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Dr. Kevin Mitchell

Assoc Prof in Developmental Neurobiolo (Genetics)
EAST END DEVELOPMENT 4/5


 Science Foundation Ireland Investigator Grant
 Science Foundation Ireland Investigator Grant
 Health Research Board Project Grant
 Science Foundation Ireland Research Frontiers Grant
 Wellcome Trust Project Grant

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McLysaght, A, Makino, T, Grayton, HM, Tropeano, M, Mitchell, KJ, Vassos, E, Collier, DA, Ohnologs are overrepresented in pathogenic copy number mutations, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, (1), 2014, p361-366 , Journal Article, PUBLISHED  DOI
Mitchell, K.J., Genetic entropy and the human intellect, Trends in Genetics, 29, (2), 2013, p59-60 , Journal Article, PUBLISHED  DOI
Dolan, J, Mitchell, KJ, Mutation of Elfn1 in Mice Causes Seizures and Hyperactivity, PLoS One, 8, (11), 2013, e80491-, Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Hanlon E, Newell FN, Mitchell KJ, Combined structural and functional imaging reveals cortical deactivations in grapheme-color synaesthesia., Frontiers in psychology, 4, 2013, p755 , Journal Article, PUBLISHED  TARA - Full Text
Mitchell, K.J., What is complex about complex disorders?, Genome Biology, 13, (1), 2012, part. no. 237 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mitchell K.J. and Porteous, D.J., Rethinking the genetic architecture of schizophrenia, Psychological Medicine , 41, (1), 2011, p19-32 , Journal Article, PUBLISHED  TARA - Full Text
Kevin J Mitchell, The genetics of neurodevelopmental disease, Current Opinion in Neurobiology, 21, (1), 2011, p197-203 , Journal Article, PUBLISHED  TARA - Full Text
Miller-Delaney, S., Lieberam, I., Jessell, T., Murphy P. and Mitchell, K. , Plxdc2 is a mitogen for neural progenitors, PLoS ONE, 6, (1), 2011, pe14565 , Journal Article, PUBLISHED  TARA - Full Text
Kevin J Mitchell, The miswired brain: making connections from neurodevelopment to psychopathology, BMC Biology, 9, (23), 2011, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Mitchell KJ, Huang ZJ, Moghaddam B, Sawa A, Following the genes: a framework for animal modeling of psychiatric disorders., BMC Biology, 9, (76), 2011, Journal Article, PUBLISHED  TARA - Full Text
  

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Mitchell, K.J., World Congress of Psychiatric Genetics, 2004, -, Notes: [On the local organising committee for the World Congress of Psychiatric Genetics, Trinity College Dublin, 2004], Miscellaneous, PUBLISHED
Mitchell, K.J., Genetics Department, Cambridge University, January, 2003, Invited Talk, PUBLISHED
Mitchell, K.J., At symposium 'Wiring the Brain', Edinburgh University , April , 2003, Invited Talk, PUBLISHED
Mitchell, K.J., Department of Anatomy and Human Genetics , Oxford University , May, 2003, Invited Talk, PUBLISHED
Mitchell, K.J., Symposium on Genomics and Proteomics, University College Dublin , June, 2003, Invited Talk, PUBLISHED
Mitchell, K.J., Biology Society seminar series, National University of Ireland, Maynooth, Nov, 2003, Invited Talk, PUBLISHED
Mitchell, K.J., MRC Centre for Developmental Neurobiology, King"s College, London, July , 2002, Invited Talk, PUBLISHED
Mitchell, K.J., Zoology Department, Trinity College Dublin, Oct. , 2002, Invited Talk, PUBLISHED
Mitchell, K.J, Dublin Molecular Medicine Centre, St. James"s Hospital, Dublin , Nov. , 2002, Invited Talk, PUBLISHED

  

Award Date
Summer Scholarship from the American Ireland Fund 1990
National Science Foundation Predoctoral Fellowship 1992 - 1995
Howard Hughes Medical Institute Postdoctoral Fellowship 1998
Jane Coffin Childs Fund for Medical Research Postdoctoral Fellowship 1998 - 2001
Wellcome Trust grant to fund the international conference 'Life and Death of the Brain' held in Trinity College Dublin, Ireland. 1999
Science Foundation Ireland Investigator Grant (€1,690,000/ five years 2002-2007
2003-2005 Health Research Board Programme Grant (€164,000/ three years) 2003 - 2005
EMBO Young Investigator Programme Award 2004
Election to Fellowship, Trinity College Dublin 2009
Appointed as Affiliate Member, MRC Centre for Developmental Neurobiology, King's College London 2010
Dr. Mitchell and colleagues are currently trying to identify guidance signals and receptors using a gene-trapping method in mice to screen for novel transmembrane proteins involved in axon guidance in the developing brain. Genes encoding these proteins are identified by bioinformatics and targeted with a vector that simultaneously mutates the gene and incorporates reporter genes to visualise the axonal projections of cells that normally express it in the brain. Any wiring defects resulting from mutation of these genes are therefore readily apparent in the mutant animals. They are also investigating the mechanism of action of a number of such signals and receptors in more detail to understand at a cellular level how they exert their effects on nerve growth and guidance. A current focus is on the role of transmembrane semaphorins, especially in the development of appropriate connections between thalamus and cortex.