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Professor Marina Lynch

Professor (Physiology)

Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience
  Age related diseases   Aging/Gerontology   Antiinflammatory Cytokines   Brain   HIPPOCAMPUS   Inflammation   POLYUNSATURATED FATTY ACIDS   PROINFLAMMATORY CYTOKINES   SYNAPTIC PLASTICITY

Details Date
2001-2005: Member of Irish government-appointed Commission on Assisted Human Reproduction; Workgroup Chair & member of drafting group for the final report. 2001-2009: Member of Board of Trinity College Institute of Neuroscience 2005-2008: Member of Board of Trinity College Dublin 2006-2009: Director, Trinity College Institute of Neuroscience
Details Date From Date To
British Neuroscience Association 1995 2017
C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316 , Journal Article, PUBLISHED  TARA - Full Text
McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12 , Journal Article, PUBLISHED  DOI
Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243 , Journal Article, PUBLISHED  DOI
McDonald C.L, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, Reilly M, Lynch M.A, Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease, Brain, Behavior, and Immunity, 58, 2016, p191 - 200, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  DOI  URL
Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 2016, p1-10 , Notes: [Export Date: 8 December 2016 Article in Press], Journal Article, IN_PRESS  DOI  URL
Costello D.A, Keenan K, McManus R.M, Falvey A, Lynch M.A, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function, Neurobiology of Aging, 43, 2016, p140 - 148, Notes: [Cited By :1 Export Date: 8 December 2016], Journal Article, PUBLISHED  DOI  URL
Drechsler S, Lynch M.A, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro R.E, Vandenbroucke R.E, Osuchowski M, Potter P.K, With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions, Mechanisms of Ageing and Development, 160, 2016, p54 - 68, Notes: [Export Date: 8 December 2016], Journal Article, PUBLISHED  DOI  URL
Andreasson K.I, Bachstetter A.D, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee D.C, Low D, Lynch M.A, Monsonego A, O'Banion M.K, Pekny M, Puschmann T, Russek-Blum N, Sandusky L.A, Selenica M.-L.B, Takata K, Teeling J, Town T, Van Eldik L.J, Targeting innate immunity for neurodegenerative disorders of the central nervous system, Journal of Neurochemistry, 2016, p653 - 693, Notes: [Cited By :1 Export Date: 8 December 2016], Journal Article, PUBLISHED  DOI  URL
Costello DA, Keenan K, McManus RM, Falvey A, Lynch MA, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function., Neurobiology of aging, 43, 2016, p140-8 , Journal Article, PUBLISHED  DOI
Lynch, MA, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR. , Brain Behaviour Immunity, 46, 2015, p70-79 , Journal Article, PUBLISHED  TARA - Full Text  DOI  Other

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Award Date
Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient 2006
Elected to membership of the Royal Irish Academy May 2009
Recipient of Tom Connor Distinguished Researcher Award In Neuroscience 2013
Recipient of the Irish Area Section of the Biochemical Society Silver Medal 2013
Elected Fellow of Trinity College, Dublin 1997
RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.