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Professor Marina Lynch

Professor (Physiology)

Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience
  Age related diseases   Aging/Gerontology   Antiinflammatory Cytokines   Brain   HIPPOCAMPUS   Inflammation   POLYUNSATURATED FATTY ACIDS   PROINFLAMMATORY CYTOKINES   SYNAPTIC PLASTICITY
Lynch, MA, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR. , Brain Behaviour Immunity, 2015, Notes: [doi: 10.1016/j.bbi.2015.01.005], Journal Article, ACCEPTED  TARA - Full Text  DOI  Other
Raasay S. Jones and Marina A. Lynch, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 2014, Journal Article, ACCEPTED  TARA - Full Text  DOI
Aedín M. Minogue, Raasay S. Jones, Ronan J. Kelly, Claire L. McDonald, Thomas J. Connor and Marina A. Lynch., Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice, Neurobiology of Aging , 2014, p1-30 , Journal Article, SUBMITTED  TARA - Full Text
Murphy, N., Grehan, B., Lynch, M.A., Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10, NeuroMolecular Medicine, 16, (1), 2014, p205-215 , Journal Article, PUBLISHED  DOI
McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Marina A Lynch, Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β, Brain Research, 2014, Journal Article, ACCEPTED  TARA - Full Text
Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17 , Journal Article, PUBLISHED  TARA - Full Text  URL
Derek A. Costello, and Marina A. Lynch., Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β, Hippocampus, 23, (8), 2013, p696-707 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Lynch MA, The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease., Immunology, 141, (3), 2013, p292-301 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Eric J. Downer, Raasay S. Jones, Claire L. McDonald, Eleonora Greco, Sabina Brennan, Thomas J. Connor, Ian H. Robertson, Marina A. Lynch, Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory, Plos One, 8, (5), 2013, ppe63194 , Journal Article, PUBLISHED  TARA - Full Text  DOI

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Award Date
2006: Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient
Elected to membership of the Royal Irish Academy May 2009
RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.