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Professor Marina Lynch

Adjunct Professor (Physiology)

Fellow Emeritus (Trinity Inst. of Neurosciences (TCIN))

Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience
  Age related diseases   Aging/Gerontology   Antiinflammatory Cytokines   Brain   HIPPOCAMPUS   Inflammation   POLYUNSATURATED FATTY ACIDS   PROINFLAMMATORY CYTOKINES   SYNAPTIC PLASTICITY

Details Date
2001-2005: Member of Irish government-appointed Commission on Assisted Human Reproduction; Workgroup Chair & member of drafting group for the final report. 2001-2009: Member of Board of Trinity College Institute of Neuroscience 2005-2008: Member of Board of Trinity College Dublin 2006-2009: Director, Trinity College Institute of Neuroscience
Details Date From Date To
British Neuroscience Association 1995 2017
Finucane O.M, Sugrue J, Rubio-Araiz A, Guillot-Sestier M.-V, Lynch M.A, The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages, Scientific Reports, 9, (1), 2019, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
McIntosh A, Mela V, Harty C, Minogue AM, Costello DA, Kerskens C, Lynch MA., Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice., Brain Pathology, 2019, p10.1111/bpa.12704. , Journal Article, PUBLISHED  DOI
Wolfe H, Rivas VM, Minogue AM, Miller AM, McGuigan C, Williams L, Lohan D, Lawlor BA, Lynch MA., Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming., Neuroscience Research, 2019, p1- , Journal Article, PUBLISHED  DOI
Holland, R. and McIntosh, A.L. and Finucane, O.M. and Mela, V. and Rubio-Araiz, A. and Timmons, G. and McCarthy, S.A. and Gun'ko, Y.K. and Lynch, M.A., Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice, Brain, Behavior, and Immunity, 2018, p183-196-, Journal Article, PUBLISHED  DOI
Wolfe H, Hannigan C, O'Sulivan M, Carrol, LB, Brennan S, Lawlor, R, Robertson, IH, Lynch, M, A shift to glycolysis accompanies the inflammatory changes in PBMCs from Individuals with an IQ-discrepant memory, Journal of Neuroimmunology, 317, 2018, p24 - 31, Journal Article, PUBLISHED  URL
Wolfe, H. and Minogue, A.M. and Rooney, S. and Lynch, M.A., Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice, Mechanisms of Ageing and Development, 173, 2018, p84-91 , Journal Article, PUBLISHED  DOI
Rubio-Araiz, A. and Finucane, O.M. and Keogh, S. and Lynch, M.A., Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid, Journal of Neuroinflammation, 15, (1), 2018, p247-, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 54, (7), 2017, p5730 - 5739, Journal Article, PUBLISHED  DOI  URL
C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316 , Journal Article, PUBLISHED  TARA - Full Text
McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12 , Journal Article, PUBLISHED  DOI

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Award Date
Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient 2006
Elected to membership of the Royal Irish Academy May 2009
Recipient of Tom Connor Distinguished Researcher Award In Neuroscience 2013
Recipient of the Irish Area Section of the Biochemical Society Silver Medal 2013
Elected Fellow of Trinity College, Dublin 1997
RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.