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Professor Mark Little

Professor/Consultant of Nephrology (Clinical Medicine)

 


  ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES   Biomarkers of disease   CRESCENTIC GLOMERULONEPHRITIS   IMMUNE-COMPLEX GLOMERULONEPHRITIS   Inflammation   MOUSE MODELS   Nephrology   NEUTROPHIL ADHESION   RAT MODEL   REGISTRY   SYSTEMIC VASCULITIS   VASCULITIS
 HELICAL - Health Data Linkage for Clinical Benefit
 AVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
 Urinary sCD163 as a biomarker in crescentic glomerulonephritis
 Irish Rare Kidney Disease Registry and Biobank
 The acute, untreated patient with vasculitis: enhancing recruitment and sampling using a national network

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Details Date
Autoimmune strand lead, RITA European Reference Network 1/3/17
Co-chair UKIVAS national vasculitis registry 2010
Co-chair UKIVAS, the vasculitis rare disease group of the UK and Ireland 2011
Registries lead, European Vasculitis Society 2014
Chair Irish Rare Kidney Disease Registry and Biobank 2012
Chair of Irish Nephrology Society research committee 2015
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Fellow of Trinity College Dublin 1/5/13
Fellow of the Royal College of Physicians 2012
American Society of Nephrology 2010
The Renal Association 2008
Scott J, Hartnett J, Mockler D, Little MA., Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review., Autoimmunity reviews, 2020, p102660 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Alan D. Salama, Mark A. Little, Coaxing Anti-Inflammatory Granulocytes to Prevent Ischemic Kidney Injury: A Fine Balance, Journal of the American Society of Nephrology, 2020, pASN.2020020146 , Journal Article, PUBLISHED  URL
Emma Leacy, Gareth Brady, Mark A Little, Pathogenesis of ANCA-associated vasculitis: an emerging role for immunometabolism, Rheumatology, 2020, Journal Article, PUBLISHED  URL
Moiseev, S., Cohen Tervaert, J.W., Arimura, Y., Bogdanos, D.P., Csernok, E., Damoiseaux, J., Ferrante, M., Flores-Suárez, L.F., Fritzler, M.J., Invernizzi, P., Jayne, D., Jennette, J.C., Little, M.A., McAdoo, S.P., Novikov, P., Pusey, C.D., Radice, A., Salama, A.D., Savige, J.A., Segelmark, M., Shoenfeld, Y., Sinico, R.A., Sousa, M.-J., Specks, U., Terrier, B., Tzioufas, A.G., Vermeire, S., Zhao, M.-H., Bossuyt, X., 2020 international consensus on ANCA testing beyond systemic vasculitis, Autoimmunity Reviews, 19, (9), 2020, Journal Article, PUBLISHED  TARA - Full Text  URL
Walls, C.A., Basu, N., Hutcheon, G., Erwig, L.P., Little, M.A., Kidder, D., A novel 4-dimensional live-cell imaging system to study leukocyte-endothelial dynamics in ANCA-associated vasculitis, Autoimmunity, 53, (3), 2020, p148-155 , Journal Article, PUBLISHED
O'Brien, E.C., White, C.A., Wyse, J., Leacy, E., Porter, R.K., Little, M.A., Hickey, F.B., Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism, Frontiers in Medicine, 7, 2020, Journal Article, PUBLISHED  TARA - Full Text
Cormican, S., Kennedy, C., Connaughton, D.M., O'Kelly, P., Murray, S., Živná, M., Kmoch, S., Fennelly, N.K., Benson, K.A., Conlon, E.T., Cavalleri, G.L., Foley, C., Doyle, B., Dorman, A., Little, M.A., Lavin, P., Kidd, K., Bleyer, A.J., Conlon, P.J., Renal transplant outcomes in patients with autosomal dominant tubulointerstitial kidney disease, Clinical Transplantation, 34, (2), 2020, Journal Article, PUBLISHED
Wang, L.-Y., Sun, X.-J., Wang, C., Chen, S.-F., Li, Z.-Y., Chen, M., Little, M.A., Zhao, M.-H., Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner, Clinical Science, 134, (12), 2020, p1475-1489 , Journal Article, PUBLISHED  TARA - Full Text
Phelan, T., Little, M.A., Brady, G., Targeting of the cGAS-STING system by DNA viruses, Biochemical Pharmacology, 174, 2020, Journal Article, PUBLISHED
Papa, R., Cant, A., Klein, C., Little, M.A., Wulffraat, N.M., Gattorno, M., Ruperto, N., Towards European harmonisation of healthcare for patients with rare immune disorders: Outcome from the ERN RITA registries survey, Orphanet Journal of Rare Diseases, 15, (1), 2020, Journal Article, PUBLISHED
  

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Award Date
President of Ireland Young Researchers Award 2012
I run a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. My principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. We are addressing the following questions: 1. What biomarkers accurately track glomerular and extra-renal inflammation in ANCA associated vasculitis? 2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult? 3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis? 4. How can we minimise the adverse events associated with existing immunosuppressive therapies? To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory.