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Professor Daniel J Kelly

Professor (Mechanical & Manuf. Eng)
PARSONS BUILDING


Dr. Daniel Kelly (BAI, MSc, Phd) is a lecturer in Mechanical Engineering (Bioengineering) in the Department of Mechanical Engineering in Trinity College Dublin, and a Principal Investigator in the Trinity Centre for Bioengineering. Before taking up his current position in TCD he worked as a Product Development Engineer in the medical device industry. His research interests are in computational and experimental mechanobiology, tissue engineering and the design and pre-clinical evaluation of next generation medical devices and implants. In 2008 he was awarded the President of Ireland Young Researcher Award (PIYRA) by Science Foundation Ireland to investigate the mechanobiology of mesenchymal stem cells. In 2009 he received a Fulbright award to spend the 2009-10 academic year at Columbia University in New York as a visiting research scholar. In 2010 he was awarded a European Research Council Starter grant to develop new stem cell based therapies for articular cartilage repair.
  Arthritis   Bioengineering   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomolecules, Bioplastics, Biopolymers   Bioreactors   Cardiovascular System   Computational Biology   Computer-Aided Engineering   Mathematical modelling   Mechanical Engineering   Mechanics   Medical Devices Engineering   Solid Mechanics   Stem Cell   STEM-CELLS   STENTS   Tissue Engineering
 Porous decellularized hypertrophic tissue engineered cartilage as a scaffold for large bone defect healing
 Novel mesenchymal stem cell based therapies for articular cartilage repair
 Mechanobiology of mesenchymal stem cells for articular cartilage repair
 A new constitutive framework to investigate the role of mechanical forces on protein synthesis and organization during differentiation of mesenchymal progenitor cells
 Design and development of a novel device to control the fabrication, confined compression and in situ delivery of cell-seeded collagen gel scaffolds

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Almeida, A.V, Cunniffe, G.M., Vinardell, T., Buckley, C.T., O'Brien, F.J., Kelly, D.J. , Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis. , Advanced Healthcare Materials, 2015, Journal Article, IN_PRESS
Gannon, A, Nagel, T., Kelly, D.J., Postnatal changes to the mechanical properties of articular cartilage are driven by the evolution of its collagen network, European Cells and Materials, 2015, Journal Article, IN_PRESS
Sheehy EJ, Mesallati T, Vinardell T, Kelly DJ, Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels., Acta biomaterialia, 2015, Journal Article, IN_PRESS  TARA - Full Text
Steward AJ, Kelly DJ, Mechanical regulation of mesenchymal stem cell differentiation., Journal of anatomy, 2015, Journal Article, IN_PRESS
Thompson EM, Matsiko A, Farrell E, Kelly DJ, O'Brien FJ, Recapitulating endochondral ossification: a promising route to in vivo bone regeneration., Journal of tissue engineering and regenerative medicine, 2015, Journal Article, IN_PRESS
Boccaccio, A., Kelly, D.J., Pappalettere, C., A mechano-regulation model to optimize design of minimally invasive percutaneous fixation devices for treatment of fractured vertebrae, Conference Proceedings of the Society for Experimental Mechanics Series, 2013 Annual Conference on Experimental and Applied Mechanics; , Lombard, IL; United States, 3-5 June, 3, 2014, pp93-98 , Notes: [ ], Conference Paper, PUBLISHED  DOI
Carroll, S.F., Buckley, C.T., Kelly, D.J., Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad. , Journal of Biomechanics, 47, (9), 2014, p2115 - 2121, Journal Article, PUBLISHED  TARA - Full Text
Almeida HV, Liu Y, Cunniffe GM, Mulhall KJ, Matsiko A, Buckley CT, O'Brien FJ, Kelly DJ, Controlled release of transforming growth factor-ß3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells., Acta biomaterialia, 10, (10), 2014, p4400-9 , Journal Article, PUBLISHED  TARA - Full Text
Burke DP, Khayyeri H, Kelly DJ, Substrate stiffness and oxygen availability as regulators of mesenchymal stem cell differentiation within a mechanically loaded bone chamber., Biomechanics and modeling in mechanobiology, 14, (1), 2014, p93-105 , Journal Article, PUBLISHED  TARA - Full Text
Liu Y, Buckley CT, Almeida HV, Mulhall KJ, Kelly DJ, Infrapatellar Fat Pad-Derived Stem Cells Maintain Their Chondrogenic Capacity in Disease and Can be Used to Engineer Cartilaginous Grafts of Clinically Relevant Dimensions., Tissue engineering. Part A, 20, (21-22), 2014, p3050-62 , Journal Article, PUBLISHED  TARA - Full Text
  

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Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010, Invited Talk, PRESENTED
Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED
Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED
Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009, Invited Talk, PRESENTED
Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009, Invited Talk, PRESENTED
Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009, Invited Talk, PRESENTED
Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009, Invited Talk, PRESENTED
Kelly DJ., In vitro and in silico models of cell based therapies for cartilage repair , QUB Biomaterials Symposium & Workshop, Queens University Belfast, April 7, 2009, Invited Talk, PRESENTED

  

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Award Date
Norman Gamble Award in Otology 2002
Hewlett Packard Prize 1999
Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008
Fulbright Award 2009
Fellow of Trinity College Dublin 2010
European Research Council Starter Award, 2010
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
Experimental and computational mechanobiology, with a particular interest in the role of environmental factors in regulating chondrogenesis of mesenchymal stem cells. Tissue engineering. Implant design and testing, including finite element modelling of implants and their interactions with the body.