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Dr. Adriele Prina Mello

Ussher Assistant Professor (Clinical Medicine)

 


Adriele Prina-Mello, PhD, is an Ussher Assistant Professor in Translational Nanomedicine, Department of Clinical Medicine at the Trinity Translational Medicine Institute, School of Medicine. AMBER centre Investigator, CRANN Principal Investigator at Trinity College, Dublin. Chair of the working group in Characterization and Toxicology at the European Technology Platform for Nanomedicine. Expert Member of Nanosafety cluster, the EC Task Force in Characterization and European Materials Characterisation Council. Founder and Director of the Laboratory for Biological Characterization of Advanced Materials, the Irish-branch of the European Nanomedicine Characterization Laboratory (EU-NCL), the flagship infrastructure project funded by the European Commission, in partnership with the US-National Cancer Institute Nano Characterization Laboratory)for enabling Translational Nanomedicine. My objective is to drive LBCAM to become a core nanomedicine enabling infrastructure for educational training (e.g., undergraduates, postgraduates) and international collaboration with academia, industry, clinicians and public bodies. Prina-Mello's research interests are focused on the translation of nanotechnology-enabled products (e.g., medical device, medicinal drugs, hybrid products such as theranostics); advanced materials and their multifunctional solutions; device and instrumentation applications into the medical research area as Nanomedicine tools with the potential to become next generation medical standards or standards of care. The key Nanomedicine areas of interest where I have developed expertise are: 1)Nanodiagnostics: advanced in vitro/ in vivo diagnostic and imaging devices and instrumentation. 2) Theranostics and Personalised Medicine: therapeutics based on nanotechnology and multilayered structures for localised and personalised medicine. 3) Regenerative Medicine: biomedical devices and nanotechnology and nanomaterials applied to tissue engineering. 4) Nanocharacterization and Safety: safe-by-design, responsible innovation development and regulatory compliance. Credited with more than 70 peer-review publications, 6 book chapters, 2 Booklets (as editor), 2 Special Issue (as topic editor), 7 invited scientific reviews, > 25 invited lectures, >50 conference proceedings, >100 posters. (all indexed in Google Scholars, Research Gate, or RSS, April 2016) Contributed to educational and learning by lecturing undergraduate students in Medicine and postgraduate Master degrees in Molecular Medicine, Translational Oncology, Pharmaceutical Science. Since 2010 provided mentoring, educational training, and transferable skills to more than 15 students who are now accomplished professionals. Prina-Mello's scientific and teaching international collaborators are the results of the extensive European Commission involvement and research projects activity. Prina-Mello is an active member at TCD of the following: Trinity Cancer committee, AMBER/CRANN Environmental, Health, and Safety (EHS) platform, the TTMI TARGET Radiobiology group, the TTMI outreach committee, the TTMI Health and Safety, the Translational Child Health and Paediatrics forum, the St. James's Intensive Care Unit research group.
  Bioelectromagnetism   Bioengineering   Biomagnetism   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomedical Engineering   Biomedical sciences   Biophysics   Bioreactors   Biosensors   Biotechnology   Cell and tissue development   Cell Communication   Cytoskelton, cell division   Intra and intercellular signalling   Mechanical Engineering   Medical Devices Engineering   Microelectronics technology   Multisensory technology, multi sensing   Nano Biotechnology   Nanochemistry   Nano-Materials   NanoMedicine   Nanotechnology   Neurobiology   Stem Cell biology and hematopoiesis   Surface and interface physics   Tissue Culture
 SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH
 EXpanding Platforms for Efficacious mRNA Therapeutics
 Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices
 European Nanomedicine Characterisation Laboratory
 Risk Management of Biomaterials

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Details Date
Academy of NanoGagliato, organising committee Dec-2016
Erasmus Mundus Joint Master Degree "Nanomedicine for Drug Delivery" (NANOMED EMJMD) - associated lecturer Dec 2018
European Commission Expert-advisor for Joint Institute for Innovation Policy (NANODATA project) Dec-2016
NANOFAR associated member for european educational doctorate Sept-2016
Nano World Cancer day - organising committee Dec-2012
European Commission Expert Advisor Task Force Characterization Mar-2016
EuroNanoForum 2013 - International Advisory Group Area Nanomedicine, Healthcare, Nanobiotechnology and Biomaterials Jan-2012
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Basic Basic Basic
Italian Fluent Fluent Fluent
Details Date From Date To
Chair of the Toxicology and Characterisation working group at the European Technology Platform in Nanomedicine (ETPN) 2012 to date
Member of European Technology Platform (ETP) in Nanomedicine 2009 to date
Vice-chairman of Nanodiagnostic Working Group - European Technology Platform in Nanomedicine 2009 2012
Member of the European Society of Molecular Imaging 2011 2015
Member of the Institution of Engineers of Ireland 1998 2008
Member of the European Society of Biomechanics 2004 2010
Member of the European Bioelectromagnetics Association 2004 2008
Membro dell'ordine degli Ingegneri Italiani 1998 2000
Member of the Bioelectromagnetics Society 2005 2006
Murphy, F.A., Poland, C.A., Duffin, R., Al-Jamal, K.T., Ali-Boucetta, H., Nunes, A., Byrne, F., Prina-Mello, A., Volkov, Y., Li, S., Mather, S.J., Bianco, A., Prato, M., MacNee, W., Wallace, W.A., Kostarelos, K., Donaldson, K. , Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura , American Journal of Pathology, 178, (6), 2011, p2587 - 2600, Journal Article, PUBLISHED
Sanhaji M, Göring J, Couleaud P, Aires A, Cortajarena AL, Courty J, Prina-Mello A, Stapf M, Ludwig R, Volkov Y, Latorre A, Somoza Á, Miranda R, Hilger I., The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt., Nanomedicine, 2019, Journal Article, PUBLISHED  DOI
Collins AR, Annangi B, Rubio L, Marcos R, Dorn M, Merker C, Estrela-Lopis I, Cimpan MR, Ibrahim M, Cimpan E, Ostermann M, Sauter A, Yamani NE, Shaposhnikov S, Chevillard S, Paget V, Grall R, Delic J, de-Cerio FG, Suarez-Merino B, High throughput toxicity screening and intracellular detection of nanomaterials., 2017, Journal Article, PUBLISHED
Gobbo OL, Sjaastad K, Radomski MW, Volkov Y, Prina-Mello A, Magnetic Nanoparticles in Cancer Theranostics., Theranostics, 5, (11), 2015, p1249-63 , Review, PUBLISHED  TARA - Full Text  DOI  URL
Multilayered Nanoparticles for Personalized Medicine: Translation into Clinical Markets in, editor(s)Bawa R., Audette G.F. and Rubinstein I. , Handbook of Clinical Nanomedicine - From Bench to Bedside, Singapore, Pan Stanford Publishing, 2016, [Movia D., Poland C., Tran L., Volkov Y., Prina-Mello A. ], Book Chapter, PUBLISHED
Bergamaschi E., Poland C., Poland C., Guseva Canu I., Guseva Canu I., Prina-Mello A., Prina-Mello A., The role of biological monitoring in nano-safety, Nano Today, 10, (3), 2015, p274 - 277, Journal Article, PUBLISHED  DOI
Kossatz S., Grandke J., Couleaud P., Latorre A., Aires A., Crosbie-Staunton K., Ludwig R., DÃ"hring H., Ettelt V., Lazaro-Carrillo A., Calero M., Sader M., Courty J., Volkov Y., Prina-Mello A., Villanueva A., Somoza à ., Cortajarena A., Miranda R., Hilger I., Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery, Breast Cancer Research, 17, (1), 2015, Journal Article, PUBLISHED  DOI
Caputo F, Clogston J, Calzolai L, Rösslein M, Prina-Mello A., Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL. A step by step approach combining orthogonal measurements with increasing complexity., Journal of controlled release : official journal of the Controlled Release Society, 299, 2019, p31-43 , Journal Article, PUBLISHED  DOI
Hole P, Sillence K, Hannell C, Maguire CM, Roesslein M, Suarez G, Capracotta S, Magdolenova Z, Horev-Azaria L, Dybowska A, Cooke L, Haase A, Contal S, Manø S, Vennemann A, Sauvain JJ, Staunton KC, Anguissola S, Luch A, Dusinska M, Korenstein R, Gutleb AC, Wiemann M, Prina-Mello A, Riediker M, Wick P, Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)., Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 15, 2013, p2101 , Journal Article, PUBLISHED
Oliveira H, Bednarkiewicz A, Falk A, Fröhlich E, Lisjak D, Prina-Mello A, Resch S, Schimpel C, Vr"ek IV, Wysoki"ska E, Gorris HH., Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403)., Advanced healthcare materials, 8, (1), 2019, pe1801233 , Journal Article, PUBLISHED  DOI
  

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Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016, Report, PUBLISHED
Prina_Mello A. , Trinity Bioelectromagnetics Seminar, 21 June, 2005, TCD, Dublin, Meetings /Conferences Organised, PUBLISHED
A. Prina-Mello, Magneto-biology at the SFI Trinity Nanoscience Laboratory, Department of Bioimaging and Bioengineering - Tokyo University, February 10th 2006, 2006, Prof. Shoogo Ueno, Invited Talk, PRESENTED
A. Prina-Mello, Cell manipulation by magnetic field in the presence of functionalised magnetic nanowires , Nanotechnology seminar, MIT-Harvard University, Langer's La, Boston, USA, 10th May 2006, 2006, Dr. Lisa Freed, Invited Talk, PRESENTED
Prina-Mello A. , Byrne F., Whelan A., Mohamed B.M., Davies A., Gun'Ko Y., Coey J.M.D., Volkov Y. (ed.), Conference on Nanotechnology: implications for human health, the environment and food safety, Proceedings of the IST 2007 Conference on Nanotechnology, Dublin, 1, November 2007, DIT - Focas institute, 2007, Proceedings of a Conference, PUBLISHED
Prina-Mello A. , MULTIFUN Dissemination Booklet, TCD , Trinity College Dublin Publisher, 2014, Notes: [Collection of all MULTIFUN dissemination activities across the 4 year project. Highlights and key event attended as small proceedings. ], Book, PUBLISHED
Coey, Sanvito, Joint European Magnetic Symposia , 2008, In:Joint European Magnetic Symposia , 2008, Dublin , 1, Proceedings of the Joint European Magnetic Symposia, Notes: [BM symposium organiser], Meetings /Conferences Organised, PUBLISHED
Prina-Mello A. and NAMDIATREAM consortium, NAMDIATREAM Dissemination Booklet, TCD, Trinity College Dublin Publisher, 2014, Notes: [NAMDIATREAM project full dissemination activity report and highlights of key events organised and chaired. NAMDIATREAM project(EC-FP7 large) - coordinated by Prof. Volkov and Prina-Mello], Book, PUBLISHED
Buckley C.T., Prina-Mello A., O'Kelly K.U., Development of biodegradable elastomeric scaffolds for mechanobiology investigations, Proceedings of the 11th Annual Conference of the Section of Bio-engineering of the Royal Academy of Medicine in Ireland, Galway, edited by FitzPatrick D.P. and Senouci M. , 2005, pp13-, Oral Presentation, PRESENTED
Santos-Martinez, M.J., Medina, C., Prina-Mello, A., Conroy, J., Samuels, S.P., Volkov, Y., Radomski, M.W., Nanobalance: a novel method for the measurement of flow-induced platelet aggregation, Nanomedicine: Seminar and Workshop, Centre for Research on Nanostructures and Nanodevices Trinity College Dublin, 29 June 2009, 2009, Poster, PUBLISHED

  

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Award Date
Malvern Invited Talk at European NanoMedicine 2017 April 2017
FutureFlash! Best EC Project competition - EuroNanoForum 2015 July 2015
M.Sc. in Translational Oncology - Best new postgraduate course award as lecturer April 2014
EuroNanoForum 2013, Poster prize June 2013
Best Toxicology Paper 2012 - Society of Toxicology March 2012
International Academy of Nanomedicine - Second World Congress of Nanomedicine October 2010
Bioelectromagnetics Society and European Bioelectromagnetics Association award 2005
IEI/Medtronic Bioengineering Award Medal 2003
Calgary Award at the World Congress of Biomechanics, Calgary (Canada) 2002
Student award, 5th International Conference on Cellular Engineering, Aachen (Germany) 2001
Prina-Mello's research interests are focused on: 1) Advanced translation research in NanoMedicine (in vitro/ in vivo diagnostic and imaging), 2) Therapeutics based on nanotechnology and multilayered structures, 3) Theranostics and Personalised Medicine, 4) Dynamic interaction between nano-developed-products and biologically relevant models (nanotoxicology, nanobiocompatibility and nanobiotechnology), 5) Microfluidic systems applied to ultra-sensitive diagnostics 6) Biomedical devices and Tissue engineering applications of nanotechnology and nanomaterials, 7) Nanomedicine Characterization and Safety 8) In vitro complex models and tissue mimetic 9) Compliance to 3Rs principle Additional interests are also in nanotechnology, biomaterials, biocompatibility, high throughput and content screening, multiparametric analysys, data mining, bioelectromagnetisms biophysics, biomechanics, single cell assay and cellular engineering.