Trinity College Dublin


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

Profile Photo

Professor Marina Lynch

Professor (Physiology)
LLOYD INSTITUTE


Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience
  Age related diseases   Aging/Gerontology   Antiinflammatory Cytokines   Brain   HIPPOCAMPUS   Inflammation   POLYUNSATURATED FATTY ACIDS   PROINFLAMMATORY CYTOKINES   SYNAPTIC PLASTICITY
Raasay S. Jones and Marina A. Lynch, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 2014, Journal Article, ACCEPTED  TARA - Full Text
Aedín M. Minogue, Raasay S. Jones, Ronan J. Kelly, Claire L. McDonald, Thomas J. Connor and Marina A. Lynch., Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice, Neurobiology of Aging , 2014, p1-30 , Journal Article, SUBMITTED  TARA - Full Text
Murphy, N., Grehan, B., Lynch, M.A., Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10, NeuroMolecular Medicine, 16, (1), 2014, p205-215 , Journal Article, PUBLISHED  DOI
McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Marina A Lynch, Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β, Brain Research, 2014, Journal Article, ACCEPTED  TARA - Full Text
Derek A. Costello, and Marina A. Lynch., Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β, Hippocampus, 23, (8), 2013, p696-707 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Lynch MA, The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease., Immunology, 141, (3), 2013, p292-301 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Eric J. Downer, Raasay S. Jones, Claire L. McDonald, Eleonora Greco, Sabina Brennan, Thomas J. Connor, Ian H. Robertson, Marina A. Lynch, Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory, Plos One, 8, (5), 2013, ppe63194 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Jones RS, Minogue AM, Connor TJ, Lynch MA, Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8, (1), 2013, p301-311 , Notes: [This work was funded by Science Foundation Ireland (07/IN.1/B949). RSJ was supported by a Health Research Board-funded structured PhD program in Neuroscience (PhD/2008/13)], Journal Article, PUBLISHED  TARA - Full Text  DOI
Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

Page 1 of 23

  

Award Date
2006: Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient
Elected to membership of the Royal Irish Academy May 2009
RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.