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Dr. Joanna Mcgouran

Assistant Professor (Chemistry)
BIOMEDICAL SCIENCES INSTITUTE


Joanna obtained a 1st class MChem Degree from the University of Oxford. Following this she completed her D.Phil. entitled "Probing sugar-plant-soil signaling" at the University of Oxford with Professor Ben Davis. Joanna then worked as a postdoctoral researcher with Professor Benedikt Kessler in the Department of Medicine, where she created novel ubiquitin-based covalent capture probes and developed inhibitor screening assays. She returned to chemistry department at the University of Oxford in 2014 to work with Professor Tom Brown where her research focused on the study of DNA cross-link repair enzymes, developing assays to study their selectivity and for inhibitor screening. In 2016, Joanna moved to Trinity College Dublin to take up the position of Schuler Assistant Professor in Translational Organic Chemistry.
  Activity-Based protein profiling   Biochemistry, Nucleic Acid   Bioconjugation   BIOORGANIC CHEMISTRY   Cellular Biology   Epigenetics   Mass Spectrometry   Organic chemistry   Proteins, enzymology and protein engineering   Proteomes, proteomics
 Disulfide modification for enhanced stability and selective delivery
 A New Approach to Inhibiting Nucleotide Excision Repair Using Cyclic Peptides
 Activity based probes for DNA processing enzymes based on modified Cytosine
 New Probes for active enzymes
 Oligonucleotide probes to study the 5' exonuclease SNM1A and its function in DNA damage repair

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Details Date
Swiss National Foundation evaluation committee of the SNSF special call on coronaviruses 2020
Reviewer for several international chemistry journals including publications from the Royal Society of Chemistry, Wiley, Elsevier and Sage 2019
Member of the Royal Society of Chemistry Local Section Committee. 2016
Reviewer for UKRI Future fellowships grant 2020
External examiner, Master's thesis, University College Dublin 2019
Details Date From Date To
Royal Society of Chemistry 2015 Present
The Irish Mass Spectrometry Society 2019 Present
Taylor, N.C. Hessman, G. Kramer, H.B. McGouran, J.F., Probing enzymatic activity - a radical approach, Chemical Sciences, (11), 2020, p2967 - 2972, Journal Article, PUBLISHED
Taylor, N.C. McGouran, J.F., Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery, Frontiers in Chemistry, 7, (914), 2020, p1-9 , Journal Article, PUBLISHED  TARA - Full Text
Thomas A.M., Brolih S., McGouran J.F., El-Sagheer A.H., Ptchelkine D., Jones M., McDonald N.Q., McHugh P.J., Brown T., Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors, Chemical Communications, 55, (78), 2019, p11671 - 11674, Journal Article, PUBLISHED  TARA - Full Text  DOI
Doherty W., Durr E.-M., Baddock H.T., Lee S.Y., McHugh P.J., Brown T., Senge M.O., Scanlan E.M., McGouran J.F., A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A, Organic and Biomolecular Chemistry, 17, (35), 2019, p8094 - 8105, Journal Article, PUBLISHED  TARA - Full Text  DOI
Unsworth, A.J., Bombik, I., Pinto-Fernandez, A., McGouran, J.F., Konietzny, R., Zahedi, R.P., Watson, S.P., Kessler, B.M., Pears, C.J., Human Platelet Protein Ubiquitylation and Changes following GPVI Activation, Thrombosis and Haemostasis, 119, (1), 2019, p104-116 , Journal Article, PUBLISHED
Berney M., McGouran J.F., Methods for detection of cytosine and thymine modifications in DNA, Nature Reviews Chemistry, 2, (11), 2018, p332 - 348, Journal Article, PUBLISHED  TARA - Full Text  DOI
Howells A., McGouran J.F., Kessler B.M., Luhn K., Dengue virus stimulation of dendritic cells induces phosphorylation- and proteolysis-dependent signalling, Malaysian Journal of Microbiology, 14, (Specialissue6), 2018, p474 - 482, Journal Article, PUBLISHED  DOI
Dürr, E.-M., Doherty, W., Lee, S.Y., El-Sagheer, A.H., Shivalingam, A., McHugh, P.J., Brown, T., McGouran, J.F., Squaramide-Based 5"-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A, ChemistrySelect, 3, (45), 2018, p12824-12829 , Journal Article, PUBLISHED  TARA - Full Text
Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117 , Journal Article, PUBLISHED  DOI
Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D., Molecular basis of USP7 inhibition by selective small-molecule inhibitors., Nature, 550, (7677), 2017, p481-486 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Joanna McGouran, DNA modification to examine 5' exonuclease activity, The 18th RSC Chemical Biology and Bioorganic Group (CBBG) Firbush conference, Edinburgh, UK, 6-8th September, 2019, Oral Presentation, PRESENTED
Joanna McGouran, Latent probes for the covalent capture of active enzymes, RSC Ireland Regional Meeting , UCD, Ireland, 7th June, 2019, Prof. Pat Guiry, Invited Talk, PRESENTED
Joanna McGouran, Activatable probes targeting deubiquitinating enzymes, Activity-Based Protein Profiling 2019, Leuven, Belgium, 27th March, 2019, Prof. Martin Witte & Prof. Steven Verhelst, Invited Talk, PRESENTED
Joanna McGouran, Chemical proteomics: Protein modification to unravel biological function, RSC Organic Symposium , TCD, Ireland, 18th May, 2018, Prof. Eoin Scanlan, Invited Talk, PRESENTED
Joanna McGouran, 5' oligonucleotide modification for enhanced nuclease binding, Young Investigators Workshop, Merton College, Oxford, UK, 23-25th August, 2018, Prof. Veronique Grouverner, Invited Talk, PRESENTED
Joanna McGouran, Proteins and DNA-New Tools through Chemical Modification, Research seminar, Nuffield Department of Medicine, University of Oxford, Target Discovery Institute, 28/02, 2020, Dr Nicola Ternette, Invited Talk, PRESENTED

  

Award Date
MA University of Oxford 2009
Scholarship, University of Oxford 2002-5