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Professor Daniel J Kelly

Professor (Mechanical & Manuf. Eng)
PARSONS BUILDING


Dr Daniel Kelly is a Professor in the School of Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering. In 2008 he was the sole recipient of Science Foundation Ireland's President of Ireland Young Researcher Award (PIYRA). In 2009 he received a Fulbright Award to take a position as a Visiting Research Scholar at the Department of Biomedical Engineering in Columbia University, New York. In 2010 he was awarded a European Research Council starter grant of €1.5 million to develop novel stem cell and biomaterial based therapies to regenerate damaged articular cartilage. In 2013 he was awarded a €1.7m Principal Investigator grant from Science Foundation Ireland to develop novel tissue engineering approaches to treat degenerative joint disease. He was recently awarded an ERC consolidator grant of €2,000,000, making him one of the few PIs to have received two such awards from the European Research Council. Dr. Kelly leads a large multidisciplinary orthopaedic tissue engineering group based in the Trinity Centre for Bioengineering. The goal of his lab is to understand how environmental factors regulate the fate of adult stem cells. This research underpins a more translational programme aimed at developing novel biomaterial and mesenchymal stem cell (MSC) based therapies to regenerate damaged and diseased orthopaedic tissues such as articular cartilage and bone. To date he has published over 115 articles in peer-reviewed journals.
  Arthritis   Bioengineering   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomolecules, Bioplastics, Biopolymers   Bioreactors   Cardiovascular System   Computational Biology   Computer-Aided Engineering   Mathematical modelling   Mechanical Engineering   Mechanics   Medical Devices Engineering   Solid Mechanics   Stem Cell   STEM-CELLS   STENTS   Tissue Engineering
 3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration. (ERC-2014-CoG -647004)
 A decellularised extracellular matrix derived scaffold incorporating freshly isolated joint tissue derived cells as a bioactive implant for cartilage repair. (CF/2014/4325)
 A tissue engineered biological joint replacement prosthesis for the treatment of degenerative joint disease (12/IA/1554)
 Porous decellularized hypertrophic tissue engineered cartilage as a scaffold for large bone defect healing
 Novel mesenchymal stem cell based therapies for articular cartilage repair

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Lu, L., Chu, J., Rajalakshmanan, E., Mulhall, K., Kelly, D. J., Engineering tissues that mimic the zonal nature of articular cartilage using decellularized cartilage explants seeded with adult stem cells., ACS Biomaterials Science & Engineering , 2016, Journal Article, PUBLISHED  DOI
Burke D, Kelly D.J, A mechanobiological model of endothelial cell migration and proliferation, Computer Methods in Biomechanics and Biomedical Engineering, 19, (1), 2016, p74 - 83, Notes: [Export Date: 26 November 2015], Journal Article, PUBLISHED  DOI  URL
Mesallati T., Buckley C.T. and Kelly D.J. , Engineering cartilaginous grafts using chondrocyte-laden hydrogels supported by a superficial layer of stem cells, Journal of Tissue Engineering and Regenerative Medicine , 2016, Journal Article, IN_PRESS  DOI
Daly, A.C., Cunniffe, G.M., Sathy, B.N., Jeon, O., Alsberg, E., Kelly, D.J., 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering, Advanced Healthcare Materials, 2016, Journal Article, PUBLISHED  DOI
OReilly, A., Hankenson, K.D., Kelly, D.J., A computational model to explore the role of angiogenic impairment on endochondral ossification during fracture healing, Biomechanics and Modeling in Mechanobiology, 15, 2016, p1279-1294 , Journal Article, PUBLISHED  DOI
Thompson, E.M., Matsiko, A., Kelly, D.J., Gleeson, J.P., O'Brien, F.J., An Endochondral Ossification-Based Approach to Bone Repair: Chondrogenically Primed Mesenchymal Stem Cell-Laden Scaffolds Support Greater Repair of Critical-Sized Cranial Defects Than Osteogenically Stimulated Constructs in Vivo, Tissue Engineering - Part A, 22, (5-6), 2016, p556-567 , Journal Article, PUBLISHED  DOI
Luo, L., O'Reilly, A.R., Thorpe, S.D., Buckley, C.T., Kelly, D.J., Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels, Journal of Tissue Engineering and Regenerative Medicine, 2016, Journal Article, PUBLISHED  DOI
Almeida, H.V., Eswaramoorthy, R., Cunniffe, G.M., Buckley, C.T., O'Brien, F.J., Kelly, D.J., Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration, Acta Biomaterialia, 36, 2016, p55-62 , Journal Article, PUBLISHED  DOI
Gonzalez-Fernandez, T., Tierney, E.G., Cunniffe, G.M., O'Brien, F.J., Kelly, D.J., Gene Delivery of TGF-ß3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering, Tissue Engineering - Part A, 22, (9-10), 2016, p776-787 , Journal Article, PUBLISHED  DOI
Pauly, H.M., Kelly, D.J., Popat, K.C., Trujillo, N.A., Dunne, N.J., McCarthy, H.O., Haut Donahue, T.L., Mechanical properties and cellular response of novel electrospun nanofibers for ligament tissue engineering: Effects of orientation and geometry, Journal of the Mechanical Behavior of Biomedical Materials, 61, 2016, p258-270 , Journal Article, PUBLISHED  DOI
  

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Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010, Conference Paper, PRESENTED
Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010, Invited Talk, PRESENTED
Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED
Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED
Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009, Invited Talk, PRESENTED
Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009, Invited Talk, PRESENTED
Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009, Invited Talk, PRESENTED
Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009, Invited Talk, PRESENTED

  

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Award Date
Norman Gamble Award in Otology 2002
Hewlett Packard Prize 1999
Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008
Fulbright Award 2009
Fellow of Trinity College Dublin 2010
European Research Council Starter Award, 2010
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
European Research Council Consolidator Award 2015
Articular cartilage tissue engineering: Dr. Kelly's lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic. Bone, joint and limb regeneration: Dr. Kelly's lab have also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting. Stem cell mechanobiology: Dr. Kelly's lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.