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Dr. Helen Sheridan

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Helen Sheridan is an Associate Professor in the School of Pharmacy and Pharmaceutical Sciences (SoPPS) at TCD where she holds the position of Director of Research. Her personal research interests lie in the broad area of Natural Product (NP) Chemistry and Traditional Medicine (TM), with an emphasis on Traditional Chinese Medicine(TCM), Ethnopharmacology and Global health. Her work focuses on finding new therapies targeted at diseases with unmet clinical need, in addition to finding natural products suitable for use as nutraceuticals and cosmeceuticals. Helen, with international collaborators, is also involved in establishing global standards for the quality, safety and efficacy of TMs including TCM; activities that are supported through her work as part of a Sino-European Consortium (previously funded by EU-FP7; http://www.gp-tcm.org/), her role on the Board of the International Natural Product Sciences Taskforce (INPST) society (The International Natural Product Sciences Taskforce (INPST) society), in her position as NP expert on the Irish medicines Board (HPRA: Health Products Regulatory Authority) and membership of NPRONET - Natural products discovery and bioengineering network UK. Helen has supervised 21 research students (PhDs and MScs) to completion, as well as 15 post-doctoral fellows. She currently have 7 researchers in her group. Helen is an NP/ organic chemist and has carried out research on a range of plant and fungal species. During her career she successfully identified a lead molecule from TM which her team brought through a programme of medicinal chemistry, through all preclinical stages of development into human clinical trials. During this period Helen co-founded a TCD Campus company, Trino Therapeutics Ltd and was co-PI on funding of approximately €13 million. The funding for this work began with a grant of €500 from the Royal Irish Academy, progressed to funding from EOLAS (the precursor of SFI) and then this work received significant translational investment from Venture Capital and the Wellcome Trust with €3.5 million as co-PI for a highly competitive Wellcome Strategic Translation Award (STA grant. Helen currently holds an SFI-TIDA award and is collaborator in a second TIDA. During this time she has also been co-applicant on seven published patents in the US, EU and Asia and has acted as patent expert on these projects with patenting agents in Ireland and the US. In latter years Helen has become more involved in ethnopharmacology on a global level, in particular the link between the established use of traditional medicine and its role in international development. She has supervised 5 research projects in this field in sub-Saharan Africa. The driving force behind her work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules. She has learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules Helen's group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development.
  ALTERNATIVE MEDICINE   Antiinflammatory drugs   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Biotransformation   Chemical Biology   Development of drugs for malaria, Cancer and inflammatory diseases   Drug discovery   Fungi   Herbal medicine   In Vitro Testing, Trial Methods   Indanes, indanones, muscel, nast cell stabilisation, immunosuppressants   Inflammation   Inflammatory Bowel Disease   Medicinal plants   Multiple Sclerosis   Natural Product Chemistry   Organic chemistry   Over-the-Counter Drugs   Pharmacognosy   Phytochemical and pharmacological evaluations of native and foreign plants   Phytomedicines   Plant and algal cell monocultures   Secondary plant metabolism   The use of cell cultures for the discovery of novel drugs   Traditional and Indigenous health systems in developing countries   Traditional Chinese Medicine
 Assessment of the therapeutic potential of two lead anti-inflammatory molecules with a novel carbon scaffold in ex-vivo colonic explant tissue.
 Novel indanes as potential therapies for auto-immune disease
 Investigation into Mechanism of action of PH46A
 A novel indane scaffold with potential anti-inflammatory agents.
  Traditional Chinese medicine research in the post-genomic era: Good practice,priorities, challenges and opportunities

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Details Date
External Examiner to Postgraduate taught Master's Degrees in University College London 2015-2018
Appointed to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee 2006 to date
Board Member of the International Natural Product Science taskforce 2017 - To date
External Examiner to Victoria University of Wellington. Wellington, New Zealand 2014
Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee. 2000 - 2006
International Foundation for Science Grant reviewer http://www.ifs.se/ 2009 to date
Grant reviewer for the Medical Research Council UK 2012
Youth Science committee of the Royal Dublin Society 1990-1992
External Examiner Cardiff University PhD Thesis 1991
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Details Date From Date To
Fellow of the Royal Society of Chemistry. 1989 To date
Board member of the Board of Directors of the Natural Product Sciences Task force INPST https://inpst.net/. 2016 To date
Life member GP-TCM RA (Good Practice in TCM Research Association). 2009 To date
Member of the SCT (Societe De Chimie Therapeutique The French Society for Medicinal Chemistry) 2014 To date
Member of the Society for Medicinal Plant and Natural Product Research. Gesellschaft für Arzneipflanzen- und Naturstoff-Forschung e.V. (GA). 2014 To date
Traditional-chinese-medicine-from-aqueous-extracts-to-therapeutic-formulae in, editor(s)Aman Dekebo ed. , Plant Extracts, london UK, IntechOpen, 2019, pp1-30 , [JinFan Wang, Astrid Sasse, Helen Sheridan], Book Chapter, PUBLISHED  DOI
Marivane Lemos, Jonas Joaquim Mangabeira da Silva, Cristiane Teixeira Vilhena Bernardes, Mariza Abreu Miranda, Hervé Louis Ghislain Rogez, Rodrigo Cássio Sola Veneziani, Sérgio Ricardo Ambrósio, Sérgio Faloni de Andrade, Astrid Sasse, Helen Sheridan, Jairo Kenupp Bastos, ATIVIDADE ANTIMICROBIANA IN VITRO E IN VIVO FRENTE À HELICOBACTER PYLORI DE EXTRATO DAS FOLHAS DE COPAIFERA OBLONGIFOLIA MART. EX HAYNE, Extensão em Foco, 6, (1), 2019, p1 - 8, Journal Article, PUBLISHED
Andy Wai Kan Yeung, Bharat Bhushan Aggarwal, Helen Sheridan, Atanas G. Atanasov et al, Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review, Animal Science Papers and Reports , 37 , (2), 2019, p103 - 118, Journal Article, PUBLISHED
Cumming, Graham; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen, Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-Inflammatory Agent , Organic Process Research & Development, 2018, p1972-1979 , Journal Article, PUBLISHED  DOI
Tao Zhang, Neil Frankish, Gaia Scalabrino and Helen Sheridan, Bioactive Indanes: Comparative in vitro Metabolism Study of PH46A, a New Potential Anti-Inflammatory Agent and Biosynthesis of its Primary Metabolite PH132 , Pharmaceutical Sciences, 9, (2), 2018, p1 - 14, Journal Article, PUBLISHED  URL
Tao Zhang , Gaia Scalabrino , Neil Frankish and Helen Sheridan, "Bioactive Indanes: Proof of Concept Study for Enantioselective Synthetic Routes to PH46A, a New Potential Anti-Inflammatory Agent" , Molecules, 23 , 2018, p1 - 18, Journal Article, PUBLISHED  DOI
Andy Wai Kan Yeung, Bharat Bhushan Aggarwal, Helen Sheridan et al., Dietary natural products and their potential to influence health and disease including animal model studies - a review, Animal Science Papers and Reports, 36, (4), 2018, p345-358 , Journal Article, PUBLISHED
Hook I, Sheridan, H, Reid C, Trichomes and naphthoquinones protect Streptocarpus dunnii Hook.f. against environmental stresses, South African Journal of Botany , Volume 119, 2018, p193 - 202, Journal Article, PUBLISHED
Zhang, T. and Scalabrino, G. and Frankish, N. and Sheridan, H., Bioactive indanes: Proof of concept study for enantioselective synthetic routes to ph46a, a new potential anti-inflammatory agent, Molecules, 23, (7), 2018, p1503-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Frankish, N.H. and McHale, B. and Sheridan, H., The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis, Journal of Pharmacy and Pharmacology, 70, (1), 2018, p101-110 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Fiona Shannon, Astrid Sasse, Michael Heinrich and Helen Sheridan, A repository of knowledge - the Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland, 'Interdisciplinary Approaches to the Study of Healing, Charms and Medicine'. , Department of Celtic languages and literature. Harvard University. , April 5-7th 2018., 2018, Conference Paper, PUBLISHED
Fiona Shannon, Astrid Sasse and Helen Sheridan. , Ethnomedicinal practices in 1930s Ireland. History of Medicine Section of the Royal Academy of Medicine, History of Medicine, Dublin, Ireland, 9th May, 2018, Conference Paper, PRESENTED
Jinfan Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , From Monograph to Metabolomics: A Scientific Evaluation of the Traditional Chinese Herbal Medicine Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - a case study, The 6th Annual Meeting of Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA). , Jordell Laboratories. Kew Gradens. London UK, July 4-6th. , 2018, Notes: [Joint First Prize], Conference Paper, PRESENTED
Ciara M Fallon, Jessica Smyth, Natalia Lajczak, Helen Sheridan and Stephen J Keely. , Neutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease, The FALK Symposium 211 XXV International Bile Acid Meeting: Bile Acids in Health and Disease. , Dublin, Ireland, July 6 - 7, 2018, Conference Paper, PUBLISHED
J. Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , Best Practice for the Scientific Evaluation of Traditional Herbal Medicines: Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - A Case Study. , 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, August 26 - 29, 2018, Conference Paper, PUBLISHED
Helen Sheridan, Fiona Shannon, Astrid Sasse and Michael Heinrich, Insight into Healing Herbs used in Post-famine Ireland, 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, China, August 26 - 29, 2018, Conference Paper, PUBLISHED
Fiona Shannon, Astrid Sasse and Helen Sheridan., A repository of knowledge. The Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland. , London, 2018, The British Society for the History of Pharmacy (BSHP)., Invited Talk, PUBLISHED
Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017, Conference Paper, PUBLISHED
Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017, Report, PUBLISHED
Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1-, Conference Paper, PUBLISHED

  

Page 1 of 3
Award Date
SFI TIDA Award 2017
Appointed to Fellowship of The Royal Society of Chemistry 2017
Wellcome Trust Strategic Translation Award (co-PI) 2013
Irish American Partnership Research Award - with Pfizer 1992
Travel awards: British Council 1991
RIA Travelling award 1990
Department of Education Post Doctoral Fellowship (UCD). 1984-1985
"1851 Overseas Traveling Scholarship". 1983-1984
French Government research Award - CNRS. Gif-Sur-Yvette 1983
NBST Young Researcher award with Dr. Hector Rubelcava (UCD) 1979
My research has always been multidisciplinary; built on collaboration with pharmacologists/ molecular-biologists/ bio-technologists/ botanists/anthropologists and sociologists and is recognised at a national and inter-national level. The driving force behind my work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules, and to improve the position on communities in the developing world who have a cultural and financial reliance on Traditional Medicine. I have learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules my group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development. My drug discovery focus, has been informed by the natural world, ethnomedical practice across the globe; molecular design, based on hybridised natural molecules; and using computer modelling to find natural molecules that target important receptors. In my natural product research I have engaged with International, multidisciplinary Consortia establishing good practice and gold standards for quality, safety and efficacy of complex natural medicines as nutraceuticals, and as food supplements. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. My current research falls under four main themes. 1) Multidisciplinary approach Drug discovery for the treatment of inflammatory disease and cancer Finding new therapies targeted at diseases with unmet clinical need. Currently I am PI on an SFI TIDA award and have 50 molecules being tested at level 2 in the Lilly Open Innovation Platform, with six significant nanomolar hits against a key target in Chemotherapy and radiation resistant cancer cells. 2) Drug discovery from the natural world is still ongoing. We use of natural materials (plants, cell cultures, microalgae) for the discovery of novel bio-active materials. 3) Traditional Herbal Medicine. Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Medicine by large populations (Asia and Africa). Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. 4) Exploring traditional medicine (TM) in Ireland and in Sub-Saharan-Africa in the context of a changing global healthcare landscape, using a community in West Pokot, Kenya as a case study. I am Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. Through this vehicle my research progressed through a significant Medicinal Chemistry programme of lead optimisation, GMP synthesis of lead, pre-clinical evaluation, regulatory approval and progression through Phase 1 Clinical trials. My ethnomedical research was presented in Harvard (2018), and my overall research work has been presented internationally and most recently on an invited lecture tour in China.