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Dr. Niamh O'Boyle

Assistant Professor (Pharmacy)
23 WESTLAND ROW


Dr. Niamh O'Boyle is a qualified pharmacist and a member of the Pharmaceutical Society of Ireland. She received her BSc(Pharm) and PhD degree from Trinity College Dublin, and subsequently was awarded a postdoctoral scholarship at University of Göteborg in Sweden investigate the allergenic activity of epoxides and epoxy resins. Niamh was awarded a Government of Ireland Postdoctoral Research Fellowship at the School of Biochemistry & Immunology, TCD, working on 'Cancer, Tubulin and Free Radicals: New Therapy'. Following a period as assistant lecturer at the School of Chemical and Pharmaceutical Sciences at Dublin Institute of Technology, she was appointed as assistant professor at the School of Pharmacy and Pharmaceutical Sciences at TCD in 2017. She also works as a locum pharmacist in community pharmacy.
  Anticancer Drug Design   ANTICANCER DRUGS   ANTI-TUBULIN ACTIVITY
 Can the stress response to reactive oxygen species in tumours be exploited to give a new class of anti-cancer drugs? Dual-targeting of the stress response to reactive oxygen species and tubulin by piperlongumine and related analogues

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
Irish Medium Basic Medium
Swedish Fluent Fluent Fluent
Details Date From Date To
Member of the Royal Society of Chemistry October 2017 Present
Member of the Irish Association for Cancer Research January 2016 Present
Member of the European Association for Cancer Research January 2016 Present
O'Boyle, NM, Barrett, I, Greene, LM, Carr, M, Fayne, D, Twamley, B, Knox, AJS, Keely, NO, Zisterer, DM, Meegan, MJ, Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity, Journal of Medicinal Chemistry, 61, (2), 2018, p514 - 534, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Niamh M. O'Boyle, Daniela M. Zisterer, Mary J. Meegan, Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity, Proceedings of the 3rd Int. Electron. Conf. Med. Chem., 3rd International Electronic Conference on Medicinal Chemistry, November 2017, 3, 2017, Conference Paper, PUBLISHED  DOI  URL
Niamh M. O'Boyle, Daniela M. Zisterer, Mary J. Meegan, Title: Microtubule-Destabilising Actions of Piperlongumine and Analogues, Proceedings of the 3rd Int. Electron. Conf. Med. Chem., 3rd International Electronic Conference on Medicinal Chemistry, November 2017, 3, 2017, Conference Paper, PUBLISHED  DOI  URL
Meegan MJ, Nathwani S, Twamley B, Zisterer DM, O'Boyle NM., Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents., European Journal of Medicinal Chemistry, 125, 2017, p453 - 463, Journal Article, PUBLISHED  TARA - Full Text  DOI
Malebari, AM, Greene, LM, Nathwani, SM, Fayne, D, O'Boyle, NM, Wang, S, Twamley, B, Zisterer, DM, Meegan, MJ, β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells, European Journal of Medicinal Chemistry, 130, 2017, p261-285 , Journal Article, PUBLISHED  DOI  URL
Hagvall, L, Niklasson, IB, Rudbäck, J, O'Boyle, NM, Niklasson, E, Luthman, K, Karlberg, A-T, Assessment of cross-reactivity of new less sensitizing epoxy resin monomers in epoxy resin-allergic individuals, Contact Dermatitis, 75, (3), 2016, p144-150 , Journal Article, PUBLISHED  DOI  URL
Greene TF, Wang S, Greene LM, Nathwani SM, Pollock JK, Malebari AM, McCabe T, Twamley B, O'Boyle NM, Zisterer DM, Meegan MJ, Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents., Journal of Medicinal Chemistry, 59, (1), 2016, p90 - 113, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Boyle, NM, Pollock, JK, Carr, M, Knox, AJS, Nathwani, SM, Wang, S, Caboni, L, Zisterer, DM, Meegan, MJ, β-Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand, Journal of Medicinal Chemistry, 57, (22), 2014, p9370 - 9382, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Boyle, NM, Niklasson, IB, Tehrani-Bagha,AR, Delaine, T, Holmberg, K, Luthman, K, Karlberg, AT, Epoxy resin monomers with reduced skin sensitizing potency, Chemical Research in Toxicology, 27, (6), 2014, p1002-1010 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Pollock, JK, Verma,NK, O'Boyle, NM, Carr, MG, Meegan, MJ, Zisterer, DM, Combretastatin (CA)-4 and its novel analogue CA-432 impair T-cell migration through the Rho/ROCK signalling pathway, Biochemical Pharmacology, 92, (4), 2014, p544-557 , Journal Article, PUBLISHED  DOI
  

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Award Date
Irish Research Council Government of Ireland Postdoctoral Fellowship 2014 - 2016
University of Gothenburg Postdoctoral Award 2010 - 2012
XVIIIth European Conference of GP2A: Best Presentation 2009
Irish Cancer Society Oncology Scholars Travel Award 2008
Trinity College Dublin Foundation Scholarship 2003
Dr. O'Boyle's research interests lie in the areas of improving patient outcomes by applying principles of medicinal chemistry. Her main research interest is in the development of new treatments for cancer, with a particular focus on breast cancer. Drug targets of interest include the protein tubulin, the estrogen and progesterone receptors, and the role of reactive oxygen species. She is also interested in developing novel chemotherapeutics from natural products. Additionally, she is interested in developing compounds that cause less skin allergy for patients suffering from occupational contact allergy. Niamh's background provides her with expertise in many areas of pharmaceutical sciences (including organic & medicinal chemistry, pharmaceutical analysis, spectroscopy) and biochemistry (cellular viability, tubulin binding, apoptosis, receptor binding studies, and reactive oxygen species using techniques including western blotting, flow cytometry and confocal microscopy).