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Dr. Vincent Kelly

Asst Prof/Academic Co-Ordinator (Biochemistry)


  Animal Biotechnology   Animal Reproduction   Embryology   Immunology, Immunotherapy   Nutrition
 Q-base; an essential nutrient for tyrosine biosynthesis.Implications for the disease phenylketonuria and transfer RNA biology.

Details Date
Since 2011, I have been the lead administrator of the Irish Transgenic Network, which co-ordinates the transgenic activities of HEIs nationally. The group has helped shape national policy for the use of transgenic animals in research.
I am the Irish representative for the EMMA (European Mouse Mutant Archive), which is a repository and distributor of mutant mouse strains for basic biomedical research.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Japanese Basic Basic Medium
Details Date From Date To
Biochemical Society 1st Oct 2000 Present date
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis., Nucleic Acids Research, 45, (4), 2017, p2029-2039 , Journal Article, PUBLISHED  DOI
Williams JM, Bezak T, Das M, Ning Z, Lucking EF, Kelly VP, Harrison P, Young P, O'Connell MJ, Dockery P, O'Halloran KD, Moore T , Psg22 null mouse embryos develop normally under normoxic and hypoxic conditions of pregnancy., Science Matters, 10, (19185), 2016, Journal Article, PUBLISHED  DOI  URL
Fergus, C., Barnes, D., Alqasem, M.A., Kelly, V.P, The queuine micronutrient: Charting a course from microbe to man , Nutrients, 7, (4), 2015, p2897-2929 , Journal Article, PUBLISHED  DOI
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ , Journal Article, PUBLISHED  TARA - Full Text  DOI
Enhancing the Teaching and Learning of Labortatory Sciences through a Virtual Learning Environment. in, editor(s)Marcus-Quinn A, Bruen C, Allen M, Dundon A, Diggins Y , The Digital Learning Revolution in Ireland : Case Studies from the National Learning Resources Service. , Cambridge, UK, Cambridge Scholars Publishing,, 2012, pp181 - 194, [Robinson GA, Nic A' Bháird N, Kelly VP], Book Chapter, PUBLISHED
Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M., Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia., Blood, 20, (1), 2011, p986 - 996, Journal Article, PUBLISHED
Rakovich T, Boland C, Bernstein I, Chikwana VM, Iwata-Reuyl D, Kelly VP, Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation., The Journal of Biological Chemistry, 286, (22), 2011, p19354-19363 , Notes: [ PubMed ID: 21487017], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Rakovich A, Rakovich T, Kelly VP, Lesnyak V, Eychmüller A, Rakovich YP, Donegan JF, Photosensitizer methylene blue-semiconductor nanocrystals hybrid system for photodynamic therapy., Journal of nanoscience and nanotechnology, 10, (4), 2010, p2656-2662 , Journal Article, PUBLISHED  DOI
MacLeod AK, Kelly VP, Higgins LG, Kelleher MO, Price SA, Bigley AL, Betton GR, Hayes JD., Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants., Drug Metabolism & Disposition, 38, (2), 2010, p341 - 346, Notes: [PMID: 19920056 ], Journal Article, PUBLISHED  DOI
Rakovich A, Savateeva D, Rakovich T, Donegan JF, Rakovich YP, Kelly VP, Lesnyak V, Eychmuller A , CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy, Nanoscale Research Letters, 1931, 2010, p7573 - 7585, Journal Article, PUBLISHED  DOI
  

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Dr. Vincent P. Kelly, RNA Modified Bases & Grammar Education for the Naiive Immune System, RNA Society Meeting, Gurdon Institute, Cambridge, UK , 24th Mar , 2016, Prof. Eric Miska, Invited Talk, PUBLISHED
Dr. Vincent P. Kelly, RNA Capture & NGS to Identify Novel Protein-RNA Substrates, 6th Irish Next Generation Sequenceing Conference, TBSI, Trinity College Dublin, 2nd Jun, 2016, Dr. Elaine Kenny, Invited Talk, PUBLISHED
Dr. Vincent P. Kelly, Intl. Conference on Tetrahydrobiopterin, Switzerland, Intl. Conference on Tetrahydrobiopterin, St. Moritz, Switzerland , 20th Mar, 2013, Prof. Beat Thony, Invited Talk, PUBLISHED
Dr. Vincent P. Kelly, Mouse Resources & Related Infrastructure in Ireland, EMMA Workshop, Athens, Greece, 18th Nov, 2013, Prof. Martin Hrabe de Angelis, Invited Talk, PUBLISHED
Dr. Vincent P. Kelly, Queuine in Cancer & Metabolism, Biochemistry Society , University of Kent, School of Biosciences, UK, 14th Feb, 2011, Prof. Martin Warren, Invited Talk, PRESENTED

  

Micronutruients are the principle area of interest for my laboratory and to date, I have raised €2,269,944 for research in this field. In particular, I have an kean interest on a bacterial metabolite called queuine that, prior to my work in the area, was very much an understudied area. Through a series of biochemical, genetic and transgenic studies from my laboratory I identified the pathways in mammals that use the queuine micronutrient and have elucidated to some degree the actual physiological purpose of this elusive molecule. The findings are of broad scienctific interest for reseaechers in the areas of metabolism, neuroscience, immunology and gut-host interactions, which is evidenced by the invited talks that I have given on the discoveries. An outstanding aspect of the queuine-micronutrient research has been the discovery that this mechanism can be used as potential treatment for Multiple Sclerosis and other autoimmune disorders. This has created considering interest in the queuine micronutrient and in the RNA modification field in general. Through close collaboration with colleagues in the School of Chemistry, Dr. Mike Southern and Prof. Stephen Connon, I successed in capturing valuable commercial assets for this research in the form of two strong patents that have passed the PCT stage and which are exclusinve IP to Trinity College. The company we co-founded, Azadyne, aims to exploit our findings further. Apart from capitalising on the commercial potential, the queuine-micronutrient still represents an exciting and fruitful area for further basic discoveries given that so little in known about the molecule. Queuine's relationship to cancer (where it is universally depleted), to neurological function (where we have published a decrease in tetrahydrobiopterin) and metabolism (a paper is currently in press) are just some of the examples of the direction the research is taking. As stated earlier, in 2011 I established a transgenic facility in Trinity College. The genesis for this work was an equiment grant that I secured from Science Foundation Ireland (€194,756; 05/IN3/B761) as Lead-PI in Dec 2006. This allowed the purchase of cryopreservation equipment to freeze away mouse embryos. Subsequently, I was the lead-applicant on a HEA-PRTLI5 workpackage to extend the transgenic capabilities that Trinity College has today and bringing together applicants from other universities to form the Irish Transgenic Newtork (for which I am the lead-Administrator). The ITN application secured €5.31 million of PTRLI5 funding in total, €3.67 million of which went to Trinity College. Apart from composing the PRTLI5 application, I have been responsible for designed the facility from the ground up; guiding and advising artitechs plans, purchasing equipment (€1.4 million), employing and training the staff, establishing a pay-for service business in addition to manging the finances, reporting and scientific direction of the unit i.e. there is a constant evolution of new technologies in the area. To have Transgencis as a service in college is a major research development. Few academics worldwide would have the skills and knowhow to develop such a facility from the ground up. The services are an integral part of delivering on the sicentific programmes of numerous research groups. Arising from my expertise in animal transgenics, I also have a keen interest in human fertility. Currently, I am working together with Kora Healthcare (an Irish SME) on an EI Innovation Partnership grant to develop products and patents for the treatment of male infertility using naturally occurring micronutrients. Apart from my work on micronutrients, I have in-dept knowledgeable across a broad range of biomedical topics and have co-authored papers in various areas including metabolism, oxidative stress, diabetes, fertility, drug detoxification and nanomaterials.