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Professor Lorraine O'Driscoll

Professor (Pharmacy)
24 WESTLAND ROW


Lorraine O'Driscoll (BSc(Hons, Pharm), MSc(Res, Clin Pharm), MA(Ed), PhD(Biotech), FTCD) Lorraine holds a BSc(Hons), pharmacology; MSc(Res), clinical pharmacology; MA, education; PhD, biotechnology. In 2012, she was elected to Fellowship in TCD. Following her PhD, Lorraine undertook biotechnology/biomedical research for US and EU industry (including Berlex; Archport Ltd-Axonobel; MediSyn Ltd; MedaNova Ltd.) before returning to academic research & teaching. At post-doctoral level, she gained experience at the Dana-Farber Harvard Cancer Institute and University of Miami. Prior to joining TCD in 2008, Lorraine most recently held the position of Senior Research Programme Leader and Lecturer in School of Biotechnology, DCU. Her research group focuses on diagnostic, prognostic and predictive biomarkers; discovering new therapeutic targets; cancer cells communication via exosomes, microvesicles and CTCs; elucidating and circumventing resistance to targets agents and classical chemotherapy; associations between obesity, metabolic syndrome and cancer. She has been a P.I. on 5 cancer clinical trials with ICORG. She is TCD's Principal Investigator on SFI-supported Molecular Therapeutics for Cancer Ireland; Strand Leader of Irish Cancer Society-supported Breast-PREDICT; and P.I. and Chair, H2020-supported European Network Cooperation in Science and Technology focussed on Exosomes & Microvesicles in Health & Disease which brings together researchers from 27 European countries, 3 US universities, Australia and 7 industry partners. In 2017, she was awarded approx. €4,000,000 as Director of a H2020 ITN aimed at training 15 PhD students in TRAIN-EV i.e. training in extracellular vesicles: for benefit in health and disease. She has developed tailored courses for academia (e.g. FEBS), semi-state bodies (e.g. IDA) and industry. Her graduates and mentees are now employed at NIH; Pfizer; Amgen; Leo; Roche; AstraZeneca; ICON plc; 2 are entrepreneurs/company CEOs; 2 are Managers of Research Centres; others hold lecturing and research posts in academia.
  Apoptosis   Apoptosis, molecular control   Bioinformatics   Biology   Biology and therapy of myeloma   Biomedical sciences   Breast cancer   Cancer genetics and cell biology including metastasis   Cell and tissue development   Cell and tissue maintenance, repair and ageing   Clinical research, trials   Diabetes and diabetic complications   Diagnostics   DNA transcription and translation   Drug development and evaluation   Drug discovery, profiling, targeting   Embryonic development   Endocrine function and disease   Gene targeting in breast cancer   Gene therapy   Gene transcription in human cancer   Human genetics   Immunoassays   In vitro testing, trial methods   Mammilian and human genetics and genomics   Medical Sciences, Research   Membrane and protein trafficking   Multiple Myeloma   Oncogenes, apoptosis and tumour development   Pathology   Prostate cancer   Regulatory methods of gene expression   RNA processing, stability and degradation   Stem Cell biology and hematopoiesis   Therapeutic and Clinical oncology
 Milking extracellular vesicles for improved infant milk formula (MilkEV)
 Exosomal Neuromedin U and miR-X: potential predictive biomarkers for HER2-targeted drugs
 European Network on Microvesicles & Exosomes in Health and Disease
 Breast-PREDICT
 Biomarkers & Therapeutics Targets: MeS, Diabetes and Cancer

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Details Date From Date To
Director, TRAIN-EV training in extracellular vesicles: for benefit in health and disease. 2017 2021
Founding Committee Member, Irish Association of Pharmacologists 2016
Invited Role Model, Inspiring Leadership - Leadership Foundation for Higher Education (Aurora), Ireland and UK 2015
Chair, European Network on Microvesicles and Exosomes in Health and Disease 2013 ------
Invited Member of Irish Association for Cancer Research (IACR) Research Capacity Building Committee 2011 present
Editorial Board Member for Encyclopaedia of Bioscience Frontier in Bioscience 2007-present
Editorial Board Member for Cancer Genomics & Proteomics 2006-present
Editor of Anticancer Research May 2004; Aug. 2007
Guest-Editor of book volume of Current Cancer Drug Targets entitled "Mechanisms of Cancer Drug Sensitivity & Resistance: A Translational Approach" 2009
Guest-Edition of Methods in Molecular Biology: Gene Expression Profiling 2009-2010
International Conference Organisng Committee Member: 8th International Conference of Anticancer Research, Kos 2008
International Conference Organisng Committee Member: Global mRNA & Protein Expression Analysis for Biomedical Applications & Biopharmaceutical Production, Dublin 2006
International Conference Organisng Committee Member: International Islet and Pancreas Transplantation Association Congress 2003
International Conference Organisng Committee Member: 1st International Conference Biotechnology Cancer and Drug Resistance 2003
International Conference Organisng Committee Member: 7th International Conference of Anticancer Research, Corfu 2004
Invited Member of the International Institute of Anticancer Research (IIAR) Scientific Advisory Board 2006-present
Deputy-President of the Irish Branch of the European Tissue Culture Society (ETCS) 2007-present
Director/Council Member of the Irish Association for Cancer Research (IACR) 2008-present
Member of the European Association for Cancer Research (EACR) 2006-present
Research Specialist: All Ireland Clinical Oncology Research Group (& Principal Investigator on Phase I & II trials) 2005-present
Member of Irish Network of Stem-Cell Investigators (INNSI) 2004-present
Member of the European Association for the Study of Diabetes (EASD) 2002-present
Board Member of the National Institute for Cellular Biotechnology 2002-present
Member of the National Institute for Cellular Biotechnology Scientific Advisory Board 2002-present
Elected Member on Dublin City University's Research Advisory Panel 2002-2008
Elected Member on Dublin City University's Faculty of Science & Health Research Committee 2003-2008
McNamee N, O'Driscoll L, Extracellular vesicles and anti-cancer drug resistance, Biochim Biophys Acta , 2018, Notes: [pii: S0304-419X(18)30096-9. doi: 10.1016/j.bbcan.2018.07.003. [Epub ahead of print]], Journal Article, PUBLISHED  URL
Lowry MC, O'Driscoll L, Can hi-jacking hypoxia inhibit extracellular vesicles in cancer?, Drug Discovery Today, 23, (6), 2018, p1267 - 1273, Notes: [10.1016/j.drudis.2018.03.006], Journal Article, PUBLISHED  URL
O'Neill S, Larsen MB, Gregersen S, Hermansen K, O'Driscoll L., miR-758-3p: a blood-based biomarker that's influence on the expression of CERP/ABCA1 may contribute to the progression of obesity to metabolic syndrome., Oncotarget, 9, (10), 2018, p9379 - 9390, Notes: [doi: 10.18632/oncotarget.24314], Journal Article, PUBLISHED  TARA - Full Text  URL
Profiling Circulating miRNAs from the Plasma of Individuals with Metabolic Syndrome in, editor(s)Rani S (ed.) , Meth. Mol. Biol., New York, Springer, 2017, pp141 - 149, [O'Neill S, O'Driscoll L], Notes: [doi: 10.1007/978-1-4939-6524-3_13 PMID: 27826924 ], Book Chapter, PUBLISHED  TARA - Full Text  URL
MicroRNA Profiling of Exosomes in, editor(s)Rani S (ed.) , Methods in Molecular Biology, New York, Springer, 2017, pp37 - 46, [Daly M, O'Driscoll L], Notes: [doi 10.1007/978-1-4939-6524-3_5 PMID: 27826916], Book Chapter, PUBLISHED  TARA - Full Text  URL
Martinez VG, O'Neill S, Salimu J, Breslin S, Clayton A, Crown J, O'Driscoll L., Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles., Oncoimmunology, 6, (12), 2017, pe1362530 , Notes: [doi: 10.1080/2162402X.2017.1362530 PMID: 29209569], Journal Article, PUBLISHED  DOI  URL
Vanesa G. Martinez, John Crown, Richard K. Porter, Lorraine O'Driscoll, Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer, International Journal of Cancer, 140, (12), 2017, p2771 - 2784, Notes: [doi: 10.1002/ijc.30705 PMID: 28340506], Journal Article, PUBLISHED  DOI  URL
EV-TRACK Consortium, Van Deun J, Mestdagh P, Agostinis P, Akay Ö, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, Buschmann D, Byrd JB, Casert C, Cheng L, Cmoch A, Daveloose D, De Smedt E, Demirsoy S, Depoorter V, Dhondt B, Driedonks TA, Dudek A, Elsharawy A, Floris I, Foers AD, Gärtner K, Garg AD, Geeurickx E, Gettemans J, Ghazavi F, Giebel B, Kormelink TG, Hancock G, Helsmoortel H, Hill AF, Hyenne V, Kalra H, Kim D, Kowal J, Kraemer S, Leidinger P, Leonelli C, Liang Y, Lippens L, Liu S, Lo Cicero A, Martin S, Mathivanan S, Mathiyalagan P, Matusek T, Milani G, Monguió-Tortajada M, Mus LM, Muth DC, Németh A, Nolte-'t Hoen EN, O'Driscoll L, Palmulli R, Pfaffl MW, Primdal-Bengtson B, Romano E, Rousseau Q, Sahoo S, Sampaio N, Samuel M, Scicluna B, Soen B, Steels A, Swinnen JV, Takatalo M, Thaminy S, Théry C, Tulkens J, Van Audenhove I, van der Grein S, Van Goethem A, van Herwijnen MJ, Van Niel G, Van Roy N, Van Vliet AR, Vandamme N, Vanhauwaert S, Vergauwen G, Verweij F, Wallaert A, Wauben M, Witwer KW, Zonneveld MI, De Wever O, Vandesompele J, Hendrix A., EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research., Nature Methods, 14, (3), 2017, p228 - 232, Notes: [Lorraine O'Driscoll is founding chair of the H2020 Consortium network. [Authorship is alphabetical]. doi: 10.1038/nmeth.4185 PMID: 28245209], Journal Article, PUBLISHED  DOI  URL
Breslin S, Lowry M, O'Driscoll L, Neratinib-resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4, British Journal of Cancer, 116, (5), 2017, p620 - 625, Notes: [doi: 10.1038/bjc.2016.445 PMID: 28152547 ], Journal Article, PUBLISHED  DOI  URL
O'Driscoll L, Stoorvogel W, Thery C, Buzas E, Nazarenko I, Siljander P, Yanez-Mo M, Fais S, Giebel B, Yliperttula M, European Network on Microvesicles and Exosomes in Health and Disease, European Journal of Pharmaceutical Sciences, 98, 2017, p1 - 3, Notes: [doi: 10.1016/j.ejps.2017.01.003 PMID: 28115061 ], Journal Article, PUBLISHED  DOI  URL
  

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Springer London(ed.), Royal Academy of Medicine in Ireland, Irish Journal of Medical Science, Brookfield Health Sciences Complex, Univeristy College Cork, 185, (Suppl. 1), 20/06/2013, Springer London Ltd, 236 Gray's Inn Road, London, 2016, S21 p, Notes: [Potential miRNA Biomarkers for Metabolic Syndrome], Proceedings of a Conference, PUBLISHED
Springer London(ed.), Royal Academy of Medicine in Ireland, Irish Journal of Medical Science, Brookfield Health Sciences Complex, Univeristy College Cork, 185, (Suppl. 1), 20/06/2013, Springer London Ltd, 236 Gray's Inn Road, London, 2013, S32-33 p, Proceedings of a Conference, PUBLISHED

  

Bi-directional translational research; cancer research; diagnostic biomarkers; prognostic biomarkers; predictive markers; novel therapeutic targets; targeted therapies; pipeline drugs; monoclonal antibodies; small molecules; clinical and industry collaborations; breast cancer; lung cancer; prostate cancer; melanoma; multiple myeloma; circulating tumour cells (CTCs); multi-drug resistance; stem cells; differentiation; diabetes; islet transplants; microarrays; proteomics; mRNAs; microRNAs (miRNAs); clinical trials