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Professor Kingston Mills

Professor (Biochemistry)

Professor (Trinity Inst. of Neurosciences (TCIN))


Kingston Mills is Professor of Experimental Immunology, School of Biochemistry and Immunology, Trinity College Dublin (TCD). He is Head of The Centre for the Study of Immunology at Trinity Biomedical Sciences Institute and Theme Champion for Immunology, Inflammation and Infection at TCD. He is a graduate of TCD and trained at as a Postdoctoral Fellow at University College London and the National Institute for Medical Research, Mill Hill, London, before joining the Scientific Staff of NIBSC, Herts, UK. He returned to Ireland in 1993 to take up an academic position at National University of Ireland, Maynooth. He was appointed to a Personal Chair at Trinity College Dublin in 2001 and was Head of the School of Biochemistry and Immunology from 2008-2011. He heads an active research team focusing on T cells in infection, autoimmunity and cancer. He is co-founder of Opsona Therapeutics and TriMod Therapeutics, biotech companies focusing on the development of immunotherapeutics for inflammatory diseases and cancer.
  ACELLULAR PERTUSSIS-VACCINE   ACTIVATION PATHWAY   ANTIGEN   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   BACTERIAL   BACTERIAL INFECTION   BACTERIAL LIPOPOLYSACCHARIDE   BACTERIAL TOXINS   BIODEGRADABLE MICROPARTICLE   BLOOD MONONUCLEAR-CELLS   BORDETELLA PERTUSSIS   CD4+ T CELLS   CELL-MEDIATED-IMMUNITY   CHOLERA-TOXIN   CYTOKINE PRODUCTION   CYTOKINES   DEMYELINATION   ENDOTOXIN   EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS   FILAMENTOUS HEMAGGLUTININ   GROWTH-FACTOR-BETA   HOST-DEFENSE   HUMAN DENDRITIC CELLS   HUMAN-IMMUNODEFICIENCY-VIRUS   IL-1   IL-1 RECEPTOR   IL-1/MAP KINASES   IL-10   IL-12   IL-4   IMMUNE-RESPONSES   IMMUNOSUPPRESSION   Immunotherapies for Cancer   Infectious Diseases   INFLAMMATION   INTERFERON-GAMMA   INTERLEUKIN-1   INTERLEUKIN-1 BETA   INTERLEUKIN-1 RECEPTOR ANTAGONIST   INTERLEUKIN-1 RECEPTORS   INTERLEUKIN-1-BETA   INTERLEUKIN-1-BETA MESSENGER-RNA   INTERLEUKIN-2   LEUKOCYTE ADHESION MOLECULES   LIPOPOLYSACCHARIDE   MACROPHAGES   MAP KINASE   MONOCLONAL-ANTIBODIES   MONOCYTE   MULTIPLE-SCLEROSIS   MURINE MACROPHAGES   MYELIN BASIC-PROTEIN   NF-KAPPA-B   NITRIC-OXIDE   PHOSPHORYLATION   PROTEINS   SEIZURE   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   SURFACE PROTEIN   T LYMPHOCYTES   T-CELL ACTIVATION   T-CELLS   TH1 CELL   TH1 CELLS   T-LYMPHOCYTE ACTIVATION   TRANSCRIPTION FACTOR   VACCINATION   Vaccines   VIRAL-INFECTIONS
 The local immune response to a respiratory pathogen
 Investigations on the mechanism of immunity to B. pertussis in a murine model
 Programme EVA "Vaccine Delivery systems for the selective induction of cellular immune responses with candidate HIV vaccines
 T cell responses to Bordetella pertussis in children and the development of an acellular pertussis vaccine
 Cellular immune responses to HIV

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Details Date
Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
Member, WHO International Committee on DNA Vaccines. 1996-2000
Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002
Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001
Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013
Member, Infection & Immunity Committee of British Society for Immunology. 1998-present
Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000
Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-
Member expert committee on Medical Devices, Irish Medicines Board. 2001-
Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-
Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003
Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-
Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003
Member of Life Science Committee of Royal Irish Academy. 2003-2004
Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004
Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006
Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013
Associate Editor. The Journal of Immunology 2007-2011
Section Editor, The Journal of Immunology 2012-present
Member of the Editorial Board. Immunology and Cell Biology 2013-
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
American Association of Immunologists 2006-
American Society for Microbiology
International Society for Mucosal Immunology
British Society for Immunology
British and Irish Society for General Microbiology
Biochemical Society
Irish Research Scientists Association
Irish Society for Immunology
Royal Academy of Medicine in Ireland
Institute of Biology of Ireland
Member, UK MRC Committee on Vaccines & Immunization Procedures 1991 1995
Member, Irish Branch Committee of the Society for General Microbiology 1994 1997
Member, Irish Area Committee of The Biochemical Society. 1998 2001
Raverdeau M, Christofi M, Malara A, Wilk M.M, Misiak A, Kuffova L, Yu T, McGinley A.M, Quinn S.M, Massilamany C, Reddy J, Forrester J.V, Mills K.H.G, Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity, EMBO Reports, 20, (5), 2019, Journal Article, PUBLISHED  DOI  URL
Quinn S.M, Raverdeau M, McGinley A.M, Mills K.H.G, Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis, European Journal of Immunology, 2019, Journal Article, PUBLISHED  DOI  URL
Wilk M.M, Borkner L, Misiak A, Curham L, Allen A.C, Mills K.H.G, Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis, Emerging Microbes and Infections, 8, (1), 2019, p169 - 185, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674 , Notes: [Published online 11 December 2018], Journal Article, PUBLISHED  TARA - Full Text  DOI
Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and AndrÀ, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and BÃŒscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and Ä iÄ in-Å ain, L. and Clerici, M. and Colombo, F.S. and Cook, L. and Cooke, A. and Cooper, A.M. and Corbett, A.J. and Cosma, A. and Cosmi, L. and Coulie, P.G. and Cumano, A. and Cvetkovic, L. and Dang, V.D. and Dang-Heine, C. and Davey, M.S. and Davies, D. and De Biasi, S. and Del Zotto, G. and Dela Cruz, G.V. and Delacher, M. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Di Santo, J.P. and Diefenbach, A. and Dieli, F. and Dolf, A. and Dörner, T. and Dress, R.J. and Dudziak, D. and Dustin, M. and Dutertre, C.-A. and Ebner, F. and Eckle, S.B.G. and Edinger, M. and Eede, P. and Ehrhardt, G.R.A. and Eich, M. and Engel, P. and Engelhardt, B. and Erdei, A. and Esser, C. and Everts, B. and Evrard, M. and Falk, C.S. and Fehniger, T.A. and Felipo-Benavent, M. and Ferry, H. and Feuerer, M. and Filby, A. and Filkor, K. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frehse, B. and Frenette, P.S. and Frischbutter, S. and Fritzsche, W. and Galbraith, D.W. and Gangaev, A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and González-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and GrÃŒtzkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and HÀmmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hernández, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and Höfer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and Höllt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.-P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and JÀck, H.-M. and Jani, P.K. and Jávega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, T. and Krueger, A. and KÃŒhne, J. and Kukat, C. and Kunkel, D. and Kunze-Schumacher, H. and Kurosaki, T. and Kurts, C. and Kvistborg, P. and Kwok, I. and Landry, J. and Lantz, O. and Lanuti, P. and LaRosa, F. and Lehuen, A. and LeibundGu, Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition), European Journal of Immunology, 49, (10), 2019, p1457-1973 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Diavatopoulos, D.A. and Mills, K.H.G. and Kester, K.E. and Kampmann, B. and Silerova, M. and Heininger, U. and van Dongen, J.J.M. and van der Most, R.G. and Huijnen, M.A. and Siena, E. and Mielcarek, N. and Ochs, M.M. and Denoël, P. and Berbers, G. and Buisman, A.M. and de Jonge, M.I. and Fenwick, C. and Gorringe, A. and He, Q. and Kelly, D. and Le Grand, R. and Locht, C. and Mascart, F. and Mertsola, J. and Orfao, A. and Pantaleo, G. and Pollard, A.J. and Preston, A. and Read, R. and Sebo, P. and van Els, C. and Vecerek, B. and Londoño-Hayes, P. and de Groot, R., PERISCOPE: road towards effective control of pertussis, The Lancet Infectious Diseases, 19, (5), 2019, pe179-e186 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Quinn, S.M. and Cunningham, K. and Raverdeau, M. and Walsh, R.J. and Curham, L. and Malara, A. and Mills, K.H.G., Anti-inflammatory trained immunity mediated by helminth products attenuates the induction of T cell-mediated autoimmune disease, Frontiers in Immunology, 10, (MAY), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Zurita, M.E. and Wilk, M.M. and Carriquiriborde, F. and Bartel, E. and Moreno, G. and Misiak, A. and Mills, K.H.G. and Hozbor, D., A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection against Bordetella pertussis, including Pertactin Deficient Strains, Frontiers in Cellular and Infection Microbiology, 9, (APR), 2019, Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Borkner L, Misiak A, Wilk M.M, Mills K.H.G, Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory, Frontiers in immunology, 9, 2018, p1764-, Journal Article, PUBLISHED  DOI  URL
  

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Award Date
Royal Academy of Medicine in Ireland Doctor award in Respiratory Medicine and best overall paper 2014
Laboratory Scientist of the year and Laboratory of the year, Irish Lab awards 2013
Elected to Fellowship of Trinity College Dublin 2004
Royal Irish Academy Award in Biochemistry 2004
Inaugural Annual Award of Irish Society for Immunology 2002
Awarded Graves Medal and present the 39th Annual Graves Lecture 1999
Elected to membership of the Institute of Biology of Ireland 1996
Elected Fellow of The Royal Academy of Medicine in Ireland 1994
Elected to fellowship of The Royal Academy of Medicine in Ireland 1994
Merit award of rapid promotion to Senior Scientist scale 1991
Young scientist award from International Union of Immunology Societies 1986
Awarded fellowship by International Network of Immunology 1987
Awarded EURATOM travelling fellowship 1977
Elected Student of the year, Wilson's Hospital, Secondary School 1972
A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on 'the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease' is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.