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Professor Daniel J Kelly

Professor (Mechanical & Manuf. Eng)
PARSONS BUILDING


Dr Daniel Kelly is the Professor of Tissue Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering (TCBE). He is also one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre based in Trinity College Dublin. Prof Kelly is a current or past recipient of a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and three European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017). His research focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. To date he has published over 130 articles in peer-reviewed journals.
  Arthritis   Bioengineering   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomolecules, Bioplastics, Biopolymers   Bioreactors   Cardiovascular System   Computational Biology   Computer-Aided Engineering   Mathematical modelling   Mechanical Engineering   Mechanics   Medical Devices Engineering   Solid Mechanics   Stem Cell   STEM-CELLS   STENTS   Tissue Engineering
 Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports
 PreclinicAl Infrastructure Resource
 CarBon - Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis
 3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration. (ERC-2014-CoG -647004)
 A decellularised extracellular matrix derived scaffold incorporating freshly isolated joint tissue derived cells as a bioactive implant for cartilage repair. (CF/2014/4325)

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Details Date
Honorary Associate Professor, Royal College of Surgeons in Ireland. 2014 -
Affiliate Associate Professor, Colorado State University, USA. 2014 -
Andrew C Daly, Binulal N Sathy and Daniel J Kelly, Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions, Journal of Tissue Engineering, 6, 2018, p1-12 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mahon, O.R. and O'Hanlon, S. and Cunningham, C.C. and McCarthy, G.M. and Hobbs, C. and Nicolosi, V. and Kelly, D.J. and Dunne, A., Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner, Acta Biomaterialia, 65, 2018, p426-435 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Amos Matsiko, Emmet M. Thompson, Cai Lloyd-Griffith, Gráinne M. Cunniffe, Tatiana Vinardell, John P. Gleeson, Daniel J. Kelly, Fergal J. O'Brien,, An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair, Journal of Tissue Engineering & Regenerative Medicine, 2018, p1- , Journal Article, IN_PRESS
Henrique V. Almeida, Anna D. Dikina, Kevin J. Mulhall, Fergal J. O"Brien, Eben Alsberg, Daniel J. Kelly, Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells, ACS Biomaterials Science & Engineering, 3, (6), 2017, p1075-1082 , Journal Article, PUBLISHED  DOI
Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 114, (10), 2017, p2400 - 2411, Journal Article, PUBLISHED  URL
Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691 , Journal Article, PUBLISHED  DOI
Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764 , Journal Article, PUBLISHED  DOI
Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436 , Journal Article, PUBLISHED  DOI
Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 11, 2017, p1700118 -, Journal Article, PUBLISHED  DOI
  

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S.Romanazzo, S.Vedicherla, C. Moran, D.J. Kelly, Meniscus ECM functionalized hydrogels containing infrapatellar fat pad derived stem cells for bioprinting of regionally defined meniscal tissue, J Tissue Eng Regen Med. , 2017, p1-10 , Journal Article, PUBLISHED
Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010, Conference Paper, PRESENTED
Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010, Invited Talk, PRESENTED
Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED
Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED
Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009, Invited Talk, PRESENTED
Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009, Invited Talk, PRESENTED
Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009, Invited Talk, PRESENTED

  

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Award Date
Norman Gamble Award in Otology 2002
Hewlett Packard Prize 1999
Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008
Fulbright Award 2009
Fellow of Trinity College Dublin 2010
European Research Council Starter Award, 2010
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
European Research Council Consolidator Award 2015
European Research Council Proof of Concept Grant 2017
Articular cartilage tissue engineering: Dr. Kelly's lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic. Bone, joint and limb regeneration: Dr. Kelly's lab have also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting. Stem cell mechanobiology: Dr. Kelly's lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.