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Professor Marina Lynch

Professor (Physiology)

Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience
  Age related diseases   Aging/Gerontology   Antiinflammatory Cytokines   Brain   HIPPOCAMPUS   Inflammation   POLYUNSATURATED FATTY ACIDS   PROINFLAMMATORY CYTOKINES   SYNAPTIC PLASTICITY
Lynch, MA, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR. , Brain Behaviour Immunity, 46, 2015, p70-79 , Journal Article, PUBLISHED  TARA - Full Text  DOI  Other
Lynch, MA, Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli., Journal of Alzheimers Disease, 44 , (3), 2015, p949-962 , Notes: [PMID: 25374107], Journal Article, PUBLISHED  TARA - Full Text  Other
McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, PMID 25957956, 2015, Journal Article, PUBLISHED  DOI  URL
Raasay S. Jones and Marina A. Lynch, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 96, (A), 2015, p3-10 , Journal Article, ACCEPTED  TARA - Full Text  DOI
Marina A Lynch, Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β, Brain Research, 2015, Journal Article, ACCEPTED  TARA - Full Text
Barrett J., Costello D., O'Sullivan J., Cowley T., Lynch M., Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli, Journal of Neuroinflammation, 12, (1), 2015, Journal Article, PUBLISHED  DOI
Barrett J., Minogue A., Falvey A., Lynch M., Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages, Experimental Cell Research, 335, (2), 2015, p258-268 , Journal Article, PUBLISHED  DOI
Raasay S. Jones, Aedín M. Minogue, Orla Fitzpatrick, Marina A. Lynch, Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice, Experimental Cell Research, 2015, Notes: [ ], Journal Article, IN_PRESS  DOI
Aedín M. Minogue, Raasay S. Jones, Ronan J. Kelly, Claire L. McDonald, Thomas J. Connor and Marina A. Lynch., Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice, Neurobiology of Aging , 2014, p1-30 , Journal Article, SUBMITTED  TARA - Full Text
Murphy, N., Grehan, B., Lynch, M.A., Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10, NeuroMolecular Medicine, 16, (1), 2014, p205-215 , Journal Article, PUBLISHED  DOI

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Award Date
2006: Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient
Elected to membership of the Royal Irish Academy May 2009
RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.