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Professor Michael Rowan

Professor of Neuropharmacology (Pharmacology & Therapeutics)

 Mechanisms of the synaptic plasticity disrupting actions of Aß
  Neurocardiovascular influences on cognitive functioning

Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang Y, Rowan M.J, Anwyl R, Han Y, Wang Q, Protection against ß-amyloid-induced synaptic and memory impairments via altering ß-amyloid assembly by bis(heptyl)-cognitin, Scientific Reports, 5, 2015, p10256-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Levites Y, O-Nuallain B, Puligedda R.D, Ondrejcak T, Adekar S.P, Chen C, Cruz P.E, Rosario A.M, Macy S, Mably A.J, Walsh D.M, Vidal R, Solomon A, Brown D, Rowan M.J, Golde T.E, Dessain S.K, A human monoclonal IgG that binds Aß assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo, Journal of Neuroscience, 35, (16), 2015, p6265 - 6276, Notes: [Export Date: 27 August 2015], Journal Article, PUBLISHED  DOI  URL
O'Malley, T.T. Oktaviani, N.A. Zhang, D. Lomakin, A. O'Nuallain, B. Linse, S. Benedek, G.B. Rowan, M.J. Mulder, F.A.A. Walsh, D.M., Aß dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies, Biochemical Journal, 461, (3), 2014, p413 - 426, Notes: [Cited By :1 Export Date: 4 March 2015], Journal Article, PUBLISHED  DOI  URL
Hu, N.-W. Nicoll, A.J. Zhang, D. Mably, A.J. O'Malley, T. Purro, S.A. Terry, C. Collinge, J. Walsh, D.M. Rowan, M.J., MGlu5 receptors and cellular prion protein mediate amyloid-ß- facilitated synaptic long-term depression in vivo, Nature Communications, 5, 2014, Notes: [Cited By :2 Export Date: 4 March 2015], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Welzel, A.T. Maggio, J.E. Shankar, G.M. Walker, D.E. Ostaszewski, B.L. Li, S. Klyubin, I. Rowan, M.J. Seubert, P. Walsh, D.M. Selkoe, D.J., Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity, Biochemistry, 53, (24), 2014, p3908 - 3921, Notes: [Export Date: 4 March 2015], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Klyubin, I. Nicoll, A.J. Khalili-Shirazi, A. Farmer, M. Canning, S. Mably, A. Linehan, J. Brown, A. Wakeling, M. Brandner, S. Walsh, D.M. Rowan, M.J. Collinge, J., Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity, Journal of Neuroscience, 34, (18), 2014, p6140 - 6145, Notes: [Cited By :3 Export Date: 4 March 2015], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ, Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aß in vivo., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369, (1633), 2014, p20130147 , Journal Article, PUBLISHED  TARA - Full Text  DOI
An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH, Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo., Molecular brain, 6, 2013, p47 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Qi Y, Hu NW, Rowan MJ, Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus., Cerebral cortex (New York, N.Y. : 1991), 23, (4), 2013, p932-9 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, Rowan MJ, Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus., European Journal of Pharmacology, 677, (1-3), 2012, p63 - 70, Journal Article, PUBLISHED  DOI

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