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Dr. Vincent Kelly

Asst Prof/Academic Co-Ordinator (Biochemistry)
BIOMEDICAL SCIENCES INSTITUTE


In November 2005, I joined the staff of the School of Biochemistry & Immunology having secured an SFI principle investigator award to study the role of a transfer RNA modification in tyrosine biosynthesis. The scope and direction of the work has diversified since to include studies on cancer and immunology using cell based and transgenic models. I performed my postdoctoral studies in the laboratory of Prof. Masayuki Yamamoto, Tsukuba, Japan where I gained expertise in mouse transgenics. My interest in transfer RNA arose from my time in Banyu Pharmaceuticals (a subsidiary of Merck) in Japan where I worked with Dr. Susumu Nishimura, generating a knockout mouse for the seleocysteine tRNA gene. My PhD was performed in the laboratory of Prof. John Hayes, at the University of Dundee, Scotland. My project focused on characterizing the AFAR1 enzyme (an Aldo-Keto Reductase family member) and research on a novel related enzyme called AFAR2, which I discovered can produce the hypnotic gamma-hydroxybutyrate, a chemical that is vital for sleep and hibernation.
  Animal Biotechnology   Animal Reproduction   Embryology   Immunology, Immunotherapy   Nutrition
 Q-base; an essential nutrient for tyrosine biosynthesis.Implications for the disease phenylketonuria and transfer RNA biology.

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Japanese Basic Basic Medium
Details Date From Date To
Biochemical Society Sept 2000 Present date
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ , Journal Article, PUBLISHED  DOI
Enhancing the Teaching and Learning of Labortatory Sciences through a Virtual Learning Environment. in, editor(s)Marcus-Quinn A, Bruen C, Allen M, Dundon A, Diggins Y , The Digital Learning Revolution in Ireland : Case Studies from the National Learning Resources Service. , Cambridge, UK, Cambridge Scholars Publishing,, 2012, pp181 - 194, [Robinson GA, Nic A' Bháird N, Kelly VP], Book Chapter, PUBLISHED
Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M., Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia., Blood, 20, (1), 2011, p986 - 996, Journal Article, PUBLISHED
Rakovich T, Boland C, Bernstein I, Chikwana VM, Iwata-Reuyl D, Kelly VP, Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation., The Journal of Biological Chemistry, 286, (22), 2011, p19354-19363 , Notes: [ PubMed ID: 21487017], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Rakovich A, Rakovich T, Kelly VP, Lesnyak V, Eychmüller A, Rakovich YP, Donegan JF, Photosensitizer methylene blue-semiconductor nanocrystals hybrid system for photodynamic therapy., Journal of nanoscience and nanotechnology, 10, (4), 2010, p2656-2662 , Journal Article, PUBLISHED  DOI
MacLeod AK, Kelly VP, Higgins LG, Kelleher MO, Price SA, Bigley AL, Betton GR, Hayes JD., Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants., Drug Metabolism & Disposition, 38, (2), 2010, p341 - 346, Notes: [PMID: 19920056 ], Journal Article, PUBLISHED  DOI
Rakovich A, Savateeva D, Rakovich T, Donegan JF, Rakovich YP, Kelly VP, Lesnyak V, Eychmuller A , CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy, Nanoscale Research Letters, 1931, 2010, p7573 - 7585, Journal Article, PUBLISHED  DOI
Chen Yi-C, Kelly VP, Stachura SV, Garcia GA. , Characterization of the human tRNA-guanine transglycosylase: confirmation of the heteromeric subunit structure, RNA, 16, (5), 2010, p958-968 , Notes: [ (MS ID#: RNA/2009/019976) PubMed ID: 20354154], Journal Article, PUBLISHED  DOI
Boland C, Hayes PA, Santa-Maria I, Nishimura S and Kelly VP, Queuosine formation in eukaryotic tRNA occurs via a mitochondrial localized heteromeric transglycoslase. , Journal of Biological Chemistry, 284, (27), 2009, p18218-18227 , Notes: [ PMID: 19414587], Journal Article, PUBLISHED  TARA - Full Text  DOI
Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M, Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2., Journal of Biological Chemistry, 283, (4), 2008, p2021-2030 , Notes: [PMID: 18039655], Journal Article, PUBLISHED  DOI
  

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Our laboratory researches on RNA. In particular we are interested in modified nucleotides and their impact on basic metabolism. The research techniques that the laboratory use are varied and include cell culture, the generation of transgenic animals, HPLC and protein purification.