletin of the Chemical Society of Japan; ChemBioChem; Chemical Communications; Chemical Physics Letters; Chemische Berichte; Chemistry an Asian Journal; Chemistry a European Journal; Coordination Chemistry Reviews; CrystEngComm; European Journal of Inorganic Chemistry; European Journal of Organic Chemistry; Inorganic Chemistry; Inorganic Chimica Acta; Journal of the Chemical Society: Dalton Transactions, Perkin Transactions 1, Perkin Transactions 2; Journal of Catalysis; Journal of Molecular Structure; Journal of Photochemistry and Photobiology, A:Chemistry; Journal of Photochemistry and Photobiology, B:Biology; Journal of Porphyrins and Phthalocyanines; Journal of Physical Chemistry B; Journal of Physical Chemistry; Journal of Physical Organic Chemistry; Letters in Organic Chemistry; Macroheterocycles; Medicinal Chemistry Communications; Mendeleev Communications; Molecules; Monatshefte Chemie; Nature Chemistry; New Journal of Chemistry; Organic & Biomolecular Chemistry; Organic Letters; Photochemical & Photobiological Sciences; Photochemistry and Photobiology; Photosynthesis Research; Physical Chemistry Chemical Physics; Physiologia Plantarum; Pure and Applied Chemistry; Synlett; Synthesis; Targets in Heterocyclic Chemistry; Tetrahedron; Tetrahedron Letters; The Journal of Organic Chemistry
Reviewer for grants: AvH, Alexander von Humboldt-Stiftung, Germany; PRF, American Chemical Society: The Petroleum Research Fund, USA; DFG, Deutsche Forschungsgemeinschaft, Germany; FCT, Fundacao para a Ciencia e a Tecnologia, Portuegese Science Fund, Portugal; GIF, German Israeli Funds, Israel; Marsden Fund, New Zealand; NSF, National Science Foundation, USA; NIH/ADAMHA Peer Review Consultant, USA; Research Council of Lithuania; South African Foundation for Research, South Africa; FWF, Austrian Science Fund: Lise-Meitner fellowships and regular research grants; The Wellcome Trust: research grants, UK.
HIST, Division of History, ACS
Current developments in using meso-(Tetra)substituted porphyrins for PDT in, editor(s)Pandey, R. K.; Kessel, D.; Dougherty, T. J. , Handbook of Photodynamic Therapy: Updates on Recent Applications of Porphyrin-Based Compounds, Singapore, World Scientific,, 2016, pp95-149 , [Shaker, Y. M.; Sweed, A. M. K.; Moylan, C.; Rogers, L.; Ryan, A. A.; Petitdemange, R.; Senge, M. O. ], Book Chapter, PUBLISHED  TARA - Full Text
De Souza T.G.B, Vivas M.G, Mendonça C.R, Plunkett S, Filatov M.A, Senge M.O, De Boni L, Studying the intersystem crossing rate and triplet quantum yield of meso-substituted porphyrins by means of pulse train fluorescence technique, Journal of Porphyrins and Phthalocyanines, 20, (1-4), 2016, p282 - 291, Notes: [Cited By :1 Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Schindler J, Kupfer S, Zedler L, WÀchtler M, GrÀfe S, Ryan A.A, Senge M.O, Dietzek B, Spectroelectrochemical Investigation of the One-Electron Reduction of Nonplanar Nickel(II) Porphyrins, ChemPhysChem, 17, (21), 2016, p3480 - 3493, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  DOI  URL
Senge M.O, Flanagan K.J, Ryan A.A, Ryppa C, Donath M, Twamley B, Conformational and structural studies of meso monosubstituted metalloporphyrins - Edge-on molecular interactions of porphyrins in crystals, Tetrahedron, 72, (1), 2016, p105 - 115, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Gutsche C.S, Ortwerth M, GrÀfe S, Flanagan K.J, Senge M.O, Reissig H.-U, Kulak N, Wiehe A, Nucleophilic Aromatic Substitution on Pentafluorophenyl-Substituted Dipyrranes and Tetrapyrroles as a Route to Multifunctionalized Chromophores for Potential Application in Photodynamic Therapy, Chemistry - A European Journal, 22, (39), 2016, p13953 - 13964, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
MacGowan S.A, Senge M.O, Contribution of bacteriochlorophyll conformation to the distribution of site-energies in the FMO protein, Biochimica et Biophysica Acta - Bioenergetics, 1857, (4), 2016, p427 - 442, Notes: [Cited By :4 Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Malara D, Mielke C, Oelgemöller M, Senge M.O, Heimann K, Sustainable water treatment in aquaculture - photolysis and photodynamic therapy for the inactivation of Vibrio species, Aquaculture Research, 2016, Notes: [Export Date: 8 December 2016 Article in Press], Journal Article, IN_PRESS  DOI  URL
Duggan S.P, Behan F.M, Kirca M, Zaheer A, McGarrigle S.A, Reynolds J.V, Vaz G.M.F, Senge M.O, Kelleher D, The characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival, Scientific Reports, 6, 2016, p32638 -, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Moylan C, Rogers L, Shaker Y.M, Davis M, Eckhardt H.-G, Eckert R, Ryan A.A, Senge M.O, Preparation of Tri- and Hexasubstituted Triptycene Synthons by Transition Metal Catalyzed Cross-Coupling Reactions for Post-Modifications, European Journal of Organic Chemistry, 2016, (1), 2016, p185 - 195, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Calatrava-Pérez E, Bright S.A, Achermann S, Moylan C, Senge M.O, Veale E.B, Williams D.C, Gunnlaugsson T, Scanlan E.M, Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes', Chemical Communications, 52, (89), 2016, p13086 - 13089, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL

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Senge, MO, INOR 321-Hydroporphyrins as conformationally designed tetrapyrrole receptors , Abstract of papers of the American Chemical Society, 236, 2008, pp321-INOR , Meeting Abstract, PUBLISHED
M. O. Senge, Synthetic Strategies for Porphyrin-based Photosensitizers, Photodiag. Photodyn. Ther. , EPPM-1, 1st Conference of the European Platform of Photomedicine, Dubrovnik, Coratia, 25.3.-27.3.2008, 5, 2008, pp63 - 64, Meeting Abstract, PUBLISHED
Mathias O. Senge, Review of Primary Processes of Photosynthesis, by G. Renger , Angew. Chem. Int. Ed., 47, 2008, p6944-6945 , Review, PUBLISHED
M. O. Senge, Review of Antimalarial Chemotheraphy, by P. J. Rosenthal (ed.) , ChemBioChem, 3, 2002, p261 , Review, PUBLISHED
Chlorophyll a, L. Roth, G. Rupp (eds.), Roth Collection of Natural Products Data, Weinheim, VCH, 1994, pp8 , [M. O. Senge], Item in dictionary or encyclopaedia, etc, PUBLISHED
Chlorophyll b, L. Roth, G. Rupp (eds.), Roth Collection of Natural Products Data, Weinheim, VCH, 1994, pp8 , [M. O. Senge], Item in dictionary or encyclopaedia, etc, PUBLISHED
Gerzevske, K. R.; Senge, M. O.; Vicente, M. G. H.; Forsyth, T. P.; Smith, K. M. , Models for the Photosynthetic Reaction Center - Synthesis and Structure of cis- and trans-ethene bridged porphyrin dimers, Biol. Chem. Hoppe-Seyler, 374, 1993, pp740 , Meeting Abstract, PUBLISHED
Senge, M. O.; Ruhlnadt-Senge, K.; Smith, K. M. , Aggregation of 2,3-Dihydroxyetiochlorin I - A Model Compound for Photodynamic Therapy and Green Heme d, Biol. Chem. Hoppe-Seyler, 374, 1993, pp787 , Meeting Abstract, PUBLISHED
Shelnutt, J. A.; Medforth, C. J.; Senge, M. O.; Smith, K. M. , Molecular design of highly substituted metalloporphyrins for alkane oxidation and CO2 oxidation, Abstracts of Papers of the American Chemical Society, 203, 1992, ppINOR-269 , Meeting Abstract, PUBLISHED
Sparks, L. D.; Park, M.-S.; Chamberlain, J. R.; Ondrias, M. R.; Shelnutt, J. A.; Medforth, C. J.; Senge, M. O.; Smith, K. M., Metal effects on the structure of nonplanar porphyrins, FASEB J., 6, 1992, pp1184 , Meeting Abstract, PUBLISHED


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Award Date
Fellow, Trinity College Dublin 2006
SFI Fellows - Research Professorship Award (2004-2009) 2004
Heisenberg-Fellowship of the Deutsche Forschungsgemeinschaft (1997-2002) 1997
Habilitation fellowship of the Deutsche Forschungsgemeinschaft (1994-1996) 1994
Post doctoral research fellowship of the Deutsche Forschungsgemeinschaft (1990-1992) 1990
Studienabschluss Stipendium des Vereins der chemischen Industrie 1989
Full time Ph.D. scholarship of the Studienstiftung des deutschen Volkes (1987-1989) 1987
Contact Scholarship of the University of Massachusetts, Amherst (1983-1984) 1983
Full time undergraduate scholarship of the Studienstiftung des deutschen Volkes (1981-1985) 1981
The main research area of my group is synthetic bioorganic chemistry and my interests focus primarily on problems of chemical biology that can be solved with a combination of modern organic synthesis and biological, and physicochemical methods. Special topics are: Bioorganic and biological chemistry; heterocyclic and natural product chemistry; development of new synthetic methods, bioinorganic chemistry; catecholase and cytochrome model reactions; regulation of enzymatic reactions on a molecular level; enantioselective catalysts; medicinal chemistry, esp. photodynamic cancer therapy, porphyrias, malaria, schizophrenia; photobiology; photosynthesis; structure and function relationship in biologically active molecules; structure determination and conformational analysis of natural products and coordination compounds. In addition we have smaller research projects in the area of novel photonics materials and enantioselective oxidation catalysts. The group has many national and international collaborations with groups from industry, medicine, physcial chemistry and structural science and is funded exclusively by external grants.