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Dr. Adriele Prina Mello

Ussher Assistant Professor (Clinical Medicine)


Adriele Prina-Mello, PhD, is an Ussher Assistant Professor in Translational Nanomedicine, Department of Clinical Medicine at the Trinity Translational Medicine Institute, School of Medicine. AMBER centre Investigator, CRANN Principal Investigator at Trinity College, Dublin. Chair of the working group in Characterization and Toxicology at the European Technology Platform for Nanomedicine. Expert Member of Nanosafety cluster, the EC Task Force in Characterization and European Materials Characterisation Council. Founder and Director of the Laboratory for Biological Characterization of Advanced Materials, the Irish-branch of the European Nanomedicine Characterization Laboratory (EU-NCL), the flagship infrastructure project funded by the European Commission, in partnership with the US-National Cancer Institute Nano Characterization Laboratory)for enabling Translational Nanomedicine. My objective is to drive LBCAM to become a core nanomedicine enabling infrastructure for educational training (e.g., undergraduates, postgraduates) and international collaboration with academia, industry, clinicians and public bodies. Prina-Mello's research interests are focused on the translation of nanotechnology-enabled products (e.g., medical device, medicinal drugs, hybrid products such as theranostics); advanced materials and their multifunctional solutions; device and instrumentation applications into the medical research area as Nanomedicine tools with the potential to become next generation medical standards or standards of care. The key Nanomedicine areas of interest where I have developed expertise are: 1)Nanodiagnostics: advanced in vitro/ in vivo diagnostic and imaging devices and instrumentation. 2) Theranostics and Personalised Medicine: therapeutics based on nanotechnology and multilayered structures for localised and personalised medicine. 3) Regenerative Medicine: biomedical devices and nanotechnology and nanomaterials applied to tissue engineering. 4) Nanocharacterization and Safety: safe-by-design, responsible innovation development and regulatory compliance. Credited with more than 70 peer-review publications, 6 book chapters, 2 Booklets (as editor), 2 Special Issue (as topic editor), 7 invited scientific reviews, > 25 invited lectures, >50 conference proceedings, >100 posters. (all indexed in Google Scholars, Research Gate, or RSS, April 2016) Contributed to educational and learning by lecturing undergraduate students in Medicine and postgraduate Master degrees in Molecular Medicine, Translational Oncology, Pharmaceutical Science. Since 2010 provided mentoring, educational training, and transferable skills to more than 15 students who are now accomplished professionals. Prina-Mello's scientific and teaching international collaborators are the results of the extensive European Commission involvement and research projects activity. Prina-Mello is an active member at TCD of the following: Trinity Cancer committee, AMBER/CRANN Environmental, Health, and Safety (EHS) platform, the TTMI TARGET Radiobiology group, the TTMI outreach committee, the TTMI Health and Safety, the Translational Child Health and Paediatrics forum, the St. James's Intensive Care Unit research group.
  Bioelectromagnetism   Bioengineering   Biomagnetism   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomedical Engineering   Biomedical sciences   Biophysics   Bioreactors   Biosensors   Biotechnology   Cell and tissue development   Cell Communication   Cytoskelton, cell division   Intra and intercellular signalling   Mechanical Engineering   Medical Devices Engineering   Microelectronics technology   Multisensory technology, multi sensing   Nano Biotechnology   Nanochemistry   Nano-Materials   NanoMedicine   Nanotechnology   Neurobiology   Stem Cell biology and hematopoiesis   Surface and interface physics   Tissue Culture
 Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices
 Quality NANO
 Barcode project

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Details Date
Academy of NanoGagliato, organising committee Dec-2016
European Commission Expert-advisor for Joint Institute for Innovation Policy (NANODATA project) Dec-2016
NANOFAR associated member for european educational doctorate Sept-2016
Nano World Cancer day - organising committee Dec-2012
European Commission Expert Advisor Task Force Characterization Mar-2016
EuroNanoForum 2013 - International Advisory Group Area Nanomedicine, Healthcare, Nanobiotechnology and Biomaterials Jan-2012
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Basic Basic Basic
Italian Fluent Fluent Fluent
Details Date From Date To
Chair of the Toxicology and Characterisation working group at the European Technology Platform in Nanomedicine (ETPN) 2012 to date
Member of European Technology Platform (ETP) in Nanomedicine 2009 to date
Vice-chairman of Nanodiagnostic Working Group - European Technology Platform in Nanomedicine 2009 2012
Member of the European Society of Molecular Imaging 2011 2015
Member of the Institution of Engineers of Ireland 1998 2008
Member of the European Society of Biomechanics 2004 2010
Member of the European Bioelectromagnetics Association 2004 2008
Membro dell'ordine degli Ingegneri Italiani 1998 2000
Member of the Bioelectromagnetics Society 2005 2006
Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids in, editor(s)Ferreira de Castro Gomes Andreia, Sárria Pereira Passos Marisa. , Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications, InTech, 2018, [Movia D., Prina-Mello A.], Book Chapter, PUBLISHED
Adriele Prina-Mello, Namrata Jain, Baiyun Liu, Jason I. Kilpatrick, Melissa A. Tutty, Alan P. Bell, Suzanne P Jarvis, Yuri Volkova, Dania Movia, Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D, Tissue and Cell, 50, 2018, p15 - 30, Journal Article, PUBLISHED  DOI
Luisana Di Cristo, Sarah Mc Carthy, Keith Paton, Dania Movia, Adriele Prina-Mello, Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages, 2D Materials, 2018, Journal Article, PUBLISHED
Adriele Prina-Mello and Ciar{\'a, Characterisation of particles in solution \textendash a perspective on light scattering and comparative technologies, Science and Technology of Advanced Materials, 2018, Journal Article, PUBLISHED  DOI
Adriele Prina-Mello and Dania Movia and Despina Bazou and Yuri Volkov and Adriele Prina-Mello, Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs, Scientific Reports, 2018, Journal Article, PUBLISHED  DOI
Clarke, G. and Rogov, A. and McCarthy, S. and Bonacina, L. and Gun'Ko, Y. and Galez, C. and Le Dantec, R. and Volkov, Y. and Mugnier, Y. and Prina-Mello, A., Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO3nanoparticles for harmonic bio-imaging, Scientific Reports, 8, (1), 2018, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Cristina Multari, Marta Miola, Sara Ferraris, Dania Movia, Kristina Žužek Rožman, Nina Kostevšek, Antonia Follenzi, Enrica Verné, Adriele Prina-Mello, Synthesis and characterization of silica-coated superparamagnetic iron oxide nanoparticles and interaction with pancreatic cancer cells, International Journal of Applied Ceramic Technology, 2018, Journal Article, PUBLISHED
Di Cristo, L. and Maguire, C.M. and Mc Quillan, K. and Aleardi, M. and Volkov, Y. and Movia, D. and Prina-Mello, A., Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials, International Journal of Environmental Research and Public Health, 15, (4), 2018, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Baird A, Easty D, Mohamed BM, Jarzabek M, Shiels L, Soltermann A, Raeppel S, McDonagh L, Clarke G, Crosbie-Staunton K, 56: Multiple RTK targeting as a therapeutic option in malignant pleural mesothelioma , Lung Cancer , 103 , 2017, pS26 -, Journal Article, PUBLISHED
Martin-Loeches Ignacio, Muriel-Bombin Arturo, Ferrer Ricard, Artigas Antonio, Sole-Violan Jordi, Lorente Leonardo, Andaluz-Ojeda David, Prina-Mello Adriele, Herran-Monge Ruben, Suberviola Borja, The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure , Annals of Intensive Care , 7 , (1 ), 2017, p44 -, Journal Article, PUBLISHED  TARA - Full Text

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Movia D., Spadavecchia J., Moustaoui H., Moore C., Maguire C.M., Casale S., Prina-Mello A., Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to a proof-of-concept in vitro studies, 10th International Cancer Conference 2016, session: "Advances in targeted therapies/Precision Medicine", Dublin, Ireland , 17-18/10/2016, 2016, Notes: [Talk], Oral Presentation, PRESENTED
Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016, Report, PUBLISHED
Movia D., Spadavecchia J., Moustaoui H., Moore C., Maguire C.M., Casale S., Prina-Mello A., Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to a proof-of-concept in vitro studies. , Nanobiotechnology International Workshop, JRC, Ispra, Italy , 23-25/11/2015, 2015, Invited Talk, PRESENTED
Prina-Mello A. , MULTIFUN Dissemination Booklet, TCD , Trinity College Dublin Publisher, 2014, Notes: [Collection of all MULTIFUN dissemination activities across the 4 year project. Highlights and key event attended as small proceedings. ], Book, PUBLISHED
Prina-Mello A. and NAMDIATREAM consortium, NAMDIATREAM Dissemination Booklet, TCD, Trinity College Dublin Publisher, 2014, Notes: [NAMDIATREAM project full dissemination activity report and highlights of key events organised and chaired. NAMDIATREAM project(EC-FP7 large) - coordinated by Prof. Volkov and Prina-Mello], Book, PUBLISHED
Adriele Prina-Mello, Yuri Volkov, Nanotechnology in Diagnostic, Monitoring and Treatment of Cancer Advanced in Molecular Imaging , 5-8 September 2012, In:World Molecular Imaging Congress 2012, 2012, Dublin, WMIS, Notes: [Abstracts online], Meetings /Conferences Organised, PUBLISHED
Santos-Martinez, M.J., Medina, C., Prina-Mello, A., Conroy, J., Samuels, S.P., Volkov, Y., Radomski, M.W., Nanobalance: a novel method for the measurement of flow-induced platelet aggregation, Nanomedicine: Seminar and Workshop, Centre for Research on Nanostructures and Nanodevices Trinity College Dublin, 29 June 2009, 2009, Poster, PUBLISHED
Coey, Sanvito, Joint European Magnetic Symposia , 2008, In:Joint European Magnetic Symposia , 2008, Dublin , 1, Proceedings of the Joint European Magnetic Symposia, Notes: [BM symposium organiser], Meetings /Conferences Organised, PUBLISHED
Prina-Mello A. , Byrne F., Whelan A., Mohamed B.M., Davies A., Gun'Ko Y., Coey J.M.D., Volkov Y. (ed.), Conference on Nanotechnology: implications for human health, the environment and food safety, Proceedings of the IST 2007 Conference on Nanotechnology, Dublin, 1, November 2007, DIT - Focas institute, 2007, Proceedings of a Conference, PUBLISHED
A. Prina-Mello, Magneto-biology at the SFI Trinity Nanoscience Laboratory, Department of Bioimaging and Bioengineering - Tokyo University, February 10th 2006, 2006, Prof. Shoogo Ueno, Invited Talk, PRESENTED


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Award Date
Malvern Invited Talk at European NanoMedicine 2017 April 2017
Student award, 5th International Conference on Cellular Engineering, Aachen (Germany) 2001
FutureFlash! Best EC Project competition - EuroNanoForum 2015 July 2015
M.Sc. in Translational Oncology - Best new postgraduate course award as lecturer April 2014
EuroNanoForum 2013, Poster prize June 2013
Best Toxicology Paper 2012 - Society of Toxicology March 2012
International Academy of Nanomedicine - Second World Congress of Nanomedicine October 2010
Bioelectromagnetics Society and European Bioelectromagnetics Association award 2005
IEI/Medtronic Bioengineering Award Medal 2003
Calgary Award at the World Congress of Biomechanics, Calgary (Canada) 2002
Prina-Mello's research interests are focused on: 1) Advanced translation research in NanoMedicine (in vitro/ in vivo diagnostic and imaging), 2) Therapeutics based on nanotechnology and multilayered structures, 3) Theranostics and Personalised Medicine, 4) Dynamic interaction between nano-developed-products and biologically relevant models (nanotoxicology, nanobiocompatibility and nanobiotechnology), 5) Microfluidic systems applied to ultra-sensitive diagnostics 6) Biomedical devices and Tissue engineering applications of nanotechnology and nanomaterials, 7) Nanomedicine Characterization and Safety 8) In vitro complex models and tissue mimetic 9) Compliance to 3Rs principle Additional interests are also in nanotechnology, biomaterials, biocompatibility, high throughput and content screening, multiparametric analysys, data mining, bioelectromagnetisms biophysics, biomechanics, single cell assay and cellular engineering.