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Professor Kingston Mills

Professor (Biochemistry)

Professor (Trinity Inst. of Neurosciences (TCIN))

Kingston Mills is Professor of Experimental Immunology, School of Biochemistry and Immunology, Trinity College Dublin (TCD). He is Head of The Centre for the Study of Immunology at Trinity Biomedical Sciences Institute and Theme Champion for Immunology, Inflammation and Infection at TCD. He is a graduate of TCD and trained at as a Postdoctoral Fellow at University College London and the National Institute for Medical Research, Mill Hill, London, before joining the Scientific Staff of NIBSC, Herts, UK. He returned to Ireland in 1993 to take up an academic position at National University of Ireland, Maynooth. He was appointed to a Personal Chair at Trinity College Dublin in 2001 and was Head of the School of Biochemistry and Immunology from 2008-2011. He heads an active research team focusing on T cells in infection, autoimmunity and cancer. He is co-founder of Opsona Therapeutics and TriMod Therapeutics, biotech companies focusing on the development of immunotherapeutics for inflammatory diseases and cancer.
 The local immune response to a respiratory pathogen
 Investigations on the mechanism of immunity to B. pertussis in a murine model
 Programme EVA "Vaccine Delivery systems for the selective induction of cellular immune responses with candidate HIV vaccines
 T cell responses to Bordetella pertussis in children and the development of an acellular pertussis vaccine
 Cellular immune responses to HIV

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Details Date
Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
Member, WHO International Committee on DNA Vaccines. 1996-2000
Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002
Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001
Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013
Member, Infection & Immunity Committee of British Society for Immunology. 1998-present
Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000
Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-
Member expert committee on Medical Devices, Irish Medicines Board. 2001-
Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-
Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003
Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-
Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003
Member of Life Science Committee of Royal Irish Academy. 2003-2004
Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004
Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006
Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013
Associate Editor. The Journal of Immunology 2007-2011
Member of the Editorial Board. Immunology and Cell Biology 2013-
Section Editor, The Journal of Immunology 2012-present
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
American Association of Immunologists 2006-
American Society for Microbiology
International Society for Mucosal Immunology
British Society for Immunology
British and Irish Society for General Microbiology
Biochemical Society
Irish Research Scientists Association
Irish Society for Immunology
Royal Academy of Medicine in Ireland
Institute of Biology of Ireland
Member, UK MRC Committee on Vaccines & Immunization Procedures 1991 1995
Member, Irish Branch Committee of the Society for General Microbiology 1994 1997
Member, Irish Area Committee of The Biochemical Society. 1998 2001
Raverdeau M, Christofi M, Malara A, Wilk M.M, Misiak A, Kuffova L, Yu T, McGinley A.M, Quinn S.M, Massilamany C, Reddy J, Forrester J.V, Mills K.H.G, Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity, EMBO Reports, 20, (5), 2019, Journal Article, PUBLISHED  DOI  URL
Quinn S.M, Raverdeau M, McGinley A.M, Mills K.H.G, Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis, European Journal of Immunology, 2019, Journal Article, PUBLISHED  DOI  URL
Wilk M.M, Borkner L, Misiak A, Curham L, Allen A.C, Mills K.H.G, Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis, Emerging Microbes and Infections, 8, (1), 2019, p169 - 185, Journal Article, PUBLISHED  DOI  URL
Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674 , Notes: [Published online 11 December 2018], Journal Article, PUBLISHED  DOI
Borkner L, Misiak A, Wilk M.M, Mills K.H.G, Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory, Frontiers in immunology, 9, 2018, p1764-, Journal Article, PUBLISHED  DOI  URL
McGinley, A.M. and Edwards, S.C. and Raverdeau, M. and Mills, K.H.G., Th17 cells, γΎ T cells and their interplay in EAE and multiple sclerosis, Journal of Autoimmunity, 87, 2018, p16-25 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Fuchs, A. and Gliwinski, M. and Grageda, N. and Spiering, R. and Abbas, A.K. and Appel, S. and Bacchetta, R. and Battaglia, M. and Berglund, D. and Blazar, B. and Bluestone, J.A. and BornhÃ"user, M. and Brinke, A. and Brusko, T.M. and Cools, N. and Cuturi, M.C. and Geissler, E. and Giannoukakis, N. and Golab, K. and Hafler, D.A. and van Ham, S.M. and Hester, J. and Hippen, K. and Di Ianni, M. and Ilic, N. and Isaacs, J. and Issa, F. and Iwaszkiewicz-Grzes, D. and Jaeckel, E. and Joosten, I. and Klatzmann, D. and Koenen, H. and Kooten, C. and Korsgren, O. and Kretschmer, K. and Levings, M. and Marek-Trzonkowska, N.M. and Martinez-Llordella, M. and Miljkovic, D. and Mills, K.H.G. and Miranda, J.P. and Piccirillo, C.A. and Putnam, A.L. and Ritter, T. and Roncarolo, M.G. and Sakaguchi, S. and Sánchez-Ramón, S. and Sawitzki, B. and Sofronic-Milosavljevic, L. and Sykes, M. and Tang, Q. and Vives-Pi, M. and Waldmann, H. and Witkowski, P. and Wood, K.J. and Gregori, S. and Hilkens, C.M.U. and Lombardi, G. and Lord, P. and Martinez-Caceres, E.M. and Trzonkowski, P., Minimum information about T regulatory cells: A step toward reproducibility and standardization, Frontiers in Immunology, 8, (JAN), 2018, p01844-, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Michelet, X. and Dyck, L. and Hogan, A. and Loftus, R.M. and Duquette, D. and Wei, K. and Beyaz, S. and Tavakkoli, A. and Foley, C. and Donnelly, R. and O†Farrelly, C. and Raverdeau, M. and Vernon, A. and Pettee, W. and O†Shea, D. and Nikolajczyk, B.S. and Mills, K.H.G. and Brenner, M.B. and Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nature Immunology, 19, (12), 2018, p1330-1340 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Allen, A.C. and Wilk, M.M. and Misiak, A. and Borkner, L. and Murphy, D. and Mills, K.H.G., Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells, Mucosal Immunology, 11, (6), 2018, p1763-1776 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Solans, L. and Debrie, A.-S. and Borkner, L. and Aguiló, N. and Thiriard, A. and Coutte, L. and Uranga, S. and Trottein, F. and Martín, C. and Mills, K.H.G. and Locht, C., IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine, Mucosal Immunology, 11, (6), 2018, p1753-1762 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI

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Award Date
Royal Academy of Medicine in Ireland Doctor award in Respiratory Medicine and best overall paper 2014
Laboratory Scientist of the year and Laboratory of the year, Irish Lab awards 2013
Elected to Fellowship of Trinity College Dublin 2004
Royal Irish Academy Award in Biochemistry 2004
Inaugural Annual Award of Irish Society for Immunology 2002
Awarded Graves Medal and present the 39th Annual Graves Lecture 1999
Elected to membership of the Institute of Biology of Ireland 1996
Elected Fellow of The Royal Academy of Medicine in Ireland 1994
Elected to fellowship of The Royal Academy of Medicine in Ireland 1994
Merit award of rapid promotion to Senior Scientist scale 1991
Young scientist award from International Union of Immunology Societies 1986
Awarded fellowship by International Network of Immunology 1987
Awarded EURATOM travelling fellowship 1977
Elected Student of the year, Wilson's Hospital, Secondary School 1972
A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on 'the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease' is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.