Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Laure Marignol

Associate Professor (Radiation Therapy)
TRINITY CENTRE, S J H - PHASE II & III


Laure is an Associate Professor in Radiobiology at the Discipline of Radiation Therapy, Trinity College Dublin, Ireland with qualifications from four European universities (B.Sc in health engineering (France, Germany), M. Sc in radiobiology (UK), PhD in clinical medicine (Ireland)). Since her tenured appointment at Trinity College Dublin in 2010, she has developed an internationally-recognised radiobiology laboratory in Ireland. In 2017, Laure was elected as a Fellow of Trinity College Dublin. A year after completion of her phD, she was the recipient of the highly competitive St Luke's Young Investigator Award of the Royal Irish Academy of Medicine for my work on tumour hypoxia and radiation response of prostate tumours. She was appointed Head of Research of the Discipline of Radiation Therapy in 2011 and in this role drove the creation of the Applied Radiation Therapy Trinity (ARTT) research group. Following award of a prostate cancer project grant of the Irish Cancer Society in 2012, she took leadership of the Translational Radiobiology and Molecular Oncology strand within that group. she has since established a unique Irish radiotherapy research network to support translation of her work into improved practice, and developed strong international links. She has built up a good publication track record and mentored a number of PhD and MD candidates. All are now holding positions at leading national and international hospitals and institutions. She was the first European member of the Scholar-In-Training Committee of the Radiation Research Society (USA) and since then, she took a leadership position for the Irish Radiation Research Society and recently became the youngest member of the Radiobiology committee, within the European Society for she holds an editorial role for the Nature Journal Scientific Reports. A passionate radiobiologist with a multi-disciplinary view of radiation oncology, her ambition is to enable the development of radiobiology into the age of personalised medicine.
  Cancer genetics and cell biology including metastasis   Mathematical modelling   Molecular Biology   Prostate cancer   Radiomics   Radiotherapy, Biological response modifiers and chemoprevention   Therapeutic and Clinical oncology   Tissue Culture   Transgene Expression
 Development of a Companion diAgnostic teSt for radiotheraPy prostAte canceR patients (CASPAR)
 Prognosis potential of miRNAs in high risk radiotherapy prostate cancer patients
 Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?

Details Date
Oral Presentation, Radiation Research Society Annual Meeting, Cancun, Mexico 16/10/2017
Invited Presentation, MAASTRO Clinic, The Nederlands. "Developing therapeutic packages for prostate cancer radiotherapy" 14/09/2016
Oral Presentation: "Developing therapeutic packages for prostate cancer radiotherapy" Biomarkers in radiation oncology Workshop, OncoRay, Dresden, Germany 24 May 2016
Poster presentation - ESTRO Annual Meeting, Turin "Therapeutic potential of the YB-1/Notch-3 interaction in prostate cancer" 29/04/2016
Poster presentation "Identification of a miRNAs signature of radioresistance in a prostate cancer model" 18/04/2015
Poster presentation -ESTRO Annual Meeting, Barcelona, 2015 "Identification of MiRNAs associated with radioresistance in a prostate cancer model" 24/04/2015
Invited Talk "5-step guide to the management of a research project" ESTRO Annual Meeting, Barcelona, September 12-16th 2010 15th September 2010
Invited Talk " The treatment Field from the Radiobiologist and Molecular Oncologist's Eye" ESTRO Treatment Planning Course June 26th 2010
Poster Presentation "Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?" Radiation Research Society Annual meeting, USA, September 2010( Winner Scholar-in-Training Travel award). September 2010
Poster Presentation "Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?" Irish Association for Radiation Research, March 2010 March 2010
Poster Presentation "Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?" ESTRO Annual Meeting, Barcelona, September 12-16th 2010 September 2010
Oral Presentation "Hypoxia may participates in disease progression and radioresistance through the induction of Notch-3 and upregulation of DNA repair genes in prostate cancer" Faculty of Radiologist Annual Meeting, Dublin, September 2009 September 2009
Poster Presentation "Hypoxia may participates in disease progression and radioresistance through the induction of Notch-3 and upregulation of DNA repair genes in prostate cancer" 11th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Ermatingen, Switzerland, June 2009 June 2009
Oral Presentation "Hypoxia in prostate tumours: detection, consequences and clinical exploitation" St Lukes Young Investigator Award, Royal Academy of Medicine in Ireland, Dublin, Ireland, January 2009 (Winner St Luke's Young Investigator medal) January 2009
Oral Presentation "Hypoxia may participates in disease progression and radioresistance through the induction of Notch-3 and upregulation of DNA repair genes in prostate cancer" Association for Radiation Research, Annual Meeting, Glasgow, UK, June 2009 June 2009
Invited talk ""Radiation Activated Gene Therapy -A review" Royal College of Surgeons in Ireland, I Faculty Annual Scientific meeting, Dublin, September 2007 20th September 2007
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Fluent Fluent Fluent
Details Date From Date To
Scholar In Training Committee member of the Radiation Research Society (USA) 2007 2010
Scholar In Training Committee member of the Association for Radiation Research (UK) 2008 2012
Scholar In Training Committee member European Society for Therapeutic Radiology and Oncology (ESTRO) 2009 2011
Treasurer, Irish Association for Radiation Research 2013 2016
Irish Association for Cancer Research 2003 Present
Secretary, Irish Association for Radiation Research November 2016 Present
Member, Radiobiology Committee, European Society for Radiotherapy and Oncology (ESTRO) May 2016 Present
Marignol L., Predicting Treatment Outcomes: The Case for Hypoxia Gene Signatures., EBioMedicine, 2018, Journal Article, PUBLISHED  DOI
Inder, S., O'Rourke, S., McDermott, N., (...), Lynch, T., Marignol, L. , The Notch-3 receptor: A molecular switch to tumorigenesis?, Cancer treatment reviews, 60, 2017, p69-76 , Journal Article, PUBLISHED  DOI
Hutchinson, J., Marignol, L. , Clinical Potential of Statins in Prostate Cancer Radiation Therapy., Anticancer research, 37, (10), 2017, p5363-5372 , Journal Article, PUBLISHED  DOI
Haruna, F., Lipsett, A., Marignol, L. , Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis., Anticancer research, 37, (10), 2017, p5343-5353 , Journal Article, PUBLISHED  DOI
Fitzpatrick C, Lynch O, Marignol L., 68Ga-PSMA-PET/CT Has a Role in Detecting Prostate Cancer Lesions in Patients with Recurrent Disease., Anticancer research, 37, (6), 2017, p2753-2760 , Journal Article, PUBLISHED  DOI
Marignol, L., Notch signalling: The true driver of small cell lung cancer?, Translational Cancer Research, 6, 2017, pS1191-S1196 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
O'Brien, R. and Marignol, L., The Notch-1 receptor in prostate tumorigenesis, Cancer Treatment Reviews, 56, 2017, p36-46 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Samsuri, N.A.B. and Leech, M. and Marignol, L., Metformin and improved treatment outcomes in radiation therapy â€" A review, Cancer Treatment Reviews, 55, 2017, p150-162 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Inder, S. and Bates, M. and McDermott, N. and Domad, J. and Schneider, J. and Erdmann, G. and Finn, S. and Manecksha, R. P. and Lynch, T. H. and Marignol, L., Profiling of radioresistant prostate cancer cells identifies deregulation of key protein, 120, 2017, pp24-24 , Poster, PUBLISHED
Devine A, Marignol L, Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis., Anticancer research, 36, (1), 2016, p5-12 , Journal Article, PUBLISHED
  

Page 1 of 9

  

Award Date
Election to Fellowship, Trinity College Dublin 10/04/2017
Irish Cancer Society, Prostate Cancer Project Grant 01/12/2012
Early Career Investigator Award 13/10/2017
6th St Lukes Young Investigator Award 2009
Travel Award, Radiation Research Society, USA 2010
Early investigator award, Association for Radiation Research 2007
Student travel award, International Conference for Radiation Research 2006
Institute for Molecular Medicine Best PhD poster competition award 2006
Nominee for the St Lukes Young Investigator Award 2006
Molecular Mechanisms of radiation resistance in prostate tumours Development of biomarkers of biochemical treatment failure following radiation therapy Relevance of tumour hypoxia to disease progression and radiation treatment planning MRI imaging of the prostate