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Professor Mani Ramaswami

Professor of Neurogenetics (Genetics)
LLOYD INSTITUTE

Professor of Neurogenetics (Zoology)

Professor of Neurogenetics (Trinity Inst. of Neurosciences (TCIN))

 Science Foundation of Ireland Investigator
 Wellcome Trust Cellular and genetic analysis of synapse assembly and function (Project Grant)
 Dept of Biotechnology, Govt of India. Circuit mechanisms of long-term habituation
  Deep sequencing of venom duct cDNAs from Indian cone snails
 Science Foundation of Ireland Research Professor.

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Ramaswami, M., Network plasticity in adaptive filtering and behavioral habituation, Neuron, 82, (6), 2014, p1216-1229 , Journal Article, PUBLISHED  DOI
Sudhakaran, IP, Hillebrand, J, Dervan, A, Das, S, Holohan, EE, Hulsmeier, J, Sarov, M, Parker, R, VijayRaghavan, K, Ramaswami, M, FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, (1), 2014, pE99-E108 , Journal Article, PUBLISHED  DOI
Twick, I. , Lee, J.A. , Ramaswami, M, Olfactory habituation in drosophila-odor encoding and its plasticity in the antennal lobe , Progress in Brain Research, 208, 2014, 3-38 , Journal Article, PUBLISHED  DOI
Sadandappa, MK, Ramaswami, M, Fly model causes neurological rethink, ELIFE, 2, 2013, pe01820-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Sadanandappa, MK, Redondo, BB, Michels, B, Rodrigues, V, Gerber, B, VijayRaghavan, K, Buchner, E, Ramaswami, M, Synapsin Function in GABA-ergic Interneurons Is Required for Short-Term Olfactory Habituation, JOURNAL OF NEUROSCIENCE, 33, (42), 2013, p16576-16585 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Redondo, BB, Bunz, M, Halder, P, Sadanandappa, MK, Muhlbauer, B, Erwin, F, Hofbauer, A, Rodrigues, V, VijayRaghavan, K, Ramaswami, M, Rieger, D, Wegener, C, Forster, C, Buchner, E, Identification and Structural Characterization of Interneurons of the Drosophila Brain by Monoclonal Antibodies of the Wurzburg Hybridoma Library, PLOS ONE, 8, (9), 2013, pe75420.-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Ramaswami, M. , Taylor, J.P. , Parker, R, Altered ribostasis: RNA-protein granules in degenerative disorders, Cell, 154, (4), 2013, p727-736 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Kangyu Pan, David Corrigan, Jens Hillebrand, Mani Ramaswami, and Anil Kokaram, A wavelet-based Bayesian framework for 3D object segmentation in microscopy, Proceedings of SPIE, 8227, 2012, part. no. 82271O , Journal Article, PUBLISHED  TARA - Full Text
Sudhakaran, I.P., Holohan, E.E., Osman, S., Rodrigues, V., Vijay Raghavan, K., Ramaswami, M., Plasticity of recurrent inhibition in the Drosophila antennal lobe, Journal of Neuroscience , 32, (21), 2012, p7225-7231 , Notes: [ ], Journal Article, PUBLISHED  TARA - Full Text  DOI
Tabone, C.J., Ramaswami, M., Is NMDA Receptor-Coincidence Detection Required for Learning and Memory?, Neuron, 74, (5), 2012, 767-769 , Notes: [ ], Journal Article, PUBLISHED  DOI
  

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Award Date
Professorial Fellowship, Trinity College Dublin. 2009
Galileo Circle Fellow, College of Science, University of Arizona. 2005
NIDA K (Career Development/ Research Leave) Award. (declined in 2008) 2004-2010
Cutting Edge Brain Research Award (CEBRA) from the NIDA. 2002
Early Tenure, University of Arizona 2000
HFSPO Research Grant Award 1999
NIH Research Career Development Award 1997-2002
McKnight Scholar's Award in Neuroscience 1995
Alfred P. Sloan Fellowship in Neuroscience 1995
HFSPO Research Grant Award 1995
Life Science Research Foundation Fellowship 1994
HFSPO Long-Term Fellowship 1992 -1993
Associate of the Indian Academy of Sciences 1991
Proctor and Gamble Research Fellowship 1990
Markey Charitable Trust Fellowship 1985-1988
Evelyn Sharp Graduate Fellowship 1985-1988
Arthur McCallum Graduate Fellowship 1984
The Institute Silver Medal (for the best student of Chemistry) Indian Institute of Technology, New Delhi 1984
Research interests 
 My laboratory is interested in understanding molecular and circuit mechanisms of simple learned behaviors. We use the genetic model organism Drosophila melanogaster to study fundamental synaptic mechanisms as well as mechanisms of simple olfactory memory. An obvious extension of these studies to ask how these mechanisms are affected in disease and we currently study disease models for fragile-X mental retardation and spinocerebellar ataxia. Five post-doctoral researchers and three postgraduate students in my lab use many in vivo approaches including Drosophila genetics, two-photon microscopy based live-brain imaging, electrophysiology, and a range of cell biological, behavioral & molecular techniques. Several collaborations, particularly with top research groups in India and the US, expand our work into other fields such as natural products and peptide neurotoxins. Recent advances in the lab include the following. 1. Primarily in collaboration with Veronica Rodrigues' group in the NCBS, Bangalore, we have discovered that gene expression- and synaptic growth dependent potentiation of GABAergic neurons drives specific forms of learned olfactory behavior. 2. In collaboration with Roy Parker at the University of Arizona, we have found that that proteins and mechanisms that control translation of mRNAs in yeast, also regulate the translation of mRNAs stored in synapses. Some of these regulatory mechanisms, required for proper neuronal homeostasis/plasticity are required for miRNA function and altered in human neurological disease.