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Dr. Ronan O'Toole

Adjunct Assistant Professor (Clinical Microbiology)


 Role of Mycobacterium tuberculosis phylogenetic lineage in TB disease in Ireland
 Determination of phylogenetic lineages of Mycobacterium tuberculosis isolates in New Zealand
 Synthetic gene array analysis for determining the mode of action of unique tuberculosis drugs
 Development of a single-target tuberculosis/HIV drug

Details Date From Date To
Working Group on New TB Drugs, Stop TB Partnership 2011 present
New Zealand Microbiological Society 2003 present
American Society for Microbiology 1999 present
Society for General Microbiology, UK 1999 present
Gautam S.S, Haug G, Cooley L.A, Mac Aogáin M, O'Toole R.F, Intercontinental translocation of latent multidrug-resistant tuberculosis to Australia demonstrated by whole genome sequencing, Medical Journal of Australia, 210, (5), 2019, p236 - 236.e1, Journal Article, PUBLISHED  DOI  URL
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR., Molecular epidemiology of multi- and extensively-drug-resistant mycobacterium tuberculosis in ireland, 2001-2014., The Journal of infection, 76, (1), 2018, p55-67 , Journal Article, PUBLISHED  DOI
Leong, K.W.C. and Cooley, L.A. and Anderson, T.L. and Gautam, S.S. and McEwan, B. and Wells, A. and Wilson, F. and Hughson, L. and O'Toole, R.F., Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis, Scientific Reports, 8, (1), 2018, p6274-, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Leong, K.W.C. and Cooley, L.A. and O'Toole, R.F., Draft genome sequence of new vancomycin-resistant Enterococcus faecium sequence type 1421, Genome Announcements, 6, (20), 2018, pe00438-18 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Gautam, S.S. and Aogáin, M.M. and Cooley, L.A. and Haug, G. and Fyfe, J.A. and Globan, M. and O†Toole, R.F., Molecular epidemiology of tuberculosis in Tasmania and genomic characterisation of its first known multi-drug resistant case, PLoS ONE, 13, (2), 2018, p1--, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Toole R.F, Development of a New Genome-Wide MLST Scheme for High-Resolution Typing of Diverse Mycobacterium tuberculosis Complex Strains, EBioMedicine, 34, 2018, p6 - 7, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Shastri M.D, Shukla S.D, Chong W.C, Dua K, Peterson G.M, Patel R.P, Hansbro P.M, Eri R, O'Toole R.F, Role of oxidative stress in the pathology and management of human tuberculosis, Oxidative Medicine and Cellular Longevity, 2018, 2018, Journal Article, PUBLISHED  DOI  URL
Hyland I.K, O'Toole R.F, Smith J.A, Bissember A.C, Progress in the Development of Platelet-Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases, ChemMedChem, 13, (18), 2018, p1873 - 1884, Journal Article, PUBLISHED  DOI  URL
O'Toole R.F, Gautam S.S, The host microbiome and impact of tuberculosis chemotherapy, Tuberculosis, 113, 2018, p26 - 29, Journal Article, PUBLISHED  DOI  URL
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR, Molecular epidemiology of multi and extensively drug-resistant Mycobacterium tuberculosis in Ireland, 2001-2004, Journal of Infection, 76, (1), 2018, p55 - 67, Notes: [ PMID: 29031637], Journal Article, PUBLISHED  DOI

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Tuberculosis, Mycobacterium Genus, Bacterial Phylogenetics, Metagenomics, Infectious Diseases, Molecular Diagnostics, Epidemiology, Healthcare Infection Control, Antibiotic Discovery, Target Validation, Drug Development, Environmental Microbiology, Bacterial Pathogenesis, Signal Transduction, Drug Resistance Mechanisms