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Dr. Joanne Lysaght

Associate Professor (Surgery)
TRINITY CENTRE, S J H


Dr. Joanne Lysaght graduated with B.Sc.(Hons) in Science from N.U.I Maynooth. She then went on to complete a PhD in 2005, in the Department of Biochemistry and Immunology in Trinity College Dublin, in the area of Tumour Immunology. Following completion of her PhD, she moved to the Cancer Molecular Diagnostic Laboratory based in St. James's Hospital, which utilises molecular techniques for the diagnosis of haematological malignancies. She then took up a post-doctoral position in the Department of Haematology and Oncology, TCD, where she worked on a novel family of chemotherapeutic drugs for the treatment of childhood leukemias. Following on from this Dr. Lysaght moved to the Department of Surgery, TCD/St. James's Hospital. Her research focused on the role of the adaptive immune system in the link between obesity and gastrointestinal cancer. Based on this work she was awarded a competitive Health Research Board Post-Doctoral Fellowship. In 2011, Dr. Lysaght was appointed Ussher Assistant Professor in Molecular Oncology and in 2015 Assistant Professor in the School of Medicine, TCD where she continues her research into obesity and cancer. Other research areas of her group include targeting chemokines to prevent obesity-driven inflammation, examining the role of adaptive immunity in pre-malignant conditions, the impact of excess visceral adipose tissue on hepatic inflammation and identifying future immunotherapeutic targets for gastrointestinal cancers. Dr. Lysaght is also the course co-ordinator for the M.Sc. in Translational Oncology in TCD, designed for clinicians and scientists focused on a career in oncology and cancer research.
  ADIPOCYTES   ADIPOSE TISSUE   ADIPOSE-TISSUE DISTRIBUTION   ADJUVANT RADIOTHERAPY   ADVANCED CANCER   Anticancer therapies   Autoimmunity   BARRETTS ESOPHAGUS   CACHEXIA   Cancer Biology   CANCER BIOPSIES   CANCER CHEMOTHERAPY   CANCER CLASSIFICATION   CANCER DEVELOPMENT   CANCER PATIENTS   CANCER RISK   Cancer Therapy   Cancer/Carcinogenesis   CD4+ T CELLS   CHEMO-RADIOTHERAPY   COMBINATION IMMUNOTHERAPY   Design and evaluation of novel anti-cancer therapies   Development of novel neo-adjuvant treatments for oesophageal and prostate cancer   ESOPHAGEAL CANCER   GASTRIC CANCER   Gastrointestinal cancer   HUMAN ESOPHAGEAL CANCER   HUMAN T-CELLS   Immune system   Immunoassays   Immunology, Immunotherapy   Immunotherapies for Cancer   Innate immunology   METABOLIC DISORDERS   NK CELLS   OBESITY   Radiotherapy, Biological response modifiers and chemoprevention   Regulatory T cells   Sarcopenia   Tumour immunology and immunotherapy   TUMOUR IMMUNOTHERAPY
 Evaluating the role of T cells in the progression of Barrett's Oesophagus to Oesophageal Adenocarcinoma: identification of novel immunotherpeutic targets
 Investigating the role of T cells in adipose tissue and hepatic inflammation in obesity associated cancer.
 Investigating the immunomodulatory properties of adipose tissue in oesophageal and colorectal cancer.

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Irish Basic Basic Medium
Details Date From Date To
Treasurer and executive committee member for the Irish Society for Immunology 2014
Irish Association for Cancer Research 2011
European Association for Cancer Research 2011
European Federation of Immunological Societies 2014
Joanne Lysaght, The 'obesity paradox' in action with cancer immunotherapy, Nature Reviews Endocrinology, 2019, Notes: [DOI 10.1038/s41574-019-0161-2], Journal Article, PUBLISHED
*Galvin KC, *Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J., Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma., Cancer Letters, 418, 2018, p230-238 , Notes: [*JOINT FIRST AUTHORSHIP], Journal Article, PUBLISHED  DOI  URL
Conroy MJ, Maher SG, Melo AM, Doyle SL, Foley E, Reynolds JV, Long A, Lysaght J., Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients., Frontiers in Immunology, 13, (9), 2018, p1867-, Journal Article, PUBLISHED
O'Sullivan J, Lysaght J, Donohoe CL, Reynolds JV., Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments, Nature Reviews Gastroenterology Hepatology, 15, (11), 2018, p699 - 714, Journal Article, PUBLISHED
O†Sullivan, J. and Lysaght, J. and Donohoe, C.L. and Reynolds, J.V., Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments, Nature Reviews Gastroenterology and Hepatology, 15, (11), 2018, p699-714 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Conroy MJ, Maher SG, Melo AM, Doyle SL, Foley E, Reynolds JV, Long A, Lysaght J., Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients., Frontiers in immunology, 9, 2018, p1867 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Melo, A.M. and Zhang, L. and Dockry, E.F. and Petrasca, A. and Ghnewa, Y.G. and Breen, E.P. and Morrissey, M.E. and O'Reilly, C. and Bruen, R. and O'Meara, A. and Lysaght, J. and Zhu, X. and Doherty, D.G., Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells, Glycobiology, 28, (7), 2018, p512-521 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
O†sullivan, K.E. and Michielsen, A.J. and O†regan, E. and Cathcart, M.C. and Moore, G. and Breen, E. and Segurado, R. and Reynolds, J.V. and Lysaght, J. and O†sullivan, J., pSTAT3 levels have divergent expression patterns and associations with survival in squamous cell carcinoma and adenocarcinoma of the oesophagus, International Journal of Molecular Sciences, 19, (6), 2018, p1720-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Das, B. and Conroy, M. and Moore, D. and Lysaght, J. and McCrory, C., Human dorsal root ganglion pulsed radiofrequency treatment modulates cerebrospinal fluid lymphocytes and neuroinflammatory markers in chronic radicular pain, Brain, Behavior, and Immunity, 70, 2018, p157-165 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Donohoe C.L, Lysaght J, O'Sullivan J, Reynolds J.V, Emerging Concepts Linking Obesity with the Hallmarks of Cancer, Trends in Endocrinology and Metabolism, 28, (1), 2017, p46 - 62, Notes: [Export Date: 23 February 2017], Journal Article, PUBLISHED  DOI  URL
  

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Award Date
HRB Fellowship 2009
CROSS Research Fellowship 2008
Dr. Lysaght's research group focus on a number of different areas around the central theme of tumour immunology and immunotherapy. A major research interest is the area of obesity and cancer, and how this impacts anti-tumour immunity. The majority of research in the tumour immunology group is focused on upper gastrointestinal cancer, particularly oesophageal cancer. Research into how the regulation and trafficking of lymphocytes can be targeted to reduced adipose tissue and liver-associated inflammation is a major theme within the group. Other areas of interest include identifying novel immunotherapeutic targets in the pre-malignant setting such as Barrett's Oesophagus, which can be used to slow or prevent progression to malignancy. We are also currently investigating the impact of chemotherapy and radiotherapy on anti-tumour immunity and immunotherapies. Another area under current investigation is the role of adaptive immunity and obesity in the debilitating cancer-associated wasting disease cachexia and sarcopenia, which is directly responsible for up to 20% of all cancer deaths.