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Dr. Edward Lavelle

Associate Prof/ Course Co-Ordinator (Biochemistry)
BIOMEDICAL SCIENCES INSTITUTE


Over the past 14 years I have engaged at teaching at many levels in Universities in Ireland and the U.K. In particular, since October 2004 I have worked as a lecturer in Immunology in the School of Biochemistry and Immunology at Trinity College Dublin. In addition to delivering lectures and tutorials to junior and senior sophister students, for the past 4 years I have also lectured to students enrolled on the MSc course in Molecular Medicine (DMMC, St James' hospital, Dublin). I was also previously engaged in lecturing at TCD and at the University of Nottingham (England). I have supervised student projects from diploma to degree level and in more recent years have supervised a number of PhD students. I have organised and chaired sessions on Immunology and vaccines for a number of national and international conferences and acted as a peer reviewer for a number of Immunology journals and for grants in both the EU and the USA. Since acquiring my PhD in 1994, my research has been principally in the fields of Immunology and vaccine adjuvant development. The projects I have worked on have included the piscine mucosal immune system, the use of biodegradable microparticles as vaccine delivery systems and the evaluation of plant lectins as bioadhesives, immunogens and immunomodulators. During this time I acquired expertise in biochemistry and immunology that is applicable to the range of projects I am now engaged in and will pursue in the future. In recent years my principal research interest has been the elucidation of the mechanism of action of adjuvants and immunomodulators. In particular I have focused on on particulate vaccine adjuvants including biodegradable microparticles, alum and the cationic polysaccharide chitosan. This work includes basic research into the mechanism by which these systems activate the immune system and more applied work on the optimisation of these adjuvants for use in injectable and mucosal vaccines. The fundamental adjuvant research includes studies into the cell signalling pathways induced by these molecules which will facilitate a better understanding of their mode(s) of action. The applied research includes studies on targeting of particles to cells in order to increase their efficacy. I have a longstanding interest in the potential of plant lectins in mucosal vaccine delivery and identified plant lectins with potent vaccine adjuvant properties. However, the mode of action of these molecules is poorly understood and the potential of detoxified derivatives or lectin B subunits has not been studied. In conjunction with a number of collaborators, (Professor Uwe Pfüller, University of Witten/Herdecke, Germany; Dr AG Tonevitsky, Moscow; Professor Tomas Girbes, Universidad de Valladolid, Spain) I am engaged in studies on into the mode of lectin action and particularly into the signalling pathways induced by the lectins in cells of the immune system. There is tremendous scope for the application of plant lectins and their derivatives in vaccine delivery and as therapeutics. The second major focus of my group if the identification of novel activators of the immune system. With support from the Meningitis Research foundation and the HRB we are investigating proteins from Neisseria meningitidis serogroup B as immunomodulatory molecules. These studies involve collaborations with a number of Academic groups and Biotech and Pharmaceutical companies
  ADENYLYL-CYCLASE ACTIVITY   ADJUVANTS   cAMP   Cell Death   CREB   IL-10   Immune System   Immunity   Immunology, Immunotherapy   Immunophysiology   Inflammation   LECTIN-BINDING   LECTINS   Life Sciences   Nanotechnology   NF-kappaB   Signal Transduction   Signal Transduction (Sensory/Cellular)   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   Toll-Like Receptors   VACCINE   VACCINE EFFICACY   Vaccines
 SFI Research Centre, Advanced Materials and Bioengineering Research (AMBER) centre
 Modulation of innate and adaptive immunity by particulate adjuvants for improved parenteral and mucosal vaccination.
 Advanced Immunization Technologies ADITEC
 HELICOVAXOR (2013), Development of novel mucosal vaccines against Helicobacter pylori infection.
 Targeted delivery of particulate vaccine adjuvants. (2011).

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Details Date
Member of the Editorial board (Drug Delivery) for Expert Opinion on Therapeutic Patents (1997-2005). Member of Scientific committee for the 2nd International Workshop in Vaccine Adjuvants and GlycoCongugates (Adjuvant2004), Varadero, Cuba. Member of Scientific committee for the 3nd International Workshop in Vaccine Adjuvants and GlycoCongugates (Adjuvant2006) to be held in Varadero, Cuba (April, 2006). Guest Editor for a special issue of Vaccine on vaccine adjuvants (2005). Member of the Irish Society for Immunology (ISI) committee. Organisation of a session on "Mucosal Immunity" for the 2005 joint meeting of the ISI and the Royal Society of Medicine. Peer reviewer of grants for the National Institutes of Health (NIH) Grand Challenges in Global Health programme (August 2004).
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Irish Medium Medium Medium
Spanish Basic Basic Basic
Details Date From Date To
Irish Society for Immunology (President) 2005 (member) 2014
European Adjuvant Advisory Group 2007 2008
European Federation of Immunology Societies 2005 2008
Member of the Society for Mucosal Immunology 2006 2014
Ismail M. Meraza, Claire H.A Hearnden, Xuewu Liua, Marie Yang, Laura Williams, Jianhua Gua, Jessica R. Rhudy, Kenji Yokoi, Ed C. Lavelle and Rita E. Serda , Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization increasing the anti-tumor efficacy of doxorubicin nanoliposomes, PLoS One, 2014, p0094703-, Journal Article, IN_PRESS  TARA - Full Text  DOI
Oleszycka, E. and Lavelle, E.C, The immunomodulatory properties of the vaccine adjuvant alum., Current Opinion in Immunology, 28C, 2014, p1 - 5, Journal Article, PUBLISHED  DOI
Arancibia, S., Espinoza, C., Salazar, F., Del Campo, M., Tampe, R., Zhong, T-Y., De Ioannes, P., Moltedo, B., Ferreira, J., Lavelle, E.C., Manubens, A., De Ioannes, A.E. and Becker, M.I., A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata exhibits outstanding anti-tumor activity in melanoma., PLoS One, 9, (1), 2014, pe87240 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Bourke J, Brereton CF, Gordon SV, Lavelle EC and Scanlan EM, The Synthesis and Biological Evaluation of Mycobacterial p-Hydroxybenzoic Acid Derivatives (p-HBADs), Organic & Biomolecular Chemistry, 12, (7), 2014, p1114-1123 , Notes: [PMID: 24424275 ], Journal Article, PUBLISHED  TARA - Full Text
Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-, Journal Article, PUBLISHED  DOI
Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050 , Journal Article, PUBLISHED  DOI
Abautret-Daly AE, Davitt CJ, Lavelle EC, Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections., Biochemical pharmacology, 2014, Journal Article, PUBLISHED  TARA - Full Text
Adjuvant Strategies in Vaccines. in, editor(s)Prendergast/Jaffee , Cancer Immunotherapy: Immune Suppression and Tumor Growth, Academic Press, 2013, pp333-349 , [Hearnden, C and Lavelle, E.C.], Notes: [Second Edition. Chapter 21], Book Chapter, PUBLISHED
Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ, Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells., Molecular cell, 49, 2013, p1-15 , Journal Article, PUBLISHED  DOI
Yang, M., Flavin, K., Kopf, I., Radics, G., Hearnden, C.H.A., McManus, G.J., Moran, B., Villalta-Cerdas, A., Echegoyen, L.A., Giordani, S. and Lavelle, E.C. , Chemical surface functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation, Small, 9, (24), 2013, p4194 - 4206, Journal Article, PUBLISHED
  

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Award Date
Fellow of Trinity College Dublin 2012
Trinity College Dublin Start-up fund for new lecturers 2006. Amount awarded was €7,500. 2006
Merrion biopharmaceutical Ltd. Support for Summer student 2008. Amount awarded was €1800. 2008
Modulation of intracellular signaling pathways by adjuvants and immunomodulators. The use of bacterial toxins and their derivatives as immunomodulators. Particulates and non-specific bioadhesives as adjuvants and vaccine delivery systems. Plant lectins as mucosal vaccine adjuvants and carriers.