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Professor Ed Lavelle

Prof/ Course Co-Ordinator (Biochemistry)

Over the past 14 years I have engaged at teaching at many levels in Universities in Ireland and the U.K. In particular, since October 2004 I have worked as a lecturer in Immunology in the School of Biochemistry and Immunology at Trinity College Dublin. In addition to delivering lectures and tutorials to junior and senior sophister students, for the past 4 years I have also lectured to students enrolled on the MSc course in Molecular Medicine (DMMC, St James' hospital, Dublin). I was also previously engaged in lecturing at TCD and at the University of Nottingham (England). I have supervised student projects from diploma to degree level and in more recent years have supervised a number of PhD students. I have organised and chaired sessions on Immunology and vaccines for a number of national and international conferences and acted as a peer reviewer for a number of Immunology journals and for grants in both the EU and the USA. Since acquiring my PhD in 1994, my research has been principally in the fields of Immunology and vaccine adjuvant development. The projects I have worked on have included the piscine mucosal immune system, the use of biodegradable microparticles as vaccine delivery systems and the evaluation of plant lectins as bioadhesives, immunogens and immunomodulators. During this time I acquired expertise in biochemistry and immunology that is applicable to the range of projects I am now engaged in and will pursue in the future. In recent years my principal research interest has been the elucidation of the mechanism of action of adjuvants and immunomodulators. In particular I have focused on on particulate vaccine adjuvants including biodegradable microparticles, alum and the cationic polysaccharide chitosan. This work includes basic research into the mechanism by which these systems activate the immune system and more applied work on the optimisation of these adjuvants for use in injectable and mucosal vaccines. The fundamental adjuvant research includes studies into the cell signalling pathways induced by these molecules which will facilitate a better understanding of their mode(s) of action. The applied research includes studies on targeting of particles to cells in order to increase their efficacy. I have a longstanding interest in the potential of plant lectins in mucosal vaccine delivery and identified plant lectins with potent vaccine adjuvant properties. However, the mode of action of these molecules is poorly understood and the potential of detoxified derivatives or lectin B subunits has not been studied. In conjunction with a number of collaborators, (Professor Uwe Pfüller, University of Witten/Herdecke, Germany; Dr AG Tonevitsky, Moscow; Professor Tomas Girbes, Universidad de Valladolid, Spain) I am engaged in studies on into the mode of lectin action and particularly into the signalling pathways induced by the lectins in cells of the immune system. There is tremendous scope for the application of plant lectins and their derivatives in vaccine delivery and as therapeutics. The second major focus of my group if the identification of novel activators of the immune system. With support from the Meningitis Research foundation and the HRB we are investigating proteins from Neisseria meningitidis serogroup B as immunomodulatory molecules. These studies involve collaborations with a number of Academic groups and Biotech and Pharmaceutical companies
  ADENYLYL-CYCLASE ACTIVITY   ADJUVANTS   cAMP   Cell Death   CREB   IL-10   Immune System   Immunity   Immunology, Immunotherapy   Immunophysiology   Inflammation   LECTIN-BINDING   LECTINS   Life Sciences   Nanotechnology   NF-kappaB   Signal Transduction   Signal Transduction (Sensory/Cellular)   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   Toll-Like Receptors   VACCINE   VACCINE EFFICACY   Vaccines
 SFI Research Centre, Advanced Materials and Bioengineering Research (AMBER) centre
 Modulation of innate and adaptive immunity by particulate adjuvants for improved parenteral and mucosal vaccination.
 Advanced Immunization Technologies ADITEC
 HELICOVAXOR (2013), Development of novel mucosal vaccines against Helicobacter pylori infection.
 Targeted delivery of particulate vaccine adjuvants. (2011).

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Details Date
Member of the Editorial board (Drug Delivery) for Expert Opinion on Therapeutic Patents (1997-2005). Member of Scientific committee for the 2nd International Workshop in Vaccine Adjuvants and GlycoCongugates (Adjuvant2004), Varadero, Cuba. Member of Scientific committee for the 3nd International Workshop in Vaccine Adjuvants and GlycoCongugates (Adjuvant2006) to be held in Varadero, Cuba (April, 2006). Guest Editor for a special issue of Vaccine on vaccine adjuvants (2005). Member of the Irish Society for Immunology (ISI) committee. Organisation of a session on "Mucosal Immunity" for the 2005 joint meeting of the ISI and the Royal Society of Medicine. Peer reviewer of grants for the National Institutes of Health (NIH) Grand Challenges in Global Health programme (August 2004).
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Irish Medium Medium Medium
Spanish Basic Basic Basic
Details Date From Date To
Irish Society for Immunology (President) 2005 (member) 2014
European Adjuvant Advisory Group 2007 2008
European Federation of Immunology Societies 2005 2008
Member of the Society for Mucosal Immunology 2006 2014
Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714 , Journal Article, PUBLISHED  DOI
Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368-79 , Journal Article, PUBLISHED  TARA - Full Text  URL
Kearney CJ, Cullen SP, Tynan GA, Henry CM, Clancy D, Lavelle EC, Martin SJ, Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production., Cell death and differentiation, 22, 2015, p1313-1327 , Journal Article, PUBLISHED  DOI
Davitt, C.J.H., Lavelle, E.C., Delivery strategies to enhance oral vaccination against enteric infections, Advanced Drug Delivery Reviews, 2015, Journal Article, IN_PRESS  TARA - Full Text  DOI
Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Oleszycka, E., Moran, H.B., Tynan, G.A., Hearnden, C.H., Coutts, G., Campbell, M., Allan, S.M., Scott, C.J., Lavelle, E.C., IL-1" and inflammasome-independent IL-1ß promote neutrophil infiltration following alum vaccination, FEBS Journal, 2015, Journal Article, PUBLISHED
McEntee, C., Lavelle, E.C., O'Hagan, D.T., Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune-Stimulating Complexes (ISCOMs), Mucosal Immunology: Fourth Edition, 1-2, 2015, p1211-1231 , Journal Article, PUBLISHED
Ismail M. Meraza, Claire H.A Hearnden, Xuewu Liua, Marie Yang, Laura Williams, Jianhua Gua, Jessica R. Rhudy, Kenji Yokoi, Ed C. Lavelle and Rita E. Serda , Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization increasing the anti-tumor efficacy of doxorubicin nanoliposomes, PLoS One, 2014, p0094703-, Journal Article, IN_PRESS  TARA - Full Text  DOI
Oleszycka, E. and Lavelle, E.C, The immunomodulatory properties of the vaccine adjuvant alum., Current Opinion in Immunology, 28C, 2014, p1 - 5, Journal Article, PUBLISHED  DOI
Arancibia, S., Espinoza, C., Salazar, F., Del Campo, M., Tampe, R., Zhong, T-Y., De Ioannes, P., Moltedo, B., Ferreira, J., Lavelle, E.C., Manubens, A., De Ioannes, A.E. and Becker, M.I., A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata exhibits outstanding anti-tumor activity in melanoma., PLoS One, 9, (1), 2014, pe87240 , Journal Article, PUBLISHED  TARA - Full Text  DOI

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Award Date
Fellow of Trinity College Dublin 2012
Trinity College Dublin Start-up fund for new lecturers 2006. Amount awarded was €7,500. 2006
Merrion biopharmaceutical Ltd. Support for Summer student 2008. Amount awarded was €1800. 2008
Modulation of intracellular signaling pathways by adjuvants and immunomodulators. The use of bacterial toxins and their derivatives as immunomodulators. Particulates and non-specific bioadhesives as adjuvants and vaccine delivery systems. Plant lectins as mucosal vaccine adjuvants and carriers.