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Dr. Marian Humphries

Research Fellow (Genetics)
EAST END DEVELOPMENT 4/5


  ABNORMALITIES   ABSENCE   ADRP   ANIMAL MODEL   APOPTOSIS   ARM   BASEMENT-MEMBRANE   B-WAVE   CAT   CELL-DEATH   CELLS   C-FOS   CHROMOSOME-3   CONE   CONGENITAL STATIONARY NIGHT BLINDNESS   CONSERVATION   CONSTITUTIVE ACTIVATION   CULTURED-CELLS   CYTOKERATIN GENES   DELETION   DETACHMENT   DISEASE   DISK MEMBRANE   DNA POLYMORPHISMS   DOMINANT RETINITIS-PIGMENTOSA   ELECTRORETINOGRAM   EPIDERMOLYSIS BULLOSA   EXPRESSION   FOLDING PROBLEM   FORM   GENE   GENETIC-HETEROGENEITY   HETEROGENEITY   HETEROZYGOUS MISSENSE MUTATION   IMMUNOFLUORESCENCE MICROSCOPY   INTERMEDIATE FILAMENTS   INTERMEDIATE-SIZED FILAMENTS   KERATIN   LIGHT   LINKAGE   LINKAGE ANALYSIS   MOLECULAR-CLONING   MUTANT MICE   MUTATION   MUTATIONS   PCR DETECTION   POINT MUTATIONS   POLYMERASE CHAIN-REACTION   PREVALENCE   RETINITIS-PIGMENTOSA   RHODOPSIN   RHODOPSIN GENE   SUBUNIT
Details Date From Date To
Irish Network of Neuronal Stem-cell Investigators
All-Ireland Retinal Researchers Network
Trinity College Neurosciences Institute (TCIN)
Association for Research in Vision and Ophthalmology (ARVO)
American Society of Human Genetics
Irish Society of Human Genetics -
European Vision Institute
Tam L.C.S, Reina-Torres E, Sherwood J.M, Cassidy P.S, Crosbie D.E, LÃ"tjen-Drecoll E, FlÃ"gel-Koch C, Perkumas K, Humphries M.M, Kiang A.-S, O'Callaghan J, Callanan J.J, Read A.T, Ethier C.R, O'Brien C, Lawrence M, Campbell M, Stamer W.D, Overby D.R, Humphries P, Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia, Scientific Reports, 7, 2017, p40717-, Notes: [Export Date: 20 February 2017], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Callaghan, J. and Crosbie, D.E. and Cassidy, P.S. and Sherwood, J.M. and FlÃŒgel-Koch, C. and LÃŒtjen-Drecoll, E. and Humphries, M.M. and Reina-Torres, E. and Wallace, D. and Kiang, A.-S. and Campbell, M. and Stamer, W.D. and Overby, D.R. and O'Brien, C. and Tam, L.C.S. and Humphries, P., Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma, Human Molecular Genetics, 26, (7), 2017, p1230-1246 , Notes: [cited By 6], Journal Article, PUBLISHED  DOI
Farrar, G.J. and Carrigan, M. and Dockery, A. and Millington-Ward, S. and Palfi, A. and Chadderton, N. and Humphries, M. and Kiang, A.S. and Kenna, P.F. and Humphries, P., Toward an elucidation of the molecular genetics of inherited retinal degenerations, Human Molecular Genetics, 26, (R1), 2017, pR2-R11 , Notes: [cited By 2], Journal Article, PUBLISHED  TARA - Full Text  DOI
C Greene, J Kealy, M M Humphries, Y Gong, J Hou, N Hudson, L M Cassidy, R Martiniano, V Shashi, S R Hooper, G A Grant, P F Kenna, K Norris, C K Callaghan, M dN Islam, S M O'Mara, Z Najda, S G Campbell, J S Pachter, J Thomas, N M Williams, P Humphries, K C Murphy, M Campbell, Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia, Molecular Psychology, 2017, Notes: [C Greene and J Kealy are joint first authors], Journal Article, PUBLISHED  DOI
Doherty C.P, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries M.M, Molloy M.G, Meaney J.F, Farrell M, Campbell M, Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy, Journal of Neuropathology and Experimental Neurology, 75, (7), 2016, p656 - 662, Notes: [Export Date: 10 January 2017], Journal Article, PUBLISHED  DOI  URL
Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M., Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier., Science Advances, 1, (8), 2015, p10.1126/sci adv.1500472 , Journal Article, PUBLISHED
Comitato A, Sanges D, Rossi A, Humphries M.M, Marigo V, Activation of Bax in three models of retinitis pigmentosa, Investigative Ophthalmology and Visual Science, 55, (6), 2014, p3555 - 3562, Notes: [Cited By :1 Export Date: 19 August 2015], Journal Article, PUBLISHED  DOI  URL
Daiger, S.P., Bowne, S.J., Sullivan, L.S., (...), Chen, R., Li, Y. , Application of next-generation sequencing to identify genes and mutations causing autosomal dominant retinitis pigmentosa (adRP)., Advances in experimental medicine and biology, 801, 2014, p123-129 , Journal Article, PUBLISHED  DOI
Kiang, A.S., Humphries, M.M., Campbell, M., Humphries, P. , Antioxidant therapy for retinal disease., Advances in experimental medicine and biology, 801, 2014, p783-789 , Journal Article, PUBLISHED  DOI
Nguyen, A.T., Campbell, M., Kiang, A.S., Humphries, M.M., Humphries, P. , Current therapeutic strategies for P23H RHO-linked RP., Advances in experimental medicine and biology, 801, 2014, p471-476 , Journal Article, PUBLISHED  DOI
  

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Humphries P, Humphries MM, Tam LC, Farrar GJ, Kenna PF, Campbell M, Kiang A-S. , Hereditary retinopathies: progress in development of genetic and molecular therapies., SpringerBriefs in Genetics, Springer NY. , 2013, Book, PUBLISHED

  

Human Molecular/Medical Genetics with special interest in hereditary neurodegenerative diseases of the retina and blistering disorders of the skin. Generation of animal models for retinal disease.