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Dr. Stephen Maher

Ussher Assistant Professor (Surgery)

 


Stephen Maher graduated from RCSI in 2004 with a PhD in Oncology. Having spent 3 years as a visiting fellow at the National Cancer Institute in the USA, in 2007 he returned to Ireland and the Department of Surgery at Trinity College Dublin, St. James's Hospital as a research fellow. In 2010 he established his on group having secured an Irish Cancer Society Fellowship and HRB project grants in 2011 and 2012, all in the area of radiation research. In 2012 Stephen moved to the University of Hull and Hull York Medical School as a senior lecturer where he lead the Cancer Biology and Therapeutics lab. During his time at Hull he gained substantial teaching experience and qualifications, and is a fellow of the UK Higher Education Academy. Subsequently he developed and directed the MSc in Translational Oncology at Hull, as well as undergraduate cancer biology teaching. Additionally, he acquired funding for and established an optical imaging and radiotherapy core at the University of Hull, and aided in establishing the local tumour biobank for translational cancer studies. He has successfully supervised 5 PhD students and has mentored several postdoctoral researchers. He has secured in excess of €1.5m in competitive research funding, and is well published in the field of microRNA, oesophageal cancer and therapeutics research. In 2016 Stephen returned to TCD as the Ussher Assistant Professor in Translational Oncology, Radiation Therapy and Chemotherapy. Here he leads programmes in translational cancer research, focusing on radiotherapy, radiobiology and chemotherapy. He has recently established new hypoxia and radiotherapy research cores at the recently opened Trinity Translational Medicine Institute. Stephen teaches various aspects of cell and cancer biology and therapy across TCD's MSc Translational Oncology and Molecular Medicine.
  Angiogenesis   Apoptosis   Apoptosis, molecular control   Autoimmune and hypersensitivity diseases   Autoimmunity   Bioinformatics   Breast cancer   Cancer genetics and cell biology including metastasis   Cell cycle control   Cell Death   Cellular, molecular and developmental immunology   Chronic Disease   Chronic inflamation   Coagulation biochemistry and disorders   Cytokines, Nitric Oxide   Cytoskelton, cell division   DNA transcription and translation   Gene targeting in breast cancer   Gene therapy   Gene transcription in human cancer   General surgery, upper GI, colorectal and breast   Genetic/Molecular epidemiology   Genomics   Haemotology   Human genetics   Immune system   Immunoassays   Immunochemistry and immunogenetics   Immunological response to surgical trauma   Immunotherapies   Immunotherapies for Cancer   Inflammation and coagulation syndromes   Inflammatory bowel disease   Innate immunology   Intra and intercellular signalling   Leukemias and lymphomas   Leukocyte Biology   Mammilian and human genetics and genomics   Membrane and protein trafficking   Mucosal immunology   Oesophageal cancer   Oesophageal, gastric, intestinal and pancreatic diseases   Oncogenes, apoptosis and tumour development   Protein processing, stability and regulation   Protein sequence, function and expression   Quantitative and molecular genetics   Radiotherapy   Radiotherapy, Biological response modifiers and chemoprevention   Regulatory methods of gene expression   RNA processing, stability and degradation   Stem Cell biology and hematopoiesis   Therapeutic and Clinical oncology   Therapeutic radiography   Tumour immunology and immunotherapy   Vascular Biology, Thrombosis
 The role of microRNA and random mitochondrial DNA mutations in a novel clinically-relevant isogenic model of radioresistance in oesophageal adenocarcinoma
 Tissue and Serum microRNA signatures for predicting response to chemoradiotherapy for oesophageal adenocarcinoma
 The role of the chemokine CCL28 (MEC) in oesophageal adenocarcinoma progression: interaction between the immune system and the tumour

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Basic Medium
Irish Medium Medium Medium
Details Date From Date To
Irish Association of Radiation Research (IRRS) 2016 Present
Association of Radiation Research (UK) 2015 Present
Biochemical Society UK 2013 Present
Clinical Trials Ireland (formerly ICORG) 2009 present
British Association of Cancer Research (BACR) 2013 Present
European Association of Cancer Research (EACR) 2009 Present
Irish Association of Cancer Research (IACR) 2008 Present
American Association of Cancer Research (AACR): Associate Member 2006 Present
British Lung Foundation 2013 2016
International Society for Interferon and Cytokine Research (ISICR) 2004 2009
MicroRNA in oncogenesis in, editor(s)Trygve Tollefsbol , Epigenetics in Human Disease, London, Elsevier, 2017, [Maher SG, Lynam-Lennon N], Notes: [Second edition], Book Chapter, APPROVED
Lynam-Lennon N, Heavey S, Sommerville G, Bibby BA, Ffrench B, Quinn J, Gasch C, O'Leary JJ, Gallagher MF, Reynolds JV, Maher SG, MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype, Oncotarget, 8, (7), 2017, p11400 - 11413, Journal Article, PUBLISHED
Moody HL, Lind MJ, Maher SG, MicroRNA-31 regulates chemosensitivity in malignant pleural mesothelioma, Molecular Therapy - Nucleic Acids, 2017, Journal Article, ACCEPTED
Bibby BA, Cawthorne C, Lynam-Lennon N, Moody HL, Reynolds JV, Maher SG, Silencing of microRNA-300-5p upregulates MMP1 expression and promotes an invasive phenotype in oesophageal adenocarcinoma, British Journal of Cancer, 2017, Journal Article, SUBMITTED
Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397 , Journal Article, PUBLISHED  DOI
Mongan AM, Lynam-Lennon N, Casey R, Maher SG, Pidgeon GP, Reynolds JV, O'Sullivan J, Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma, Clinical Translational Oncology, 18, 2016, p632 - 640, Journal Article, PUBLISHED
Moore C, Wood T, Cawthorne C, Hilton K, Maher SG, Saunderson J, Archibald SJ, Beavis AW, A method to calibrate the RS2000 X-ray biological irradiator for radiobiological flank irradiation of mice, Biomedical Physics and Engineering Express, 2, 2016, p037001 , Journal Article, PUBLISHED
MicroRNA and cancer in, editor(s)Steven G Gray , Epigenetic cancer therapy, London, Elsevier, 2015, pp67 - 90, [Maher SG, Bibby B, Moody H, Reid G], Book Chapter, PUBLISHED
Bibby B.A.S, Reynolds J.V, Maher S.G, MicroRNA-330-5p as a putative modulator of neoadjuvant chemoradiotherapy sensitivity in oesophageal adenocarcinoma, PLoS ONE, 10, (7), 2015, p013418-, Notes: [Cited By :3 Export Date: 23 February 2017], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Reynolds JV, O'Sullivan J, Dysfunctional mitochondria and enhanced metabolic plasticity is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE, 9, 2014, pe100738 , Journal Article, PUBLISHED
  

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Cawthorne C, Maher SG, Ahmed N, Beavis AW, Improving the application of PET to radiotherapy via preclinical research: status and potential, RAD Magazine, 42, (492), 2016, p29 - 30, Review Article, PUBLISHED
Maher SG, Reynolds JV, Oesophageal cancer: The potential of modern molecular tools in treatment, Cancer Professional, 6, 2012, p21 - 25, Review Article, PUBLISHED

  

Award Date
iMig Young Investigator Award (Supervisor) 2016
Researcher of the Year, Hull York Medical School (Supervisor) 2016
NCRI Hamilton-Fairley Young Investigator Awards (double-shortlisting) (Supervisor) 2015
1st Prize, Best Research Paper, 12th Annual International Medical Postgraduate Conference, Charles University in Prague (Supervisor) 2015
1st Prize, Best Poster, UK Radiation Oncology (UKRO) Annual Meeting (Supervisor) 2015
1st Prize, Best Research Paper, 11th Annual International Medical Postgraduate Conference, Charles University in Prague (Supervisor) 2014
Biochemical Society Summer Studentship (Supervisor) 2013
Researcher of the Year, Irish Cancer Society 2013
Patey Prize, SARS Annual Meeting 2011
Fellowship, Irish Cancer Society 2010
Roche Researcher of the Year, TCD (Supervisor) 2010
Poster Prize, 7th International Cancer Conference (Dublin) 2009
First Prize, TCD Molecular Medicine Entrepreneurship Course 2009
Travel Award, St. James's Hospital Dublin 2009
Donald Weir Medal for Research, Trinity College Dublin 2008
Oncology Scholars Travel Award, Irish Cancer Society 2008
Irish Representative at 39th LIYSF 1997
Fellowship, National Cancer Institute (USA) 2004