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Dr. Lydia Lynch

Associate Professor in Immunology (Biochemistry)


My lab is interested in understanding the cross-talk between the innate immune system and the metabolic system, and the key molecules involved. A major focus is to understand the cellular metabolic decisions controlling the effector fate of leukocytes that may ultimately open doors to manipulate the immune system in metabolic disorders. This also extends to other situations of altered metabolism, such as in the tumor microenvironment. The goal is to integrate the two aspects of immunometabolism (systemic and intrinsic bioenergetics) to enable us to find metabolic targets for immune cell modulation and ultimately manipulate them in human disease.
Dyck, L. and Lynch, L., Cancer, obesity and immunometabolism â€" Connecting the dots, Cancer Letters, 417, 2018, p11-20 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S., Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes, Molecular Metabolism, 12, 2018, p25-38 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Kohlgruber, A.C. and Gal-Oz, S.T. and Lamarche, N.M. and Shimazaki, M. and Duquette, D. and Nguyen, H.N. and Mina, A.I. and Paras, T. and Tavakkoli, A. and Von Andrian, U. and Banks, A.S. and Shay, T. and Brenner, M.B. and Lynch, L., γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis /631/250/256 /631/250/2504 article, Nature Immunology, 19, (5), 2018, p464-474 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
LaMarche, N.M. and Lynch, L., Adipose Dendritic Cells Come Out of Hiding, Cell Metabolism, 27, (3), 2018, p485-486 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dyck, L. and Lynch, L., New Job for NK Cells: Architects of the Tumor Microenvironment, Immunity, 48, (1), 2018, p9-11 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses, Nature Immunology, 18, (11), 2017, p1197 - 1206, Journal Article, PUBLISHED  DOI  URL
Chang, S.K. and Kohlgruber, A.C. and Mizoguchi, F. and Michelet, X. and Wolf, B.J. and Wei, K. and Lee, P.Y. and Lynch, L. and Duquette, D. and Ceperuelo-Mallafré, V. and Banks, A.S. and Brenner, M.B., Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes, Journal of Clinical Investigation, 127, (9), 2017, p3300-3312 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Boulenouar, S. and Michelet, X. and Duquette, D. and Alvarez, D. and Hogan, A.E. and Dold, C. and O'Connor, D. and Stutte, S. and Tavakkoli, A. and Winters, D. and Exley, M.A. and O'Shea, D. and Brenner, M.B. and von Andrian, U. and Lynch, L., Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity, Immunity, 46, (2), 2017, p273-286 , Notes: [cited By 10], Journal Article, PUBLISHED  DOI
PrÃŒss, H. and Tedeschi, A. and Thiriot, A. and Lynch, L. and Loughhead, S.M. and Stutte, S. and Mazo, I.B. and Kopp, M.A. and Brommer, B. and Blex, C. and Geurtz, L.-C. and Liebscher, T. and Niedeggen, A. and Dirnagl, U. and Bradke, F. and Volz, M.S. and DeVivo, M.J. and Chen, Y. and Von Andrian, U.H. and Schwab, J.M., Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex, Nature Neuroscience, 20, (11), 2017, p1549-1559 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Kohlgruber, A.C. and LaMarche, N.M. and Lynch, L., Adipose tissue at the nexus of systemic and cellular immunometabolism, Seminars in Immunology, 28, (5), 2016, p431-440 , Notes: [cited By 5], Journal Article, PUBLISHED  DOI

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