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Professor Ed Lavelle

Prof/ Course Co-Ordinator (Biochemistry)

Head of School (Sch Office - Biochemistry & Immunology)


I am an Immunologist and have been Head of the School of Biochemistry and Immunology since 2017. I have engaged at teaching at many levels in Universities in Ireland and the U.K. In particular, since October 2004 I have worked as a lecturer, senior lecturer and Professor in Immunology in the School of Biochemistry and Immunology at Trinity College Dublin. In addition to delivering lectures and tutorials to junior and senior sophister students, I have also lectured to students enrolled on the MSc courses in Molecular Medicine, Immunology and Translational Oncology. I was also previously engaged in lecturing at TCD and at the University of Nottingham (England). I have supervised student projects from diploma to Masters degree level and have supervised 17 PhD students to completion. I have been President of the Irish Society for Immunology since 2012, organised a number of National and International conferences, chaired sessions on Immunology and vaccines for a number of national and international conferences and acted as a peer reviewer for leading Immunology journals and for funding bodies in both the EU and the USA. Since acquiring my PhD in 1994, my research has been principally in the fields of Immunology and vaccine adjuvant development. The projects I have worked on have included the piscine mucosal immune system, the use of biodegradable micro and nanoparticles as vaccine adjuvants and the evaluation of plant lectins as bioadhesives, immunogens and immunomodulators. During this time I acquired broad expertise that is applicable to the range of projects I am now engaged in and will pursue in the future. In recent years my principal research interest has been the elucidation of the mechanism of action of adjuvants and immunomodulators. In particular I have focused on on particulate vaccine adjuvants including biodegradable microparticles, alum and the cationic polysaccharide chitosan. This work includes basic research into the mechanism by which these systems activate the immune system and more applied work on the optimisation of these adjuvants for use in injectable and mucosal vaccines. The fundamental adjuvant research includes studies into the cell signalling pathways induced by these molecules which will facilitate a better understanding of their mode(s) of action. In addition, over the past number of years my team have worked closely with our collaborators within AMBER to address the potential of novel biomaterials to drive beneficial immune responses underpinning tissue regeneration. Across all of our activities we depend on building and sustaining close collaborations with national and international academic and industrial collaborators.
  ADENYLYL-CYCLASE ACTIVITY   ADJUVANTS   cAMP   Cell Death   CREB   IL-10   Immune System   Immunity   Immunology, Immunotherapy   Immunophysiology   Inflammation   LECTIN-BINDING   LECTINS   Life Sciences   Nanotechnology   NF-kappaB   Signal Transduction   Signal Transduction (Sensory/Cellular)   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   Toll-Like Receptors   VACCINE   VACCINE EFFICACY   Vaccines
 Sugar coating immunity for enhancement of biomaterials.
 Irish Society for Immunology meeting 2018.
 European Congress of Immunology
 Investigating the role of Mal/TIRAP and the Mal- S180L SNP as determinants of susceptibility to pneumococcal disease and antipneumoco ccal vaccine efficacy
 SFI Research Centre, Advanced Materials and Bioengineering Research (AMBER) centre

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Details Date
Chair of the Steering committee for the Centre for Global Vaccine Research, University of Liverpool, U.K. (2017-2019).
Main organiser of 5 Immunology meetings including the Irish Society for Immunology meetings (2013-2018; average attendance 160-200 participants) and the European Mucosal Immunology Group (EMIG) 2012 meeting (300 participants), held in Dublin.
Member of the advisory board for the EU funded ITN, PHA-ST-TRAIN-VAC between the University of Strathclyde and GSK Vaccines (2017-2019).
National representative and member of the core group of the COST Action ENOVA (European Network of Vaccine adjuvants) 2018-2022.
Member of the Scientific Advisory Panel for 13 international conferences since 2006.
Won the bid to host the 2024 European Congress of Immunology in Dublin in 2024. I will lead the committee in planning for this meeting for the coming 5 years.
Member of the Editorial Board of Biochemical Pharmacology and Frontiers in Immunology
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Irish Medium Medium Medium
Spanish Basic Basic Basic
Details Date From Date To
Irish Society for Immunology (President) 2005 (member) 2019
European Adjuvant Advisory Group 2007 2008
European Federation of Immunology Societies 2005 2019
Society for Mucosal Immunology 2006 2019
The American Association of Immunologists 2018 2019
O'Grady, K., Hearnden, C.C.H., Bento, D., Oleszycka, E., Andersen, P., Muñoz-Wolf, N. and Lavelle, E.C. , IL-33 is a negative regulator of vaccine-induced antigen-specific cellular immunity, The Journal of Immunology, 2019, Journal Article, IN_PRESS
Nazmi, A., Field, R.H., Griffin, E.W., Haugh, O., Hennessy, E., Cox, D., Reis, R., Tortorelli, L., Murray, C.L., Lopez-Rodriguez, A.B., Lavelle, E.C., Dunne, A. and Cunningham,C. , Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression, Glia, 67, 2019, p1254 - 1276 , Journal Article, PUBLISHED  DOI
Davitt, C.J.H. and Longet, S. and Albutti, A. and Aversa, V. and Nordqvist, S. and Hackett, B. and McEntee, C.P. and Rosa, M. and Coulter, I.S. and Lebens, M. and Tobias, J. and Holmgren, J. and Lavelle, E.C., Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines, Mucosal Immunology, 12, (4), 2019, p1055-1064 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÃŒrtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Lebre, F. and Lavelle, E.C. and Borges, O., Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies, Journal of Pharmacy and Pharmacology, 71, (6), 2019, p920-928 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Liddicoat, A.M. and Lavelle, E.C., Modulation of innate immunity by cyclosporine A, Biochemical Pharmacology, 163, 2019, p472-480 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
McEntee, C.P. and Finlay, C.M. and Lavelle, E.C., Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation, Frontiers in Immunology, 10, (JUN), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Jiménez, J.M. and Salazar, M.L. and Arancibia, S. and Villar, J. and Salazar, F. and Brown, G.D. and Lavelle, E.C. and Martínez-Pomares, L. and Ortiz-Quintero, J. and Lavandero, S. and Manubens, A. and Becker, M.I., TLR4, but neither dectin-1 nor dectin-2, participates in the mollusk hemocyanin-induced proinflammatory effects in antigen-presenting cells from mammals, Frontiers in Immunology, 10, (MAY), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Sinéad Kenealy∗, Joan Manils∗, Mathilde Raverdeau Natalia Munoz-Wolf, Gillian Barber, Alex Liddicoat, Ed C.Lavelle Emma M.Creagh , Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis, Journal of Investigative Dermatology, 2019, Journal Article, IN_PRESS  DOI
Moran, H.B.T., Turley, J., Andersen, M. and Lavelle, E.C , Immunomodulatory properties of chitosan polymers. , Biomaterials, 184, 2018, p1 - 9, Journal Article, PUBLISHED  DOI
  

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Award Date
Fellow of Trinity College Dublin 2012
Made an ambassador of the Dublin Convention Centre 2018
Elected President of the Irish Society for Immunology 2013
My research is principally focused on how vaccine adjuvants enhance and direct innate and adaptive immune responses. Adjuvants are essential components of vaccines that can profoundly affect the magnitude and type of adaptive immunity induced. My group concentrates on particulate adjuvants and over recent years has made key discoveries that enhance our understanding of how the physicochemical properties of particles influence the induction of innate and adaptive immunity. We have provided new insights into how particles engage innate cellular sensing pathways, particularly DNA sensing pathways and inflammasomes, pursuing the specific roles of interferons and cytokines of the IL-1 family in adjuvanticity. In addition, we have made advances in the development of novel injectable and mucosal vaccines, demonstrating that the optimal type of adjuvant depends the antigen and mode of vaccination. In particular, in collaboration with our industrial and academic colleagues we have worked on developing an effective oral delivery system that has significant potential for vaccines against ETEC, cholera and Helicobacter pylori. We are currently exploring avenues to progress this work towards clinical application. The expertise we have developed in assessing particulate regulation of immune responses has relevance in the field of biomaterial interaction with the immune system. As a result we now have a substantial research programme in this area as part of the AMBER centre. Being a CRANN PI and an AMBER funded investigator has led to my group beng closely connected to colleagues in Bioengineering, Chemistry and Physics and I see this cross-disciplinary dimension as a key driver of my research over the coming 5 years. I believe that this also underscores and supports the principal focus of the laboratory on dissecting how particulates can regulate immune responses and how fundamental understanding of the underlying processes can help us develop novel vaccine adjuvant systems but also enhanced biomaterials.