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Professor Aoife Mc Lysaght

Professor (Genetics)

 Gene expression level as a keystone to understanding gene duplication: evolutionary constraints, opportunities, and disease
 SFI ERC Supplement
 Dosage-sensitive genes in evolution and disease
 Origin and Evolution of Vertebrate de novo Genes
 Gene Gains, Losses and Relocations during Vertebrate Evolution

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Italian Basic Basic Basic
Details Date From Date To
President, Society for Molecular Biology and Evolution 2018 2020
Treasurer, Society for Molecular Biology and Evolution 2012 2014
Member - Society for Molecular Biology and Evolution (SMBE) 2005 present
Member - Genetics Society (UK) 1999 present
Vakirlis N, McLysaght A., Computational Prediction of De Novo Emerged Protein-Coding Genes., Methods in molecular biology (Clifton, N.J.), 1851, 2019, p63-81 , Journal Article, PUBLISHED  DOI
Yoichiro Nakatani and Aoife McLysaght, Macrosyntenyanalysisshowstheabsenceofancient whole-genome duplication in lepidopteran insects, Proceedings of the National Academy of Sciences (USA), 2019, Journal Article, IN_PRESS
O'Toole, Ã .N. and Hurst, L.D. and McLysaght, A., Faster Evolving Primate Genes Are More Likely to Duplicate, Molecular Biology and Evolution, 35, (1), 2018, p107-118 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Bracken AP., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities., Molecular Cell, 70, (3), 2018, p408-421 , Journal Article, PUBLISHED  DOI
Glenfield C, McLysaght A., Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis., Molecular biology and evolution, 35, (12), 2018, p2886-2899 , Journal Article, PUBLISHED  DOI
Rice A., McLysaght A., Dosage sensitivity is a major determinant of human copy number variant pathogenicity, Nature Communications, 8, 2017, p14366 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Nakatani Y, McLysaght A, Genomes as documents of evolutionary history: A probabilistic macrosynteny model for the reconstruction of ancestral genomes, Bioinformatics, 33, (14), 2017, pi369 - i378, Journal Article, PUBLISHED  DOI  URL
Rice A.M, McLysaght A, Dosage-sensitive genes in evolution and disease, BMC Biology, 15, (1), 2017, p78-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
McLysaght A, Hurst L.D, Open questions in the study of de novo genes: What, how and why, Nature Reviews Genetics, 17, (9), 2016, p567 - 578, Notes: [Export Date: 27 September 2016], Journal Article, PUBLISHED  DOI  URL
Xie T, Yang QY, Wang XT, McLysaght A, Zhang HY., Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance., Molecular biology and evolution, 33, (9), 2016, p2368-2375 , Journal Article, PUBLISHED  DOI

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Computational Tools and Resources in Plant Genome Informatics. in, editor(s)Paul Christou and Harry Klee , Handbook of Plant Biotechnology, Wiley, 2004, pp1 - 28, [Vision, T.J. and McLysaght, A.], Book Chapter, PUBLISHED


Award Date
European Research Council (ERC) Consolidator Award 2017
JBS Haldane Prize Lectures (Genetics Society UK) 2016
Selected for portrait in RIA as part of Women on Walls project: 2016
European Research Council (ERC) Starting Researcher Award 2013-2018
President of Ireland Young Researcher's Award (Science Foundation Ireland) 2005