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Dr. Howard Voorheis

Fellow Emeritus (Biochemistry)


  ACIDIC REPETITIVE PROTEIN   AFRICAN TRYPANOSOMES   AGGREGATION   ANEMIA   ANTIBODIES   BLOOD   BLOOD-STREAM   BLOOD-STREAM FORMS   BOVINE   CARASSIUS-AURATUS   CATTLE   CELL-SURFACE   CONCANAVALIN-A   CRYPTOBIA-SALMOSITICA   CYCLICAMP   CYCLIC-AMP   DANILEWSKYI   DIFFERENTIATION   DISAGGREGATION   DISTINCT   ENDOSOME   EXPRESSION SITE   FISHES   GAIRDNERI   GOLDFISH   GUANYLATE-CYCLASE   HEMOFLAGELLATE   IMMUNITY   IMMUNOGLOBULIN-A   INOSITOL-ACYLATION   LAVERAN   LIPOPHILIC CATION   MEMBRANE   MEMBRANE-POTENTIAL CHANGES   MESNIL   MITOGENIC STIMULATION   NA+/H+ EXCHANGE   NEURO-BLASTOMA   ONCORHYNCHUS   PH GRADIENTS   PHORBOL ESTER   PLASMA-MEMBRANE   PROCYCLIC FORMS   PROTEIN KINASE   PROTEIN-KINASE-C   PROTEOLYSIS   PROTON PUMP   PROTON-MOTIVE FORCE   RAINBOW-TROUT   SACCHAROMYCES-CEREVISIAE   SALMOSITICA KATZ   STREPTOCOCCUS-LACTIS   TRYPANOSOMA BRUCEI   VARIANT SURFACE GLYCOPROTEIN
 The bioenergetics of parasite (Trypanosoma brucei) adaption to life in an insect vector (Tsetse fly)
 Development of 3-D displays of confocal images & Modelling the movement & docking of membrane proteins
 Development of a mathematical model for fitting integrated rate equations to fluorescence data from a pre-steady state, single turn-over assay of the endocytotic - exocytotic cycle
 Confocal laser scanning fluorescence microscopic localization of invariant stage-specific surface glycoproteins in Trypanosoma brucei as part of the effort to develop an anti-trypanosomal vaccine
 The role of a new phosphotransferase in generating ATP anaerobically in Trypanosoma brucei

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Basic
German Medium Medium Medium
Korean Basic Basic Basic
Hanrahan O, Webb H, O'Byrne R, Brabazon E, Treumann A, Sunter JD, Carrington M, Voorheis HP, The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation., PLoS Pathogens, 5, (6), 2009, pe1000468 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Alison E. Adams, Orla Hanrahan, Derek N. Nolan, H. Paul Voorheis, Padraic Fallon and Richard K. Porter, Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy , Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777, (2), 2008, p115 - 117 , Notes: [PMID: 17996719], Journal Article, PUBLISHED  TARA - Full Text  DOI
Bridges DJ, Pitt AR, Hanrahan O, Brennan K, Voorheis HP, Herzyk P, de Koning HP, Burchmore RJ, Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei., Proteomics, 8, (1), 2008, p83-99 , Journal Article, PUBLISHED  DOI
O'Beirne, C. & Voorheis, H. P., Progression of Surface Immune Complexes to the Flagellar Pocket and through the Endosomal System of T. brucei assessed by Confocal Laser Scanning Fluorescence Microscopy, J. Cell Sci., 2005, Journal Article, SUBMITTED
O'Beirne, C., & Voorheis, H. P., Single-cycle, real-time, fluorescence characterization of the cycle of endocytosis - exocytosis of surface immune complexes in bloodstream forms of Trypanosoma brucei, Biochemistry, 2005, Journal Article, SUBMITTED
O'Beirne, C. & Voorheis, H. P., The fate of IgM and IgG anti-VSG antibodies following binding to the surface coat of Trypanosoma brucei', J. Biol. Chem., 2005, Notes: [ ], Journal Article, PUBLISHED
Chattopadhyay, A., Jones, N. G., Nietlispach, D., Nielsen, P. R., Voorheis, H. P., Mott, H. R. & Carrington, M., Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat 1.2, Journal of Biological Chemistry, 280, (8), 2005, p7228 - 7235, Notes: [PubMed ID: 15557330], Journal Article, PUBLISHED  DOI
Nolan, D.P., Jackson, D.G., Biggs, M.J., Brabazon, E.D., Pays, A., Van Laethem, F., Paturiaux-Hanocq, F., (...), Pays, E., Erratum: Characterization of a novel alanine-rich protein located in surface microdomains in Trypanosoma, brucei (Journal of Biological Chemistry (2000) 275 (4072-4080)) , 2005, - 31340 , Miscellaneous, PUBLISHED
Smith, G. A. & Voorheis, H. P., European Patent Office, Patent for Submission, Fluorescent pH Probes, 2004, Patent, PUBLISHED
Voorheis, H. P. & Smith, G. A., European Patent Office, Patent Pending, Phospholipid Derivatives, 2004, Patent, PUBLISHED
  

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O'Conor, K., Voorheis, H. P. and O'Sullivan, C. , Visualisation of Confocal Fluorescence Microscopy Data, Proceedings of the fifth Irish Workshop on Computer Graphics, 2004, pp1-6 , Conference Paper, PUBLISHED

  

Award Date
Fellow of Trinity College, Dublin, Ireland 1979
US Army Commendation Medal 1967
Distinguished Service Citation, Kyong Sang Puk Do Provincial Government, Taegu, Korea 1966
Victor Vaughn Honory Medical Society, Ann Arbor, Michigan, USA 1964
National Honor Society, Detroit, Michigan, USA 1957
The main thrust of my research work has been the study of membrane processes in Trypanosomes. SIGNIFICANT MILESTONES IN THIS WORK: A. First studies of amino acid transport in trypanosomes, (refs 1-2, 5-8, 10 & 14) B. Development of the current method used for the commercial production of [32P]ATP (ref 9) C. First production of isolated plasma membranes in trypanosomes (ref 12) D. Development of a mild method for selectively and reversibly permeablizing plasma membranes to small molecules while leaving other cellular membranes unaffected, (ref 16) E. First series of studies characterizing the adenylate cyclase in bloodstream form trypanosomal plasma membranes and discovery of the regulation of this enzyme by Ca2+, (ref 11, 16-17, 20 & 38) F. First study of glycoprotein biosythesis in trypanosomes, (ref 15) G. Discovery of the phosphodiester linkage of the variant surface glycoprotein to the lipid anchor and its cleavage during release from the cell surface, (ref 18-19, 21, 23 & 25) H. First series of studies of the bioenergetics of bloodstream form trypanosomes, (refs 31,33,35, 44-45) I. Discovery and characterization of invariant surface glycoproteins on the surface of bloodstream form trypanosomes and demonstration of their life cycle specificity, (ref 40, 43 & 47) J. Discovery of the ability of bloodstream stage trypanosomes to defend themselves against antibody without cell damage, (ref 41 & 49) K. First 3-D structure of the C-terminal folding domain of the variant surface glycoprotein (VSG) in trypanosomes (ref. 48) L. Development of a new continuous, pre-steady state, single turn-over fluorescence assay for the endocytotic-exocytotic cycle and its use to characterize the endocytosis of surface immune complexes and nutritional factors, (refs 49-50) M. Development of Specific Fluorescent Phospholipid Probes for the Plasma Membrane of all Eukaryotic Cells (Patent Pending, European Patent Office, submitted 2004) N. Development of a new class of Fluorescent Probes (PHRODO) that can be linked to proteins and respond with increased fluorescence as pH drops (Patent Pending, European Patent Office, submitted 2004)