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Professor George Mellotte

Clinical Associate Professor (Clinical Medicine)

Professor George Mellotte is Consultant Nephrologist to St James's Hospital and to Tallaght University Hospital, Dublin since 1995. A graduate of National University of Ireland, Galway, he trained in nephrology in Dublin and London. He has a M.Sc. in Biochemistry from King's College, University of London. He has served as Clinical Lead Nephrologist for the Dublin Midlands Hospital Group prior to taking up his current role as National Clinical Lead for Renal Services. He is Clinical Associate Professor, School of Medicine in Trinity College Dublin. His main research interest is in peritoneal dialysis and has published widely on this and other related topics. He has served on a several National and International clinical advisory boards and research groups. He was chair of the LOC for EuroPD 2017 conference that was held in Dublin. He has led clinical services on both Saint James's and Tallaght Hospital sites, overseeing a significant expansion of services, including home therapies and satellite dialysis centres.
Details Date
National Clinical Lead - Nephrology National Clinical Director: National Renal Office 1/11/18
Details Date From Date To
Irish Nephrology Society (President 2006-10) 1997
ERA-EDTA (European Renal Association- Dialysis Transplant association) 1993
International Society of Peritoneal Dialysis 2004
O'Reilly VP, Wong L, Kennedy C, Elliot LA, O'Meachair S, Coughlan AM, O'Brien EC, Ryan MM, Sandoval D, Connolly E, Dekkema GJ, Lau J, Abdulahad WH, Sanders JS, Heeringa P, Buckley C, O'Brien C, Finn S, Cohen CD, Lindemeyer MT, Hickey FB, O'Hara PV, Feighery C, Moran SM, Mellotte G, Clarkson MR, Dorman AJ, Murray PT, Little MA., Urinary Soluble CD163 in Active Renal Vasculitis., Journal of the American Society of Nephrology, 27, (9), 2016, p2906 - 2916, Journal Article, PUBLISHED  DOI  URL
Mellotte GJ, Ho CA, Morgan SH, Bending MR, Eisinger AJ, Peritoneal dialysis catheters: a comparison between percutaneous and conventional surgical placement techniques., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 8, (7), 1993, p626-30 , Journal Article, PUBLISHED
Medani S, Hussein W, Shantier M, Flynn R, Wall C, Mellotte G, COMPARISON OF PERCUTANEOUS AND OPEN SURGICAL TECHNIQUES FOR FIRST-TIME PERITONEAL DIALYSIS CATHETER PLACEMENT IN THE UNBREACHED PERITONEUM., Peritoneal Dialysis International, (pdi.2013.00003), 2014, Notes: [Perit Dial Int. 2014 Jul 31. pii: pdi.2013.00003. [Epub ahead of print] Medani S1, Hussein W2, Shantier M2, Flynn R3, Wall C2, Mellotte G2], Journal Article, PUBLISHED  URL
Medani S, Shantier M, Hussein W, Wall C, Mellotte G, A comparative analysis of percutaneous and open surgical techniques for peritoneal catheter placement., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 32, (6), 2012, p628-35 , Journal Article, PUBLISHED
Foxall PJ, Mellotte GJ, Bending MR, Lindon JC, Nicholson JK, NMR spectroscopy as a novel approach to the monitoring of renal transplant function., Kidney international, 43, (1), 1993, p234-45 , Journal Article, PUBLISHED
Davies SJ, Brown EA, Reigel W, Clutterbuck E, Heimbürger O, Diaz NV, Mellote GJ, Perez-Contreras J, Scanziani R, D'Auzac C, Kuypers D, Divino Filho JC, What is the link between poor ultrafiltration and increased mortality in anuric patients on automated peritoneal dialysis? Analysis of data from EAPOS., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 26, (4), 2006, p458-65 , Journal Article, PUBLISHED
Gunning H, Taylor G, Smyth A, Mellotte G, Fennell J, Murphy P, Lavin P, Wall C, An Approach to Optimise Therapeutic Vancomycin Dosage in a Haemodialysis Population., Irish Medical Journal, 109, (9), 2016, p465-, Notes: [Haemodialysis patients are at risk of gram-positive bacteraemia and commonly require intravenous vancomycin. Intravenously administered vancomycin is primarily excreted by the kidney and exhibits complex pharmacokinetics in haemodialysis patients; achieving therapeutic levels can be challenging. An audit in our unit showed current practises of vancomycin administration resulted in a high proportion of sub-therapeutic levels. A new protocol was developed with fixed weight-based loading and subsequent dosing guided by pre-dialysis levels, target levels were 10-20mg/L. Its effectiveness was prospectively evaluated between 24th September 2012, and 8th February 2013. During this period 25 patients commenced vancomycin, 15 were included. In total, 112 vancomycin levels were taken, 94 (84%) were therapeutic, this was a significant improvement compared to previous practise (odds ratio 5.4, CI 3.1-9.4, p<0.0001). In conclusion, our study shows this protocol can consistently and reliably achieve therapeutic vancomycin levels.], Journal Article, PUBLISHED
Pate GE, Hogan MC, FitzSimon N, Mellotte GJ, A review of the epidemiology of leptospirosis in the Republic of Ireland., Irish medical journal, 93, (4), 2000, p114-7 , Journal Article, PUBLISHED
Smyth A, McCann E, Redahan L, Lambert B, Mellotte GJ, Wall CA, Peritoneal dialysis in an ageing population: a 10-year experience., International urology and nephrology, 44, (1), 2012, p283 - 293, Journal Article, PUBLISHED
Mellotte GJ, Morgan SH, Smith SA, Bending MR, Eisinger AJ., Partial correction of dialysis associated anaemia does not reduce erythropoietin dose or incidence of side effects.,, Nephron, 64, (3), 1993, p465 - 467, Journal Article, PUBLISHED

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48. Connell J, Casserly L, Conlon P, Crowley B, Donlon S, Mellotte GJ, Thornton T. , 'Blood-Borne Viruses in the Haemodialysis, CAPD and Renal Transplantation Setting 2013',, HSE, 2013, -, Protocol or guideline, PUBLISHED
Mellotte GJ, Nephrology in the ICU. , Registrars review in Nephrology, (4), 1993, p13 - 15, Journal Article, PUBLISHED
Allcutt D, Bedford D, Bennett D, Byrne J, Carroll P, Cummins G, Cusack D, Delargy I, Dolan M, Farrell B, Faughnan C, Fearon P, Finnerty D, Fitzpatrick P, Flannery W, Gormley M, Guéret P, Joyce Cooney J, Keane L, Keelan E, Lane G, Logan P, McCabe P, McMahon S, McNicholas W, Mellotte G, Mullan R, Norman D, O'Brien M, O'Callaghan S, Patterson I, Roberts G, Robinson D, Sludds K, Stapleton T, Treacy G, Wallace E, Walsh K, Whelan D, Williams D, O'Neill D. , 'Medical Fitness to Drive Guidelines Report, ',, Road safety Authority, 2015, 1 - 98, Protocol or guideline, PUBLISHED
Glynn LG, Reddan D, Hayes L, Stack A, Casserly L, Mellotte GJ., New guidelines for the management of chronic kidney disease in primary care, Irish Pharmacist , 8, (11), 2008, p34 - 37, Journal Article, PUBLISHED
Mellotte, Epoetin - An Important Advance, Drugs And Therapeutics Bulletin, 30, (8), 1992, p29 - 32, Journal Article, PUBLISHED
Casey, MC, Walsh JB, Mellotte GJ, et al, Joint Specialist Care for Elderly Renal Transplants, British Medical Journal, (9), 2004, Journal Article, PUBLISHED