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Professor Paula Murphy

Professor (Zoology)

Registrar (Registrar)

Paula Murphy's research interests are in the genetic regulation of embryonic development, and she has been carrying out research in this field since starting postgraduate studies towards her doctoral degree in 1987. The relationship between gene expression patterns and gene function has been a prominent part of her work, and detailed expression analysis is one of her specialisations. She currently focuses this interest on development of the limbs and facial region of vertebrate embryos.
  3d Imaging   Developmental Biology   Embryology   Expression Analysis   Genetics   In Situ Hybridisation   Morphogenesis   Wnt Signalling Pathway
Shea C.A., Rolfe R.A., McNeill H., AND Murphy P., Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation, Developmental Dynamics , 2019, Journal Article, IN_PRESS  TARA - Full Text  DOI  Other
V Sotiriou, RA Rolfe, P Murphy, NC Nowlan, Effects of abnormal muscle forces on prenatal joint morphogenesis in mice, Jounral of Orthopaedic Research, 2019, Journal Article, PUBLISHED  DOI
Rolfe R., Shea C., Singh P., Bandyopadhyay A., Murphy P., Uncovering the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint, Philosophical Transactions B, 373, (1759), 2018, p1 - 12, Journal Article, PUBLISHED  DOI
Mohammadkhah M, Murphy P, Simms CK., Collagen fibril organization in chicken and porcine skeletal muscle perimysium under applied tension and compression., Journal of the Mechanical Behavior of Biomedical Materials, 77, 2018, p734 - 744, Journal Article, PUBLISHED  DOI  URL
Pratik Narendra Pratap Singh, Claire Shea, Shashank Kumar Sonker, Rebecca Rolfe, Ayan Ray, Sandeep Kumar, Pankaj Gupta, Paula Murphy, Amitabha Bandyopadhyay, Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement, Development, 145, (5), 2018, pdev153460-, Journal Article, PUBLISHED  DOI  URL
Rolfe RA, Shea CA, Singh PNP, Bandyopadhyay A, Murphy P, Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint, Philisophical Transactions of the Royal society, 2018, Journal Article, PUBLISHED  DOI  URL
Mohammadkhah M, Simms C.K, Murphy P, Visualisation of Collagen in fixed skeletal muscle tissue using fluorescently tagged Collagen binding protein CNA35, Journal of the Mechanical Behavior of Biomedical Materials, 66, 2017, p37 - 44, Notes: [Export Date: 16 February 2017], Journal Article, PUBLISHED  DOI  URL
Saha, A., Rolfe, R., Carroll, S., Kelly, D.J., Murphy, P., Chondrogenesis of embryonic limb bud cells in micromass culture progresses rapidly to hypertrophy and is modulated by hydrostatic pressure, Cell and Tissue Research, 368, (1), 2017, p47-59 , Journal Article, PUBLISHED  DOI  URL
Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J, Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis., American journal of physiology. Renal physiology, 311, (1), 2016, pF35-F45 , Journal Article, PUBLISHED  DOI  URL
Mc Laughlin D, Murphy P, Puri P, Notochord manipulation does not impact oesophageal and tracheal formation from isolated foregut in 3D explant culture., Pediatric surgery international, 32, (1), 2016, p29-35 , Journal Article, PUBLISHED  DOI  URL

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Nowlan, N. C., P. Murphy & P. J. Prendergast. , The influence of mechanical forces in the growing embryonic limb. , Transactions of the 52nd Annual Meeting of the Orthopaedic Research Society, the 52nd Annual Meeting of the Orthopaedic Research Society, Chicago, Illinois, edited by Burr, D. B , 31, 2006, ppno. 123-, Conference Paper, PUBLISHED
Miller S.F., Runker A.E., Kerjan G., Friedel R.H., Murphy P., Mitchell K.J., TEM7R in the developing mammalian nervous system. , International Journal of Developmental Neuroscience , 24, 2006, p598 - 598, Journal Article, PUBLISHED


Award Date
Fellow of Trinity College Dublin 2008
Welcome Trust Research Grant 2010-2014
Science Foundation Ireland. Investigator Programme Grant September 2003 - September 2007
Norwegian Cancer Society (Den Norske Kreftforening) research grants 1996, 1997, 1998, 1999
Human Frontiers Science Program fellowship 1993
EMBO long term research fellowship 1991
Medical Research Council Studentship 1988